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Aliases for MIR135A1 Gene

Subcategory (RNA class) for MIR135A1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR135A1 Gene

  • MicroRNA 135a-1 2 3 5
  • MicroRNA 135-1 2 3
  • Hsa-Mir-135a-1 3
  • Hsa-Mir-135-1 3
  • Mir-135a-1 3
  • MIRN135-1 3
  • MIRN135A1 3

External Ids for MIR135A1 Gene

Previous HGNC Symbols for MIR135A1 Gene

  • MIRN135-1
  • MIRN135A1

Previous GeneCards Identifiers for MIR135A1 Gene

  • GC03M052306
  • GC03M052328

Summaries for MIR135A1 Gene

Entrez Gene Summary for MIR135A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A1 Gene

MIR135A1 (MicroRNA 135a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR135A1 Gene

Genomics for MIR135A1 Gene

Regulatory Elements for MIR135A1 Gene

Enhancers for MIR135A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052339 0.5 Ensembl ENCODE 12.2 -45.5 -45526 0.3 NFRKB ARID4B YBX1 FEZF1 DMAP1 ZBTB40 ZNF2 RAD21 ZNF391 CREM DNAH1 GLYCTK-AS1 MIR135A1 WDR82 GLYCTK TWF2 LOC101929054 ENSG00000173366 TLR9 PPM1M
GH03F052341 0.2 Ensembl 12.1 -47.4 -47393 0.2 GLYCTK-AS1 MIR135A1 WDR82 GLYCTK PPM1M TWF2 LOC101929054 ENSG00000173366 TLR9 DNAH1
GH03F052342 0.2 Ensembl 12.1 -46.8 -46793 0.2 GLYCTK-AS1 MIR135A1 WDR82 GLYCTK TWF2 LOC101929054 ENSG00000173366 TLR9 DNAH1 PPP2R5CP
GH03F052243 1 FANTOM5 ENCODE 11.7 +48.4 48423 4.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SP3 PBRM1 PPM1M LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03F052215 0.6 Ensembl ENCODE 11.4 +75.9 75899 5.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 ZNF143 GLYCTK PPM1M WDR82 MIR135A1 GLYCTK-AS1 DUSP7 TWF2 PARP3 SERBP1P3 ENSG00000280003
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR135A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR135A1 Gene

Chromosome:
3
Start:
52,294,219 bp from pter
End:
52,294,308 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR135A1 Gene

Genes around MIR135A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A1 Gene

Proteins for MIR135A1 Gene

Post-translational modifications for MIR135A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A1 Gene

Domains & Families for MIR135A1 Gene

Gene Families for MIR135A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135A1 Gene

Function for MIR135A1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A1 Gene

Localization for MIR135A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR135A1 Gene

Pathways & Interactions for MIR135A1 Gene

genes like me logo Genes that share pathways with MIR135A1: view

Pathways by source for MIR135A1 Gene

1 BioSystems pathway for MIR135A1 Gene
1 KEGG pathway for MIR135A1 Gene

Interacting Proteins for MIR135A1 Gene

Gene Ontology (GO) - Biological Process for MIR135A1 Gene

None

No data available for SIGNOR curated interactions for MIR135A1 Gene

Transcripts for MIR135A1 Gene

mRNA/cDNA for MIR135A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A1 Gene

No ASD Table

Relevant External Links for MIR135A1 Gene

GeneLoc Exon Structure for
MIR135A1
ECgene alternative splicing isoforms for
MIR135A1

Expression for MIR135A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR135A1 Gene

mRNA differential expression in normal tissues according to GTEx for MIR135A1 Gene

This gene is overexpressed in Liver (x21.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR135A1 Gene:

MIR135A1
genes like me logo Genes that share expression patterns with MIR135A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR135A1 Gene

Orthologs for MIR135A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135a-1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135a-1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135a-1 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-1 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-1 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135b 35
  • 66 (a)
OneToOne
Species where no ortholog for MIR135A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135A1 Gene

ENSEMBL:
Gene Tree for MIR135A1 (if available)
TreeFam:
Gene Tree for MIR135A1 (if available)

Paralogs for MIR135A1 Gene

No data available for Paralogs for MIR135A1 Gene

Variants for MIR135A1 Gene

Sequence variations from dbSNP and Humsavar for MIR135A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111230618 -- 52,294,160(+) GGGAG(A/C/G)TGCCA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs114320703 -- 52,295,702(+) CCTCA(A/G)GGGCT downstream-variant-500B, upstream-variant-2KB
rs114516529 -- 52,294,827(+) GGCCT(G/T)GCAGC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs115083870 -- 52,295,716(+) GATGG(C/T)GACAC downstream-variant-500B, upstream-variant-2KB
rs11708811 -- 52,294,591(+) GGCAC(C/T)GCTTC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR135A1 Gene

Variant ID Type Subtype PubMed ID
esv3402579 CNV duplication 20981092
nsv470572 CNV loss 18288195
nsv519445 CNV gain+loss 19592680
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897
nsv834696 CNV loss 17160897
nsv954859 CNV deletion 24416366

Relevant External Links for MIR135A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR135A1 Gene

Disorders for MIR135A1 Gene

Relevant External Links for MIR135A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR135A1

No disorders were found for MIR135A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135A1 Gene

Publications for MIR135A1 Gene

  1. Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2. (PMID: 25065599) Kroiss A. … Allioli N. (Oncogene 2015) 3 64
  2. MicroRNAs associated with initiation and progression of colonic polyp: a feasibility study. (PMID: 25496852) Aslam M.I. … Pringle J.H. (Int J Surg 2015) 3 64
  3. Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. (PMID: 25634212) TaipaleenmAoki H. … Lian J.B. (Cancer Res. 2015) 3 64
  4. Mir-135a enhances cellular proliferation through post-transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancer. (PMID: 25888950) Mao X.P. … Chen J.X. (J Transl Med 2015) 3 64
  5. miR-135 family members mediate podocyte injury through the activation of Wnt/I^-catenin signaling. (PMID: 26134897) Yang X. … Li G. (Int. J. Mol. Med. 2015) 3 64

Products for MIR135A1 Gene

Sources for MIR135A1 Gene

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