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Aliases for MIR125B2 Gene

Subcategory (RNA class) for MIR125B2 Gene


Quality Score for this RNA gene is


Aliases for MIR125B2 Gene

  • MicroRNA 125b-2 2 3
  • MIRN125B2 3 6
  • Hsa-Mir-125b-2 3

External Ids for MIR125B2 Gene

Previous HGNC Symbols for MIR125B2 Gene

  • MIRN125B2

Previous GeneCards Identifiers for MIR125B2 Gene

  • GC21P016887
  • GC21P017962

Summaries for MIR125B2 Gene

Entrez Gene Summary for MIR125B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125B2 Gene

MIR125B2 (MicroRNA 125b-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR125B2 Gene

Genomics for MIR125B2 Gene

Genomic Location for MIR125B2 Gene

16,590,237 bp from pter
16,590,325 bp from pter
89 bases
Plus strand

Genomic View for MIR125B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR125B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125B2 Gene

No data available for Regulatory Elements for MIR125B2 Gene

Proteins for MIR125B2 Gene

Post-translational modifications for MIR125B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125B2 Gene

Domains for MIR125B2 Gene

Gene Families for MIR125B2 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR125B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR125B2 Gene

Function for MIR125B2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR125B2 Gene

Localization for MIR125B2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR125B2 Gene

Pathways for MIR125B2 Gene

genes like me logo Genes that share pathways with MIR125B2: view

Pathways by source for MIR125B2 Gene

1 KEGG pathway for MIR125B2 Gene

Interacting Proteins for MIR125B2 Gene

Gene Ontology (GO) - Biological Process for MIR125B2 Gene


Transcripts for MIR125B2 Gene

mRNA/cDNA for MIR125B2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125B2 Gene

No ASD Table

Relevant External Links for MIR125B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR125B2 Gene

mRNA expression in normal human tissues for MIR125B2 Gene

genes like me logo Genes that share expressions with MIR125B2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR125B2 Gene

Orthologs for MIR125B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-125b-2 36
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-125b-2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-mir-125b-1 36
  • 87 (a)
(Mus musculus)
Mammalia Mir125b-2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
(Pan troglodytes)
Mammalia ptr-mir-125b-2 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-125b 36
  • 90 (a)
(Anolis carolinensis)
Reptilia aca-mir-100 36
  • 44 (a)
(Danio rerio)
Actinopterygii dre-mir-125b-1 36
  • 39 (a)
Species with no ortholog for MIR125B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125B2 Gene

Gene Tree for MIR125B2 (if available)
Gene Tree for MIR125B2 (if available)

Paralogs for MIR125B2 Gene

No data available for Paralogs for MIR125B2 Gene

Variants for MIR125B2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR125B2 Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV Deletion 23290073

Relevant External Links for MIR125B2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR125B2 Gene

Disorders for MIR125B2 Gene

Relevant External Links for MIR125B2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MIR125B2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR125B2 Gene

Publications for MIR125B2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48
  2. MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf. (PMID: 19471102) Xia H.F. … Ma X. (Cell. Physiol. Biochem. 2009) 3
  3. Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha. (PMID: 20158877) Koh W. … Tanavde V. (BMC Genomics 2010) 3
  4. MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. (PMID: 20460378) Zhou M. … Tan M. (J. Biol. Chem. 2010) 3
  5. MiR-125b targets BCL3 and suppresses ovarian cancer proliferation. (PMID: 20658525) Guan Y. … Sun K. (Int. J. Cancer 2011) 3

Products for MIR125B2 Gene

Sources for MIR125B2 Gene

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