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Aliases for MIR1304 Gene

Subcategory (RNA class) for MIR1304 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1304 Gene

  • MicroRNA 1304 2 3
  • TAF1D 4 5
  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit D 5
  • RNA Polymerase I-Specific TBP-Associated Factor 41 KDa 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit D 4
  • TATA Box-Binding Protein-Associated Factor 1D 4
  • TBP-Associated Factor 1D 4
  • Hsa-Mir-1304 3
  • MIRN1304 3
  • TAFI41 4
  • JOSD3 4

External Ids for MIR1304 Gene

Previous HGNC Symbols for MIR1304 Gene

  • MIRN1304

Previous GeneCards Identifiers for MIR1304 Gene

  • GC00U922944
  • GC11M093196
  • GC11M093466
  • GC11M093739
  • GC11M093751
  • GC11M093761
  • GC11M093771

Summaries for MIR1304 Gene

Entrez Gene Summary for MIR1304 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1304 Gene

MIR1304 (MicroRNA 1304) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase I Promoter Escape.

UniProtKB/Swiss-Prot for MIR1304 Gene

  • Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1304 Gene

Genomics for MIR1304 Gene

Regulatory Elements for MIR1304 Gene

Enhancers for MIR1304 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F093733 0.6 ENCODE 11.5 +46.1 46056 9.9 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 CBX5 FOS MED17 C11orf54 CEP295 ANKRD49 MRE11 MIR1304 TAF1D ENSG00000255445 SNORA1 SMCO4
GH11F093654 0.6 Ensembl ENCODE 11 +129.0 128991 1.6 GATA3 SCRT2 MAX C11orf54 MIR1304 TAF1D SNORA1 SNORA25 SNORA32 SNORD6 MED17 SNORA18 SNORA40
GH11F093814 0.4 ENCODE 10.8 -30.9 -30852 1.9 POLR2A HLF C11orf54 VSTM5 MED17 MIR1304 TAF1D GC11P093800 GC11P093828
GH11F093817 0.5 ENCODE 10.7 -33.2 -33213 0.8 C11orf54 VSTM5 MED17 MIR1304 TAF1D GC11P093828 GC11P093800
GH11F093818 0.2 ENCODE 10.7 -33.7 -33739 0.2 VSTM5 MED17 MIR1304 TAF1D GC11P093828 GC11P093800
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1304 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1304 Gene

Chromosome:
11
Start:
93,729,948 bp from pter
End:
93,784,391 bp from pter
Size:
54,444 bases
Orientation:
Minus strand

Genomic View for MIR1304 Gene

Genes around MIR1304 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1304 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1304 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1304 Gene

Proteins for MIR1304 Gene

  • Protein details for MIR1304 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5J8-TAF1D_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit D
    Protein Accession:
    Q9H5J8
    Secondary Accessions:
    • Q6I9Y6

    Protein attributes for MIR1304 Gene

    Size:
    278 amino acids
    Molecular mass:
    32058 Da
    Quaternary structure:
    • Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
    • Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.

neXtProt entry for MIR1304 Gene

Post-translational modifications for MIR1304 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR1304 Gene

Domains & Families for MIR1304 Gene

Gene Families for MIR1304 Gene

Protein Domains for MIR1304 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1304: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1304 Gene

Function for MIR1304 Gene

Molecular function for MIR1304 Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1304 Gene

Localization for MIR1304 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1304 Gene

Gene Ontology (GO) - Cellular Components for MIR1304 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005668 RNA polymerase transcription factor SL1 complex IEA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with MIR1304: view

No data available for Subcellular locations from COMPARTMENTS for MIR1304 Gene

Pathways & Interactions for MIR1304 Gene

genes like me logo Genes that share pathways with MIR1304: view

Gene Ontology (GO) - Biological Process for MIR1304 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
genes like me logo Genes that share ontologies with MIR1304: view

No data available for SIGNOR curated interactions for MIR1304 Gene

Transcripts for MIR1304 Gene

mRNA/cDNA for MIR1304 Gene

(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1304 Gene

No ASD Table

Relevant External Links for MIR1304 Gene

GeneLoc Exon Structure for
MIR1304
ECgene alternative splicing isoforms for
MIR1304

Expression for MIR1304 Gene

mRNA expression in normal human tissues for MIR1304 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1304 Gene:

MIR1304
genes like me logo Genes that share expression patterns with MIR1304: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1304 Gene

Orthologs for MIR1304 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR1304 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF1D 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TAF1D 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf1d 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF1D 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF1D 35
  • 10 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF1D 35
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF1D 35
  • 36 (a)
OneToOne
Species where no ortholog for MIR1304 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1304 Gene

ENSEMBL:
Gene Tree for MIR1304 (if available)
TreeFam:
Gene Tree for MIR1304 (if available)

Paralogs for MIR1304 Gene

No data available for Paralogs for MIR1304 Gene

Variants for MIR1304 Gene

Sequence variations from dbSNP and Humsavar for MIR1304 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1063080 -- 93,734,928(-) AAATT(A/G)GCTGG downstream-variant-500B, upstream-variant-2KB
rs115206477 -- 93,734,089(+) CTTCA(A/G)TATTG upstream-variant-2KB
rs116789819 -- 93,734,702(+) TGAAA(C/T)TGGAA downstream-variant-500B, upstream-variant-2KB
rs116863270 -- 93,735,514(+) AAAAA(A/T)ACAAA intron-variant, upstream-variant-2KB
rs116938419 -- 93,733,912(+) CAACT(C/G)CAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1304 Gene

Variant ID Type Subtype PubMed ID
esv3627294 CNV gain 21293372
nsv832232 CNV gain 17160897

Relevant External Links for MIR1304 Gene

Human Gene Mutation Database (HGMD)
MIR1304
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1304

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1304 Gene

Disorders for MIR1304 Gene

Relevant External Links for MIR1304

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1304

No disorders were found for MIR1304 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1304 Gene

Publications for MIR1304 Gene

  1. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64
  4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64
  5. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64

Products for MIR1304 Gene

Sources for MIR1304 Gene

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