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Aliases for MIR129-1 Gene

Subcategory (RNA class) for MIR129-1 Gene


Quality Score for this RNA gene is


Aliases for MIR129-1 Gene

  • MicroRNA 129-1 2 3 5
  • Hsa-Mir-129-1 3
  • Mir-129-1 3
  • MIRN129-1 3
  • MIR-129b 3

External Ids for MIR129-1 Gene

ORGUL Members for MIR129-1 Gene

Previous HGNC Symbols for MIR129-1 Gene

  • MIRN129-1

Previous GeneCards Identifiers for MIR129-1 Gene

  • GC07P127637
  • GC07P127847

Summaries for MIR129-1 Gene

Entrez Gene Summary for MIR129-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR129-1 Gene

MIR129-1 (MicroRNA 129-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Additional gene information for MIR129-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR129-1 Gene

Genomics for MIR129-1 Gene

Regulatory Elements for MIR129-1 Gene

Enhancers for MIR129-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H128209 1 ENCODE 0.7 +2.1 2081 0.2 HDGF PKNOX1 ATF1 ARNT ARID4B FEZF1 ZNF2 ZNF143 ATF7 RUNX3 LEP LRRC4 SND1 ENSG00000240790 MIR129-1 LOC105375494
GH07H128214 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +9.6 9625 5.4 CTCF ATF1 ZMYM3 CEBPG CTBP1 POLR2A ZNF366 ATF7 CREM BHLHE40 LEP METTL2B LRRC4 SND1 IMPDH1 MIR129-1 LOC105375494
GH07H128221 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +14.2 14231 1.1 PKNOX1 JUN RFX5 FOSL1 ZNF316 GATA3 GATA2 POLR2A FOS RCOR1 IMPDH1 LOC105375494 MIR129-1
GH07H128222 0.7 ENCODE dbSUPER 0.4 +14.9 14891 0.2 POLR2A RCOR1 LOC105375494 MIR129-1
GH07H128223 0.7 Ensembl dbSUPER 0.4 +15.2 15229 0.2 MAX ZIC2 LOC105375494 MIR129-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR129-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR129-1 Gene

Genomic Locations for MIR129-1 Gene
72 bases
Plus strand

Genomic View for MIR129-1 Gene

Genes around MIR129-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR129-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR129-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR129-1 Gene

Proteins for MIR129-1 Gene

Post-translational modifications for MIR129-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR129-1 Gene

Domains & Families for MIR129-1 Gene

Gene Families for MIR129-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR129-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR129-1 Gene

Function for MIR129-1 Gene

Phenotypes From GWAS Catalog for MIR129-1 Gene

Gene Ontology (GO) - Molecular Function for MIR129-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23390134
genes like me logo Genes that share ontologies with MIR129-1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR129-1 Gene

Localization for MIR129-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR129-1 Gene

Pathways & Interactions for MIR129-1 Gene

genes like me logo Genes that share pathways with MIR129-1: view

Pathways by source for MIR129-1 Gene

1 BioSystems pathway for MIR129-1 Gene
1 KEGG pathway for MIR129-1 Gene

Interacting Proteins for MIR129-1 Gene

Gene Ontology (GO) - Biological Process for MIR129-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23390134
genes like me logo Genes that share ontologies with MIR129-1: view

No data available for SIGNOR curated interactions for MIR129-1 Gene

Drugs & Compounds for MIR129-1 Gene

No Compound Related Data Available

Transcripts for MIR129-1 Gene

mRNA/cDNA for MIR129-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR129-1 Gene

No ASD Table

Relevant External Links for MIR129-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR129-1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR129-1 Gene

Orthologs for MIR129-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR129-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia cfa-mir-129-1 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-129-1 34
  • 100 (a)
(Mus musculus)
Mammalia Mir129-1 34
  • 95 (a)
(Monodelphis domestica)
Mammalia mdo-mir-129 34
  • 93 (a)
(Bos Taurus)
Mammalia bta-mir-129-1 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-129 34
  • 55 (a)
(Anolis carolinensis)
Reptilia aca-mir-129b 34
  • 68 (a)
(Danio rerio)
Actinopterygii BX927136.1 34
  • 55 (a)
Species where no ortholog for MIR129-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR129-1 Gene

Gene Tree for MIR129-1 (if available)
Gene Tree for MIR129-1 (if available)

Paralogs for MIR129-1 Gene

No data available for Paralogs for MIR129-1 Gene

Variants for MIR129-1 Gene

Sequence variations from dbSNP and Humsavar for MIR129-1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000539017 -- 128,206,208(+) GGGAC(A/C)TGCCA upstream-variant-2KB
rs1000885460 -- 128,207,726(+) TCCTC(C/T)CCCCC intron-variant, upstream-variant-2KB
rs1002666426 -- 128,208,376(+) GAAAT(C/G)TGTAA intron-variant, downstream-variant-500B
rs1004187767 -- 128,206,997(+) CGGAC(A/G)CCATC nc-transcript-variant, upstream-variant-2KB
rs1004455548 -- 128,205,963(+) AAGGA(A/G)CCAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR129-1 Gene

Variant ID Type Subtype PubMed ID
esv33413 CNV gain 17666407

Relevant External Links for MIR129-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR129-1 Gene

Disorders for MIR129-1 Gene

Relevant External Links for MIR129-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR129-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR129-1 Gene

Publications for MIR129-1 Gene

  1. MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p. (PMID: 28346809) Liu K … Li W (Cell cycle (Georgetown, Tex.) 2017) 3 60
  2. MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β-Catenin Signaling Pathway. (PMID: 28535514) Zhang P … Wang X (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  3. Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p. (PMID: 26180082) Ouyang Q … Yi L (Neuro-oncology 2016) 3 60
  4. MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1. (PMID: 26510428) Kouhkan F … Soleimani M (Journal of medical genetics 2016) 3 60
  5. MiR-129 triggers autophagic flux by regulating a novel Notch-1/ E2F7/Beclin-1 axis to impair the viability of human malignant glioma cells. (PMID: 26824182) Chen X … Liu W (Oncotarget 2016) 3 60

Products for MIR129-1 Gene

Sources for MIR129-1 Gene

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