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Aliases for MIR133A2 Gene

Subcategory (RNA class) for MIR133A2 Gene


Quality Score for this RNA gene is


Aliases for MIR133A2 Gene

  • MicroRNA 133a-2 2 3
  • Hsa-Mir-133a-2 3
  • MIRN133A2 3

External Ids for MIR133A2 Gene

ORGUL Members for MIR133A2 Gene

Previous HGNC Symbols for MIR133A2 Gene

  • MIRN133A2

Previous GeneCards Identifiers for MIR133A2 Gene

  • GC20P060573
  • GC20P061162

Summaries for MIR133A2 Gene

Entrez Gene Summary for MIR133A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A2 Gene

MIR133A2 (MicroRNA 133a-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A2 include lung squamous cell carcinoma. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A2 Gene

Genomics for MIR133A2 Gene

Genomic Location for MIR133A2 Gene

62,564,912 bp from pter
62,565,013 bp from pter
102 bases
Plus strand

Genomic View for MIR133A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR133A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A2 Gene

No data available for Regulatory Elements for MIR133A2 Gene

Proteins for MIR133A2 Gene

Post-translational modifications for MIR133A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A2 Gene

Domains for MIR133A2 Gene

Gene Families for MIR133A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A2 Gene

Function for MIR133A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A2 Gene

Localization for MIR133A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133A2 Gene

Pathways for MIR133A2 Gene

genes like me logo Genes that share pathways with MIR133A2: view

Pathways by source for MIR133A2 Gene

Interacting Proteins for MIR133A2 Gene

Gene Ontology (GO) - Biological Process for MIR133A2 Gene


Transcripts for MIR133A2 Gene

mRNA/cDNA for MIR133A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A2 Gene

No ASD Table

Relevant External Links for MIR133A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR133A2 Gene

mRNA expression in normal human tissues for MIR133A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR133A2 Gene

This gene is overexpressed in Muscle - Skeletal (51.1).
genes like me logo Genes that share expressions with MIR133A2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR133A2 Gene

Orthologs for MIR133A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-133a-1 36
  • 91 (a)
(Canis familiaris)
Mammalia cfa-mir-133c 36
  • 95 (a)
(Monodelphis domestica)
Mammalia mdo-mir-133a-2 36
  • 89 (a)
(Mus musculus)
Mammalia Mir133a-2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-133a-2 36
  • 96 (a)
(Pan troglodytes)
Mammalia ptr-mir-133a-2 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-133a-2 36
  • 93 (a)
(Anolis carolinensis)
Reptilia aca-mir-133a-1 36
  • 95 (a)
(Danio rerio)
Actinopterygii dre-mir-133a-2 36
  • 94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 36
  • 44 (a)
Species with no ortholog for MIR133A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR133A2 Gene

Gene Tree for MIR133A2 (if available)
Gene Tree for MIR133A2 (if available)

Paralogs for MIR133A2 Gene

No data available for Paralogs for MIR133A2 Gene

Variants for MIR133A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133A2 Gene

Variant ID Type Subtype PubMed ID
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv4608n71 CNV Loss 21882294
dgv4610n71 CNV Loss 21882294
nsv459068 CNV Gain 19166990
essv22589 CNV CNV 17122850
nsv913101 CNV Loss 21882294
nsv913103 CNV Loss 21882294

Relevant External Links for MIR133A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR133A2 Gene

Disorders for MIR133A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR133A2 Gene in MalaCards »

(1) Disease for MIR133A2 Gene

Relevant External Links for MIR133A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR133A2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR133A2 Gene

Publications for MIR133A2 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. (PMID: 22089643) Moriya Y. … Seki N. (J. Hum. Genet. 2012) 3
  4. Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. (PMID: 22766685) Chen W.S. … Tsai K.W. (Oncol. Rep. 2012) 3
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3

Products for MIR133A2 Gene

Sources for MIR133A2 Gene

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