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Aliases for MIR133A2 Gene

Subcategory (RNA class) for MIR133A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR133A2 Gene

  • MicroRNA 133a-2 2 3 5
  • Hsa-Mir-133a-2 3
  • Mir-133a-2 3
  • MIRN133A2 3

External Ids for MIR133A2 Gene

ORGUL Members for MIR133A2 Gene

Previous HGNC Symbols for MIR133A2 Gene

  • MIRN133A2

Previous GeneCards Identifiers for MIR133A2 Gene

  • GC20P060573
  • GC20P061162
  • GC20P062653
  • GC20P062659

Summaries for MIR133A2 Gene

Entrez Gene Summary for MIR133A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A2 Gene

MIR133A2 (MicroRNA 133a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A2 Gene

Genomics for MIR133A2 Gene

Regulatory Elements for MIR133A2 Gene

Enhancers for MIR133A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR133A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR133A2 Gene

Chromosome:
20
Start:
62,564,912 bp from pter
End:
62,565,013 bp from pter
Size:
102 bases
Orientation:
Plus strand

Genomic View for MIR133A2 Gene

Genes around MIR133A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A2 Gene

Proteins for MIR133A2 Gene

Post-translational modifications for MIR133A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A2 Gene

Domains & Families for MIR133A2 Gene

Gene Families for MIR133A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A2 Gene

Function for MIR133A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A2 Gene

Localization for MIR133A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133A2 Gene

Pathways & Interactions for MIR133A2 Gene

genes like me logo Genes that share pathways with MIR133A2: view

Pathways by source for MIR133A2 Gene

Interacting Proteins for MIR133A2 Gene

Gene Ontology (GO) - Biological Process for MIR133A2 Gene

None

No data available for SIGNOR curated interactions for MIR133A2 Gene

Drugs & Compounds for MIR133A2 Gene

No Compound Related Data Available

Transcripts for MIR133A2 Gene

mRNA/cDNA for MIR133A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A2 Gene

No ASD Table

Relevant External Links for MIR133A2 Gene

GeneLoc Exon Structure for
MIR133A2
ECgene alternative splicing isoforms for
MIR133A2

Expression for MIR133A2 Gene

mRNA expression in normal human tissues for MIR133A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR133A2 Gene

This gene is overexpressed in Muscle - Skeletal (x51.1).
genes like me logo Genes that share expression patterns with MIR133A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR133A2 Gene

Orthologs for MIR133A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-133a-1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-133c 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-133a-2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir133a-2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-133a-2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-133a-2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-133a-2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-133a-1 36
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-133a-2 36
  • 94 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 36
  • 44 (a)
OneToMany
Species with no ortholog for MIR133A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR133A2 Gene

ENSEMBL:
Gene Tree for MIR133A2 (if available)
TreeFam:
Gene Tree for MIR133A2 (if available)

Paralogs for MIR133A2 Gene

No data available for Paralogs for MIR133A2 Gene

Variants for MIR133A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133A2 Gene

Variant ID Type Subtype PubMed ID
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv4608n71 CNV Loss 21882294
dgv4610n71 CNV Loss 21882294
nsv459068 CNV Gain 19166990
essv22589 CNV CNV 17122850
nsv913101 CNV Loss 21882294
nsv913103 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR133A2 Gene

Disorders for MIR133A2 Gene

Relevant External Links for MIR133A2

Genetic Association Database (GAD)
MIR133A2
Human Genome Epidemiology (HuGE) Navigator
MIR133A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR133A2

No disorders were found for MIR133A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR133A2 Gene

Publications for MIR133A2 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48 67
  2. Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. (PMID: 25780292) Gong Y. … Tang L.M. (World J. Gastroenterol. 2015) 3
  3. Identification of miRNomes in human stomach and gastric carcinoma reveals miR-133b/a-3p as therapeutic target for gastric cancer. (PMID: 26276722) Liu Y. … Cai Q. (Cancer Lett. 2015) 3
  4. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. (PMID: 24816813) Wang L.K. … Yang P.C. (PLoS ONE 2014) 3
  5. microRNA-133: expression, function and therapeutic potential in muscle diseases and cancer. (PMID: 24975488) Yu H. … Wang Q. (Curr Drug Targets 2014) 3

Products for MIR133A2 Gene

Sources for MIR133A2 Gene

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