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Aliases for MIR133A2 Gene

Subcategory (RNA class) for MIR133A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR133A2 Gene

  • MicroRNA 133a-2 2 3
  • MIR1-1 Host Gene 5
  • Hsa-Mir-133a-2 3
  • Mir-133a-2 3
  • MIRN133A2 3
  • MIR1-1HG 5

External Ids for MIR133A2 Gene

Previous HGNC Symbols for MIR133A2 Gene

  • MIRN133A2

Previous GeneCards Identifiers for MIR133A2 Gene

  • GC20P060573
  • GC20P061162
  • GC20P062653
  • GC20P062659
  • GC20P062715
  • GC20P062778

Summaries for MIR133A2 Gene

Entrez Gene Summary for MIR133A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A2 Gene

MIR133A2 (MicroRNA 133a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TarBasePathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A2 Gene

Genomics for MIR133A2 Gene

Regulatory Elements for MIR133A2 Gene

Enhancers for MIR133A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062589 1.1 FANTOM5 Ensembl ENCODE 12 +39.7 39725 1.8 GTF2F1 TBP MXI1 TAF1 MAX SIN3A RAD21 POLR2A SMC3 RCOR1 MIR1-1HG C20orf166-AS1 ENSG00000229882 ENSG00000232121 MIR133A2 MIR1-1 ENSG00000264490 WI2-87327B8.2
GH20F062595 1.2 Ensembl ENCODE 12 +45.4 45448 0.6 KLF1 KLF17 MAX ZIC2 ZFHX2 GLIS2 POLR2A ZNF207 PRDM10 ZNF600 MIR1-1HG ENSG00000229882 ENSG00000232121 MIR133A2 MIR1-1 C20orf166-AS1 ENSG00000264490 WI2-87327B8.2
GH20F062598 0.8 Ensembl ENCODE 11.6 +48.7 48725 1.6 HDGF HDAC1 ATF1 CREB3L1 KLF17 SIN3A BRCA1 RCOR1 KLF7 CREM ENSG00000229882 ENSG00000232121 MIR1-1 C20orf166-AS1 MIR1-1HG MIR133A2 ENSG00000264490 WI2-87327B8.2
GH20F062452 0.7 ENCODE 11.4 -97.6 -97647 0.9 BCOR KLF1 ESRRA ZMYM3 PLRG1 ZNF48 HIC1 GATA3 MTA3 CTBP1 MIR133A2 C20orf166-AS1 MIR1-1HG MIR1-1 GATA5 LOC105372710
GH20F062449 0.4 ENCODE 11.4 -99.9 -99938 1.8 CTCF ZNF146 ZNF169 HNF4A ZBTB33 ZNF600 MNT RAD21 ZIC2 MIR133A2 MIR1-1HG C20orf166-AS1 MIR1-1 LOC105372710 CABLES2 GATA5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR133A2 on UCSC Golden Path with GeneCards custom track

Promoters for MIR133A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001839126 247 601 CTCF ZNF366 GLIS1 ZBTB8A ZIC2 ZZZ3 ZBTB26 EZH2
ENSR00001021581 1047 601 GLIS2 PATZ1 GLIS1 ZBTB8A ZIC2 ZBTB20 EZH2

Genomic Location for MIR133A2 Gene

Chromosome:
20
Start:
62,550,453 bp from pter
End:
62,570,764 bp from pter
Size:
20,312 bases
Orientation:
Plus strand

Genomic View for MIR133A2 Gene

Genes around MIR133A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A2 Gene

Proteins for MIR133A2 Gene

Post-translational modifications for MIR133A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A2 Gene

Domains & Families for MIR133A2 Gene

Gene Families for MIR133A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A2 Gene

Function for MIR133A2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A2 Gene

Localization for MIR133A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133A2 Gene

Pathways & Interactions for MIR133A2 Gene

SuperPathways for MIR133A2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR133A2: view

Pathways by source for MIR133A2 Gene

1 BioSystems pathway for MIR133A2 Gene
1 KEGG pathway for MIR133A2 Gene

Interacting Proteins for MIR133A2 Gene

Gene Ontology (GO) - Biological Process for MIR133A2 Gene

None

No data available for SIGNOR curated interactions for MIR133A2 Gene

Transcripts for MIR133A2 Gene

mRNA/cDNA for MIR133A2 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A2 Gene

No ASD Table

Relevant External Links for MIR133A2 Gene

GeneLoc Exon Structure for
MIR133A2
ECgene alternative splicing isoforms for
MIR133A2

Expression for MIR133A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR133A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR133A2 Gene

This gene is overexpressed in Muscle - Skeletal (x51.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR133A2 Gene:

MIR133A2
genes like me logo Genes that share expression patterns with MIR133A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR133A2 Gene

Orthologs for MIR133A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR133A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20orf166 35
  • 97 (a)
OneToOne
Species where no ortholog for MIR133A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR133A2 Gene

ENSEMBL:
Gene Tree for MIR133A2 (if available)
TreeFam:
Gene Tree for MIR133A2 (if available)

Paralogs for MIR133A2 Gene

No data available for Paralogs for MIR133A2 Gene

Variants for MIR133A2 Gene

Sequence variations from dbSNP and Humsavar for MIR133A2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111509987 -- 62,565,026(+) CGGCC(A/G/T)CAGGT downstream-variant-500B, reference, missense
rs111916454 -- 62,565,065(+) TGGCG(C/T)GGGGA downstream-variant-500B, reference, missense
rs112279683 -- 62,565,044(+) CCGTG(A/G)AGAGG downstream-variant-500B, reference, missense
rs112669601 -- 62,564,726(+) TCTGA(-/GT)GTGTG intron-variant, upstream-variant-2KB
rs114654293 -- 62,563,675(+) CCTGA(A/G)GGGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR133A2 Gene

Variant ID Type Subtype PubMed ID
dgv4343n100 CNV gain 25217958
dgv4344n100 CNV gain 25217958
esv2422398 CNV duplication 17116639
nsv459065 CNV gain 19166990
nsv459068 CNV gain 19166990
nsv470556 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv586501 CNV gain 21841781
nsv953302 CNV deletion 24416366

Relevant External Links for MIR133A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR133A2 Gene

Disorders for MIR133A2 Gene

Relevant External Links for MIR133A2

Genetic Association Database (GAD)
MIR133A2
Human Genome Epidemiology (HuGE) Navigator
MIR133A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR133A2

No disorders were found for MIR133A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR133A2 Gene

Publications for MIR133A2 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. (PMID: 25780292) Gong Y. … Tang L.M. (World J. Gastroenterol. 2015) 3 64
  3. Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation. (PMID: 26005035) Li Y.D. … Zhang Y. (Mol Med Rep 2015) 3 64
  4. Identification of miRNomes in human stomach and gastric carcinoma reveals miR-133b/a-3p as therapeutic target for gastric cancer. (PMID: 26276722) Liu Y. … Cai Q. (Cancer Lett. 2015) 3 64
  5. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. (PMID: 24816813) Wang L.K. … Yang P.C. (PLoS ONE 2014) 3 64

Products for MIR133A2 Gene

Sources for MIR133A2 Gene

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