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Aliases for MIR130A Gene

Subcategory (RNA class) for MIR130A Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR130A Gene

  • MicroRNA 130a 2 3 5
  • Hsa-Mir-130a 3
  • MiRNA130A 3
  • Mir-130a 3
  • MIRN130A 3

External Ids for MIR130A Gene

ORGUL Members for MIR130A Gene

Previous HGNC Symbols for MIR130A Gene

  • MIRN130A

Previous GeneCards Identifiers for MIR130A Gene

  • GC11P057169
  • GC11P057408

Summaries for MIR130A Gene

Entrez Gene Summary for MIR130A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130A Gene

MIR130A (MicroRNA 130a) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Hematopoietic Stem Cell Differentiation.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130A Gene

Genomics for MIR130A Gene

Regulatory Elements for MIR130A Gene

Enhancers for MIR130A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G057496 1.6 Ensembl ENCODE dbSUPER 10.7 -141.3 -141270 6.7 HDGF PKNOX1 FOXA2 ARID4B DMAP1 YY1 FOS SP3 SP5 JUNB TIMM10 RTN4RL2 RN7SKP259 MIR130A SLC43A3 ENSG00000254979 SSRP1 P2RX3 ENSG00000254602 CLP1
GH11G057529 1.1 ENCODE 11.5 -110.5 -110509 2.5 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MIR130A UBE2L6 RPS4XP13 ENSG00000254602 CLP1 YPEL4 P2RX3 SSRP1 RTN4RL2 RN7SKP259
GH11G057527 0.9 ENCODE 10.3 -113.9 -113856 0.2 HDAC1 HDGF RB1 TBL1XR1 ARNT ZFP64 ARID4B ZNF2 ZSCAN9 RAD21 RTN4RL2 RN7SKP259 P2RX3 SSRP1 MIR130A SLC43A3 ENSG00000254602 ENSG00000254979 CLP1 YPEL4
GH11G057552 0.8 ENCODE 11.4 -88.6 -88556 0.1 SOX13 SAP130 CEBPG ZNF644 TEAD3 NR2F6 CREM TCF7L2 GATAD2A TEAD1 TIMM10 MIR130A SLC43A1 SERPING1 ENSG00000254979 SLC43A3 SMTNL1 UBE2L6
GH11G057395 0.9 dbSUPER 9.5 -244.9 -244926 1.4 HDAC1 YBX3 HDGF NFRKB TCF12 ZNF766 GATA2 ZBTB2 ZBTB11 CEBPB SLC43A3 PRG2 ENSG00000254979 TIMM10 RN7SKP259 RTN4RL2 TNKS1BP1 ENSG00000254662 SSRP1 P2RX3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR130A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR130A Gene

Chromosome:
11
Start:
57,641,198 bp from pter
End:
57,641,286 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR130A Gene

Genes around MIR130A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130A Gene

Proteins for MIR130A Gene

Post-translational modifications for MIR130A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130A Gene

Domains & Families for MIR130A Gene

Gene Families for MIR130A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130A Gene

Function for MIR130A Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130A Gene

Localization for MIR130A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR130A Gene

Pathways & Interactions for MIR130A Gene

genes like me logo Genes that share pathways with MIR130A: view

Pathways by source for MIR130A Gene

Interacting Proteins for MIR130A Gene

Gene Ontology (GO) - Biological Process for MIR130A Gene

None

No data available for SIGNOR curated interactions for MIR130A Gene

Drugs & Compounds for MIR130A Gene

No Compound Related Data Available

Transcripts for MIR130A Gene

mRNA/cDNA for MIR130A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130A Gene

No ASD Table

Relevant External Links for MIR130A Gene

GeneLoc Exon Structure for
MIR130A
ECgene alternative splicing isoforms for
MIR130A

Expression for MIR130A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR130A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR130A Gene:

MIR130A
genes like me logo Genes that share expression patterns with MIR130A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR130A Gene

Orthologs for MIR130A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR130A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-130a 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130a 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-130a 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-130a 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir130a 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-130a 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-130c 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-130a-2 35
  • 65 (a)
OneToMany
aca-mir-130a-1 35
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130c-1 35
  • 38 (a)
ManyToMany
Species where no ortholog for MIR130A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR130A Gene

ENSEMBL:
Gene Tree for MIR130A (if available)
TreeFam:
Gene Tree for MIR130A (if available)

Paralogs for MIR130A Gene

No data available for Paralogs for MIR130A Gene

Variants for MIR130A Gene

Sequence variations from dbSNP and Humsavar for MIR130A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000153126 -- 57,640,897(+) GGGGA(C/T)TGCTA upstream-variant-2KB
rs1000232063 -- 57,640,641(+) TCCCC(A/G)CCTGG upstream-variant-2KB
rs1000890600 -- 57,640,512(+) GAAAG(C/T)CTATC upstream-variant-2KB
rs1001388447 -- 57,639,894(+) ATCCA(A/G)TTCCC upstream-variant-2KB
rs1005742064 -- 57,639,323(+) TGAAG(A/G)AGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR130A Gene

Variant ID Type Subtype PubMed ID
esv992553 CNV deletion 20482838
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Relevant External Links for MIR130A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR130A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130A Gene

Disorders for MIR130A Gene

Relevant External Links for MIR130A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR130A

No disorders were found for MIR130A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR130A Gene

Publications for MIR130A Gene

  1. microRNA-130a Promotes Human Keratinocyte Viability and Migration and Inhibits Apoptosis Through Direct Regulation of STK40-Mediated NF-I_B Pathway and Indirect Regulation of SOX9-Meditated JNK/MAPK Pathway: A Potential Role in Psoriasis. (PMID: 28085489) Xiong Y. … Zhao Y. (DNA Cell Biol. 2017) 3 64
  2. Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke. (PMID: 27246008) Choi G.H. … Kim N.K. (Int. J. Mol. Med. 2016) 3 64
  3. Nuclear factor-I_B-dependent microRNA-130a upregulation promotes cervical cancer cell growth by targeting phosphatase and tensin homolog. (PMID: 27040383) Feng Y. … Sun L. (Arch. Biochem. Biophys. 2016) 3 64
  4. MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN. (PMID: 27035216) Chen J. … Shu Q. (Oncol. Rep. 2016) 3 64
  5. MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells. (PMID: 26817584) Liu Y. … Wu Q. (J. Exp. Clin. Cancer Res. 2016) 3 64

Products for MIR130A Gene

Sources for MIR130A Gene

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