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Aliases for MIR125A Gene

Subcategory (RNA class) for MIR125A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR125A Gene

  • MicroRNA 125a 2 3
  • MIRN125A 3 6
  • Hsa-Mir-125a 3
  • MiRNA125A 3

External Ids for MIR125A Gene

ORGUL Members for MIR125A Gene

Previous Symbols for MIR125A Gene

  • MIRN125A

Summaries for MIR125A Gene

Entrez Gene Summary for MIR125A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR125A Gene

MIR125A (MicroRNA 125a) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR125A include verrucous carcinoma and familial breast cancer. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR125A Gene

Genomics for MIR125A Gene

Genomic Location for MIR125A Gene

Start:
51,693,254 bp from pter
End:
51,693,339 bp from pter
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR125A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR125A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR125A Gene

No data available for Regulatory Elements for MIR125A Gene

Proteins for MIR125A Gene

Post-translational modifications for MIR125A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR125A Gene

Domains for MIR125A Gene

Gene Families for MIR125A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR125A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR125A Gene

Function for MIR125A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR125A Gene

Localization for MIR125A Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR125A Gene

Pathways for MIR125A Gene

SuperPathways for MIR125A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR125A: view

Pathways by source for MIR125A Gene

1 KEGG pathway for MIR125A Gene

Interacting Proteins for MIR125A Gene

Gene Ontology (GO) - Biological Process for MIR125A Gene

None

Transcripts for MIR125A Gene

mRNA/cDNA for MIR125A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR125A Gene

No ASD Table

Relevant External Links for MIR125A Gene

GeneLoc Exon Structure for
MIR125A
ECgene alternative splicing isoforms for
MIR125A

Expression for MIR125A Gene

No Expression Related Data Available

Orthologs for MIR125A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR125A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-125a 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-125a 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-125a 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir125a 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-10c 37
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-125a-1 37
  • 76 (a)
OneToMany
dre-mir-125a-2 37
  • 56 (a)
OneToMany
Species with no ortholog for MIR125A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR125A Gene

ENSEMBL:
Gene Tree for MIR125A (if available)
TreeFam:
Gene Tree for MIR125A (if available)

Paralogs for MIR125A Gene

No data available for Paralogs for MIR125A Gene

Variants for MIR125A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR125A Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv912296 CNV Loss 21882294
nsv9742 CNV Gain+Loss 18304495

Relevant External Links for MIR125A Gene

HapMap Linkage Disequilibrium report
MIR125A
Human Gene Mutation Database (HGMD)
MIR125A

No data available for Sequence variations from dbSNP and Humsavar for MIR125A Gene

Disorders for MIR125A Gene

Relevant External Links for MIR125A

Genetic Association Database (GAD)
MIR125A
Human Genome Epidemiology (HuGE) Navigator
MIR125A
genes like me logo Genes that share disorders with MIR125A: view

No data available for UniProtKB/Swiss-Prot for MIR125A Gene

Publications for MIR125A Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 49
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 49
  3. Germline mutation of microRNA-125a is associated with breast cancer. (PMID: 19411564) Li W. … Jin P. (J. Med. Genet. 2009) 3
  4. Epidermal growth factor receptor-regulated miR-125a-5p--a metastatic inhibitor of lung cancer. (PMID: 19702827) Wang G. … Ye J. (FEBS J. 2009) 3
  5. MicroRNA 125a and its regulation of the p53 tumor suppressor gene. (PMID: 19818772) Zhang Y. … Ramratnam B. (FEBS Lett. 2009) 3

Products for MIR125A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR125A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR125A
    • Block miRNA regulation of MIR125A using miScript Target Protectors

    Sources for MIR125A Gene

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