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Aliases for MIR1292 Gene

Subcategory (RNA class) for MIR1292 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1292 Gene

  • MicroRNA 1292 2 3
  • NOP56 4 5
  • NOP56 Ribonucleoprotein 5
  • Nucleolar Protein 5A 4
  • Hsa-Mir-1292 3
  • Mir-1292 3
  • MIRN1292 3
  • NOL5A 4

External Ids for MIR1292 Gene

Previous HGNC Symbols for MIR1292 Gene

  • MIRN1292

Previous GeneCards Identifiers for MIR1292 Gene

  • GC00U922844
  • GC20P002614
  • GC20P002634
  • GC20P002641
  • GC20P002650
  • GC20P002660
  • GC20P002672
  • GC20P002683
  • GC20P002692
  • GC20P002700
  • GC20P002712
  • GC20P002725
  • GC20P002740
  • GC20P002759
  • GC20P002767
  • GC20P002784

Summaries for MIR1292 Gene

Entrez Gene Summary for MIR1292 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1292 Gene

MIR1292 (MicroRNA 1292) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1292 include Spinocerebellar Ataxia 36.

UniProtKB/Swiss-Prot for MIR1292 Gene

  • Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1292 Gene

Genomics for MIR1292 Gene

Regulatory Elements for MIR1292 Gene

Enhancers for MIR1292 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR1292 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1292 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR1292 Gene

Chromosome:
20
Start:
2,652,145 bp from pter
End:
2,658,393 bp from pter
Size:
6,249 bases
Orientation:
Plus strand

Genomic View for MIR1292 Gene

Genes around MIR1292 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1292 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1292 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1292 Gene

Proteins for MIR1292 Gene

  • Protein details for MIR1292 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00567-NOP56_HUMAN
    Recommended name:
    Nucleolar protein 56
    Protein Accession:
    O00567
    Secondary Accessions:
    • Q2M3T6
    • Q9NQ05

    Protein attributes for MIR1292 Gene

    Size:
    594 amino acids
    Molecular mass:
    66050 Da
    Quaternary structure:
    • Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1.
    • Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1.
    SequenceCaution:
    • Sequence=CAA72789.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MIR1292 Gene

Post-translational modifications for MIR1292 Gene

  • Ubiquitination at Lys 288, Lys 320, Lys 333, Lys 375, and Lys 396
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR1292 Gene

No data available for DME Specific Peptides for MIR1292 Gene

Domains & Families for MIR1292 Gene

Gene Families for MIR1292 Gene

Protein Domains for MIR1292 Gene

Graphical View of Domain Structure for InterPro Entry

O00567

UniProtKB/Swiss-Prot:

NOP56_HUMAN :
  • Contains 1 Nop domain.
  • Belongs to the NOP5/NOP56 family.
Domain:
  • Contains 1 Nop domain.
Family:
  • Belongs to the NOP5/NOP56 family.
genes like me logo Genes that share domains with MIR1292: view

No data available for Suggested Antigen Peptide Sequences for MIR1292 Gene

Function for MIR1292 Gene

Molecular function for MIR1292 Gene

UniProtKB/Swiss-Prot Function:
Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.

Gene Ontology (GO) - Molecular Function for MIR1292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS --
GO:0005515 protein binding IPI --
GO:0030515 snoRNA binding IDA --
GO:0044822 poly(A) RNA binding IDA --
GO:1990226 histone methyltransferase binding IPI --
genes like me logo Genes that share ontologies with MIR1292: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1292 Gene

Localization for MIR1292 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1292 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus, nucleoplasm.

Gene Ontology (GO) - Cellular Components for MIR1292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005732 small nucleolar ribonucleoprotein complex IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA --
genes like me logo Genes that share ontologies with MIR1292: view

No data available for Subcellular locations from COMPARTMENTS for MIR1292 Gene

Pathways & Interactions for MIR1292 Gene

SuperPathways for MIR1292 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with MIR1292: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1292 Gene

Drugs & Compounds for MIR1292 Gene

No Compound Related Data Available

Transcripts for MIR1292 Gene

mRNA/cDNA for MIR1292 Gene

(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1292 Gene

No ASD Table

Relevant External Links for MIR1292 Gene

GeneLoc Exon Structure for
MIR1292
ECgene alternative splicing isoforms for
MIR1292

Expression for MIR1292 Gene

mRNA expression in normal human tissues for MIR1292 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1292 Gene:

MIR1292
genes like me logo Genes that share expression patterns with MIR1292: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1292 Gene

Orthologs for MIR1292 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR1292 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOP56 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP56 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOP56 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop56 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOP56 35
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOP56 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOP56 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP56 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nop56 35
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nop56 35
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K07C5.4 35
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP56 35
  • 51 (a)
OneToOne
NOP56 37
Species where no ortholog for MIR1292 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1292 Gene

ENSEMBL:
Gene Tree for MIR1292 (if available)
TreeFam:
Gene Tree for MIR1292 (if available)

Paralogs for MIR1292 Gene

Pseudogenes.org Pseudogenes for MIR1292 Gene

genes like me logo Genes that share paralogs with MIR1292: view

No data available for Paralogs for MIR1292 Gene

Variants for MIR1292 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1292 Gene

Variant ID Type Subtype PubMed ID
esv3644998 CNV gain 21293372
nsv1057464 CNV gain 25217958
nsv470535 CNV gain 18288195

Relevant External Links for MIR1292 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1292

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR1292 Gene

Disorders for MIR1292 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1292 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 36
  • spinocerebellar ataxia type 36
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NOP56_HUMAN
  • Spinocerebellar ataxia 36 (SCA36) [MIM:614153]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA36 is characterized by complicated clinical features, with ataxia as the first symptom, followed by characteristic late-onset involvement of the motor neuron system. Ataxic symptoms, such as gait and truncal instability, ataxic dysarthria, and uncoordinated limbs, start in late forties to fifties. Characteristically, affected individuals exhibit tongue atrophy with fasciculation. Progression of motor neuron involvement is typically limited to the tongue and main proximal skeletal muscles in both upper and lower extremities. {ECO:0000269 PubMed:21683323}. Note=The disease is caused by mutations affecting the gene represented in this entry. Caused by large hexanucleotide CGCCTG repeat expansions within intron 1. These expansions induce RNA foci and sequester the RNA-binding protein SRSF2. In addition, the transcription of MIR1292, a microRNA gene located just 19 bp 3 of the GGCCTG repeat, is significantly decreased.

Relevant External Links for MIR1292

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1292
genes like me logo Genes that share disorders with MIR1292: view

No data available for Genatlas for MIR1292 Gene

Publications for MIR1292 Gene

  1. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 65
  2. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 65
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65

Products for MIR1292 Gene

Sources for MIR1292 Gene

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