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Aliases for MIR133B Gene

Subcategory (RNA class) for MIR133B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR133B Gene

  • MicroRNA 133b 2 3 5
  • Hsa-Mir-133b 3
  • MiRNA133B 3
  • Mir-133b 3
  • MIRN133B 3

External Ids for MIR133B Gene

ORGUL Members for MIR133B Gene

Previous HGNC Symbols for MIR133B Gene

  • MIRN133B

Previous GeneCards Identifiers for MIR133B Gene

  • GC06P052123
  • GC06P052013

Summaries for MIR133B Gene

Entrez Gene Summary for MIR133B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is considered a canonical myomiR and is important for normal cardiac and skeletal muscle development. It is additionally important for normal development in non-muscle tissues, and is abnormally expressed in a variety of cancers. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]

GeneCards Summary for MIR133B Gene

MIR133B (MicroRNA 133b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and miRs in Muscle Cell Differentiation.

Additional gene information for MIR133B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133B Gene

Genomics for MIR133B Gene

Regulatory Elements for MIR133B Gene

Enhancers for MIR133B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H052317 1.3 Ensembl ENCODE dbSUPER 9.1 +169.6 169642 1 EBF1 CEBPG BATF TEAD3 FOSL1 ZNF121 EED ZNF143 RCOR1 FOS PAQR8 MCM3 LINCMD1 MIR133B GC06M052308
GH06H052063 1.1 Ensembl ENCODE 10.1 -85.2 -85174 1 CTCF ATF1 ETV1 CEBPG ZBTB40 RAD21 IRF9 ELK1 SMC3 ZNF143 PKHD1 MIR133B LINCMD1 SLC25A20P1 IL17F GC06P052010
GH06H052263 0.8 ENCODE 10.4 +115.0 114995 0 CTCF RB1 RAD21 RFX5 SMC3 ZNF143 NR2F6 THAP11 ZNF654 MAZ LINCMD1 MIR133B PKHD1 MIR206 IL17A PIR36045 SLC25A20P1
GH06H052116 0.7 ENCODE dbSUPER 11.7 -32.4 -32405 0 GLIS1 FEZF1 MIR133B LINCMD1 PKHD1 MIR206 GC06P052124
GH06H052101 0.7 ENCODE dbSUPER 10.9 -45.8 -45849 3 CTCF KLF1 CREB1 MIR133B LINCMD1 MIR206 IL17A IL17F SLC25A20P1 PKHD1 GC06P052124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR133B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR133B Gene

Chromosome:
6
Start:
52,148,923 bp from pter
End:
52,149,041 bp from pter
Size:
119 bases
Orientation:
Plus strand

Genomic View for MIR133B Gene

Genes around MIR133B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133B Gene

Proteins for MIR133B Gene

Post-translational modifications for MIR133B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133B Gene

Domains & Families for MIR133B Gene

Gene Families for MIR133B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133B Gene

Function for MIR133B Gene

Gene Ontology (GO) - Molecular Function for MIR133B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21351259
genes like me logo Genes that share ontologies with MIR133B: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR133B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133B Gene

Localization for MIR133B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR133B Gene

Pathways & Interactions for MIR133B Gene

genes like me logo Genes that share pathways with MIR133B: view

Interacting Proteins for MIR133B Gene

Gene Ontology (GO) - Biological Process for MIR133B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010831 positive regulation of myotube differentiation ISS --
GO:0035195 gene silencing by miRNA IDA 21351259
GO:0035278 miRNA mediated inhibition of translation IDA 23296701
GO:0070373 negative regulation of ERK1 and ERK2 cascade ISS --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISS --
genes like me logo Genes that share ontologies with MIR133B: view

No data available for SIGNOR curated interactions for MIR133B Gene

Drugs & Compounds for MIR133B Gene

No Compound Related Data Available

Transcripts for MIR133B Gene

mRNA/cDNA for MIR133B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR133B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133B Gene

No ASD Table

Relevant External Links for MIR133B Gene

GeneLoc Exon Structure for
MIR133B
ECgene alternative splicing isoforms for
MIR133B

Expression for MIR133B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR133B Gene

mRNA differential expression in normal tissues according to GTEx for MIR133B Gene

This gene is overexpressed in Muscle - Skeletal (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR133B Gene:

MIR133B
genes like me logo Genes that share expression patterns with MIR133B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133B Gene

Orthologs for MIR133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-133b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-133b 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-133b 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir133b 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-133b 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-133b 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-133a-1 34
  • 61 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 34
  • 47 (a)
OneToMany
Species where no ortholog for MIR133B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR133B Gene

ENSEMBL:
Gene Tree for MIR133B (if available)
TreeFam:
Gene Tree for MIR133B (if available)

Paralogs for MIR133B Gene

No data available for Paralogs for MIR133B Gene

Variants for MIR133B Gene

Sequence variations from dbSNP and Humsavar for MIR133B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000442664 -- 52,148,508(+) ATATC(A/G)TACTT intron-variant, upstream-variant-2KB
rs1000878717 -- 52,148,719(+) TGAAG(A/T)CATGC intron-variant, upstream-variant-2KB
rs1004756805 -- 52,147,828(+) CTACC(A/C)CATCA intron-variant, upstream-variant-2KB
rs1005352419 -- 52,149,140(+) GAAGG(A/G)AGAGA intron-variant, downstream-variant-500B
rs1006647407 -- 52,148,824(+) CCTGG(C/T)ATTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR133B Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Relevant External Links for MIR133B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR133B Gene

Disorders for MIR133B Gene

Relevant External Links for MIR133B

Genetic Association Database (GAD)
MIR133B
Human Genome Epidemiology (HuGE) Navigator
MIR133B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR133B

No disorders were found for MIR133B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR133B Gene

Publications for MIR133B Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60
  2. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. (PMID: 19654003) Crawford M … Nana-Sinkam SP (Biochemical and biophysical research communications 2009) 3 22 60
  3. [MiR-133b Affect the Proliferation and Drug Sensitivity in A549 Lung Cancer Stem Cells by Targeting PKM2]. (PMID: 28641694) Mi Y … Liu B (Zhongguo fei ai za zhi = Chinese journal of lung cancer 2017) 3 60
  4. Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours. (PMID: 28377929) Boštjančič E … Volavšek M (BioMed research international 2017) 3 60
  5. MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. (PMID: 28098895) Chen Y … Li X (Oncology reports 2017) 3 60

Products for MIR133B Gene

Sources for MIR133B Gene

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