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Aliases for MIR135A1 Gene

Subcategory (RNA class) for MIR135A1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR135A1 Gene

  • MicroRNA 135a-1 2 3 5
  • MicroRNA 135-1 2 3
  • Hsa-Mir-135a-1 3
  • Hsa-Mir-135-1 3
  • Mir-135a-1 3
  • MIRN135-1 3
  • MIRN135A1 3

External Ids for MIR135A1 Gene

Previous HGNC Symbols for MIR135A1 Gene

  • MIRN135-1
  • MIRN135A1

Previous GeneCards Identifiers for MIR135A1 Gene

  • GC03M052306
  • GC03M052328

Summaries for MIR135A1 Gene

Entrez Gene Summary for MIR135A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A1 Gene

MIR135A1 (MicroRNA 135a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR135A1 Gene

Genomics for MIR135A1 Gene

Regulatory Elements for MIR135A1 Gene

Enhancers for MIR135A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR135A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR135A1 Gene

Chromosome:
3
Start:
52,294,219 bp from pter
End:
52,294,308 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR135A1 Gene

Genes around MIR135A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A1 Gene

Proteins for MIR135A1 Gene

Post-translational modifications for MIR135A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A1 Gene

Domains & Families for MIR135A1 Gene

Gene Families for MIR135A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR135A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR135A1 Gene

Function for MIR135A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A1 Gene

Localization for MIR135A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR135A1 Gene

Pathways & Interactions for MIR135A1 Gene

SuperPathways for MIR135A1 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135A1: view

Pathways by source for MIR135A1 Gene

1 KEGG pathway for MIR135A1 Gene

Interacting Proteins for MIR135A1 Gene

Gene Ontology (GO) - Biological Process for MIR135A1 Gene

None

No data available for SIGNOR curated interactions for MIR135A1 Gene

Drugs & Compounds for MIR135A1 Gene

No Compound Related Data Available

Transcripts for MIR135A1 Gene

mRNA/cDNA for MIR135A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A1 Gene

No ASD Table

Relevant External Links for MIR135A1 Gene

GeneLoc Exon Structure for
MIR135A1
ECgene alternative splicing isoforms for
MIR135A1

Expression for MIR135A1 Gene

mRNA expression in normal human tissues for MIR135A1 Gene

mRNA differential expression in normal tissues according to GTEx for MIR135A1 Gene

This gene is overexpressed in Liver (x21.3).
genes like me logo Genes that share expression patterns with MIR135A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR135A1 Gene

Orthologs for MIR135A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-135a-1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135a-1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135a-1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-1 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135b 36
  • 66 (a)
OneToOne
Species with no ortholog for MIR135A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135A1 Gene

ENSEMBL:
Gene Tree for MIR135A1 (if available)
TreeFam:
Gene Tree for MIR135A1 (if available)

Paralogs for MIR135A1 Gene

No data available for Paralogs for MIR135A1 Gene

Variants for MIR135A1 Gene

Sequence variations from dbSNP and Humsavar for MIR135A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs34896089 -- 52,295,883(+) CTGTG(-/G)TGTGT upstream-variant-2KB
rs143608424 -- 52,295,880(+) ACATC(-/TG)TGTGT upstream-variant-2KB
rs145115445 -- 52,295,828(+) TGCGC(A/G)GTTGA upstream-variant-2KB
rs183446674 -- 52,295,826(+) CATGC(A/G)CAGTT upstream-variant-2KB
rs187835329 -- 52,296,083(+) CCGAG(A/G)GAGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR135A1 Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR135A1 Gene

Disorders for MIR135A1 Gene

Relevant External Links for MIR135A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR135A1

No disorders were found for MIR135A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135A1 Gene

Publications for MIR135A1 Gene

  1. Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2. (PMID: 25065599) Kroiss A. … Allioli N. (Oncogene 2015) 3 67
  2. MicroRNAs associated with initiation and progression of colonic polyp: a feasibility study. (PMID: 25496852) Aslam M.I. … Pringle J.H. (Int J Surg 2015) 3
  3. Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. (PMID: 25634212) TaipaleenmAoki H. … Lian J.B. (Cancer Res. 2015) 3
  4. Mir-135a enhances cellular proliferation through post-transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancer. (PMID: 25888950) Mao X.P. … Chen J.X. (J Transl Med 2015) 3
  5. MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells. (PMID: 26235874) Shi H. … Fang P. (Biochem. Biophys. Res. Commun. 2015) 3

Products for MIR135A1 Gene

Sources for MIR135A1 Gene

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