Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR130B Gene

Subcategory (RNA class) for MIR130B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR130B Gene

  • MicroRNA 130b 2 3 5
  • Hsa-Mir-130b 3
  • Mir-130b 3
  • MIRN130B 3

External Ids for MIR130B Gene

Previous HGNC Symbols for MIR130B Gene

  • MIRN130B

Previous GeneCards Identifiers for MIR130B Gene

  • GC22P020340
  • GC22P022008
  • GC22P022009
  • GC22P022012
  • GC22P022017
  • GC22P022023
  • GC22P021778
  • GC22P021817
  • GC22P021833
  • GC22P021861

Summaries for MIR130B Gene

Entrez Gene Summary for MIR130B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130B Gene

MIR130B (MicroRNA 130b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130B Gene

Genomics for MIR130B Gene

Regulatory Elements for MIR130B Gene

Enhancers for MIR130B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F021580 0.2 Ensembl 11.2 -72.2 -72170 0.2 BCOR BRD4 HDGF ZMYM3 RELA CTBP1 POLR2A ADNP HLF NRF1 CCDC116 YDJC SDF2L1 MIR130B MIR301B PPIL2 ENSG00000275293 PIR33609
GH22F021582 0.4 Ensembl 11.2 -69.4 -69370 0.2 ZNF263 ZNF687 NR4A1 CEBPB IRF9 ZFHX2 KLF13 EGR2 CCDC116 YDJC SDF2L1 MIR130B MIR301B PPIL2 ENSG00000275293 PIR33609
GH22F021650 0.2 ENCODE 0.8 +0.1 62 2.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 KLF7 FOS KLF13 PPIL2 THAP7 IGLV5-52 THAP7-AS1 CCDC116 YDJC ABHD17AP4 ENSG00000234630 ENSG00000272779 GC22P021882
GH22F021643 0.2 ENCODE 0.4 -8.4 -8424 0.2 GATA2 POLR2A NR4A1 HDAC8 E2F6 KLF13 SETDB1 PIR47183 MIR130B
GH22F021646 0.5 ENCODE 0.4 -5.2 -5199 0.8 ELF3 CTCF IRF2 SAP130 TBL1XR1 ARID4B RAD21 ZKSCAN1 ZNF121 FOSL1 PPIL2 PIR47183 MIR130B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR130B on UCSC Golden Path with GeneCards custom track

Promoters for MIR130B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000615629 130 2001 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 KLF7 FOS KLF13 SP3

Genomic Location for MIR130B Gene

Chromosome:
22
Start:
21,652,270 bp from pter
End:
21,670,237 bp from pter
Size:
17,968 bases
Orientation:
Plus strand

Genomic View for MIR130B Gene

Genes around MIR130B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130B Gene

Proteins for MIR130B Gene

Post-translational modifications for MIR130B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130B Gene

Domains & Families for MIR130B Gene

Gene Families for MIR130B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130B Gene

Function for MIR130B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130B Gene

Localization for MIR130B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR130B Gene

Pathways & Interactions for MIR130B Gene

genes like me logo Genes that share pathways with MIR130B: view

Pathways by source for MIR130B Gene

1 BioSystems pathway for MIR130B Gene

Interacting Proteins for MIR130B Gene

Gene Ontology (GO) - Biological Process for MIR130B Gene

None

No data available for SIGNOR curated interactions for MIR130B Gene

Transcripts for MIR130B Gene

mRNA/cDNA for MIR130B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130B Gene

No ASD Table

Relevant External Links for MIR130B Gene

GeneLoc Exon Structure for
MIR130B
ECgene alternative splicing isoforms for
MIR130B

Expression for MIR130B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR130B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR130B Gene:

MIR130B
genes like me logo Genes that share expression patterns with MIR130B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR130B Gene

Orthologs for MIR130B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR130B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-130b 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-130b 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-130b 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir130b 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130b 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-130c 35
  • 58 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-130a 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-130c 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130b 35
  • 77 (a)
OneToOne
Species where no ortholog for MIR130B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR130B Gene

ENSEMBL:
Gene Tree for MIR130B (if available)
TreeFam:
Gene Tree for MIR130B (if available)

Paralogs for MIR130B Gene

No data available for Paralogs for MIR130B Gene

Variants for MIR130B Gene

Sequence variations from dbSNP and Humsavar for MIR130B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs113004736 -- 21,653,298(+) AGGCA(C/T)TGGCA downstream-variant-500B, upstream-variant-2KB
rs114836161 -- 21,651,522(+) TCTCC(A/G)CAAAG upstream-variant-2KB
rs12628594 -- 21,651,590(+) GATCC(A/C)AAAGA upstream-variant-2KB
rs140403670 -- 21,653,372(+) AAAGG(A/G)CATCG nc-transcript-variant, downstream-variant-500B
rs143383459 -- 21,652,716(+) CTTTG(A/T)GTGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR130B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Relevant External Links for MIR130B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR130B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130B Gene

Disorders for MIR130B Gene

Relevant External Links for MIR130B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR130B

No disorders were found for MIR130B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR130B Gene

Publications for MIR130B Gene

  1. miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells. (PMID: 26902120) Li Z. … Zeng X. (Biochem. Biophys. Res. Commun. 2016) 3 64
  2. miR-130b-3p Modulates Epithelial-Mesenchymal Crosstalk in Lung Fibrosis by Targeting IGF-1. (PMID: 26953888) Li S. … Dai H. (PLoS ONE 2016) 3 64
  3. [The expression and clinopathological significance of miR-130b in human hepatocellular carcinoma]. (PMID: 26927562) Xu Q. … Liu X. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2016) 3 64
  4. Identification of miRa89130b as an oncogene in renal cell carcinoma. (PMID: 26717956) Li Y. … Lai Y. (Mol Med Rep 2016) 3 64
  5. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T. … Chan S.Y. (J. Biol. Chem. 2015) 3 64

Products for MIR130B Gene

Sources for MIR130B Gene

Content
Loading form....