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Aliases for MIR126 Gene

Subcategory (RNA class) for MIR126 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR126 Gene

  • MicroRNA 126 2 3 5
  • Hsa-Mir-126 3
  • MiRNA126 3
  • Mir-126 3
  • MIRN126 3

External Ids for MIR126 Gene

ORGUL Members for MIR126 Gene

Previous HGNC Symbols for MIR126 Gene

  • MIRN126

Previous GeneCards Identifiers for MIR126 Gene

  • GC09P138685
  • GC09P139566
  • GC09P139569
  • GC09P139572

Summaries for MIR126 Gene

Entrez Gene Summary for MIR126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR126 Gene

MIR126 (MicroRNA 126) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are EV release from cardiac cells and their functional effects and MicroRNAs in cancer.

Additional gene information for MIR126 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR126 Gene

Genomics for MIR126 Gene

Regulatory Elements for MIR126 Gene

Enhancers for MIR126 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H136673 1.2 ENCODE dbSUPER 0.7 +4.9 4900 3 HNRNPUL1 ATF1 ARID4B YY1 GLIS2 SP5 PPARG NFIL3 MYNN GLIS1 EHMT1 SNHG7 AGPAT2 INPP5E ANAPC2 DPH7 FAM69B SEC16A SNAPC4 MAN1B1
GH09H136671 1.1 ENCODE dbSUPER 0.7 +1.4 1419 1 HNRNPUL1 CTCF PTBP1 RB1 ZIC2 ZNF2 RAD21 CCNT2 HIC1 ZFHX2 SNHG7 SEC16A DPH7 EHMT1 ANAPC2 FAM69B AGPAT2 EXD3 MAN1B1 QSOX2
GH09H136672 1 ENCODE dbSUPER 0.7 +2.3 2342 0 HNRNPUL1 MTA2 SMAD5 BHLHE40 CCNT2 NFIC RUNX1 HDAC2 MTA1 POLR2A SNHG7 EHMT1 FAM69B SEC16A MIR126 AGPAT2
GH09H136674 1 ENCODE dbSUPER 0.7 +2.6 2632 0 HNRNPUL1 PTBP1 CCNT2 POLR2A NCOR1 SMAD5 MTA2 BHLHE40 RUNX1 NFIC SNHG7 EHMT1 FAM69B SEC16A AGPAT2 MIR126
GH09H136684 1.3 ENCODE dbSUPER 0.4 +16.6 16552 4 ATF1 SIN3A GLI4 YY1 ZNF121 GLIS2 ZNF143 ZNF207 KLF7 ATF7 DPH7 INPP5E ANAPC2 EHMT1 NPDC1 C9orf172 SNAPC4 MAN1B1 EXD3 AGPAT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR126 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR126 Gene

Chromosome:
9
Start:
136,670,602 bp from pter
End:
136,670,686 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR126 Gene

Genes around MIR126 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR126 Gene

Proteins for MIR126 Gene

Post-translational modifications for MIR126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR126 Gene

Domains & Families for MIR126 Gene

Gene Families for MIR126 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR126: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR126 Gene

Function for MIR126 Gene

Gene Ontology (GO) - Molecular Function for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
genes like me logo Genes that share ontologies with MIR126: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR126
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR126 Gene

Localization for MIR126 Gene

Gene Ontology (GO) - Cellular Components for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIR126: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR126 Gene

Pathways & Interactions for MIR126 Gene

genes like me logo Genes that share pathways with MIR126: view

Pathways by source for MIR126 Gene

1 KEGG pathway for MIR126 Gene

Interacting Proteins for MIR126 Gene

Gene Ontology (GO) - Biological Process for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 26646931
GO:0070374 positive regulation of ERK1 and ERK2 cascade ISS --
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS --
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS --
GO:1904018 positive regulation of vasculature development ISS --
genes like me logo Genes that share ontologies with MIR126: view

No data available for SIGNOR curated interactions for MIR126 Gene

Drugs & Compounds for MIR126 Gene

No Compound Related Data Available

Transcripts for MIR126 Gene

mRNA/cDNA for MIR126 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR126
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR126 Gene

No ASD Table

Relevant External Links for MIR126 Gene

GeneLoc Exon Structure for
MIR126
ECgene alternative splicing isoforms for
MIR126

Expression for MIR126 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR126 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR126 Gene:

MIR126
genes like me logo Genes that share expression patterns with MIR126: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR126 Gene

Orthologs for MIR126 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR126 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-126 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-126 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-126 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-126 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir126 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-126 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-126 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-126 34
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-126b 34
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-126 34
  • 49 (a)
OneToOne
Species where no ortholog for MIR126 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR126 Gene

ENSEMBL:
Gene Tree for MIR126 (if available)
TreeFam:
Gene Tree for MIR126 (if available)

Paralogs for MIR126 Gene

No data available for Paralogs for MIR126 Gene

Variants for MIR126 Gene

Sequence variations from dbSNP and Humsavar for MIR126 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000037301 -- 136,669,195(+) CCTGC(C/T)GGGGG intron-variant, upstream-variant-2KB
rs1002822631 -- 136,669,886(+) ACTGA(A/G)CTGGT intron-variant, upstream-variant-2KB
rs1002950372 -- 136,670,112(+) GGGAG(C/T)TGTGT intron-variant, upstream-variant-2KB
rs1005206809 -- 136,669,111(+) CCCTG(-/A)AATGT intron-variant, upstream-variant-2KB
rs1005905531 -- 136,669,205(+) GAGGG(A/G)CCTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR126 Gene

Variant ID Type Subtype PubMed ID
dgv13005n54 CNV loss 21841781
dgv13006n54 CNV loss 21841781
dgv955n27 CNV loss 19166990
dgv957n27 CNV loss 19166990
esv2422220 CNV deletion 17116639
esv2759720 CNV loss 17122850
esv32979 CNV gain 17666407
nsv1053781 CNV gain 25217958
nsv469918 CNV loss 18288195
nsv509334 CNV insertion 20534489
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Relevant External Links for MIR126 Gene

Human Gene Mutation Database (HGMD)
MIR126
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR126

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR126 Gene

Disorders for MIR126 Gene

Relevant External Links for MIR126

Human Genome Epidemiology (HuGE) Navigator
MIR126
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR126

No disorders were found for MIR126 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR126 Gene

Publications for MIR126 Gene

  1. The association of miR-126-3p, miR-126-5p and miR-664-3p expression profiles with outcomes of patients with metastatic colorectal cancer treated with bevacizumab. (PMID: 28714375) Fiala O … Finek J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. Loss of tumor suppressor miR-126 contributes to the development of hepatitis B virus-related hepatocellular carcinoma metastasis through the upregulation of ADAM9. (PMID: 28639884) Xiang LY … Yang DH (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  3. Protective Effects of MicroRNA-126 on Human Cardiac Microvascular Endothelial Cells Against Hypoxia/Reoxygenation-Induced Injury and Inflammatory Response by Activating PI3K/Akt/eNOS Signaling Pathway. (PMID: 28578351) Yang HH … Yao JM (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  4. ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126. (PMID: 28260063) Wang J … Zhu Z (Oncology reports 2017) 3 60
  5. Pseudohypoxia Induced by miR-126 Deactivation Promotes Migration and Therapeutic Resistance in Renal Cell Carcinoma. (PMID: 28257806) Liu W … Wang X (Cancer letters 2017) 3 60

Products for MIR126 Gene

Sources for MIR126 Gene

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