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Aliases for MIR125B1 Gene

Subcategory (RNA class) for MIR125B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR125B1 Gene

  • MicroRNA 125b-1 2 3 5
  • Hsa-Mir-125b-1 3
  • Mir-125b-1 3
  • MIRN125B1 3

External Ids for MIR125B1 Gene

Previous HGNC Symbols for MIR125B1 Gene

  • MIRN125B1

Previous GeneCards Identifiers for MIR125B1 Gene

  • GC11M121478
  • GC11M121970

Summaries for MIR125B1 Gene

Entrez Gene Summary for MIR125B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125B1 Gene

MIR125B1 (MicroRNA 125b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mesodermal Commitment Pathway and MicroRNAs in cardiomyocyte hypertrophy.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR125B1 Gene

Genomics for MIR125B1 Gene

Regulatory Elements for MIR125B1 Gene

Enhancers for MIR125B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G122043 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +54.0 54044 3.6 JUND GATA2 JUN FOS MAFK BLID MIR100HG MIR125B1 GC11P122016 GC11P122071
GH11G122035 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +63.5 63539 1.3 MAFK MIR125B1 GC11P122016 GC11P122071
GH11G122069 1.1 Ensembl ENCODE dbSUPER 10.6 +29.7 29667 1.2 CTCF PKNOX1 MXI1 RFX1 MAX BMI1 EP300 RFX3 TRIM28 MIR125B1 GC11P122071 GC11P122016
GH11G122037 1 Ensembl ENCODE dbSUPER 10.8 +60.5 60527 3.3 JUND BHLHE40 TEAD4 POU5F1 MIR125B1 GC11P122016 GC11P122071
GH11G122032 0.6 ENCODE dbSUPER 10.8 +66.1 66115 3.2 CEBPB BLID MIR100HG MIR125B1 GC11P122016 GC11P122071
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR125B1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR125B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000046116 744 5801 CTCF MXI1 FOXA2 TEAD4 HLF SIN3A CEBPB EP300 RAD21 JUND

Genomic Location for MIR125B1 Gene

Chromosome:
11
Start:
122,099,757 bp from pter
End:
122,099,844 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR125B1 Gene

Genes around MIR125B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR125B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR125B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125B1 Gene

Proteins for MIR125B1 Gene

Post-translational modifications for MIR125B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125B1 Gene

Domains & Families for MIR125B1 Gene

Gene Families for MIR125B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR125B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR125B1 Gene

Function for MIR125B1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR125B1 Gene

Localization for MIR125B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR125B1 Gene

Pathways & Interactions for MIR125B1 Gene

genes like me logo Genes that share pathways with MIR125B1: view

Pathways by source for MIR125B1 Gene

Interacting Proteins for MIR125B1 Gene

Gene Ontology (GO) - Biological Process for MIR125B1 Gene

None

No data available for SIGNOR curated interactions for MIR125B1 Gene

Drugs & Compounds for MIR125B1 Gene

No Compound Related Data Available

Transcripts for MIR125B1 Gene

mRNA/cDNA for MIR125B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125B1 Gene

No ASD Table

Relevant External Links for MIR125B1 Gene

GeneLoc Exon Structure for
MIR125B1
ECgene alternative splicing isoforms for
MIR125B1

Expression for MIR125B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR125B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR125B1 Gene:

MIR125B1
genes like me logo Genes that share expression patterns with MIR125B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR125B1 Gene

Orthologs for MIR125B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125b-1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir125b-1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-125b-1 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-125b-2 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-125b-1 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-125 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-125b-1 35
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-125b-2 35
  • 76 (a)
OneToOne
Species where no ortholog for MIR125B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125B1 Gene

ENSEMBL:
Gene Tree for MIR125B1 (if available)
TreeFam:
Gene Tree for MIR125B1 (if available)

Paralogs for MIR125B1 Gene

No data available for Paralogs for MIR125B1 Gene

Variants for MIR125B1 Gene

Sequence variations from dbSNP and Humsavar for MIR125B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000150146 -- 122,100,153(+) GCCCA(A/G)GTTTT intron-variant, upstream-variant-2KB
rs1002658336 -- 122,101,078(+) TGGGA(A/G)GATGA intron-variant, upstream-variant-2KB
rs1003328934 -- 122,100,466(+) TGGGC(A/G)AGGTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1003694286 -- 122,100,811(+) AGAGC(A/G)AGCAC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1004303700 -- 122,100,853(+) AGGGC(G/T)GGGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR125B1 Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897

Relevant External Links for MIR125B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR125B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR125B1 Gene

Disorders for MIR125B1 Gene

Relevant External Links for MIR125B1

Genetic Association Database (GAD)
MIR125B1
Human Genome Epidemiology (HuGE) Navigator
MIR125B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR125B1

No disorders were found for MIR125B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR125B1 Gene

Publications for MIR125B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  2. Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. (PMID: 28378642) Wang H.H. … Lee H. (Tumour Biol. 2017) 3 64
  3. Upregulation of microRNA-125b-5p is involved in the pathogenesis of osteoarthritis by downregulating SYVN1. (PMID: 28260078) Ge F.X. … Yin X. (Oncol. Rep. 2017) 3 64
  4. MiR-125b inhibits anaplastic thyroid cancer cell migration and invasion by targeting PIK3CD. (PMID: 28122310) Bu Q. … Zhang J. (Biomed. Pharmacother. 2017) 3 64
  5. Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion. (PMID: 28032929) Fujino Y. … Takayama T. (Cancer Sci. 2017) 3 64

Products for MIR125B1 Gene

Sources for MIR125B1 Gene

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