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Aliases for MIR126 Gene

Subcategory (RNA class) for MIR126 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR126 Gene

  • MicroRNA 126 2 3
  • MIRN126 3 6
  • Hsa-Mir-126 3
  • MiRNA126 3

External Ids for MIR126 Gene

ORGUL Members for MIR126 Gene

Previous Symbols for MIR126 Gene

  • MIRN126

Summaries for MIR126 Gene

Entrez Gene Summary for MIR126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR126 Gene

MIR126 (MicroRNA 126) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR126 Gene

Genomics for MIR126 Gene

Genomic Location for MIR126 Gene

Start:
136,670,602 bp from pter
End:
136,670,686 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR126 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR126 Gene

No data available for Regulatory Elements for MIR126 Gene

Proteins for MIR126 Gene

Post-translational modifications for MIR126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR126 Gene

Domains for MIR126 Gene

Gene Families for MIR126 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR126: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR126 Gene

Function for MIR126 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR126 Gene

Localization for MIR126 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR126 Gene

Pathways for MIR126 Gene

SuperPathways for MIR126 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR126: view

Pathways by source for MIR126 Gene

1 KEGG pathway for MIR126 Gene

Interacting Proteins for MIR126 Gene

Gene Ontology (GO) - Biological Process for MIR126 Gene

None

Transcripts for MIR126 Gene

mRNA/cDNA for MIR126 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR126 Gene

No ASD Table

Relevant External Links for MIR126 Gene

GeneLoc Exon Structure for
MIR126
ECgene alternative splicing isoforms for
MIR126

Expression for MIR126 Gene

mRNA expression in normal human tissues for MIR126 Gene

genes like me logo Genes that share expressions with MIR126: view

Orthologs for MIR126 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR126 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-126 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-126 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-126 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir126 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-126 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-126 37
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-126 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-126 37
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-126b 37
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-126 37
  • 49 (a)
OneToOne
Species with no ortholog for MIR126:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR126 Gene

ENSEMBL:
Gene Tree for MIR126 (if available)
TreeFam:
Gene Tree for MIR126 (if available)

Paralogs for MIR126 Gene

No data available for Paralogs for MIR126 Gene

Variants for MIR126 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR126 Gene

Variant ID Type Subtype PubMed ID
dgv8385n71 CNV Loss 21882294
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8396n71 CNV Loss 21882294
dgv8400n71 CNV Loss 21882294
nsv894386 CNV Loss 21882294
nsv894387 CNV Gain 21882294
nsv8579 CNV Gain 18304495
dgv8401n71 CNV Loss 21882294
nsv509334 CNV Insertion 20534489
dgv8404n71 CNV Loss 21882294
dgv2427e1 CNV Complex 17122850
dgv955n27 CNV Loss 19166990
esv2422220 CNV Deletion 17116639
dgv8407n71 CNV Loss 21882294
dgv8408n71 CNV Loss 21882294
nsv894415 CNV Gain 21882294
nsv894429 CNV Loss 21882294
dgv957n27 CNV Loss 19166990
nsv894430 CNV Loss 21882294
dgv8410n71 CNV Loss 21882294
nsv894433 CNV Loss 21882294
nsv894434 CNV Loss 21882294
dgv8411n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
esv32979 CNV Gain 17666407
nsv894446 CNV Loss 21882294

Relevant External Links for MIR126 Gene

HapMap Linkage Disequilibrium report
MIR126
Human Gene Mutation Database (HGMD)
MIR126

No data available for Sequence variations from dbSNP and Humsavar for MIR126 Gene

Disorders for MIR126 Gene

Relevant External Links for MIR126

Human Genome Epidemiology (HuGE) Navigator
MIR126
genes like me logo Genes that share disorders with MIR126: view

No data available for UniProtKB/Swiss-Prot for MIR126 Gene

Publications for MIR126 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. (PMID: 18193184) Musiyenko A. … Barik S. (J. Mol. Med. 2008) 3
  5. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. (PMID: 18227515) Harris T.A. … Lowenstein C.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3

Products for MIR126 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR126
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR126
    • Block miRNA regulation of MIR126 using miScript Target Protectors

    Sources for MIR126 Gene

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