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Aliases for MIR128-2 Gene

Subcategory (RNA class) for MIR128-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR128-2 Gene

  • MicroRNA 128-2 2 3
  • MicroRNA 128b 2 3
  • MIRN128-2 3 6
  • MIR128B 3 6
  • Hsa-Mir-128-2 3
  • Hsa-Mir-128b 3
  • Mir-128b 3
  • MIRN128B 3

External Ids for MIR128-2 Gene

ORGUL Members for MIR128-2 Gene

Previous Symbols for MIR128-2 Gene

  • MIRN128B
  • MIRN128-2

Summaries for MIR128-2 Gene

Entrez Gene Summary for MIR128-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR128-2 Gene

MIR128-2 (MicroRNA 128-2) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR128-2 include familial breast cancer. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR128-2 Gene

Genomics for MIR128-2 Gene

Genomic Location for MIR128-2 Gene

Start:
35,744,476 bp from pter
End:
35,744,559 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR128-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR128-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR128-2 Gene

No data available for Regulatory Elements for MIR128-2 Gene

Proteins for MIR128-2 Gene

Post-translational modifications for MIR128-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR128-2 Gene

Domains for MIR128-2 Gene

Gene Families for MIR128-2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR128-2: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR128-2 Gene

Function for MIR128-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR128-2 Gene

Localization for MIR128-2 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR128-2 Gene

Pathways for MIR128-2 Gene

SuperPathways for MIR128-2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR128-2: view

Pathways by source for MIR128-2 Gene

1 KEGG pathway for MIR128-2 Gene

Interacting Proteins for MIR128-2 Gene

Gene Ontology (GO) - Biological Process for MIR128-2 Gene

None

Transcripts for MIR128-2 Gene

mRNA/cDNA for MIR128-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR128-2 Gene

No ASD Table

Relevant External Links for MIR128-2 Gene

GeneLoc Exon Structure for
MIR128-2
ECgene alternative splicing isoforms for
MIR128-2

Expression for MIR128-2 Gene

mRNA expression in normal human tissues for MIR128-2 Gene

genes like me logo Genes that share expressions with MIR128-2: view

Orthologs for MIR128-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR128-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-128-2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-128-2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-128-2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir128-2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-128a 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-128-2 37
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-128-2 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-128-1 37
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-128-2 37
  • 48 (a)
OneToOne
Species with no ortholog for MIR128-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR128-2 Gene

ENSEMBL:
Gene Tree for MIR128-2 (if available)
TreeFam:
Gene Tree for MIR128-2 (if available)

Paralogs for MIR128-2 Gene

No data available for Paralogs for MIR128-2 Gene

Variants for MIR128-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR128-2 Gene

Variant ID Type Subtype PubMed ID
nsv526191 CNV Loss 19592680

Relevant External Links for MIR128-2 Gene

HapMap Linkage Disequilibrium report
MIR128-2

No data available for Sequence variations from dbSNP and Humsavar for MIR128-2 Gene

Disorders for MIR128-2 Gene

(1) MalaCards Diseases for MIR128-2 Gene

Search for MIR128-2 Gene in MalaCards »

Relevant External Links for MIR128-2

Genetic Association Database (GAD)
MIR128-2
Human Genome Epidemiology (HuGE) Navigator
MIR128-2
genes like me logo Genes that share disorders with MIR128-2: view

No data available for UniProtKB/Swiss-Prot for MIR128-2 Gene

Publications for MIR128-2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 49
  2. MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. (PMID: 19713529) Evangelisti C. … CiafrA" S.A. (FASEB J. 2009) 3
  3. miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. (PMID: 19749093) Kotani A. … Lodish H.F. (Blood 2009) 3
  4. A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. (PMID: 20237425) Kotani A. … Lodish H.F. (Cell Cycle 2010) 3
  5. MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function. (PMID: 22193543) Donzelli S. … Blandino G. (Cell Death Differ. 2012) 3

Products for MIR128-2 Gene

Sources for MIR128-2 Gene

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