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Aliases for MIR1287 Gene

Subcategory (RNA class) for MIR1287 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1287 Gene

  • MicroRNA 1287 2 3
  • PYROXD2 4 5
  • Pyridine Nucleotide-Disulphide Oxidoreductase Domain 2 5
  • Hsa-Mir-1287 3
  • EC 1.-.-.- 4
  • Mir-1287 3
  • MIRN1287 3
  • C10orf33 4

External Ids for MIR1287 Gene

Previous HGNC Symbols for MIR1287 Gene

  • MIRN1287

Previous GeneCards Identifiers for MIR1287 Gene

  • GC00U923096
  • GC10M100145
  • GC10M100154

Summaries for MIR1287 Gene

Entrez Gene Summary for MIR1287 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1287 Gene

MIR1287 (MicroRNA 1287) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR1287 Gene

  • Probable oxidoreductase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1287 Gene

Genomics for MIR1287 Gene

Regulatory Elements for MIR1287 Gene

Enhancers for MIR1287 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F098373 0.8 Ensembl ENCODE 13 +40.6 40647 2.1 PKNOX1 MAFG ZIC2 ZNF316 NFE2 FOS MAFK EMSY NFE2L2 PYROXD2 LOXL4 MIR1287 LOC105378449 GC10P098406
GH10F098382 0.5 ENCODE 11.3 +31.8 31825 1.7 JUND FOS PYROXD2 LOXL4 MIR1287 GC10P098406 LOC105378449
GH10F098344 1 Ensembl ENCODE 11 +70.3 70324 1.0 FOXP2 RAD21 NR2F2 PYROXD2 MIR1287 GC10M098326 LOC105378449
GH10F098459 1.2 Ensembl ENCODE 10.5 -45.7 -45709 2.4 PKNOX1 ARNT ARID4B SIN3A FEZF1 FOS DEK JUNB REST MEF2D MIR1287 PYROXD2 LOXL4 HPS1 HPSE2 PIR35546 GC10M098426
GH10F098457 0.7 ENCODE 10.4 -42.8 -42765 0.0 ARID1B GATA3 NCOR1 TAL1 IKZF1 MIR1287 PYROXD2 PIR35546 GC10P098452
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1287 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1287 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117142 284 601 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 SLC30A9 GLIS2 ZNF263

Genomic Location for MIR1287 Gene

Chromosome:
10
Start:
98,383,565 bp from pter
End:
98,415,184 bp from pter
Size:
31,620 bases
Orientation:
Minus strand

Genomic View for MIR1287 Gene

Genes around MIR1287 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1287 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1287 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1287 Gene

Proteins for MIR1287 Gene

  • Protein details for MIR1287 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2H3-PYRD2_HUMAN
    Recommended name:
    Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
    Protein Accession:
    Q8N2H3
    Secondary Accessions:
    • D3DR61
    • Q5TAA9
    • Q9BRQ1

    Protein attributes for MIR1287 Gene

    Size:
    581 amino acids
    Molecular mass:
    63068 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR1287 Gene

Post-translational modifications for MIR1287 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR1287 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR1287 Gene

Domains & Families for MIR1287 Gene

Gene Families for MIR1287 Gene

Protein Domains for MIR1287 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2H3

UniProtKB/Swiss-Prot:

PYRD2_HUMAN :
  • Belongs to the carotenoid/retinoid oxidoreductase family.
Family:
  • Belongs to the carotenoid/retinoid oxidoreductase family.
genes like me logo Genes that share domains with MIR1287: view

No data available for Suggested Antigen Peptide Sequences for MIR1287 Gene

Function for MIR1287 Gene

Molecular function for MIR1287 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for MIR1287 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1287 Gene

Localization for MIR1287 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1287 Gene

Pathways & Interactions for MIR1287 Gene

SuperPathways for MIR1287 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MIR1287: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1287 Gene

Transcripts for MIR1287 Gene

mRNA/cDNA for MIR1287 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1287 Gene

No ASD Table

Relevant External Links for MIR1287 Gene

GeneLoc Exon Structure for
MIR1287
ECgene alternative splicing isoforms for
MIR1287

Expression for MIR1287 Gene

mRNA expression in normal human tissues for MIR1287 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1287 Gene:

MIR1287
genes like me logo Genes that share expression patterns with MIR1287: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1287 Gene

Orthologs for MIR1287 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1287 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYROXD2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PYROXD2 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PYROXD2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pyroxd2 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PYROXD2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PYROXD2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PYROXD2 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PYROXD2 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pyroxd2 35
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F37C4.6 35
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
Species where no ortholog for MIR1287 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1287 Gene

ENSEMBL:
Gene Tree for MIR1287 (if available)
TreeFam:
Gene Tree for MIR1287 (if available)

Paralogs for MIR1287 Gene

No data available for Paralogs for MIR1287 Gene

Variants for MIR1287 Gene

Sequence variations from dbSNP and Humsavar for MIR1287 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10883085 -- 98,395,856(+) GGAGA(A/T)GGCTG intron-variant, upstream-variant-2KB
rs10883086 -- 98,395,986(+) GTCTG(A/G)CACAT intron-variant, upstream-variant-2KB
rs10883087 -- 98,397,233(+) ACTGA(A/T)CCCAG intron-variant, upstream-variant-2KB
rs111652430 -- 98,396,472(+) AATGA(-/TT)TTTTT intron-variant, upstream-variant-2KB
rs111685811 -- 98,397,129(+) CCCAC(A/G)CATAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1287 Gene

Variant ID Type Subtype PubMed ID
nsv515723 CNV loss 19592680

Relevant External Links for MIR1287 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1287

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1287 Gene

Disorders for MIR1287 Gene

Relevant External Links for MIR1287

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1287

No disorders were found for MIR1287 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1287 Gene

Publications for MIR1287 Gene

  1. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  2. Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. (PMID: 24238754) Wang Y. … Xiao B. (Cancer Genet 2013) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. (PMID: 21931564) Nicholson G. … Holmes C.C. (PLoS Genet. 2011) 3 64
  5. Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing. (PMID: 19508715) Nygaard S. … Litman T. (BMC Med Genomics 2009) 3 64

Products for MIR1287 Gene

Sources for MIR1287 Gene

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