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Aliases for MIR132 Gene

Subcategory (RNA class) for MIR132 Gene


Quality Score for this RNA gene is


Aliases for MIR132 Gene

  • MicroRNA 132 2 3
  • Hsa-Mir-132 3
  • MiRNA132 3
  • Mir-132 3
  • MIRN132 3

External Ids for MIR132 Gene

Previous HGNC Symbols for MIR132 Gene

  • MIRN132

Previous GeneCards Identifiers for MIR132 Gene

  • GC17M001927
  • GC17M001930
  • GC17M001953

Summaries for MIR132 Gene

Entrez Gene Summary for MIR132 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR132 Gene

MIR132 (MicroRNA 132) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR132 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR132

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR132 Gene

Genomics for MIR132 Gene

Genomic Location for MIR132 Gene

2,049,908 bp from pter
2,050,008 bp from pter
101 bases
Minus strand

Genomic View for MIR132 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR132 Gene

ORGUL Member Location for MIR132 Gene

ORGUL Member Location for MIR132 gene

No data available for Regulatory Elements for MIR132 Gene

Proteins for MIR132 Gene

Post-translational modifications for MIR132 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR132 Gene

Domains & Families for MIR132 Gene

Gene Families for MIR132 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR132: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR132 Gene

Function for MIR132 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR132 Gene

Localization for MIR132 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR132 Gene

Pathways & Interactions for MIR132 Gene

SuperPathways for MIR132 Gene

No Data Available

Interacting Proteins for MIR132 Gene

Gene Ontology (GO) - Biological Process for MIR132 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR132 Gene

Drugs & Compounds for MIR132 Gene

No Compound Related Data Available

Transcripts for MIR132 Gene

fRNAdb Secondary structures for MIR132 Gene

  • FR274966

mRNA/cDNA for MIR132 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR132 Gene

No ASD Table

Relevant External Links for MIR132 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR132 Gene

mRNA expression in normal human tissues for MIR132 Gene

genes like me logo Genes that share expression patterns with MIR132: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR132 Gene

Orthologs for MIR132 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR132 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-132 36
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-132 36
  • 99 (a)
(Monodelphis domestica)
Mammalia mdo-mir-132 36
  • 92 (a)
(Mus musculus)
Mammalia Mir132 36
  • 98 (a)
(Danio rerio)
Actinopterygii dre-mir-132-3 36
  • 54 (a)
Species with no ortholog for MIR132:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR132 Gene

Gene Tree for MIR132 (if available)
Gene Tree for MIR132 (if available)

Paralogs for MIR132 Gene

No data available for Paralogs for MIR132 Gene

Variants for MIR132 Gene

Sequence variations from dbSNP and Humsavar for MIR132 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2957924 -- 2,049,743(-) GCGCG(G/T)CCTGC downstream-variant-500B
rs3803807 -- 2,049,434(+) GGGGA(C/G)CCTTC downstream-variant-500B
rs3803808 -- 2,049,683(+) GGCTG(A/G)GATAC downstream-variant-500B
rs111329457 -- 2,049,738(+) ACTCC(A/G)CAGGA downstream-variant-500B
rs183274447 -- 2,049,564(+) ACTGT(C/T)TTCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR132 Gene

Variant ID Type Subtype PubMed ID
nsv907523 CNV Loss 21882294
nsv827857 CNV Gain 20364138
nsv907526 CNV Loss 21882294
dgv3035n71 CNV Loss 21882294
esv33884 CNV Gain 17666407

Relevant External Links for MIR132 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR132 Gene

Disorders for MIR132 Gene

Relevant External Links for MIR132

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR132: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR132 Gene

Publications for MIR132 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 67
  2. Upregulation of the miR-212/132 cluster suppresses proliferation of human lung cancer cells. (PMID: 25435090) Jiang X. … Zhou X. (Oncol. Rep. 2015) 67
  3. MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5. (PMID: 25305447) Renjie W. … Haiqian L. (Cancer Lett. 2015) 67
  4. TGF-I^ induced miR-132 enhances the activation of TGF-I^ signaling through inhibiting SMAD7 expression in glioma cells. (PMID: 25983322) Wang Z.H. … Zheng D.L. (Biochem. Biophys. Res. Commun. 2015) 67
  5. Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212. (PMID: 25645730) Tavolaro S. … Guarini A. (Genes Chromosomes Cancer 2015) 67

Products for MIR132 Gene

Sources for MIR132 Gene

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