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Aliases for MIR135A1 Gene

Subcategory (RNA class) for MIR135A1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR135A1 Gene

  • MicroRNA 135a-1 2 3 5
  • MicroRNA 135-1 2 3
  • Hsa-Mir-135a-1 3
  • Hsa-Mir-135-1 3
  • Mir-135a-1 3
  • MIRN135-1 3
  • MIRN135A1 3

External Ids for MIR135A1 Gene

Previous HGNC Symbols for MIR135A1 Gene

  • MIRN135-1
  • MIRN135A1

Previous GeneCards Identifiers for MIR135A1 Gene

  • GC03M052306
  • GC03M052328

Summaries for MIR135A1 Gene

Entrez Gene Summary for MIR135A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A1 Gene

MIR135A1 (MicroRNA 135a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR135A1 Gene

Genomics for MIR135A1 Gene

Regulatory Elements for MIR135A1 Gene

Enhancers for MIR135A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G052243 1.8 FANTOM5 ENCODE dbSUPER 11.7 +48.4 48423 4.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PBRM1 PPM1M LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03G052236 1.7 FANTOM5 ENCODE dbSUPER 11.4 +55.5 55520 5.2 HDGF PKNOX1 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 GLYCTK LOC101929054 RAD54L2 WDR82 MIR135A1 GLYCTK-AS1 RRP9 TWF2 PPM1M PBRM1
GH03G052210 1.6 Ensembl ENCODE dbSUPER 11.3 +83.2 83213 2.1 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000173366 LOC101929054 TWF2 PPM1M WDR82 MIR135A1 GLYCTK-AS1 GLYCTK POC1A DUSP7
GH03G052427 1.7 VISTA Ensembl ENCODE 10.5 -135.2 -135233 3.2 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 GATA2 ZNF143 FOS SP5 TNNC1 NISCH GLYCTK-AS1 MIR135A1 GLYCTK WDR82 GNL3 SNORD69 PBRM1 NT5DC2
GH03G052215 1.5 Ensembl ENCODE dbSUPER 11.4 +76.0 75980 5.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 ZNF48 YY1 ZNF121 GATA2 GLYCTK PPM1M WDR82 MIR135A1 GLYCTK-AS1 DUSP7 TWF2 PARP3 SERBP1P3 ENSG00000280003
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR135A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR135A1 Gene

Chromosome:
3
Start:
52,294,219 bp from pter
End:
52,294,308 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR135A1 Gene

Genes around MIR135A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A1 Gene

Proteins for MIR135A1 Gene

Post-translational modifications for MIR135A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A1 Gene

Domains & Families for MIR135A1 Gene

Gene Families for MIR135A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135A1 Gene

Function for MIR135A1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A1 Gene

Localization for MIR135A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR135A1 Gene

Pathways & Interactions for MIR135A1 Gene

genes like me logo Genes that share pathways with MIR135A1: view

Pathways by source for MIR135A1 Gene

1 BioSystems pathway for MIR135A1 Gene
1 KEGG pathway for MIR135A1 Gene

Interacting Proteins for MIR135A1 Gene

Gene Ontology (GO) - Biological Process for MIR135A1 Gene

None

No data available for SIGNOR curated interactions for MIR135A1 Gene

Drugs & Compounds for MIR135A1 Gene

No Compound Related Data Available

Transcripts for MIR135A1 Gene

mRNA/cDNA for MIR135A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A1 Gene

No ASD Table

Relevant External Links for MIR135A1 Gene

GeneLoc Exon Structure for
MIR135A1
ECgene alternative splicing isoforms for
MIR135A1

Expression for MIR135A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR135A1 Gene

mRNA differential expression in normal tissues according to GTEx for MIR135A1 Gene

This gene is overexpressed in Liver (x21.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR135A1 Gene:

MIR135A1
genes like me logo Genes that share expression patterns with MIR135A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135A1 Gene

Orthologs for MIR135A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135a-1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135a-1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135a-1 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-1 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-1 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135b 35
  • 66 (a)
OneToOne
Species where no ortholog for MIR135A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135A1 Gene

ENSEMBL:
Gene Tree for MIR135A1 (if available)
TreeFam:
Gene Tree for MIR135A1 (if available)

Paralogs for MIR135A1 Gene

No data available for Paralogs for MIR135A1 Gene

Variants for MIR135A1 Gene

Sequence variations from dbSNP and Humsavar for MIR135A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000301029 -- 52,295,347(+) CCTGG(C/T)CCAGC downstream-variant-500B, upstream-variant-2KB
rs1002819752 -- 52,294,795(+) GGAGA(A/G)CTGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1008323993 -- 52,294,222(+) GCTGT(C/T)CCCGC nc-transcript-variant, utr-variant-3-prime
rs1009053283 -- 52,295,759(+) GCAGA(A/C/T)GTGTT upstream-variant-2KB
rs1009413494 -- 52,295,941(+) TAGTG(C/T)AGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR135A1 Gene

Variant ID Type Subtype PubMed ID
esv3402579 CNV duplication 20981092
nsv470572 CNV loss 18288195
nsv519445 CNV gain+loss 19592680
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897
nsv834696 CNV loss 17160897
nsv954859 CNV deletion 24416366

Relevant External Links for MIR135A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR135A1 Gene

Disorders for MIR135A1 Gene

Relevant External Links for MIR135A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR135A1

No disorders were found for MIR135A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135A1 Gene

Publications for MIR135A1 Gene

  1. Serum microRNA-135a-5p as an auxiliary diagnostic biomarker for colorectal cancer. (PMID: 27126269) Wang Q. … Ju S. (Ann. Clin. Biochem. 2017) 3 64
  2. hsa-miR-135a-1 inhibits prostate cancer cell growth and migration by targeting EGFR. (PMID: 27524492) Xu B. … Chen M. (Tumour Biol. 2016) 3 64
  3. Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer. (PMID: 27525941) Zhang Y.K. … Sui G. (Genet. Mol. Res. 2016) 3 64
  4. miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. (PMID: 27710896) Zhou W. … Sun L. (Biomed. Pharmacother. 2016) 3 64
  5. Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson's Disease. (PMID: 27842305) Liu Y. … Yang Q. (Cell. Physiol. Biochem. 2016) 3 64

Products for MIR135A1 Gene

Sources for MIR135A1 Gene

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