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Aliases for MIR130A Gene

Subcategory (RNA class) for MIR130A Gene

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Quality Score for this RNA gene is

3

Aliases for MIR130A Gene

  • MicroRNA 130a 2 3 5
  • Hsa-Mir-130a 3
  • MiRNA130A 3
  • Mir-130a 3
  • MIRN130A 3

External Ids for MIR130A Gene

ORGUL Members for MIR130A Gene

Previous HGNC Symbols for MIR130A Gene

  • MIRN130A

Previous GeneCards Identifiers for MIR130A Gene

  • GC11P057169
  • GC11P057408

Summaries for MIR130A Gene

Entrez Gene Summary for MIR130A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130A Gene

MIR130A (MicroRNA 130a) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Hematopoietic Stem Cell Differentiation and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways.

Additional gene information for MIR130A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130A Gene

Genomics for MIR130A Gene

GeneHancer (GH) Regulatory Elements for MIR130A Gene

Promoters and enhancers for MIR130A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057637 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.7 -1684 4.5 HDGF FOXA2 ARID4B SIN3A GLI4 ZNF48 YY1 ETS1 SLC30A9 GLIS2 ENSG00000254602 MIR130A UBE2L6 RPS4XP13 SERPING1 MED19 TIMM10 PRG3 YPEL4 OR9Q1
GH11I057529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 -110.5 -110509 2.5 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 TIMM10 PIR40820 PIR39300 SSRP1 CLP1 MIR130A UBE2L6 RPS4XP13 ENSG00000254602 YPEL4
GH11I057496 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 10.8 -141.3 -141269 6.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 TIMM10 RTN4RL2 RN7SKP259 MIR130A SLC43A3 ENSG00000254979 P2RX3 SSRP1 ENSG00000254602 CLP1
GH11I057527 Enhancer 0.9 ENCODE 10.3 -113.9 -113855 0.2 HDAC1 HDGF RB1 ARNT ARID4B SIN3A ZNF2 ZSCAN9 RAD21 SLC30A9 RN7SL605P PIR40820 PIR39300 SSRP1 RTN4RL2 RN7SKP259 P2RX3 MIR130A SLC43A3 ENSG00000254602
GH11I057395 Enhancer 0.9 dbSUPER 9.5 -244.9 -244926 1.4 HDGF HDAC1 YBX3 NFRKB TCF12 ZNF766 GATA2 ATF7 RXRA ZBTB2 SSRP1 SLC43A3 CLP1 PRG2 ENSG00000254979 TIMM10 RN7SKP259 RTN4RL2 ENSG00000254662 TNKS1BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR130A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR130A Gene

Genomic Locations for MIR130A Gene
chr11:57,641,198-57,641,286
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr11:57,408,671-57,408,759
(GRCh37/hg19)

Genomic View for MIR130A Gene

Genes around MIR130A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130A Gene

Proteins for MIR130A Gene

Post-translational modifications for MIR130A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130A Gene

Domains & Families for MIR130A Gene

Gene Families for MIR130A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130A Gene

Function for MIR130A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130A Gene

Localization for MIR130A Gene

Gene Ontology (GO) - Cellular Components for MIR130A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR130A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR130A Gene

Pathways & Interactions for MIR130A Gene

genes like me logo Genes that share pathways with MIR130A: view

Pathways by source for MIR130A Gene

Interacting Proteins for MIR130A Gene

Gene Ontology (GO) - Biological Process for MIR130A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045766 positive regulation of angiogenesis IMP 23136161
genes like me logo Genes that share ontologies with MIR130A: view

No data available for SIGNOR curated interactions for MIR130A Gene

Drugs & Compounds for MIR130A Gene

No Compound Related Data Available

Transcripts for MIR130A Gene

mRNA/cDNA for MIR130A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130A Gene

No ASD Table

Relevant External Links for MIR130A Gene

GeneLoc Exon Structure for
MIR130A
ECgene alternative splicing isoforms for
MIR130A

Expression for MIR130A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR130A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR130A Gene:

MIR130A
genes like me logo Genes that share expression patterns with MIR130A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR130A Gene

Orthologs for MIR130A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR130A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-130a 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130a 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-130a 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-130a 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir130a 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-130a 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-130c 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-130a-2 34
  • 65 (a)
OneToMany
aca-mir-130a-1 34
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130c-1 34
  • 38 (a)
ManyToMany
Species where no ortholog for MIR130A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR130A Gene

ENSEMBL:
Gene Tree for MIR130A (if available)
TreeFam:
Gene Tree for MIR130A (if available)

Paralogs for MIR130A Gene

No data available for Paralogs for MIR130A Gene

Variants for MIR130A Gene

Sequence variations from dbSNP and Humsavar for MIR130A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000153126 -- 57,640,897(+) T/C upstream_transcript_variant
rs1000232063 -- 57,640,641(+) G/A upstream_transcript_variant
rs1000890600 -- 57,640,512(+) C/T upstream_transcript_variant
rs1001388447 -- 57,639,894(+) G/A upstream_transcript_variant
rs1005742064 -- 57,639,323(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR130A Gene

Variant ID Type Subtype PubMed ID
esv992553 CNV deletion 20482838
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Additional Variant Information for MIR130A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR130A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130A Gene

Disorders for MIR130A Gene

Additional Disease Information for MIR130A

No disorders were found for MIR130A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR130A Gene

Publications for MIR130A Gene

  1. miR-130a Deregulates PTEN and Stimulates Tumor Growth. (PMID: 28935812) Wei H … Croce CM (Cancer research 2017) 3 58
  2. Downregulation of miR-130a promotes cell growth and epithelial to mesenchymal transition by activating HMGB2 in glioma. (PMID: 28851665) Tang C … Qi S (The international journal of biochemistry & cell biology 2017) 3 58
  3. Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China. (PMID: 28628920) Jia QW … Jia EZ (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  4. Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene. (PMID: 28514291) An Z … Fu JL (Medicine 2017) 3 58
  5. Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor 2 through FAK/PI3K/Rac1/mdm2 signaling. (PMID: 28393235) Gao F … Huo R (International journal of oncology 2017) 3 58

Products for MIR130A Gene

Sources for MIR130A Gene

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