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Aliases for MIR126 Gene

Subcategory (RNA class) for MIR126 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR126 Gene

  • MicroRNA 126 2 3 5
  • Hsa-Mir-126 3
  • MiRNA126 3
  • Mir-126 3
  • MIRN126 3

External Ids for MIR126 Gene

ORGUL Members for MIR126 Gene

Previous HGNC Symbols for MIR126 Gene

  • MIRN126

Previous GeneCards Identifiers for MIR126 Gene

  • GC09P138685
  • GC09P139566
  • GC09P139569
  • GC09P139572

Summaries for MIR126 Gene

Entrez Gene Summary for MIR126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR126 Gene

MIR126 (MicroRNA 126) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Melatonin metabolism and effects and MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR126 Gene

Genomics for MIR126 Gene

Regulatory Elements for MIR126 Gene

Enhancers for MIR126 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136673 1.2 ENCODE dbSUPER 0.7 +4.9 4900 3.7 HNRNPUL1 ATF1 AGO1 ARID4B YY1 GLIS2 GATA2 FOS TAF15 SP5 AGPAT2 FAM69B SNHG7 SEC16A DNLZ MIR126
GH09G136671 1.1 ENCODE dbSUPER 0.7 +1.4 1419 1.3 HNRNPUL1 PTBP1 RB1 AGO1 ZNF2 RAD21 GLIS2 EGR1 ZNF143 EGR2 FAM69B SNHG7 AGPAT2 SEC16A NCLP1 MIR126
GH09G136674 1 ENCODE dbSUPER 0.7 +2.6 2632 0.2 HNRNPUL1 PTBP1 AGO1 UBTF CCNT2 NCOR1 POLR2A KDM5B MTA2 SMAD5 FAM69B SNHG7 SEC16A AGPAT2 MIR126
GH09G136672 1 ENCODE dbSUPER 0.7 +2.3 2342 0.2 HNRNPUL1 AGO1 CCNT2 POLR2A NCOR1 KDM5B MTA2 SMAD5 NR2F1 BHLHE40 FAM69B SNHG7 SEC16A MIR126 AGPAT2
GH09G136684 1.3 ENCODE dbSUPER 0.4 +16.6 16552 4.7 CREB3L1 AGO1 SIN3A YY1 ZNF143 ZNF207 KLF13 ZNF263 JUNB SMARCB1 NPDC1 C9orf172 DPH7 AGPAT2 MIR126
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR126 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR126 Gene

Chromosome:
9
Start:
136,670,602 bp from pter
End:
136,670,686 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR126 Gene

Genes around MIR126 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR126 Gene

Proteins for MIR126 Gene

Post-translational modifications for MIR126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR126 Gene

Domains & Families for MIR126 Gene

Gene Families for MIR126 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR126: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR126 Gene

Function for MIR126 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR126 Gene

Localization for MIR126 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR126 Gene

Pathways & Interactions for MIR126 Gene

genes like me logo Genes that share pathways with MIR126: view

Pathways by source for MIR126 Gene

1 KEGG pathway for MIR126 Gene

Interacting Proteins for MIR126 Gene

Gene Ontology (GO) - Biological Process for MIR126 Gene

None

No data available for SIGNOR curated interactions for MIR126 Gene

Drugs & Compounds for MIR126 Gene

No Compound Related Data Available

Transcripts for MIR126 Gene

mRNA/cDNA for MIR126 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR126 Gene

No ASD Table

Relevant External Links for MIR126 Gene

GeneLoc Exon Structure for
MIR126
ECgene alternative splicing isoforms for
MIR126

Expression for MIR126 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR126 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR126 Gene:

MIR126
genes like me logo Genes that share expression patterns with MIR126: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR126 Gene

Orthologs for MIR126 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR126 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-126 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-126 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-126 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-126 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir126 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-126 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-126 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-126 35
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-126b 35
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-126 35
  • 49 (a)
OneToOne
Species where no ortholog for MIR126 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR126 Gene

ENSEMBL:
Gene Tree for MIR126 (if available)
TreeFam:
Gene Tree for MIR126 (if available)

Paralogs for MIR126 Gene

No data available for Paralogs for MIR126 Gene

Variants for MIR126 Gene

Sequence variations from dbSNP and Humsavar for MIR126 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000037301 -- 136,669,195(+) CCTGC(C/T)GGGGG intron-variant, upstream-variant-2KB
rs1002822631 -- 136,669,886(+) ACTGA(A/G)CTGGT intron-variant, upstream-variant-2KB
rs1002950372 -- 136,670,112(+) GGGAG(C/T)TGTGT intron-variant, upstream-variant-2KB
rs1005206809 -- 136,669,111(+) CCCTG(-/A)AATGT intron-variant, upstream-variant-2KB
rs1005905531 -- 136,669,205(+) GAGGG(A/G)CCTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR126 Gene

Variant ID Type Subtype PubMed ID
dgv13005n54 CNV loss 21841781
dgv13006n54 CNV loss 21841781
dgv955n27 CNV loss 19166990
dgv957n27 CNV loss 19166990
esv2422220 CNV deletion 17116639
esv2759720 CNV loss 17122850
esv32979 CNV gain 17666407
nsv1053781 CNV gain 25217958
nsv469918 CNV loss 18288195
nsv509334 CNV insertion 20534489
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Relevant External Links for MIR126 Gene

Human Gene Mutation Database (HGMD)
MIR126
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR126

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR126 Gene

Disorders for MIR126 Gene

Relevant External Links for MIR126

Human Genome Epidemiology (HuGE) Navigator
MIR126
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR126

No disorders were found for MIR126 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR126 Gene

Publications for MIR126 Gene

  1. Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients. (PMID: 27321479) Al-Kafaji G. … Salem A.H. (Biomarkers 2017) 3 64
  2. ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126. (PMID: 28260063) Wang J. … Zhu Z. (Oncol. Rep. 2017) 3 64
  3. miR-126-3p and miR-451a correlate with clinicopathological features of lung adenocarcinoma: The underlying molecular mechanisms. (PMID: 27277197) Chen Q. … Wang J. (Oncol. Rep. 2016) 3 64
  4. Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line. (PMID: 27665734) An Q. … Kan Q. (Mol Med Rep 2016) 3 64
  5. miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia. (PMID: 27300437) Nucera S. … Naldini L. (Cancer Cell 2016) 3 64

Products for MIR126 Gene

Sources for MIR126 Gene

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