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Aliases for MIR133B Gene

Subcategory (RNA class) for MIR133B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR133B Gene

  • MicroRNA 133b 2 3 5
  • Hsa-Mir-133b 3
  • MiRNA133B 3
  • Mir-133b 3
  • MIRN133B 3

External Ids for MIR133B Gene

ORGUL Members for MIR133B Gene

Previous HGNC Symbols for MIR133B Gene

  • MIRN133B

Previous GeneCards Identifiers for MIR133B Gene

  • GC06P052123
  • GC06P052013

Summaries for MIR133B Gene

Entrez Gene Summary for MIR133B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133B Gene

MIR133B (MicroRNA 133b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133B Gene

Genomics for MIR133B Gene

Genomic Location for MIR133B Gene

Chromosome:
6
Start:
52,148,923 bp from pter
End:
52,149,041 bp from pter
Size:
119 bases
Orientation:
Plus strand

Genomic View for MIR133B Gene

Genes around MIR133B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133B Gene

No data available for Regulatory Elements for MIR133B Gene

Proteins for MIR133B Gene

Post-translational modifications for MIR133B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133B Gene

Domains & Families for MIR133B Gene

Gene Families for MIR133B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133B Gene

Function for MIR133B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133B Gene

Localization for MIR133B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133B Gene

Pathways & Interactions for MIR133B Gene

genes like me logo Genes that share pathways with MIR133B: view

Pathways by source for MIR133B Gene

Interacting Proteins for MIR133B Gene

Gene Ontology (GO) - Biological Process for MIR133B Gene

None

No data available for SIGNOR curated interactions for MIR133B Gene

Drugs & Compounds for MIR133B Gene

No Compound Related Data Available

Transcripts for MIR133B Gene

mRNA/cDNA for MIR133B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133B Gene

No ASD Table

Relevant External Links for MIR133B Gene

GeneLoc Exon Structure for
MIR133B
ECgene alternative splicing isoforms for
MIR133B

Expression for MIR133B Gene

mRNA expression in normal human tissues for MIR133B Gene

mRNA differential expression in normal tissues according to GTEx for MIR133B Gene

This gene is overexpressed in Muscle - Skeletal (x53.0).
genes like me logo Genes that share expression patterns with MIR133B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR133B Gene

Orthologs for MIR133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-133b 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-133b 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir133b 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-133b 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-133b 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-133b 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-133a-1 36
  • 61 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 36
  • 47 (a)
OneToMany
Species with no ortholog for MIR133B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR133B Gene

ENSEMBL:
Gene Tree for MIR133B (if available)
TreeFam:
Gene Tree for MIR133B (if available)

Paralogs for MIR133B Gene

No data available for Paralogs for MIR133B Gene

Variants for MIR133B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133B Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897
nsv522645 CNV Gain 19592680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR133B Gene

Disorders for MIR133B Gene

Relevant External Links for MIR133B

Genetic Association Database (GAD)
MIR133B
Human Genome Epidemiology (HuGE) Navigator
MIR133B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR133B

No disorders were found for MIR133B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR133B Gene

Publications for MIR133B Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48 67
  2. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. (PMID: 19654003) Crawford M. … Nana-Sinkam S.P. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers. (PMID: 25125495) BoA!tjanA8iA8 E. … Zidar N. (Exp. Biol. Med. (Maywood) 2015) 3
  4. MiR-133b contributes to arsenic-induced apoptosis in U251 glioma cells by targeting the hERG channel. (PMID: 25355491) Wang J. … Jiang C. (J. Mol. Neurosci. 2015) 3
  5. MicroRNAa89133b inhibits connective tissue growth factor in colorectal cancer and correlates with the clinical stage of the disease. (PMID: 25501363) Guo Y. … Deng H. (Mol Med Rep 2015) 3

Products for MIR133B Gene

Sources for MIR133B Gene

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