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Aliases for MIR125B1 Gene

Subcategory (RNA class) for MIR125B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR125B1 Gene

  • MicroRNA 125b-1 2 3
  • MIRN125B1 3 6
  • Hsa-Mir-125b-1 3

External Ids for MIR125B1 Gene

Previous HGNC Symbols for MIR125B1 Gene

  • MIRN125B1

Previous GeneCards Identifiers for MIR125B1 Gene

  • GC11M121478
  • GC11M121970

Summaries for MIR125B1 Gene

Entrez Gene Summary for MIR125B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125B1 Gene

MIR125B1 (MicroRNA 125b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR125B1 include oral squamous cell carcinoma and b-cell lymphomas. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR125B1 Gene

Genomics for MIR125B1 Gene

Genomic Location for MIR125B1 Gene

Start:
122,099,757 bp from pter
End:
122,099,844 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR125B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR125B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125B1 Gene

No data available for Regulatory Elements for MIR125B1 Gene

Proteins for MIR125B1 Gene

Post-translational modifications for MIR125B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125B1 Gene

Domains for MIR125B1 Gene

Gene Families for MIR125B1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR125B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR125B1 Gene

Function for MIR125B1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR125B1 Gene

Localization for MIR125B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR125B1 Gene

Pathways for MIR125B1 Gene

genes like me logo Genes that share pathways with MIR125B1: view

Pathways by source for MIR125B1 Gene

1 KEGG pathway for MIR125B1 Gene

Interacting Proteins for MIR125B1 Gene

Gene Ontology (GO) - Biological Process for MIR125B1 Gene

None

Transcripts for MIR125B1 Gene

mRNA/cDNA for MIR125B1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR125B1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125B1 Gene

No ASD Table

Relevant External Links for MIR125B1 Gene

GeneLoc Exon Structure for
MIR125B1
ECgene alternative splicing isoforms for
MIR125B1

Expression for MIR125B1 Gene

mRNA expression in normal human tissues for MIR125B1 Gene

genes like me logo Genes that share expressions with MIR125B1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR125B1 Gene

Orthologs for MIR125B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125b-1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-125b-1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-125b-1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir125b-1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-125b-2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-125 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-125b-1 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-125b-2 36
  • 76 (a)
OneToOne
Species with no ortholog for MIR125B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125B1 Gene

ENSEMBL:
Gene Tree for MIR125B1 (if available)
TreeFam:
Gene Tree for MIR125B1 (if available)

Paralogs for MIR125B1 Gene

No data available for Paralogs for MIR125B1 Gene

Variants for MIR125B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR125B1 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV Gain 17160897

Relevant External Links for MIR125B1 Gene

HapMap Linkage Disequilibrium report
MIR125B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR125B1 Gene

Disorders for MIR125B1 Gene

Relevant External Links for MIR125B1

Genetic Association Database (GAD)
MIR125B1
Human Genome Epidemiology (HuGE) Navigator
MIR125B1
genes like me logo Genes that share disorders with MIR125B1: view

No data available for UniProtKB/Swiss-Prot for MIR125B1 Gene

Publications for MIR125B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48
  2. MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf. (PMID: 19471102) Xia H.F. … Ma X. (Cell. Physiol. Biochem. 2009) 3
  3. Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha. (PMID: 20158877) Koh W. … Tanavde V. (BMC Genomics 2010) 3
  4. A three-stage genome-wide association study of general cognitive ability: hunting the small effects. (PMID: 20306291) Davis O.S. … Plomin R. (Behav. Genet. 2010) 3
  5. Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. (PMID: 20347935) Pogue A.I. … Lukiw W.J. (Neurosci. Lett. 2010) 3

Products for MIR125B1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR125B1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR125B1
    • Block miRNA regulation of MIR125B1 using miScript Target Protectors

    Sources for MIR125B1 Gene

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