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Aliases for MIR133A1 Gene

Subcategory (RNA class) for MIR133A1 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR133A1 Gene

  • MicroRNA 133a-1 2 3 5
  • Hsa-Mir-133a-1 3
  • Mir-133a-1 3
  • MIRN133A1 3

External Ids for MIR133A1 Gene

Previous HGNC Symbols for MIR133A1 Gene

  • MIRN133A1

Previous GeneCards Identifiers for MIR133A1 Gene

  • GC18M017666
  • GC18M019405

Summaries for MIR133A1 Gene

Entrez Gene Summary for MIR133A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A1 Gene

MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include Bladder Carcinoma In Situ. Among its related pathways are MicroRNAs in cancer and TarBasePathway.

Additional gene information for MIR133A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A1 Gene

Genomics for MIR133A1 Gene

Regulatory Elements for MIR133A1 Gene

Enhancers for MIR133A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H021852 0.8 Ensembl ENCODE 11.3 -27.3 -27301 1 HDGF PKNOX1 RUNX3 SPI1 RFX5 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 RPL34P32 MIR133A1HG
GH18H021803 0.7 Ensembl 12.2 +22.3 22285 0 ELF3 SOX5 SOX13 GATAD2A SAP130 TEAD1 HLF CEBPB CEBPG HMG20A MIB1 MIR133A1 MIR320C1 RN7SL233P GC18P021818
GH18H021804 0.6 Ensembl 12.2 +21.7 21685 0 ELF3 SOX5 SOX13 GATAD2A SAP130 TEAD1 HMG20A NFIL3 CEBPA KDM1A MIR133A1 MIR320C1 MIB1 RN7SL233P GC18P021818
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR133A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR133A1 Gene

Chromosome:
18
Start:
21,825,698 bp from pter
End:
21,825,785 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR133A1 Gene

Genes around MIR133A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR133A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A1 Gene

ORGUL Member Location for MIR133A1 Gene

ORGUL Member Location for MIR133A1 gene

Proteins for MIR133A1 Gene

Post-translational modifications for MIR133A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A1 Gene

Domains & Families for MIR133A1 Gene

Gene Families for MIR133A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR133A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A1 Gene

Function for MIR133A1 Gene

Gene Ontology (GO) - Molecular Function for MIR133A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22163007
genes like me logo Genes that share ontologies with MIR133A1: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR133A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A1 Gene

Localization for MIR133A1 Gene

Gene Ontology (GO) - Cellular Components for MIR133A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with MIR133A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR133A1 Gene

Pathways & Interactions for MIR133A1 Gene

SuperPathways for MIR133A1 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR133A1: view

Pathways by source for MIR133A1 Gene

1 BioSystems pathway for MIR133A1 Gene
1 KEGG pathway for MIR133A1 Gene

Interacting Proteins for MIR133A1 Gene

Gene Ontology (GO) - Biological Process for MIR133A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007194 negative regulation of adenylate cyclase activity ISS --
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010628 positive regulation of gene expression IDA 23069713
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
genes like me logo Genes that share ontologies with MIR133A1: view

No data available for SIGNOR curated interactions for MIR133A1 Gene

Drugs & Compounds for MIR133A1 Gene

No Compound Related Data Available

Transcripts for MIR133A1 Gene

mRNA/cDNA for MIR133A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR133A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A1 Gene

No ASD Table

Relevant External Links for MIR133A1 Gene

GeneLoc Exon Structure for
MIR133A1
ECgene alternative splicing isoforms for
MIR133A1

Expression for MIR133A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR133A1 Gene:

MIR133A1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133A1 Gene

Orthologs for MIR133A1 Gene

Evolution for MIR133A1 Gene

ENSEMBL:
Gene Tree for MIR133A1 (if available)
TreeFam:
Gene Tree for MIR133A1 (if available)

No data available for Orthologs for MIR133A1 Gene

Paralogs for MIR133A1 Gene

No data available for Paralogs for MIR133A1 Gene

Variants for MIR133A1 Gene

Sequence variations from dbSNP and Humsavar for MIR133A1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000882824 -- 21,826,465(+) TAATT(C/T)AACCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002195393 -- 21,825,632(+) TGTAA(A/G)TAAGT intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002256781 -- 21,825,356(+) AGGTG(-/A)ACCTT intron-variant, downstream-variant-500B
rs1004501796 -- 21,825,521(+) GTCAT(C/G)CATAC intron-variant, nc-transcript-variant, downstream-variant-500B
rs1008107368 -- 21,826,842(+) ACTAA(A/G)TATAT intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR133A1 Gene

Variant ID Type Subtype PubMed ID
nsv2222 CNV insertion 18451855

Relevant External Links for MIR133A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR133A1 Gene

Disorders for MIR133A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR133A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bladder carcinoma in situ
  • bladder ca in situ
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR133A1

Genetic Association Database (GAD)
MIR133A1
Human Genome Epidemiology (HuGE) Navigator
MIR133A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR133A1
genes like me logo Genes that share disorders with MIR133A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR133A1 Gene

Publications for MIR133A1 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60
  2. miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1. (PMID: 28466778) Li W … Xu Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  3. USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway. (PMID: 28286270) Cai J … Liu A (Biochemical and biophysical research communications 2017) 3 60
  4. Dysregulated miR-133a Mediates Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 9 (MMP9) in Human Intervertebral Disc Degeneration. (PMID: 26656045) Xu YQ … Feng SQ (Spine 2016) 3 60
  5. MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. (PMID: 26936647) Wang J … Yan Y (Molecular medicine reports 2016) 3 60

Products for MIR133A1 Gene

Sources for MIR133A1 Gene

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