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Aliases for MIR130B Gene

Subcategory (RNA class) for MIR130B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR130B Gene

  • MicroRNA 130b 2 3 5
  • Hsa-Mir-130b 3
  • Mir-130b 3
  • MIRN130B 3

External Ids for MIR130B Gene

Previous HGNC Symbols for MIR130B Gene

  • MIRN130B

Previous GeneCards Identifiers for MIR130B Gene

  • GC22P020340
  • GC22P022008
  • GC22P022009
  • GC22P022012
  • GC22P022017
  • GC22P022023
  • GC22P021778
  • GC22P021817
  • GC22P021833
  • GC22P021861
  • GC22P021877
  • GC22P021915
  • GC22P021953

Summaries for MIR130B Gene

Entrez Gene Summary for MIR130B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130B Gene

MIR130B (MicroRNA 130b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

Additional gene information for MIR130B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130B Gene

Genomics for MIR130B Gene

GeneHancer (GH) Regulatory Elements for MIR130B Gene

Promoters and enhancers for MIR130B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I021650 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 550.8 -1.0 -973 2.8 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 GATA2 GC22P021989 GC22P021991 MIR130B MIR301B PPIL2 CCDC116 YDJC ABHD17AP4 PIR47183
GH22I021655 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.8 +4.1 4090 2.9 HDGF SMAD1 MLX ARID4B ZNF48 ZNF121 GLIS2 GATA2 ZNF207 ZNF143 ENSG00000284630 PPIL2 SNAP29 YPEL1 MIR130B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR130B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR130B Gene

Genomic Locations for MIR130B Gene
chr22:21,653,304-21,653,385
(GRCh38/hg38)
Size:
82 bases
Orientation:
Plus strand
chr22:22,007,593-22,007,674
(GRCh37/hg19)

Genomic View for MIR130B Gene

Genes around MIR130B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130B Gene

Proteins for MIR130B Gene

Post-translational modifications for MIR130B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130B Gene

Domains & Families for MIR130B Gene

Gene Families for MIR130B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130B Gene

Function for MIR130B Gene

Gene Ontology (GO) - Molecular Function for MIR130B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26501192
genes like me logo Genes that share ontologies with MIR130B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130B Gene

Localization for MIR130B Gene

Gene Ontology (GO) - Cellular Components for MIR130B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR130B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR130B Gene

Pathways & Interactions for MIR130B Gene

genes like me logo Genes that share pathways with MIR130B: view

Pathways by source for MIR130B Gene

1 BioSystems pathway for MIR130B Gene

Interacting Proteins for MIR130B Gene

Gene Ontology (GO) - Biological Process for MIR130B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 26501192
GO:0042953 lipoprotein transport IDA 26501192
GO:0090370 negative regulation of cholesterol efflux IDA 26501192
genes like me logo Genes that share ontologies with MIR130B: view

No data available for SIGNOR curated interactions for MIR130B Gene

Drugs & Compounds for MIR130B Gene

No Compound Related Data Available

Transcripts for MIR130B Gene

mRNA/cDNA for MIR130B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130B Gene

No ASD Table

Relevant External Links for MIR130B Gene

GeneLoc Exon Structure for
MIR130B
ECgene alternative splicing isoforms for
MIR130B

Expression for MIR130B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR130B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR130B Gene:

MIR130B
genes like me logo Genes that share expression patterns with MIR130B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR130B Gene

Orthologs for MIR130B Gene

Evolution for MIR130B Gene

ENSEMBL:
Gene Tree for MIR130B (if available)
TreeFam:
Gene Tree for MIR130B (if available)

No data available for Orthologs for MIR130B Gene

Paralogs for MIR130B Gene

No data available for Paralogs for MIR130B Gene

Variants for MIR130B Gene

Sequence variations from dbSNP and Humsavar for MIR130B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1001230778 -- 21,652,187(+) G/C upstream_transcript_variant
rs1002427025 -- 21,652,800(+) T/A upstream_transcript_variant
rs1003179449 -- 21,651,454(+) C/G upstream_transcript_variant
rs1004394849 -- 21,653,139(+) C/T upstream_transcript_variant
rs1005132352 -- 21,651,732(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR130B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Additional Variant Information for MIR130B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR130B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130B Gene

Disorders for MIR130B Gene

Additional Disease Information for MIR130B

No disorders were found for MIR130B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR130B Gene

Publications for MIR130B Gene

  1. miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. (PMID: 28748534) Satterfield L … Yustein JT (International journal of cancer 2017) 3 58
  2. C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition. (PMID: 28192399) Cannistraci A … Bonci D (Oncogene 2017) 3 58
  3. miR-130b-3p inhibits cell invasion and migration by targeting the Notch ligand Delta-like 1 in breast carcinoma. (PMID: 28163094) Shui Y … Ma C (Gene 2017) 3 58
  4. MTDH promotes glioma invasion through regulating miR-130b-ceRNAs. (PMID: 28107197) Tong L … Wei L (Oncotarget 2017) 3 58
  5. NRP1 is targeted by miR-130a and miR-130b, and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis. (PMID: 26573160) Chen C … Li L (Molecular medicine reports 2016) 3 58

Products for MIR130B Gene

Sources for MIR130B Gene

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