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Aliases for MIR128-1 Gene

Subcategory (RNA class) for MIR128-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR128-1 Gene

  • MicroRNA 128-1 2 3 5
  • MicroRNA 128a 2 3
  • Hsa-Mir-128-1 3
  • Hsa-Mir-128a 3
  • Mir-128-1 3
  • MIRN128-1 3
  • MIRN128A 3
  • MIR128A 3

External Ids for MIR128-1 Gene

Previous HGNC Symbols for MIR128-1 Gene

  • MIRN128A
  • MIRN128-1

Previous GeneCards Identifiers for MIR128-1 Gene

  • GC02P136141
  • GC02P136422

Summaries for MIR128-1 Gene

Entrez Gene Summary for MIR128-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR128-1 Gene

MIR128-1 (MicroRNA 128-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR128-1 include familial breast cancer. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR128-1 Gene

Genomics for MIR128-1 Gene

Genomic Location for MIR128-1 Gene

Chromosome:
2
Start:
135,665,383 bp from pter
End:
135,665,493 bp from pter
Size:
111 bases
Orientation:
Plus strand

Genomic View for MIR128-1 Gene

Genes around MIR128-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR128-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR128-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR128-1 Gene

No data available for Regulatory Elements for MIR128-1 Gene

Proteins for MIR128-1 Gene

Post-translational modifications for MIR128-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR128-1 Gene

Domains & Families for MIR128-1 Gene

Gene Families for MIR128-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR128-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR128-1 Gene

Function for MIR128-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR128-1 Gene

Localization for MIR128-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR128-1 Gene

Pathways & Interactions for MIR128-1 Gene

SuperPathways for MIR128-1 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR128-1: view

Pathways by source for MIR128-1 Gene

1 KEGG pathway for MIR128-1 Gene

Interacting Proteins for MIR128-1 Gene

Gene Ontology (GO) - Biological Process for MIR128-1 Gene

None

No data available for SIGNOR curated interactions for MIR128-1 Gene

Drugs & Compounds for MIR128-1 Gene

No Compound Related Data Available

Transcripts for MIR128-1 Gene

mRNA/cDNA for MIR128-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR128-1 Gene

No ASD Table

Relevant External Links for MIR128-1 Gene

GeneLoc Exon Structure for
MIR128-1
ECgene alternative splicing isoforms for
MIR128-1

Expression for MIR128-1 Gene

mRNA expression in normal human tissues for MIR128-1 Gene

genes like me logo Genes that share expression patterns with MIR128-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR128-1 Gene

Orthologs for MIR128-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR128-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-128-1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-128-1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-128-1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir128-1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-128b 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-128-1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-128-1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-128-2 36
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01102274.1 36
  • 80 (a)
OneToOne
Species with no ortholog for MIR128-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR128-1 Gene

ENSEMBL:
Gene Tree for MIR128-1 (if available)
TreeFam:
Gene Tree for MIR128-1 (if available)

Paralogs for MIR128-1 Gene

No data available for Paralogs for MIR128-1 Gene

Variants for MIR128-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR128-1 Gene

Variant ID Type Subtype PubMed ID
esv34026 CNV Loss 18971310

Relevant External Links for MIR128-1 Gene

HapMap Linkage Disequilibrium report
MIR128-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR128-1 Gene

Disorders for MIR128-1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR128-1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR128-1

Genetic Association Database (GAD)
MIR128-1
Human Genome Epidemiology (HuGE) Navigator
MIR128-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR128-1
genes like me logo Genes that share disorders with MIR128-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR128-1 Gene

Publications for MIR128-1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48 67
  2. miR-128 modulates chemosensitivity and invasion of prostate cancer cells through targeting ZEB1. (PMID: 25921099) Sun X. … Zhang J. (Jpn. J. Clin. Oncol. 2015) 3
  3. [MiR-128, a key regulator of oncogenic properties]. (PMID: 25916109) Huang D.Q. … Luo L.Y. (Mol. Biol. (Mosk.) 2015) 3
  4. Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes. (PMID: 24682535) Ciccacci C. … Spallone V. (Acta Diabetol 2014) 3
  5. Up-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer. (PMID: 24046120) Takahashi Y. … Mimori K. (Ann. Surg. Oncol. 2014) 3

Products for MIR128-1 Gene

Sources for MIR128-1 Gene

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