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Aliases for MIR1260B Gene

Subcategory (RNA class) for MIR1260B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1260B Gene

  • MicroRNA 1260b 2 3 5
  • Hsa-Mir-1260b 3
  • Mir-1260b 3

External Ids for MIR1260B Gene

Previous GeneCards Identifiers for MIR1260B Gene

  • GC11U901694
  • GC11P092141
  • GC11P096074

Summaries for MIR1260B Gene

Entrez Gene Summary for MIR1260B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1260B Gene

MIR1260B (MicroRNA 1260b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1260B Gene

Genomics for MIR1260B Gene

Regulatory Elements for MIR1260B Gene

Enhancers for MIR1260B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F096337 1.3 FANTOM5 ENCODE 0.8 -1.0 -973 6.9 HDGF ATF1 PKNOX1 WRNIP1 SIN3A ARID4B ZNF48 GATA2 ZNF143 FOS MAML2 FAM76B CCDC82 JRKL GC11M096338 MIR1260B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1260B on UCSC Golden Path with GeneCards custom track

Promoters for MIR1260B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000186827 562 3601 HDGF WRNIP1 SIN3A ARID4B ZNF48 ZNF143 FOS KDM4B DEK GTF2B

Genomic Location for MIR1260B Gene

Chromosome:
11
Start:
96,341,438 bp from pter
End:
96,341,526 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR1260B Gene

Genes around MIR1260B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1260B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1260B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1260B Gene

Proteins for MIR1260B Gene

Post-translational modifications for MIR1260B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1260B Gene

Domains & Families for MIR1260B Gene

Gene Families for MIR1260B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1260B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1260B Gene

Function for MIR1260B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1260B Gene

Localization for MIR1260B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1260B Gene

Pathways & Interactions for MIR1260B Gene

SuperPathways for MIR1260B Gene

No Data Available

Interacting Proteins for MIR1260B Gene

Gene Ontology (GO) - Biological Process for MIR1260B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1260B Gene

Transcripts for MIR1260B Gene

mRNA/cDNA for MIR1260B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1260B Gene

No ASD Table

Relevant External Links for MIR1260B Gene

GeneLoc Exon Structure for
MIR1260B
ECgene alternative splicing isoforms for
MIR1260B

Expression for MIR1260B Gene

mRNA expression in normal human tissues for MIR1260B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1260B Gene:

MIR1260B
genes like me logo Genes that share expression patterns with MIR1260B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1260B Gene

Orthologs for MIR1260B Gene

Evolution for MIR1260B Gene

ENSEMBL:
Gene Tree for MIR1260B (if available)
TreeFam:
Gene Tree for MIR1260B (if available)

No data available for Orthologs for MIR1260B Gene

Paralogs for MIR1260B Gene

No data available for Paralogs for MIR1260B Gene

Variants for MIR1260B Gene

Sequence variations from dbSNP and Humsavar for MIR1260B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11021541 -- 96,341,713(+) GCCCT(A/G)CCTCG intron-variant, downstream-variant-500B, reference, synonymous-codon
rs111342696 -- 96,340,412(+) CCACC(A/G)GAGGC intron-variant, upstream-variant-2KB
rs115585226 -- 96,341,224(+) TAGGC(A/G)CATGA intron-variant, upstream-variant-2KB
rs115818767 -- 96,339,804(+) ACCCC(C/G)CTCCT intron-variant, upstream-variant-2KB
rs116404720 -- 96,339,536(+) CTTCA(C/T)GGCCC intron-variant, upstream-variant-2KB

Relevant External Links for MIR1260B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1260B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR1260B Gene

Disorders for MIR1260B Gene

Relevant External Links for MIR1260B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1260B

No disorders were found for MIR1260B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1260B Gene

Publications for MIR1260B Gene

  1. Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells. (PMID: 24504368) Hirata H. … Dahiya R. (Br. J. Cancer 2014) 3 64
  2. Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells. (PMID: 23591200) Hirata H. … Dahiya R. (Br. J. Cancer 2013) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1260B Gene

Sources for MIR1260B Gene

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