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Aliases for MIR135A1 Gene

Subcategory (RNA class) for MIR135A1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR135A1 Gene

  • MicroRNA 135a-1 2 3
  • MicroRNA 135-1 2 3
  • Hsa-Mir-135a-1 3
  • Hsa-Mir-135-1 3
  • MIRN135-1 3
  • MIRN135A1 3

External Ids for MIR135A1 Gene

Previous Symbols for MIR135A1 Gene

  • MIRN135-1
  • MIRN135A1

Summaries for MIR135A1 Gene

Entrez Gene Summary for MIR135A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A1 Gene

MIR135A1 (MicroRNA 135a-1) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR135A1 include colorectal cancer and adenomatous polyposis coli. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR135A1 Gene

Genomics for MIR135A1 Gene

Genomic Location for MIR135A1 Gene

Start:
52,294,219 bp from pter
End:
52,294,308 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR135A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR135A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A1 Gene

No data available for Regulatory Elements for MIR135A1 Gene

Proteins for MIR135A1 Gene

Post-translational modifications for MIR135A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A1 Gene

Domains for MIR135A1 Gene

Gene Families for MIR135A1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR135A1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR135A1 Gene

Function for MIR135A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR135A1 Gene

Localization for MIR135A1 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR135A1 Gene

Pathways for MIR135A1 Gene

SuperPathways for MIR135A1 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135A1: view

Pathways by source for MIR135A1 Gene

1 KEGG pathway for MIR135A1 Gene

Interacting Proteins for MIR135A1 Gene

Gene Ontology (GO) - Biological Process for MIR135A1 Gene

None

Transcripts for MIR135A1 Gene

mRNA/cDNA for MIR135A1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A1 Gene

No ASD Table

Relevant External Links for MIR135A1 Gene

GeneLoc Exon Structure for
MIR135A1
ECgene alternative splicing isoforms for
MIR135A1

Expression for MIR135A1 Gene

mRNA expression in normal human tissues for MIR135A1 Gene

mRNA differential expression in normal tissues according to GTEx for MIR135A1 Gene

This gene is overexpressed in Liver (21.3).
genes like me logo Genes that share expressions with MIR135A1: view

Orthologs for MIR135A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135a-1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135a-1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135a-1 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-2 37
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-1 37
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135b 37
  • 66 (a)
OneToOne
Species with no ortholog for MIR135A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135A1 Gene

ENSEMBL:
Gene Tree for MIR135A1 (if available)
TreeFam:
Gene Tree for MIR135A1 (if available)

Paralogs for MIR135A1 Gene

No data available for Paralogs for MIR135A1 Gene

Variants for MIR135A1 Gene

Sequence variations from dbSNP and Humsavar for MIR135A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs34896089 -- 52,295,883(+) CTGTG(-/G)TGTGT upstream-variant-2KB
rs143608424 -- 52,295,880(+) ACATC(-/TG)TGTGT upstream-variant-2KB
rs145115445 -- 52,295,828(+) TGCGC(A/G)GTTGA upstream-variant-2KB
rs183446674 -- 52,295,826(+) CATGC(A/G)CAGTT upstream-variant-2KB
rs187835329 -- 52,296,083(+) CCGAG(A/G)GAGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR135A1 Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897

Relevant External Links for MIR135A1 Gene

HapMap Linkage Disequilibrium report
MIR135A1

Disorders for MIR135A1 Gene

genes like me logo Genes that share disorders with MIR135A1: view

No data available for UniProtKB/Swiss-Prot for MIR135A1 Gene

Publications for MIR135A1 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. (PMID: 18632633) Nagel R. … Agami R. (Cancer Res. 2008) 3

Products for MIR135A1 Gene

Sources for MIR135A1 Gene

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