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Aliases for MIR133B Gene

Subcategory (RNA class) for MIR133B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR133B Gene

  • MicroRNA 133b 2 3
  • MIRN133B 3 6
  • Hsa-Mir-133b 3
  • MiRNA133B 3
  • Mir-133b 3

External Ids for MIR133B Gene

ORGUL Members for MIR133B Gene

Previous Symbols for MIR133B Gene

  • MIRN133B

Summaries for MIR133B Gene

Entrez Gene Summary for MIR133B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133B Gene

MIR133B (MicroRNA 133b) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133B Gene

Genomics for MIR133B Gene

Genomic Location for MIR133B Gene

Start:
52,148,923 bp from pter
End:
52,149,041 bp from pter
Size:
119 bases
Orientation:
Plus strand

Genomic View for MIR133B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133B Gene

No data available for Regulatory Elements for MIR133B Gene

Proteins for MIR133B Gene

Post-translational modifications for MIR133B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133B Gene

Domains for MIR133B Gene

Gene Families for MIR133B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR133B: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR133B Gene

Function for MIR133B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR133B Gene

Localization for MIR133B Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR133B Gene

Pathways for MIR133B Gene

genes like me logo Genes that share pathways with MIR133B: view

Pathways by source for MIR133B Gene

Interacting Proteins for MIR133B Gene

Gene Ontology (GO) - Biological Process for MIR133B Gene

None

Transcripts for MIR133B Gene

mRNA/cDNA for MIR133B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133B Gene

No ASD Table

Relevant External Links for MIR133B Gene

GeneLoc Exon Structure for
MIR133B
ECgene alternative splicing isoforms for
MIR133B

Expression for MIR133B Gene

mRNA expression in normal human tissues for MIR133B Gene

mRNA differential expression in normal tissues according to GTEx for MIR133B Gene

This gene is overexpressed in Muscle - Skeletal (53.0).
genes like me logo Genes that share expressions with MIR133B: view

Orthologs for MIR133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-133b 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-133b 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-133b 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir133b 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-133b 37
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-133b 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-133a-1 37
  • 61 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 37
  • 47 (a)
OneToMany
Species with no ortholog for MIR133B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR133B Gene

ENSEMBL:
Gene Tree for MIR133B (if available)
TreeFam:
Gene Tree for MIR133B (if available)

Paralogs for MIR133B Gene

No data available for Paralogs for MIR133B Gene

Variants for MIR133B Gene

Sequence variations from dbSNP and Humsavar for MIR133B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9463761 -- 52,148,133(+) CAGGC(G/T)TGATG upstream-variant-2KB
rs9463762 -- 52,148,200(+) TCAGG(A/G)GTTTG upstream-variant-2KB
rs10948678 -- 52,147,488(+) AACCA(A/G)TGGGT upstream-variant-2KB
rs10948679 -- 52,148,075(+) GAAAG(C/T)AATAG upstream-variant-2KB
rs12111564 -- 52,148,678(+) TTCTA(C/T)TTGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR133B Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897
nsv522645 CNV Gain 19592680

Relevant External Links for MIR133B Gene

HapMap Linkage Disequilibrium report
MIR133B

Disorders for MIR133B Gene

Relevant External Links for MIR133B

Genetic Association Database (GAD)
MIR133B
Human Genome Epidemiology (HuGE) Navigator
MIR133B
genes like me logo Genes that share disorders with MIR133B: view

No data available for UniProtKB/Swiss-Prot for MIR133B Gene

Publications for MIR133B Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 49
  2. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. (PMID: 19654003) Crawford M. … Nana-Sinkam S.P. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3

Products for MIR133B Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR133B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR133B
    • Block miRNA regulation of MIR133B using miScript Target Protectors

    Sources for MIR133B Gene

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