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Aliases for MIR130B Gene

Subcategory (RNA class) for MIR130B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR130B Gene

  • MicroRNA 130b 2 3 5
  • Hsa-Mir-130b 3
  • Mir-130b 3
  • MIRN130B 3

External Ids for MIR130B Gene

ORGUL Members for MIR130B Gene

Previous HGNC Symbols for MIR130B Gene

  • MIRN130B

Previous GeneCards Identifiers for MIR130B Gene

  • GC22P020340
  • GC22P022008
  • GC22P022009
  • GC22P022012
  • GC22P022017
  • GC22P022023
  • GC22P021778
  • GC22P021817

Summaries for MIR130B Gene

Entrez Gene Summary for MIR130B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130B Gene

MIR130B (MicroRNA 130b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130B Gene

Genomics for MIR130B Gene

Regulatory Elements for MIR130B Gene

Promoters for MIR130B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR130B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR130B Gene

Chromosome:
22
Start:
21,653,304 bp from pter
End:
21,653,385 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR130B Gene

Genes around MIR130B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130B Gene

Proteins for MIR130B Gene

Post-translational modifications for MIR130B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130B Gene

Domains & Families for MIR130B Gene

Gene Families for MIR130B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130B Gene

Function for MIR130B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130B Gene

Localization for MIR130B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR130B Gene

Pathways & Interactions for MIR130B Gene

genes like me logo Genes that share pathways with MIR130B: view

Pathways by source for MIR130B Gene

1 BioSystems pathway for MIR130B Gene

Interacting Proteins for MIR130B Gene

Gene Ontology (GO) - Biological Process for MIR130B Gene

None

No data available for SIGNOR curated interactions for MIR130B Gene

Drugs & Compounds for MIR130B Gene

No Compound Related Data Available

Transcripts for MIR130B Gene

mRNA/cDNA for MIR130B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130B Gene

No ASD Table

Relevant External Links for MIR130B Gene

GeneLoc Exon Structure for
MIR130B
ECgene alternative splicing isoforms for
MIR130B

Expression for MIR130B Gene

mRNA expression in normal human tissues for MIR130B Gene

genes like me logo Genes that share expression patterns with MIR130B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR130B Gene

Orthologs for MIR130B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR130B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-130b 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-130b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130b 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir130b 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
oan-mir-130c 36
  • 58 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-130b 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-130a 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-130c 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130b 36
  • 77 (a)
OneToOne
Species with no ortholog for MIR130B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR130B Gene

ENSEMBL:
Gene Tree for MIR130B (if available)
TreeFam:
Gene Tree for MIR130B (if available)

Paralogs for MIR130B Gene

No data available for Paralogs for MIR130B Gene

Variants for MIR130B Gene

Sequence variations from dbSNP and Humsavar for MIR130B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs34237391 -- 21,653,753(+) CCAGT(-/C)CCTTG downstream-variant-500B
rs59398496 -- 21,653,601(+) GCAGA(C/T)CTCCC downstream-variant-500B
rs144882595 -- 21,653,807(+) TGGGT(A/G)GCAGT downstream-variant-500B
rs150287538 -- 21,653,755(+) CAGTC(C/G)TTGCT downstream-variant-500B
rs537668631 -- 21,653,824(+) AGGGG(A/G)TAAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR130B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv914458 CNV Loss 21882294
dgv4881n71 CNV Loss 21882294
dgv4882n71 CNV Loss 21882294
nsv914469 CNV Loss 21882294

Relevant External Links for MIR130B Gene

HapMap Linkage Disequilibrium report
MIR130B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130B Gene

Disorders for MIR130B Gene

Relevant External Links for MIR130B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR130B

No disorders were found for MIR130B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR130B Gene

Publications for MIR130B Gene

  1. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T. … Chan S.Y. (J. Biol. Chem. 2015) 3
  2. MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer. (PMID: 24468585) Zhu J. … Zhang X. (Hum. Immunol. 2014) 3
  3. MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin I^1 [corrected]. (PMID: 24498407) Zhao Y. … Qi R. (PLoS ONE 2014) 3
  4. Mir-23b and miR-130b expression is downregulated in pituitary adenomas. (PMID: 24681352) Leone V. … Fusco A. (Mol. Cell. Endocrinol. 2014) 3
  5. MicroRNA 130b enhances drug resistance in human ovarian cancer cells. (PMID: 25155039) Zong C. … Shi T.M. (Tumour Biol. 2014) 3

Products for MIR130B Gene

Sources for MIR130B Gene

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