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Aliases for MIR129-2 Gene

Subcategory (RNA class) for MIR129-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR129-2 Gene

  • MicroRNA 129-2 2 3 5
  • Hsa-Mir-129-2 3
  • Mir-129-2 3
  • MIRN129-2 3
  • MIR-129b 3

External Ids for MIR129-2 Gene

ORGUL Members for MIR129-2 Gene

Previous HGNC Symbols for MIR129-2 Gene

  • MIRN129-2

Previous GeneCards Identifiers for MIR129-2 Gene

  • GC11P043562
  • GC11P043602
  • GC11P043592
  • GC11P043593

Summaries for MIR129-2 Gene

Entrez Gene Summary for MIR129-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR129-2 Gene

MIR129-2 (MicroRNA 129-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR129-2 Gene

Genomics for MIR129-2 Gene

Regulatory Elements for MIR129-2 Gene

Enhancers for MIR129-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F043546 1.3 FANTOM5 Ensembl ENCODE 10.8 -33.8 -33781 2.0 CBX3 ZIC2 ZFHX2 E2F6 CREM EGR2 L3MBTL2 RNF2 BHLHE40 NR4A1 MIR129-2 HSD17B12 C11orf96 GC11P043551 CTBP2P6
GH11F043868 1.3 Ensembl ENCODE 9.3 +287.8 287794 1.6 PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 YY1 CBX5 ZNF143 ZNF207 JUNB ALKBH3-AS1 C11orf96 API5 HSD17B12 MIR129-2 ALKBH3 ENSG00000283375 LOC105376644
GH11F043643 1.1 ENCODE 10.9 +63.1 63067 2.1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 HSD17B12 ALKBH3 ENSG00000244953 ENSG00000255165 ACCS EXT2 C11orf96 SEC14L1P1 API5 MIR129-2
GH11F043830 1.1 Ensembl ENCODE 10.3 +249.8 249849 1.9 INSM2 SIN3A FEZF1 RAD21 ZEB1 ZNF366 FOS ZNF362 ZNF654 CEBPB HSD17B12 MIR129-2 ALKBH3-AS1 ENSG00000254409 ENSG00000283375 PIR48162
GH11F043685 1 Ensembl ENCODE 10.1 +105.8 105807 2.8 CTCF TEAD4 TSC22D4 BMI1 RAD21 ZNF316 GATA2 ADNP NFE2 MAFK HSD17B12 MIR129-2 RPL23AP63
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR129-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR129-2 Gene

Chromosome:
11
Start:
43,581,394 bp from pter
End:
43,581,483 bp from pter
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR129-2 Gene

Genes around MIR129-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR129-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR129-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR129-2 Gene

Proteins for MIR129-2 Gene

Post-translational modifications for MIR129-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR129-2 Gene

Domains & Families for MIR129-2 Gene

Gene Families for MIR129-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR129-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR129-2 Gene

Function for MIR129-2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR129-2 Gene

Localization for MIR129-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR129-2 Gene

Pathways & Interactions for MIR129-2 Gene

genes like me logo Genes that share pathways with MIR129-2: view

Pathways by source for MIR129-2 Gene

1 BioSystems pathway for MIR129-2 Gene
1 KEGG pathway for MIR129-2 Gene

Interacting Proteins for MIR129-2 Gene

Gene Ontology (GO) - Biological Process for MIR129-2 Gene

None

No data available for SIGNOR curated interactions for MIR129-2 Gene

Transcripts for MIR129-2 Gene

mRNA/cDNA for MIR129-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR129-2 Gene

No ASD Table

Relevant External Links for MIR129-2 Gene

GeneLoc Exon Structure for
MIR129-2
ECgene alternative splicing isoforms for
MIR129-2

Expression for MIR129-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR129-2 Gene

genes like me logo Genes that share expression patterns with MIR129-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR129-2 Gene

Orthologs for MIR129-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR129-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-129-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-129-2 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir129-2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-129-2 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-129a 35
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR376745.1 35
  • 89 (a)
ManyToMany
dre-mir-129-2 35
  • 87 (a)
ManyToMany
dre-mir-129-1 35
  • 79 (a)
ManyToMany
Species where no ortholog for MIR129-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR129-2 Gene

ENSEMBL:
Gene Tree for MIR129-2 (if available)
TreeFam:
Gene Tree for MIR129-2 (if available)

Paralogs for MIR129-2 Gene

No data available for Paralogs for MIR129-2 Gene

Variants for MIR129-2 Gene

Sequence variations from dbSNP and Humsavar for MIR129-2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111261832 -- 43,581,066(+) TGATA(A/G)GGAGA upstream-variant-2KB
rs113330871 -- 43,579,658(+) CGGAG(C/G)CCCTC upstream-variant-2KB
rs113768224 -- 43,581,236(+) GAAAT(G/T)GAGAC upstream-variant-2KB
rs117003502 -- 43,581,174(+) CCCCT(C/T)CTCGC upstream-variant-2KB
rs117604922 -- 43,581,092(+) GGCAG(A/G)CGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR129-2 Gene

Variant ID Type Subtype PubMed ID
nsv951606 CNV deletion 24416366

Relevant External Links for MIR129-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR129-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR129-2 Gene

Disorders for MIR129-2 Gene

Relevant External Links for MIR129-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR129-2

No disorders were found for MIR129-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR129-2 Gene

Publications for MIR129-2 Gene

  1. Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers. (PMID: 26519551) Pronina I.V. … Braga E.A. (Gene 2016) 3 64
  2. Demethylation-mediated miR-129-5p up-regulation inhibits malignant phenotype of osteogenic osteosarcoma by targeting Homo sapiens valosin-containing protein (VCP). (PMID: 25566966) Long X.H. … Liu Z.L. (Tumour Biol. 2015) 3 64
  3. MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. (PMID: 25716201) Li J. … Ni S. (Tumour Biol. 2015) 3 64
  4. A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. (PMID: 25895125) Tan G. … Li H. (Oncotarget 2015) 3 64
  5. MicroRNA-129-5p inhibits hepatocellular carcinoma cell metastasis and invasion via targeting ETS1. (PMID: 25912876) Ma N. … Wang Q. (Biochem. Biophys. Res. Commun. 2015) 3 64

Products for MIR129-2 Gene

Sources for MIR129-2 Gene

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