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Aliases for MIR133B Gene

Subcategory (RNA class) for MIR133B Gene


Quality Score for this RNA gene is


Aliases for MIR133B Gene

  • MicroRNA 133b 2 3 5
  • Hsa-Mir-133b 3
  • MiRNA133B 3
  • Mir-133b 3
  • MIRN133B 3

External Ids for MIR133B Gene

ORGUL Members for MIR133B Gene

Previous HGNC Symbols for MIR133B Gene

  • MIRN133B

Previous GeneCards Identifiers for MIR133B Gene

  • GC06P052123
  • GC06P052013

Summaries for MIR133B Gene

Entrez Gene Summary for MIR133B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133B Gene

MIR133B (MicroRNA 133b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cardiomyocyte hypertrophy.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133B Gene

Genomics for MIR133B Gene

Regulatory Elements for MIR133B Gene

Enhancers for MIR133B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G052317 1.3 Ensembl ENCODE dbSUPER 9.1 +169.6 169642 1.7 ESRRA CEBPG EBF1 TEAD3 FOSL1 ZNF121 ARID3A EED ZNF143 RCOR1 PAQR8 MCM3 MIR133B LINCMD1 GC06M052308
GH06G052063 1.1 Ensembl ENCODE 10 -85.2 -85174 1.2 CBX3 ATF1 BMI1 ZBTB40 RAD21 CBX5 ELK1 ZNF143 ETV6 RELB PKHD1 LINCMD1 MIR133B IL17F SLC25A20P1 GC06P052010
GH06G052101 0.8 ENCODE dbSUPER 10.9 -45.8 -45849 3.8 MAFF KLF1 ZNF316 CREB1 MAFG EMSY MAFK MIR133B LINCMD1 MIR206 IL17A IL17F SLC25A20P1 PKHD1 GC06P052124
GH06G052179 0.8 dbSUPER 10.3 +36.4 36405 11.9 CTCF TBL1XR1 CEBPG RAD21 ARID3A SMC3 NFE2 MAFK NFE2L2 ZNF263 IL17F SLC25A20P1 LINCMD1 MIR133B MIR206 PKHD1 IL17A GC06P052177
GH06G052263 0.8 ENCODE 10.3 +115.0 114995 0.2 CTCF ZNF48 RAD21 RFX5 ZNF143 SMC3 NR2F6 THAP11 ZNF654 MAZ MIR133B LINCMD1 PKHD1 MIR206 IL17A SLC25A20P1 PIR36045
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR133B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR133B Gene

52,148,923 bp from pter
52,149,041 bp from pter
119 bases
Plus strand

Genomic View for MIR133B Gene

Genes around MIR133B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133B Gene

Proteins for MIR133B Gene

Post-translational modifications for MIR133B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133B Gene

Domains & Families for MIR133B Gene

Gene Families for MIR133B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133B Gene

Function for MIR133B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133B Gene

Localization for MIR133B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133B Gene

Pathways & Interactions for MIR133B Gene

genes like me logo Genes that share pathways with MIR133B: view

Interacting Proteins for MIR133B Gene

Gene Ontology (GO) - Biological Process for MIR133B Gene


No data available for SIGNOR curated interactions for MIR133B Gene

Drugs & Compounds for MIR133B Gene

No Compound Related Data Available

Transcripts for MIR133B Gene

mRNA/cDNA for MIR133B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133B Gene

No ASD Table

Relevant External Links for MIR133B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR133B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR133B Gene

mRNA differential expression in normal tissues according to GTEx for MIR133B Gene

This gene is overexpressed in Muscle - Skeletal (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR133B Gene:

genes like me logo Genes that share expression patterns with MIR133B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133B Gene

Orthologs for MIR133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-133b 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-133b 35
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-133b 35
  • 100 (a)
(Mus musculus)
Mammalia Mir133b 35
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-133b 35
  • 87 (a)
(Gallus gallus)
Aves gga-mir-133b 35
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
(Danio rerio)
Actinopterygii dre-mir-133a-1 35
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 35
  • 47 (a)
Species where no ortholog for MIR133B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR133B Gene

Gene Tree for MIR133B (if available)
Gene Tree for MIR133B (if available)

Paralogs for MIR133B Gene

No data available for Paralogs for MIR133B Gene

Variants for MIR133B Gene

Sequence variations from dbSNP and Humsavar for MIR133B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000442664 -- 52,148,508(+) ATATC(A/G)TACTT intron-variant, upstream-variant-2KB
rs1000878717 -- 52,148,719(+) TGAAG(A/T)CATGC intron-variant, upstream-variant-2KB
rs1004756805 -- 52,147,828(+) CTACC(A/C)CATCA intron-variant, upstream-variant-2KB
rs1005352419 -- 52,149,140(+) GAAGG(A/G)AGAGA intron-variant, downstream-variant-500B
rs1006647407 -- 52,148,824(+) CCTGG(C/T)ATTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR133B Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Relevant External Links for MIR133B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR133B Gene

Disorders for MIR133B Gene

Relevant External Links for MIR133B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR133B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR133B Gene

Publications for MIR133B Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. (PMID: 19654003) Crawford M. … Nana-Sinkam S.P. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  3. Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours. (PMID: 28377929) BoA!tjanA8iA8 E. … VolavA!ek M. (Biomed Res Int 2017) 3 64
  4. MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. (PMID: 28098895) Chen Y. … Li X. (Oncol. Rep. 2017) 3 64
  5. MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3. (PMID: 26755652) Yao C. … He Z. (Oncotarget 2016) 3 64

Products for MIR133B Gene

Sources for MIR133B Gene

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