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Aliases for MIR133A1 Gene

Subcategory (RNA class) for MIR133A1 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR133A1 Gene

  • MicroRNA 133a-1 2 3
  • Hsa-Mir-133a-1 3
  • MIRN133A1 3

External Ids for MIR133A1 Gene

Previous HGNC Symbols for MIR133A1 Gene

  • MIRN133A1

Previous GeneCards Identifiers for MIR133A1 Gene

  • GC18M017666
  • GC18M019405

Summaries for MIR133A1 Gene

Entrez Gene Summary for MIR133A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A1 Gene

MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include bladder carcinoma in situ and lung squamous cell carcinoma. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A1 Gene

Genomics for MIR133A1 Gene

Genomic Location for MIR133A1 Gene

Start:
21,825,698 bp from pter
End:
21,825,785 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR133A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR133A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A1 Gene

ORGUL Member Location for MIR133A1 Gene

ORGUL Member Location for MIR133A1 gene

No data available for Regulatory Elements for MIR133A1 Gene

Proteins for MIR133A1 Gene

Post-translational modifications for MIR133A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A1 Gene

Domains for MIR133A1 Gene

Gene Families for MIR133A1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A1 Gene

Function for MIR133A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR133A1 Gene

Localization for MIR133A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133A1 Gene

Pathways for MIR133A1 Gene

genes like me logo Genes that share pathways with MIR133A1: view

Pathways by source for MIR133A1 Gene

Interacting Proteins for MIR133A1 Gene

Gene Ontology (GO) - Biological Process for MIR133A1 Gene

None

Transcripts for MIR133A1 Gene

mRNA/cDNA for MIR133A1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR133A1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A1 Gene

No ASD Table

Relevant External Links for MIR133A1 Gene

GeneLoc Exon Structure for
MIR133A1
ECgene alternative splicing isoforms for
MIR133A1

Expression for MIR133A1 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR133A1 Gene

Orthologs for MIR133A1 Gene

Evolution for MIR133A1 Gene

ENSEMBL:
Gene Tree for MIR133A1 (if available)
TreeFam:
Gene Tree for MIR133A1 (if available)

No data available for Orthologs for MIR133A1 Gene

Paralogs for MIR133A1 Gene

No data available for Paralogs for MIR133A1 Gene

Variants for MIR133A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133A1 Gene

Variant ID Type Subtype PubMed ID
nsv909450 CNV Gain 21882294
nsv2222 CNV Insertion 18451855

Relevant External Links for MIR133A1 Gene

HapMap Linkage Disequilibrium report
MIR133A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR133A1 Gene

Disorders for MIR133A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR133A1 Gene in MalaCards »

(2) Diseases for MIR133A1 Gene including...

Relevant External Links for MIR133A1

Genetic Association Database (GAD)
MIR133A1
Human Genome Epidemiology (HuGE) Navigator
MIR133A1
genes like me logo Genes that share disorders with MIR133A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR133A1 Gene

Publications for MIR133A1 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  2. High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. (PMID: 20520763) Fred R.G. … Welsh N. (PLoS ONE 2010) 3
  3. Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer. (PMID: 20843712) Chiyomaru T. … Nakagawa M. (Urol. Oncol. 2012) 3
  4. miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. (PMID: 21351259) Kano M. … Matsubara H. (Int. J. Cancer 2010) 3
  5. MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines. (PMID: 21396852) Uchida Y. … Nakagawa M. (Urol. Oncol. 2013) 3

Products for MIR133A1 Gene

Sources for MIR133A1 Gene

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