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Aliases for MIR134 Gene

Subcategory (RNA class) for MIR134 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR134 Gene

  • MicroRNA 134 2 3 5
  • Hsa-Mir-134 3
  • Mir-134 3
  • MIRN134 3

External Ids for MIR134 Gene

ORGUL Members for MIR134 Gene

Previous HGNC Symbols for MIR134 Gene

  • MIRN134

Previous GeneCards Identifiers for MIR134 Gene

  • GC14P100832
  • GC14P100922
  • GC14P101523
  • GC14P101552
  • GC14P101587
  • GC14P101626
  • GC14P101654
  • GC14P101688
  • GC14P101725
  • GC14P101766
  • GC14P101824
  • GC14P101964
  • GC14P102161
  • GC14P101264
  • GC14P101875
  • GC14P102195
  • GC14P102365
  • GC14P102535

Summaries for MIR134 Gene

Entrez Gene Summary for MIR134 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR134 Gene

MIR134 (MicroRNA 134) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR134 Gene

Genomics for MIR134 Gene

Regulatory Elements for MIR134 Gene

Enhancers for MIR134 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G101096 1.1 FANTOM5 ENCODE 10.9 +43.7 43661 3.2 CTCF SUZ12 JUN ZIC2 RAD21 ZNF335 GLIS2 ZNF366 GATA2 POLR2A RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14G101004 0.8 Ensembl ENCODE 11 -49.6 -49603 1.9 GATA3 MNT MYC ZIC2 TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14G101176 0.6 ENCODE 10.7 +122.7 122680 2.0 ZNF680 ZFP3 ZBTB33 REST FOXP2 ZNF507 MIR377 MIR496 MIR154 MIR134 MIR323B MIR487A MIR485 SNORD113-2 SNORD113-3 ENSG00000222185
GH14G101008 0.4 ENCODE 11 -46.0 -45989 0.2 ZNF263 KDM1A MIR487A MIR323B MIR485 MIR134 MIR154 MIR377 MIR496 MIR376C MIR654 MIR300
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR134 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR134 Gene

Chromosome:
14
Start:
101,054,687 bp from pter
End:
101,054,759 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR134 Gene

Genes around MIR134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR134 Gene

Proteins for MIR134 Gene

Post-translational modifications for MIR134 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR134 Gene

Domains & Families for MIR134 Gene

Gene Families for MIR134 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR134: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR134 Gene

Function for MIR134 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR134 Gene

Localization for MIR134 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR134 Gene

Pathways & Interactions for MIR134 Gene

genes like me logo Genes that share pathways with MIR134: view

Pathways by source for MIR134 Gene

1 BioSystems pathway for MIR134 Gene

Interacting Proteins for MIR134 Gene

Gene Ontology (GO) - Biological Process for MIR134 Gene

None

No data available for SIGNOR curated interactions for MIR134 Gene

Drugs & Compounds for MIR134 Gene

No Compound Related Data Available

Transcripts for MIR134 Gene

mRNA/cDNA for MIR134 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR134 Gene

No ASD Table

Relevant External Links for MIR134 Gene

GeneLoc Exon Structure for
MIR134
ECgene alternative splicing isoforms for
MIR134

Expression for MIR134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR134 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR134 Gene:

MIR134
genes like me logo Genes that share expression patterns with MIR134: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR134 Gene

Orthologs for MIR134 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-134 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-134 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir134 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-134 35
  • 83 (a)
OneToOne
Species where no ortholog for MIR134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR134 Gene

ENSEMBL:
Gene Tree for MIR134 (if available)
TreeFam:
Gene Tree for MIR134 (if available)

Paralogs for MIR134 Gene

No data available for Paralogs for MIR134 Gene

Variants for MIR134 Gene

Sequence variations from dbSNP and Humsavar for MIR134 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1001787824 -- 101,053,450(+) GAAAG(A/G)GGTAA upstream-variant-2KB
rs1002220641 -- 101,053,138(+) ACCAT(C/G)ATTTT upstream-variant-2KB
rs1002933201 -- 101,054,171(+) CCAGT(C/G)TGTTC upstream-variant-2KB
rs1003488050 -- 101,054,234(+) GGATG(A/G)TGGTT upstream-variant-2KB
rs1003864116 -- 101,054,505(+) TAGCT(G/T)TAAGT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR134 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR134 Gene

Disorders for MIR134 Gene

Relevant External Links for MIR134

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR134

No disorders were found for MIR134 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR134 Gene

Publications for MIR134 Gene

  1. MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A. (PMID: 28043921) Chang C. … Chen J. (Gene 2017) 3 64
  2. miR-134 suppresses the migration and invasion of nona89small cell lung cancer by targeting ITGB1. (PMID: 28075475) Qin Q. … Li B. (Oncol. Rep. 2017) 3 64
  3. MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3. (PMID: 28260021) Liu Y. … Zhao A. (Oncol. Rep. 2017) 3 64
  4. Decision-making microRNAs (miR-124, -133a/b, -34a and -134) in patients with occluded target vessel in acute coronary syndrome. (PMID: 26365938) GacoA8 J. … PrzewA8ocki T. (Kardiol Pol 2016) 3 64
  5. MicroRNA-134 actives lipoprotein lipase-mediated lipid accumulation and inflammatory response by targeting angiopoietin-like 4 in THP-1 macrophages. (PMID: 26546816) Lan G. … Tang C.K. (Biochem. Biophys. Res. Commun. 2016) 3 64

Products for MIR134 Gene

Sources for MIR134 Gene

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