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Aliases for MIR125B2 Gene

Subcategory (RNA class) for MIR125B2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR125B2 Gene

  • MicroRNA 125b-2 2 3 5
  • Hsa-Mir-125b-2 3
  • Mir-125b-2 3
  • MIRN125B2 3

External Ids for MIR125B2 Gene

Previous HGNC Symbols for MIR125B2 Gene

  • MIRN125B2

Previous GeneCards Identifiers for MIR125B2 Gene

  • GC21P016887
  • GC21P017962

Summaries for MIR125B2 Gene

Entrez Gene Summary for MIR125B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125B2 Gene

MIR125B2 (MicroRNA 125b-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TFs Regulate miRNAs related to cardiac hypertrophy and MicroRNAs in cancer.

Additional gene information for MIR125B2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR125B2 Gene

Genomics for MIR125B2 Gene

GeneHancer (GH) Regulatory Elements for MIR125B2 Gene

Promoters and enhancers for MIR125B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I016586 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.8 -2.5 -2492 3 ELF3 FOXA2 SIN3A RAD21 RFX5 YY1 ZNF335 GLIS2 ZNF143 RCOR1 MIR99A MIRLET7C MIR125B2 ENSG00000269950 MIR99AHG
GH21I016596 Enhancer 0.4 VISTA 0.4 +7.5 7467 2.8 PKNOX1 POLR2A GC21P016605 MIR125B2 MIR99AHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR125B2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR125B2 Gene

Genomic Locations for MIR125B2 Gene
chr21:16,590,237-16,590,325
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr21:17,962,557-17,962,645
(GRCh37/hg19)

Genomic View for MIR125B2 Gene

Genes around MIR125B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR125B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR125B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125B2 Gene

Proteins for MIR125B2 Gene

Post-translational modifications for MIR125B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125B2 Gene

Domains & Families for MIR125B2 Gene

Gene Families for MIR125B2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR125B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR125B2 Gene

Function for MIR125B2 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125B2 Gene

Localization for MIR125B2 Gene

Gene Ontology (GO) - Cellular Components for MIR125B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR125B2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR125B2 Gene

Pathways & Interactions for MIR125B2 Gene

genes like me logo Genes that share pathways with MIR125B2: view

Pathways by source for MIR125B2 Gene

1 KEGG pathway for MIR125B2 Gene

Interacting Proteins for MIR125B2 Gene

Gene Ontology (GO) - Biological Process for MIR125B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1905065 positive regulation of vascular smooth muscle cell differentiation IMP 18548003
genes like me logo Genes that share ontologies with MIR125B2: view

No data available for SIGNOR curated interactions for MIR125B2 Gene

Drugs & Compounds for MIR125B2 Gene

No Compound Related Data Available

Transcripts for MIR125B2 Gene

mRNA/cDNA for MIR125B2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125B2 Gene

No ASD Table

Relevant External Links for MIR125B2 Gene

GeneLoc Exon Structure for
MIR125B2
ECgene alternative splicing isoforms for
MIR125B2

Expression for MIR125B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR125B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR125B2 Gene:

MIR125B2
genes like me logo Genes that share expression patterns with MIR125B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125B2 Gene

Orthologs for MIR125B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125B2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-125b-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125b-2 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-125b-2 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir125b-2 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-125b-1 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-125b 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-100 34
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-125b-1 34
  • 39 (a)
ManyToMany
Species where no ortholog for MIR125B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125B2 Gene

ENSEMBL:
Gene Tree for MIR125B2 (if available)
TreeFam:
Gene Tree for MIR125B2 (if available)

Paralogs for MIR125B2 Gene

No data available for Paralogs for MIR125B2 Gene

Variants for MIR125B2 Gene

Sequence variations from dbSNP and Humsavar for MIR125B2 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000487755 -- 16,590,278(+) A/G non_coding_transcript_variant
rs1000760385 -- 16,588,556(+) A/C/G upstream_transcript_variant
rs1001506999 -- 16,590,778(+) G/T downstream_transcript_variant
rs1005451279 -- 16,590,818(+) T/C downstream_transcript_variant
rs1006403585 -- 16,589,322(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR125B2 Gene

Variant ID Type Subtype PubMed ID
esv2723192 CNV deletion 23290073

Additional Variant Information for MIR125B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR125B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR125B2 Gene

Disorders for MIR125B2 Gene

Additional Disease Information for MIR125B2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR125B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR125B2 Gene

Publications for MIR125B2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  2. Upregulation of microRNA-125b-5p is involved in the pathogenesis of osteoarthritis by downregulating SYVN1. (PMID: 28260078) Ge FX … Yin X (Oncology reports 2017) 3 58
  3. Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. (PMID: 28378642) Wang HH … Lee H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. Serum miR-21 and miR-125b as markers predicting neoadjuvant chemotherapy response and prognosis in stage II/III breast cancer. (PMID: 28412211) Liu B … Zhang J (Human pathology 2017) 3 58
  5. Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification. (PMID: 28522697) Chao CT … Chen HW (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 58

Products for MIR125B2 Gene

Sources for MIR125B2 Gene

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