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Aliases for MIR1281 Gene

Subcategory (RNA class) for MIR1281 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1281 Gene

  • MicroRNA 1281 2 3
  • EC 2.3.1.48 4 61
  • EP300 4 5
  • E1A-Associated Protein P300 4
  • E1A Binding Protein P300 5
  • Hsa-Mir-1281 3
  • P300 HAT 4
  • MIRN1281 3
  • EC 2.3.1 61
  • P300 4

External Ids for MIR1281 Gene

Previous HGNC Symbols for MIR1281 Gene

  • MIRN1281

Previous GeneCards Identifiers for MIR1281 Gene

  • GC00U922887
  • GC22P039819
  • GC22P041488

Summaries for MIR1281 Gene

Entrez Gene Summary for MIR1281 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1281 Gene

MIR1281 (MicroRNA 1281) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1281 include Rubinstein-Taybi Syndrome and Rubinstein-Taybi Syndrome 2. An important paralog of this gene is CREBBP.

UniProtKB/Swiss-Prot for MIR1281 Gene

  • Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at Lys-122 (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at Lys-27 (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates Lys-131 of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at Lys-626 which is essential for its transcriptional coactivator activity (PubMed:10733570, PubMed:11430825, PubMed:11701890, PubMed:12402037, PubMed:12586840, PubMed:12929931, PubMed:14645221, PubMed:15186775, PubMed:15890677, PubMed:16617102, PubMed:16762839, PubMed:18722353, PubMed:18995842, PubMed:23415232, PubMed:23911289, PubMed:23934153, PubMed:8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1281 Gene

Genomics for MIR1281 Gene

Regulatory Elements for MIR1281 Gene

Enhancers for MIR1281 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR1281 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1281 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR1281 Gene

Chromosome:
22
Start:
41,091,786 bp from pter
End:
41,180,079 bp from pter
Size:
88,294 bases
Orientation:
Plus strand

Genomic View for MIR1281 Gene

Genes around MIR1281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1281 Gene

Proteins for MIR1281 Gene

  • Protein details for MIR1281 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09472-EP300_HUMAN
    Recommended name:
    Histone acetyltransferase p300
    Protein Accession:
    Q09472
    Secondary Accessions:
    • B1AKC2

