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Aliases for MIR129-2 Gene

Subcategory (RNA class) for MIR129-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR129-2 Gene

  • MicroRNA 129-2 2 3 5
  • Hsa-Mir-129-2 3
  • Mir-129-2 3
  • MIRN129-2 3
  • MIR-129b 3

External Ids for MIR129-2 Gene

ORGUL Members for MIR129-2 Gene

Previous HGNC Symbols for MIR129-2 Gene

  • MIRN129-2

Previous GeneCards Identifiers for MIR129-2 Gene

  • GC11P043562
  • GC11P043602
  • GC11P043592
  • GC11P043593
  • GC11P043594
  • GC11P043596
  • GC11P043604

Summaries for MIR129-2 Gene

Entrez Gene Summary for MIR129-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR129-2 Gene

MIR129-2 (MicroRNA 129-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR129-2 include Univentricular Heart. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Additional gene information for MIR129-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR129-2 Gene

Genomics for MIR129-2 Gene

GeneHancer (GH) Regulatory Elements for MIR129-2 Gene

Promoters and enhancers for MIR129-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I043580 Enhancer 0.7 ENCODE 550.8 -1.8 -1768 0.2 CTCF MXI1 ZSCAN4 ZNF76 SIN3A ZNF335 ZFHX2 POLR2A SCRT2 PRDM10 ENSG00000283341 GC11P043603 GC11P043605 GC11P043607 MIR129-2 HSD17B12 ENSG00000283217 LOC101928704
GH11I043643 Promoter/Enhancer 1.6 Ensembl ENCODE 11 +63.1 63067 2.1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 ZNF143 HSD17B12 MIR129-2 ALKBH3 LOC105376644 GC11P043610 ENSG00000283341 ENSG00000283217 LOC101928704
GH11I043546 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.9 -33.8 -33781 2 USF1 BACH1 ZIC2 ZNF335 ZFHX2 EGR1 VEZF1 CREM EGR2 EZH2 GC11P043551 MIR129-2 HSD17B12 C11orf96 CTBP2P6
GH11I043868 Enhancer 1.2 Ensembl ENCODE 9.3 +287.8 287754 1.5 PKNOX1 SMAD1 ARNT IRF4 YY1 ZNF766 ZNF207 JUNB REST MEF2D ALKBH3-AS1 C11orf96 HSD17B12 ALKBH3 MIR129-2 ENSG00000283375 LOC105376644
GH11I043830 Enhancer 1 Ensembl ENCODE 10.3 +249.8 249848 1.9 INSM2 SIN3A FEZF1 ETS1 ZEB1 EGR1 ZNF366 FOS ZNF362 CEBPB HSD17B12 MIR129-2 ENSG00000254409 ALKBH3-AS1 ENSG00000283375 LOC105376644 PIR48162 ENSG00000283341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR129-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR129-2 Gene

Genomic Locations for MIR129-2 Gene
chr11:43,581,394-43,581,483
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr11:43,602,944-43,603,033
(GRCh37/hg19)

Genomic View for MIR129-2 Gene

Genes around MIR129-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR129-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR129-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR129-2 Gene

Proteins for MIR129-2 Gene

Post-translational modifications for MIR129-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR129-2 Gene

Domains & Families for MIR129-2 Gene

Gene Families for MIR129-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR129-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR129-2 Gene

Function for MIR129-2 Gene

Phenotypes From GWAS Catalog for MIR129-2 Gene

Gene Ontology (GO) - Molecular Function for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23390134
genes like me logo Genes that share ontologies with MIR129-2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR129-2 Gene

Localization for MIR129-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR129-2 Gene

Pathways & Interactions for MIR129-2 Gene

genes like me logo Genes that share pathways with MIR129-2: view

Pathways by source for MIR129-2 Gene

1 BioSystems pathway for MIR129-2 Gene
1 KEGG pathway for MIR129-2 Gene

Interacting Proteins for MIR129-2 Gene

Gene Ontology (GO) - Biological Process for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23390134
genes like me logo Genes that share ontologies with MIR129-2: view

No data available for SIGNOR curated interactions for MIR129-2 Gene

Drugs & Compounds for MIR129-2 Gene

No Compound Related Data Available

Transcripts for MIR129-2 Gene

mRNA/cDNA for MIR129-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR129-2 Gene

No ASD Table

Relevant External Links for MIR129-2 Gene

GeneLoc Exon Structure for
MIR129-2
ECgene alternative splicing isoforms for
MIR129-2

Expression for MIR129-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR129-2 Gene

genes like me logo Genes that share expression patterns with MIR129-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR129-2 Gene

Orthologs for MIR129-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR129-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-129-2 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-129-2 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir129-2 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-129-2 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-129a 34
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR376745.1 34
  • 89 (a)
ManyToMany
dre-mir-129-2 34
  • 87 (a)
ManyToMany
dre-mir-129-1 34
  • 79 (a)
ManyToMany
Species where no ortholog for MIR129-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR129-2 Gene

ENSEMBL:
Gene Tree for MIR129-2 (if available)
TreeFam:
Gene Tree for MIR129-2 (if available)

Paralogs for MIR129-2 Gene

No data available for Paralogs for MIR129-2 Gene

Variants for MIR129-2 Gene

Sequence variations from dbSNP and Humsavar for MIR129-2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000362805 -- 43,580,592(+) TTT/TT upstream_transcript_variant
rs1002682720 -- 43,579,664(+) T/A upstream_transcript_variant
rs1003123822 -- 43,579,454(+) G/A upstream_transcript_variant
rs1005120272 -- 43,579,467(+) T/C upstream_transcript_variant
rs1006196411 -- 43,579,394(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR129-2 Gene

Variant ID Type Subtype PubMed ID
nsv951606 CNV deletion 24416366

Additional Variant Information for MIR129-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR129-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR129-2 Gene

Disorders for MIR129-2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR129-2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
univentricular heart
  • double inlet left ventricle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR129-2

genes like me logo Genes that share disorders with MIR129-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR129-2 Gene

Publications for MIR129-2 Gene

  1. MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p. (PMID: 28346809) Liu K … Li W (Cell cycle (Georgetown, Tex.) 2017) 3 58
  2. MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β-Catenin Signaling Pathway. (PMID: 28535514) Zhang P … Wang X (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  3. Suberoylanilide hydroxamic acid induces thioredoxin1-mediated apoptosis in lung cancer cells via up-regulation of miR-129-5p. (PMID: 28667779) You BR … Park WH (Molecular carcinogenesis 2017) 3 58
  4. Plasma microvesicle analysis identifies microRNA 129-5p as a biomarker of heart failure in univentricular heart disease. (PMID: 28859128) Ramachandran S … Bernstein HS (PloS one 2017) 3 58
  5. Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers. (PMID: 26519551) Pronina IV … Braga EA (Gene 2016) 3 58

Products for MIR129-2 Gene

Sources for MIR129-2 Gene

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