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Aliases for MIR1260B Gene

Subcategory (RNA class) for MIR1260B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1260B Gene

  • MicroRNA 1260b 2 3 5
  • Hsa-Mir-1260b 3
  • Mir-1260b 3

External Ids for MIR1260B Gene

Previous GeneCards Identifiers for MIR1260B Gene

  • GC11U901694
  • GC11P092141
  • GC11P096074

Summaries for MIR1260B Gene

Entrez Gene Summary for MIR1260B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1260B Gene

MIR1260B (MicroRNA 1260b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1260B Gene

Genomics for MIR1260B Gene

Regulatory Elements for MIR1260B Gene

Enhancers for MIR1260B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G096337 1.7 FANTOM5 ENCODE dbSUPER 0.7 -1.0 -973 6.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A CBX5 ZNF143 FOS DEK MAML2 FAM76B CCDC82 JRKL GC11M096338 MIR1260B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1260B on UCSC Golden Path with GeneCards custom track

Promoters for MIR1260B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000265475 -538 201 CTCF FOXA2 IKZF1
ENSR00000043762 962 2401 HDGF WRNIP1 ARID4B SIN3A ZNF48 CBX5 ZNF143 FOS KDM4B DEK

Genomic Location for MIR1260B Gene

Chromosome:
11
Start:
96,341,438 bp from pter
End:
96,341,526 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR1260B Gene

Genes around MIR1260B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1260B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1260B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1260B Gene

Proteins for MIR1260B Gene

Post-translational modifications for MIR1260B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1260B Gene

Domains & Families for MIR1260B Gene

Gene Families for MIR1260B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1260B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1260B Gene

Function for MIR1260B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1260B Gene

Localization for MIR1260B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1260B Gene

Pathways & Interactions for MIR1260B Gene

SuperPathways for MIR1260B Gene

No Data Available

Interacting Proteins for MIR1260B Gene

Gene Ontology (GO) - Biological Process for MIR1260B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1260B Gene

Drugs & Compounds for MIR1260B Gene

No Compound Related Data Available

Transcripts for MIR1260B Gene

mRNA/cDNA for MIR1260B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1260B Gene

No ASD Table

Relevant External Links for MIR1260B Gene

GeneLoc Exon Structure for
MIR1260B
ECgene alternative splicing isoforms for
MIR1260B

Expression for MIR1260B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1260B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1260B Gene:

MIR1260B
genes like me logo Genes that share expression patterns with MIR1260B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1260B Gene

Orthologs for MIR1260B Gene

Evolution for MIR1260B Gene

ENSEMBL:
Gene Tree for MIR1260B (if available)
TreeFam:
Gene Tree for MIR1260B (if available)

No data available for Orthologs for MIR1260B Gene

Paralogs for MIR1260B Gene

No data available for Paralogs for MIR1260B Gene

Variants for MIR1260B Gene

Sequence variations from dbSNP and Humsavar for MIR1260B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000028235 -- 96,341,989(+) TGTGA(A/G)CTCAG intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1000897580 -- 96,341,215(+) CATGA(A/T)GAGTA intron-variant, upstream-variant-2KB
rs1001147571 -- 96,340,764(+) GGAAT(C/T)AGAGA intron-variant, upstream-variant-2KB
rs1003195565 -- 96,341,519(+) GTGGG(A/G)GCGGT intron-variant, nc-transcript-variant, reference, missense
rs1005599279 -- 96,340,844(+) CTGAG(G/T)GGACA intron-variant, upstream-variant-2KB

Relevant External Links for MIR1260B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1260B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR1260B Gene

Disorders for MIR1260B Gene

Relevant External Links for MIR1260B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1260B

No disorders were found for MIR1260B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1260B Gene

Publications for MIR1260B Gene

  1. miR-1260b is a Potential Prognostic Biomarker in Colorectal Cancer. (PMID: 27399918) Liu D.R. … Kang H.X. (Med. Sci. Monit. 2016) 3 64
  2. miRa891246 and miRa894644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. (PMID: 27573701) Machida T. … Morita M. (Oncol. Rep. 2016) 3 64
  3. Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells. (PMID: 24504368) Hirata H. … Dahiya R. (Br. J. Cancer 2014) 3 64
  4. Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells. (PMID: 23591200) Hirata H. … Dahiya R. (Br. J. Cancer 2013) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR1260B Gene

Sources for MIR1260B Gene

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