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Aliases for MIR126 Gene

Subcategory (RNA class) for MIR126 Gene


Quality Score for this RNA gene is


Aliases for MIR126 Gene

  • MicroRNA 126 2 3 5
  • Hsa-Mir-126 3
  • MiRNA126 3
  • Mir-126 3
  • MIRN126 3

External Ids for MIR126 Gene

ORGUL Members for MIR126 Gene

Previous HGNC Symbols for MIR126 Gene

  • MIRN126

Previous GeneCards Identifiers for MIR126 Gene

  • GC09P138685
  • GC09P139566
  • GC09P139569
  • GC09P139572

Summaries for MIR126 Gene

Entrez Gene Summary for MIR126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR126 Gene

MIR126 (MicroRNA 126) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR126 include Clear Cell Renal Cell Carcinoma. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR126 Gene

Genomics for MIR126 Gene

Regulatory Elements for MIR126 Gene

Enhancers for MIR126 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR126 on UCSC Golden Path with GeneCards custom track

Promoters for MIR126 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR126 Gene

136,670,602 bp from pter
136,670,686 bp from pter
85 bases
Plus strand

Genomic View for MIR126 Gene

Genes around MIR126 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR126 Gene

Proteins for MIR126 Gene

Post-translational modifications for MIR126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR126 Gene

Domains & Families for MIR126 Gene

Gene Families for MIR126 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR126: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR126 Gene

Function for MIR126 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR126 Gene

Localization for MIR126 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR126 Gene

Pathways & Interactions for MIR126 Gene

SuperPathways for MIR126 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR126: view

Pathways by source for MIR126 Gene

1 KEGG pathway for MIR126 Gene

Interacting Proteins for MIR126 Gene

Gene Ontology (GO) - Biological Process for MIR126 Gene


No data available for SIGNOR curated interactions for MIR126 Gene

Drugs & Compounds for MIR126 Gene

No Compound Related Data Available

Transcripts for MIR126 Gene

mRNA/cDNA for MIR126 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR126 Gene

No ASD Table

Relevant External Links for MIR126 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR126 Gene

mRNA expression in normal human tissues for MIR126 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR126 Gene:

genes like me logo Genes that share expression patterns with MIR126: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR126 Gene

Orthologs for MIR126 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR126 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-126 35
  • 96 (a)
(Canis familiaris)
Mammalia cfa-mir-126 35
  • 97 (a)
(Monodelphis domestica)
Mammalia mdo-mir-126 35
  • 93 (a)
(Mus musculus)
Mammalia Mir126 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-126 35
  • 65 (a)
(Pan troglodytes)
Mammalia ptr-mir-126 35
  • 100 (a)
(Gallus gallus)
Aves gga-mir-126 35
  • 90 (a)
(Anolis carolinensis)
Reptilia aca-mir-126 35
  • 79 (a)
(Danio rerio)
Actinopterygii dre-mir-126b 35
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-126 35
  • 49 (a)
Species where no ortholog for MIR126 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR126 Gene

Gene Tree for MIR126 (if available)
Gene Tree for MIR126 (if available)

Paralogs for MIR126 Gene

No data available for Paralogs for MIR126 Gene

Variants for MIR126 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR126 Gene

Variant ID Type Subtype PubMed ID
dgv13005n54 CNV loss 21841781
dgv13006n54 CNV loss 21841781
dgv955n27 CNV loss 19166990
dgv957n27 CNV loss 19166990
esv2422220 CNV deletion 17116639
esv2759720 CNV loss 17122850
esv32979 CNV gain 17666407
nsv1053781 CNV gain 25217958
nsv469918 CNV loss 18288195
nsv509334 CNV insertion 20534489
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Relevant External Links for MIR126 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR126 Gene

Disorders for MIR126 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR126 Gene - From: GeneCards

Disorder Aliases PubMed IDs
clear cell renal cell carcinoma
  • clear cell rcc
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR126

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR126: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR126 Gene

Publications for MIR126 Gene

  1. microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway. (PMID: 26723864) Gao J. … Zhao D.B. (Exp. Mol. Pathol. 2016) 3 65
  2. The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs. (PMID: 26826707) Kuosmanen S.M. … Levonen A.L. (Nucleic Acids Res. 2016) 3 65
  3. Interactive role of miR-126 on VEGF-A and progression of papillary and undifferentiated thyroid carcinoma. (PMID: 27067785) Salajegheh A. … Lam A.K. (Hum. Pathol. 2016) 3 65
  4. miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. (PMID: 26832662) Lechman E.R. … Dick J.E. (Cancer Cell 2016) 3 65
  5. Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma. (PMID: 26756996) Ghosh A. … Banerjee S. (Int. J. Cancer 2016) 3 65

Products for MIR126 Gene

Sources for MIR126 Gene

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