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Aliases for MIR130B Gene

Subcategory (RNA class) for MIR130B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR130B Gene

  • MicroRNA 130b 2 3 5
  • Hsa-Mir-130b 3
  • Mir-130b 3
  • MIRN130B 3

External Ids for MIR130B Gene

ORGUL Members for MIR130B Gene

Previous HGNC Symbols for MIR130B Gene

  • MIRN130B

Previous GeneCards Identifiers for MIR130B Gene

  • GC22P020340
  • GC22P022008
  • GC22P022009
  • GC22P022012
  • GC22P022017
  • GC22P022023
  • GC22P021778
  • GC22P021817
  • GC22P021833
  • GC22P021861
  • GC22P021877

Summaries for MIR130B Gene

Entrez Gene Summary for MIR130B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130B Gene

MIR130B (MicroRNA 130b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130B Gene

Genomics for MIR130B Gene

Regulatory Elements for MIR130B Gene

Enhancers for MIR130B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G021655 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +4.1 4090 2.9 HDGF HNRNPUL1 MLX CREB3L1 ARID4B SIN3A YBX1 ZNF143 ZNF207 KLF13 PPIL2 THAP7 IGLV5-52 THAP7-AS1 ENSG00000234630 ENSG00000272779 SNAP29 YPEL1 MIR130B ENSG00000272954
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR130B on UCSC Golden Path with GeneCards custom track

Promoters for MIR130B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144040 -1104 1201 HNRNPUL1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF207 KLF7 FOS

Genomic Location for MIR130B Gene

Chromosome:
22
Start:
21,653,304 bp from pter
End:
21,653,385 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR130B Gene

Genes around MIR130B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130B Gene

Proteins for MIR130B Gene

Post-translational modifications for MIR130B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130B Gene

Domains & Families for MIR130B Gene

Gene Families for MIR130B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130B Gene

Function for MIR130B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130B Gene

Localization for MIR130B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR130B Gene

Pathways & Interactions for MIR130B Gene

genes like me logo Genes that share pathways with MIR130B: view

Pathways by source for MIR130B Gene

1 BioSystems pathway for MIR130B Gene

Interacting Proteins for MIR130B Gene

Gene Ontology (GO) - Biological Process for MIR130B Gene

None

No data available for SIGNOR curated interactions for MIR130B Gene

Drugs & Compounds for MIR130B Gene

No Compound Related Data Available

Transcripts for MIR130B Gene

mRNA/cDNA for MIR130B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130B Gene

No ASD Table

Relevant External Links for MIR130B Gene

GeneLoc Exon Structure for
MIR130B
ECgene alternative splicing isoforms for
MIR130B

Expression for MIR130B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR130B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR130B Gene:

MIR130B
genes like me logo Genes that share expression patterns with MIR130B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR130B Gene

Orthologs for MIR130B Gene

Evolution for MIR130B Gene

ENSEMBL:
Gene Tree for MIR130B (if available)
TreeFam:
Gene Tree for MIR130B (if available)

No data available for Orthologs for MIR130B Gene

Paralogs for MIR130B Gene

No data available for Paralogs for MIR130B Gene

Variants for MIR130B Gene

Sequence variations from dbSNP and Humsavar for MIR130B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1001230778 -- 21,652,187(+) TCAGC(C/G)GGTTA upstream-variant-2KB
rs1002427025 -- 21,652,800(+) CCACC(A/T)CAATC upstream-variant-2KB
rs1003179449 -- 21,651,454(+) CCGTT(C/G)AACAG upstream-variant-2KB
rs1004394849 -- 21,653,139(+) CCTCC(C/T)CCCTA downstream-variant-500B, upstream-variant-2KB
rs1005132352 -- 21,651,732(+) CCACG(G/T)CCAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR130B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Relevant External Links for MIR130B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR130B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130B Gene

Disorders for MIR130B Gene

Relevant External Links for MIR130B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR130B

No disorders were found for MIR130B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR130B Gene

Publications for MIR130B Gene

  1. miR-130b-3p inhibits cell invasion and migration by targeting the Notch ligand Delta-like 1 in breast carcinoma. (PMID: 28163094) Shui Y. … Ma C. (Gene 2017) 3 64
  2. Genome-Wide Screen of miRNAs and Targeting mRNAs Reveals the Negatively Regulatory Effect of miR-130b-3p on PTEN by PI3K and Integrin I^1 Signaling Pathways in Bladder Carcinoma. (PMID: 28042869) Lv M. … Chen J. (Int J Mol Sci 2016) 3 64
  3. MicroRNA-130b promotes cell proliferation and invasion by inhibiting peroxisome proliferator-activated receptor-I^ in human glioma cells. (PMID: 27122306) Gu J.J. … Wang S.S. (Int. J. Mol. Med. 2016) 3 64
  4. miR-130b-3p Modulates Epithelial-Mesenchymal Crosstalk in Lung Fibrosis by Targeting IGF-1. (PMID: 26953888) Li S. … Dai H. (PLoS ONE 2016) 3 64
  5. [The expression and clinopathological significance of miR-130b in human hepatocellular carcinoma]. (PMID: 26927562) Xu Q. … Liu X. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2016) 3 64

Products for MIR130B Gene

Sources for MIR130B Gene

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