    Protein attributes for MIR1281 Gene

    Size:
    2414 amino acids
    Molecular mass:
    264161 Da
    Quaternary structure:
    • Interacts with phosphorylated CREB1. Interacts with HIF1A; the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the interaction requires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1 (unphosphorylated form preferentially and via C-terminus). Interacts with ESR1; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, TP53, DDX5, DDX17, SATB1, SRCAP, TTC5, JMY and TRERF1. The TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5. Interacts with the C-terminal region of CITED4. Non-sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST. Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interaction is inhibited by NR0B2. Interacts with TCF3. Interacts (via CREB-binding domain) with MYOCD (via C-terminus). Binds to HIPK2. Interacts with ROCK2 and PPARG. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and this interaction enhances acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interaction acetylates FOXO1 and enhances its transcriptional activity. Interacts with ALKBH4 and DDIT3/CHOP. Interacts with KLF15. Interacts with CEBPB and RORA. Interacts with HTLV-1 Tax and p30II. Interacts with and acetylates HIV-1 Tat. Interacts with NPAS2, ARNTL/BMAL1 and CLOCK. Interacts with SIRT2 isoform 1, isoform 2 and isoform 5. Interacts with MTA1. Interacts with HDAC4 and HDAC5 in the presence of TFAP2C (PubMed:10545121, PubMed:10722728, PubMed:10823961, PubMed:11073989, PubMed:11073990, PubMed:11080476, PubMed:11349124, PubMed:11430825, PubMed:11463834, PubMed:11481323, PubMed:11518699, PubMed:11559821, PubMed:11564735, PubMed:11581164, PubMed:11581372, PubMed:11701890, PubMed:11744733, PubMed:11864910, PubMed:11959990, PubMed:11997499, PubMed:12446687, PubMed:12527917, PubMed:12586840, PubMed:12750254, PubMed:12778114, PubMed:12837748, PubMed:12929931, PubMed:14605447, PubMed:14645221, PubMed:14716005, PubMed:14752053, PubMed:15075319, PubMed:15186775, PubMed:15297880, PubMed:15509808, PubMed:15731352, PubMed:15890677, PubMed:16478997, PubMed:16574662, PubMed:16617102, PubMed:16864582, PubMed:17226766, PubMed:17872950, PubMed:18273021, PubMed:19217391, PubMed:19680224, PubMed:20081228, PubMed:23145062, PubMed:23999430, PubMed:24177535, PubMed:24413532, PubMed:8684459, PubMed:8917528, PubMed:9528808, PubMed:9590696, PubMed:9862959, PubMed:9887100). Interacts with TRIP4 (PubMed:25219498). Directly interacts with ZBTB49; this interaction leads to synergistic transactivation of CDKN1A (PubMed:25245946). Interacts with NR4A3 (By similarity). Interacts with ZNF451 (PubMed:24324267). Interacts with human adenovirus 5 E1A protein; this interaction stimulates the acetylation of RB1 by recruiting EP300 and RB1 into a multimeric-protein complex (PubMed:11433299). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).
    • Interacts with phosphorylated CREB1. Interacts with HIF1A; the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the interaction requires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1 (unphosphorylated form preferentially and via C-terminus). Interacts with ESR1; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, TP53, DDX5, DDX17, SATB1, SRCAP, TTC5, JMY and TRERF1. The TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5. Interacts with the C-terminal region of CITED4. Non-sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST. Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interaction is inhibited by NR0B2. Interacts with TCF3. Interacts (via CREB-binding domain) with MYOCD (via C-terminus). Binds to HIPK2. Interacts with ROCK2 and PPARG. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and this interaction enhances acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interaction acetylates FOXO1 and enhances its transcriptional activity. Interacts with ALKBH4 and DDIT3/CHOP. Interacts with KLF15. Interacts with CEBPB and RORA. Interacts with HTLV-1 Tax and p30II. Interacts with and acetylates HIV-1 Tat. Interacts with NPAS2, ARNTL/BMAL1 and CLOCK. Interacts with SIRT2 isoform 1, isoform 2 and isoform 5. Interacts with MTA1. Interacts with HDAC4 and HDAC5 in the presence of TFAP2C (PubMed:10545121, PubMed:10722728, PubMed:10823961, PubMed:11073989, PubMed:11073990, PubMed:11080476, PubMed:11349124, PubMed:11430825, PubMed:11463834, PubMed:11481323, PubMed:11518699, PubMed:11559821, PubMed:11564735, PubMed:11581164, PubMed:11581372, PubMed:11701890, PubMed:11744733, PubMed:11864910, PubMed:11959990, PubMed:11997499, PubMed:12446687, PubMed:12527917, PubMed:12586840, PubMed:12750254, PubMed:12778114, PubMed:12837748, PubMed:12929931, PubMed:14605447, PubMed:14645221, PubMed:14716005, PubMed:14752053, PubMed:15075319, PubMed:15186775, PubMed:15297880, PubMed:15509808, PubMed:15731352, PubMed:15890677, PubMed:16478997, PubMed:16574662, PubMed:16617102, PubMed:16864582, PubMed:17226766, PubMed:17872950, PubMed:18273021, PubMed:19217391, PubMed:19680224, PubMed:20081228, PubMed:23145062, PubMed:23999430, PubMed:24177535, PubMed:24413532, PubMed:8684459, PubMed:8917528, PubMed:9528808, PubMed:9590696, PubMed:9862959, PubMed:9887100). Interacts with TRIP4 (PubMed:25219498). Directly interacts with ZBTB49; this interaction leads to synergistic transactivation of CDKN1A (PubMed:25245946). Interacts with NR4A3 (By similarity). Interacts with ZNF451 (PubMed:24324267). Interacts with human adenovirus 5 E1A protein; this interaction stimulates the acetylation of RB1 by recruiting EP300 and RB1 into a multimeric-protein complex (PubMed:11433299). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).

    Three dimensional structures from OCA and Proteopedia for MIR1281 Gene

neXtProt entry for MIR1281 Gene

Selected DME Specific Peptides for MIR1281 Gene

Post-translational modifications for MIR1281 Gene

  • Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional repression domain (CRD1) by SIRT1, preferentially at Lys-1020. Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.
  • Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1.
  • Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction with NCOA2/GRIP1.
  • Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1 is associated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity. Phosphorylation at Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG.
  • Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation.
  • Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.
  • Ubiquitination at Lys 1637
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR1281 Gene

Domains & Families for MIR1281 Gene

Gene Families for MIR1281 Gene

Graphical View of Domain Structure for InterPro Entry

Q09472

UniProtKB/Swiss-Prot:

EP300_HUMAN :
  • The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300 responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation and acetylation sites and the same lysine residues may be targeted for the respective modifications. It is proposed that deacetylation by SIRT1 allows sumoylation leading to suppressed activity.
  • Contains 2 TAZ-type zinc fingers.
Domain:
  • The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300 responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation and acetylation sites and the same lysine residues may be targeted for the respective modifications. It is proposed that deacetylation by SIRT1 allows sumoylation leading to suppressed activity.
  • Contains 1 bromo domain.
  • Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.
  • Contains 1 KIX domain.
Similarity:
  • Contains 2 TAZ-type zinc fingers.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with MIR1281: view

No data available for Suggested Antigen Peptide Sequences for MIR1281 Gene

Function for MIR1281 Gene

Molecular function for MIR1281 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at Lys-122 (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at Lys-27 (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates Lys-131 of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at Lys-626 which is essential for its transcriptional coactivator activity (PubMed:10733570, PubMed:11430825, PubMed:11701890, PubMed:12402037, PubMed:12586840, PubMed:12929931, PubMed:14645221, PubMed:15186775, PubMed:15890677, PubMed:16617102, PubMed:16762839, PubMed:18722353, PubMed:18995842, PubMed:23415232, PubMed:23911289, PubMed:23934153, PubMed:8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D.

