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Aliases for MIR127 Gene

Subcategory (RNA class) for MIR127 Gene


Quality Score for this RNA gene is


Aliases for MIR127 Gene

  • MicroRNA 127 2 3 5
  • Hsa-Mir-127 3
  • MiRNA127 3
  • Mir-127 3
  • MIRN127 3

External Ids for MIR127 Gene

Previous HGNC Symbols for MIR127 Gene

  • MIRN127

Previous GeneCards Identifiers for MIR127 Gene

  • GC14P100467
  • GC14P100849
  • GC14P101349
  • GC14P101059
  • GC14P101284

Summaries for MIR127 Gene

Entrez Gene Summary for MIR127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR127 Gene

MIR127 (MicroRNA 127) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR127 Gene

Genomics for MIR127 Gene

Genomic Location for MIR127 Gene

100,882,965 bp from pter
100,883,075 bp from pter
111 bases
Plus strand

Genomic View for MIR127 Gene

Genes around MIR127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR127 Gene

No data available for Regulatory Elements for MIR127 Gene

Proteins for MIR127 Gene

Post-translational modifications for MIR127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR127 Gene

Domains & Families for MIR127 Gene

Gene Families for MIR127 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR127 Gene

Function for MIR127 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR127 Gene

Localization for MIR127 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR127 Gene

Pathways & Interactions for MIR127 Gene

SuperPathways for MIR127 Gene

No Data Available

Interacting Proteins for MIR127 Gene

Gene Ontology (GO) - Biological Process for MIR127 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR127 Gene

Drugs & Compounds for MIR127 Gene

No Compound Related Data Available

Transcripts for MIR127 Gene

mRNA/cDNA for MIR127 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR127 Gene

No ASD Table

Relevant External Links for MIR127 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR127 Gene

mRNA expression in normal human tissues for MIR127 Gene

genes like me logo Genes that share expression patterns with MIR127: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR127 Gene

Orthologs for MIR127 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR127 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-127 36
  • 83 (a)
(Canis familiaris)
Mammalia cfa-mir-127 36
  • 100 (a)
(Mus musculus)
Mammalia Mir127 36
  • 99 (a)
(Pan troglodytes)
Mammalia ptr-mir-127 36
  • 100 (a)
Species with no ortholog for MIR127:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR127 Gene

Gene Tree for MIR127 (if available)
Gene Tree for MIR127 (if available)

Paralogs for MIR127 Gene

No data available for Paralogs for MIR127 Gene

Variants for MIR127 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR127 Gene

Variant ID Type Subtype PubMed ID
nsv902240 CNV Loss 21882294
nsv509549 CNV Insertion 20534489
nsv902241 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR127 Gene

Disorders for MIR127 Gene

Relevant External Links for MIR127

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR127 Gene

Publications for MIR127 Gene

  1. Plasma miR-127 and miR-218 Might Serve as Potential Biomarkers for Cervical Cancer. (PMID: 25701838) You W. … Zheng J. (Reprod Sci 2015) 3 67
  2. MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7. (PMID: 24604520) Jiang H. … Lin B. (Oncol. Rep. 2014) 3
  3. MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. (PMID: 24854842) Zhou J. … Jiao B. (Cell. Physiol. Biochem. 2014) 3
  4. Prognostic and biological significance of microRNA-127 expression in human breast cancer. (PMID: 25477702) Wang S. … Li Q. (Dis. Markers 2014) 3
  5. A feedback inhibition between miRNA-127 and TGFI^/c-Jun cascade in HCC cell migration via MMP13. (PMID: 23762330) Yang Z. … Wang L. (PLoS ONE 2013) 3

Products for MIR127 Gene

Sources for MIR127 Gene