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Aliases for MIR133A1 Gene

Subcategory (RNA class) for MIR133A1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR133A1 Gene

  • MicroRNA 133a-1 2 3
  • MIR133A1 Host Gene 5
  • Hsa-Mir-133a-1 3
  • MIR133A1HG 5
  • Mir-133a-1 3
  • MIRN133A1 3

External Ids for MIR133A1 Gene

Previous HGNC Symbols for MIR133A1 Gene

  • MIRN133A1

Previous GeneCards Identifiers for MIR133A1 Gene

  • GC18M017666
  • GC18M019405

Summaries for MIR133A1 Gene

Entrez Gene Summary for MIR133A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A1 Gene

MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include Bladder Carcinoma In Situ. Among its related pathways are TarBasePathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A1 Gene

Genomics for MIR133A1 Gene

Regulatory Elements for MIR133A1 Gene

Enhancers for MIR133A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F021803 0.2 Ensembl 12.1 +27.5 27510 1.0 GATAD2A ELF3 SOX5 SOX13 SAP130 TEAD1 HLF CEBPB CEBPG HMG20A MIB1 MIR133A1 MIR320C1 GC18P021818 RN7SL233P
GH18F021852 1.2 Ensembl ENCODE 11.3 -21.7 -21676 1.1 HDGF PKNOX1 RAD51 MTA2 SPI1 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 RPL34P32 MIR133A1HG
GH18F021825 0.9 Ensembl ENCODE 5 +1.9 1886 7.9 ZNF316 MAFF MAFG IRF1 EMSY MAFK MIB1 MIR320C1 MIR133A1 ABHD3 GC18M021829 MIR1-2 MIR133A1HG
GH18F021735 1 Ensembl ENCODE 4.8 +95.6 95612 1.4 ATF1 ARNT CREB3L1 ZNF48 YY1 ELK1 SP5 NCOA1 KAT8 SMARCA4 MIR320C1 MIB1 MIR133A1 ENSG00000200750 RN7SL233P
GH18F022489 1.2 FANTOM5 Ensembl ENCODE 4.1 -661.0 -660980 6.1 PKNOX1 ZNF133 FEZF1 YY1 ZNF121 ZNF302 GATA2 KLF7 NFYC TSHZ1 MIR133A1 GC18P022454 RPS4XP18
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR133A1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR133A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001811781 809 2799 ZNF316 MAFF MAFG IRF1 EMSY MAFK

Genomic Location for MIR133A1 Gene

Chromosome:
18
Start:
21,825,487 bp from pter
End:
21,831,410 bp from pter
Size:
5,924 bases
Orientation:
Minus strand

Genomic View for MIR133A1 Gene

Genes around MIR133A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A1 Gene

Proteins for MIR133A1 Gene

Post-translational modifications for MIR133A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A1 Gene

Domains & Families for MIR133A1 Gene

Gene Families for MIR133A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A1 Gene

Function for MIR133A1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A1 Gene

Localization for MIR133A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR133A1 Gene

Pathways & Interactions for MIR133A1 Gene

SuperPathways for MIR133A1 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR133A1: view

Pathways by source for MIR133A1 Gene

1 BioSystems pathway for MIR133A1 Gene
1 KEGG pathway for MIR133A1 Gene

Interacting Proteins for MIR133A1 Gene

Gene Ontology (GO) - Biological Process for MIR133A1 Gene

None

No data available for SIGNOR curated interactions for MIR133A1 Gene

Transcripts for MIR133A1 Gene

mRNA/cDNA for MIR133A1 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A1 Gene

No ASD Table

Relevant External Links for MIR133A1 Gene

GeneLoc Exon Structure for
MIR133A1
ECgene alternative splicing isoforms for
MIR133A1

Expression for MIR133A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR133A1 Gene:

MIR133A1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR133A1 Gene

Orthologs for MIR133A1 Gene

Evolution for MIR133A1 Gene

ENSEMBL:
Gene Tree for MIR133A1 (if available)
TreeFam:
Gene Tree for MIR133A1 (if available)

No data available for Orthologs for MIR133A1 Gene

Paralogs for MIR133A1 Gene

No data available for Paralogs for MIR133A1 Gene

Variants for MIR133A1 Gene

Sequence variations from dbSNP and Humsavar for MIR133A1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs111418677 -- 21,825,325(+) GTACA(A/G)TCCCA intron-variant, downstream-variant-500B
rs112388603 -- 21,826,347(+) TTTAT(A/G)AATAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs115634447 -- 21,827,284(+) AGATA(A/G)GTTAA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs139102927 -- 21,827,344(+) GCCTG(C/T)CATTT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs139563822 -- 21,826,026(+) ATCTT(C/T)GCTTC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR133A1 Gene

Variant ID Type Subtype PubMed ID
nsv2222 CNV insertion 18451855

Relevant External Links for MIR133A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR133A1 Gene

Disorders for MIR133A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR133A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bladder carcinoma in situ
  • bladder ca in situ
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR133A1

Genetic Association Database (GAD)
MIR133A1
Human Genome Epidemiology (HuGE) Navigator
MIR133A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR133A1
genes like me logo Genes that share disorders with MIR133A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR133A1 Gene

Publications for MIR133A1 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L. … Alvarez V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. MicroRNA-133a Inhibits Osteosarcoma Cells Proliferation and Invasion via Targeting IGF-1R. (PMID: 26845446) Chen G. … Yan W. (Cell. Physiol. Biochem. 2016) 3 64
  3. miR-133a mediates the hypoxia-induced apoptosis by inhibiting TAGLN2 expression in cardiac myocytes. (PMID: 25421410) Li A.Y. … Yang K. (Mol. Cell. Biochem. 2015) 3 64
  4. Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. (PMID: 25518741) Mataki H. … Seki N. (J. Hum. Genet. 2015) 3 64
  5. Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. (PMID: 25780292) Gong Y. … Tang L.M. (World J. Gastroenterol. 2015) 3 64

Products for MIR133A1 Gene

Sources for MIR133A1 Gene

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