Enzyme Numbers (IUBMB) for MIR1281 Gene

Gene Ontology (GO) - Molecular Function for MIR1281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001047 core promoter binding IDA --
GO:0001085 RNA polymerase II transcription factor binding IEA --
GO:0001102 RNA polymerase II activating transcription factor binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with MIR1281: view

Animal Model Products

Transcription Factor Targets for MIR1281 Gene

Selected GeneGlobe predicted Target genes for MIR1281

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for MIR1281 Gene

Localization for MIR1281 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1281 Gene

Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.

Gene Ontology (GO) - Cellular Components for MIR1281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MIR1281: view

No data available for Subcellular locations from COMPARTMENTS for MIR1281 Gene

Pathways & Interactions for MIR1281 Gene

SuperPathways for MIR1281 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA --
GO:0001756 somitogenesis IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MIR1281: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1281 Gene

Drugs & Compounds for MIR1281 Gene

No Compound Related Data Available

Transcripts for MIR1281 Gene

mRNA/cDNA for MIR1281 Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1281 Gene

No ASD Table

Relevant External Links for MIR1281 Gene

GeneLoc Exon Structure for
MIR1281
ECgene alternative splicing isoforms for
MIR1281

Expression for MIR1281 Gene

mRNA expression in normal human tissues for MIR1281 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1281 Gene:

MIR1281
genes like me logo Genes that share expression patterns with MIR1281: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1281 Gene

Orthologs for MIR1281 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR1281 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EP300 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EP300 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EP300 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ep300 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia EP300 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves EP300 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EP300 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ep300a 35
  • 56 (a)
OneToMany
ep300b 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nej 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea bet-1 35
  • 23 (a)
ManyToMany
bet-2 35
  • 17 (a)
ManyToMany
C29F9.6 35
  • 36 (a)
ManyToMany
cbp-1 35
  • 38 (a)
ManyToMany
F13C5.2 35
  • 26 (a)
ManyToMany
F40F12.7 35
  • 43 (a)
ManyToMany
K03H1.10 35
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BDF1 35
  • 22 (a)
ManyToMany
BDF2 35
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 71 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
Species where no ortholog for MIR1281 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1281 Gene

ENSEMBL:
Gene Tree for MIR1281 (if available)
TreeFam:
Gene Tree for MIR1281 (if available)

Paralogs for MIR1281 Gene

Paralogs for MIR1281 Gene

genes like me logo Genes that share paralogs with MIR1281: view

Variants for MIR1281 Gene

Sequence variations from dbSNP and Humsavar for MIR1281 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs7286559 -- 41,090,551(+) TTTTA(A/C)CCGTA upstream-variant-2KB
rs527356341 -- 41,090,526(+) CCACC(G/T)TGCCT upstream-variant-2KB
rs148848638 -- 41,090,598(+) ACTTA(C/T)ACCCC upstream-variant-2KB
rs552018147 -- 41,090,587(+) CTTTC(A/G)GGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1281 Gene

Variant ID Type Subtype PubMed ID
nsv1058653 CNV gain 25217958
nsv524585 CNV loss 19592680
nsv589048 CNV loss 21841781

Relevant External Links for MIR1281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1281 Gene

Disorders for MIR1281 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR1281 Gene - From: GeneCards

Disorder Aliases PubMed IDs
rubinstein-taybi syndrome
  • rubinstein-taybi syndrome 1
rubinstein-taybi syndrome 2
  • rubinstein-taybi syndrome due to ep300 haploinsufficiency
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

EP300_HUMAN
  • Note=Chromosomal aberrations involving EP300 may be a cause of acute myeloid leukemias. Translocation t(8;22)(p11;q13) with KAT6A.
  • Note=Defects in EP300 may play a role in epithelial cancer.
  • Rubinstein-Taybi syndrome 2 (RSTS2) [MIM:613684]: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. Some individuals with RSTS2 have less severe mental impairment, more severe microcephaly, and a greater degree of changes in facial bone structure than RSTS1 patients. {ECO:0000269 PubMed:15706485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR1281

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1281
genes like me logo Genes that share disorders with MIR1281: view

No data available for Genatlas for MIR1281 Gene

Publications for MIR1281 Gene

  1. Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm. (PMID: 25916817) Zhang W. … Liu C. (Clin. Biochem. 2015) 3 65
  2. Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. (PMID: 24177535) Rack J.G. … Ziegler M. (J. Mol. Biol. 2014) 4 65
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  4. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-I^ signaling. (PMID: 24324267) Feng Y. … Feng X.H. (J. Biol. Chem. 2014) 4 65
  5. Differential Regulation of Estrogen Receptor I+ Expression in Breast Cancer Cells by Metastasis-Associated Protein 1. (PMID: 24413532) Kang H.J. … Lee M.O. (Cancer Res. 2014) 4 65

Products for MIR1281 Gene

Sources for MIR1281 Gene

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