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Aliases for MIR130A Gene

Subcategory (RNA class) for MIR130A Gene

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Quality Score for this RNA gene is

3

Aliases for MIR130A Gene

  • MicroRNA 130a 2 3
  • MIRN130A 3 6
  • Hsa-Mir-130a 3
  • MiRNA130A 3

External Ids for MIR130A Gene

ORGUL Members for MIR130A Gene

Previous Symbols for MIR130A Gene

  • MIRN130A

Summaries for MIR130A Gene

Entrez Gene Summary for MIR130A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130A Gene

MIR130A (MicroRNA 130a) is a RNA Gene, and belongs to undefined RNA class. Diseases associated with MIR130A include hepatitis c virus.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130A Gene

Genomics for MIR130A Gene

Genomic Location for MIR130A Gene

Start:
57,641,198 bp from pter
End:
57,641,286 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR130A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR130A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130A Gene

No data available for Regulatory Elements for MIR130A Gene

Proteins for MIR130A Gene

Post-translational modifications for MIR130A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130A Gene

Domains for MIR130A Gene

Gene Families for MIR130A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR130A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR130A Gene

Function for MIR130A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR130A Gene

Localization for MIR130A Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR130A Gene

Pathways for MIR130A Gene

SuperPathways for MIR130A Gene

No Data Available

Interacting Proteins for MIR130A Gene

Gene Ontology (GO) - Biological Process for MIR130A Gene

None

No data available for Pathways by source for MIR130A Gene

Transcripts for MIR130A Gene

mRNA/cDNA for MIR130A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130A Gene

No ASD Table

Relevant External Links for MIR130A Gene

GeneLoc Exon Structure for
MIR130A
ECgene alternative splicing isoforms for
MIR130A

Expression for MIR130A Gene

mRNA expression in normal human tissues for MIR130A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR130A: view

Orthologs for MIR130A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR130A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-130a 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-130a 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-130a 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir130a 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130a 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-130a 37
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-130c 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-130a-1 37
  • 64 (a)
OneToMany
aca-mir-130a-2 37
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130c-1 37
  • 38 (a)
ManyToMany
Species with no ortholog for MIR130A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR130A Gene

ENSEMBL:
Gene Tree for MIR130A (if available)
TreeFam:
Gene Tree for MIR130A (if available)

Paralogs for MIR130A Gene

No data available for Paralogs for MIR130A Gene

Variants for MIR130A Gene

Sequence variations from dbSNP and Humsavar for MIR130A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs731384 -- 57,640,909(-) GAAAA(C/T)GGCTA upstream-variant-2KB
rs3974449 -- 57,641,306(-) GCTGA(-/GGA)GGCAG downstream-variant-500B
rs10579466 -- 57,639,225(+) GAGTT(-/TG)TGTGT upstream-variant-2KB
rs12787077 -- 57,639,249(+) gtgtg(G/T)ggtgt upstream-variant-2KB
rs34500536 -- 57,641,304(+) GGCTG(-/CCT)CCTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR130A Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
esv992553 CNV Deletion 20482838

Relevant External Links for MIR130A Gene

HapMap Linkage Disequilibrium report
MIR130A

Disorders for MIR130A Gene

(1) MalaCards Diseases for MIR130A Gene

Search for MIR130A Gene in MalaCards »
genes like me logo Genes that share disorders with MIR130A: view

No data available for UniProtKB/Swiss-Prot for MIR130A Gene

Publications for MIR130A Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. MicroRNA fingerprints during human megakaryocytopoiesis. (PMID: 16549775) Garzon R. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3

Products for MIR130A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR130A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR130A
    • Block miRNA regulation of MIR130A using miScript Target Protectors

    Sources for MIR130A Gene

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