Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR1258 Gene

Subcategory (RNA class) for MIR1258 Gene


Quality Score for this RNA gene is


Aliases for MIR1258 Gene

  • MicroRNA 1258 2 3 5
  • Hsa-Mir-1258 3
  • Mir-1258 3
  • MIRN1258 3

External Ids for MIR1258 Gene

Previous HGNC Symbols for MIR1258 Gene

  • MIRN1258

Previous GeneCards Identifiers for MIR1258 Gene

  • GC00U923048
  • GC02M180434
  • GC02M180725

Summaries for MIR1258 Gene

Entrez Gene Summary for MIR1258 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1258 Gene

MIR1258 (MicroRNA 1258) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1258 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1258 Gene

Genomics for MIR1258 Gene

Regulatory Elements for MIR1258 Gene

Enhancers for MIR1258 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H179860 0.8 FANTOM5 0.7 +0.6 572 0 MAZ ZFP37 ZNF398 ZNF324 ZFHX2 ZNF366 ZBTB48 SCRT2 PATZ1 ZNF600 ZNF385B MIR1258 LOC100131482
GH02H179861 0.7 ENCODE 0.7 -0.7 -651 0 KLF1 ZIC2 ZNF2 GLIS2 PATZ1 ZBTB20 EZH2 L3MBTL2 SP2 ZNF501 MIR1258 ZNF385B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1258 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1258 Gene

179,860,836 bp from pter
179,860,908 bp from pter
73 bases
Minus strand

Genomic View for MIR1258 Gene

Genes around MIR1258 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1258 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1258 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1258 Gene

Proteins for MIR1258 Gene

Post-translational modifications for MIR1258 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1258 Gene

Domains & Families for MIR1258 Gene

Gene Families for MIR1258 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1258: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1258 Gene

Function for MIR1258 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR1258
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1258 Gene

Localization for MIR1258 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1258 Gene

Pathways & Interactions for MIR1258 Gene

SuperPathways for MIR1258 Gene

No Data Available

Interacting Proteins for MIR1258 Gene

Gene Ontology (GO) - Biological Process for MIR1258 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR1258 Gene

Drugs & Compounds for MIR1258 Gene

No Compound Related Data Available

Transcripts for MIR1258 Gene

mRNA/cDNA for MIR1258 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR1258
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1258 Gene

No ASD Table

Relevant External Links for MIR1258 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1258 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1258 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1258 Gene

Orthologs for MIR1258 Gene

Evolution for MIR1258 Gene

Gene Tree for MIR1258 (if available)
Gene Tree for MIR1258 (if available)

No data available for Orthologs for MIR1258 Gene

Paralogs for MIR1258 Gene

No data available for Paralogs for MIR1258 Gene

Variants for MIR1258 Gene

Sequence variations from dbSNP and Humsavar for MIR1258 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000724385 -- 179,860,607(+) CTGGG(C/T)TCTGC intron-variant, downstream-variant-500B
rs1001008898 -- 179,860,969(+) CGGGA(C/G)GGGGG intron-variant, upstream-variant-2KB
rs1002524952 -- 179,861,307(+) CCGGC(A/G)CGGCC upstream-variant-2KB, utr-variant-5-prime
rs1003119349 -- 179,862,254(+) AGGGA(-/T)TTTTT upstream-variant-2KB, utr-variant-5-prime
rs1004624763 -- 179,862,722(+) AACAT(A/G)AGCTA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR1258 Gene

Variant ID Type Subtype PubMed ID
nsv3062 CNV insertion 18451855

Relevant External Links for MIR1258 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1258 Gene

Disorders for MIR1258 Gene

Relevant External Links for MIR1258

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR1258 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1258 Gene

Publications for MIR1258 Gene

  1. [Novel miRNA genes hypermethylated in breast cancer]. (PMID: 27830681) Loginov VI … Braga EA (Molekuliarnaia biologiia 2016) 3 60
  2. Inhibition of Kaposi's sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. (PMID: 24554664) Yan Q … Lu C (Journal of virology 2014) 3 60
  3. The expression and clinical significance of microRNA-1258 and heparanase in human breast cancer. (PMID: 23415719) Tang D … Tian L (Clinical biochemistry 2013) 3 60
  4. The expression of heparanase and microRNA-1258 in human non-small cell lung cancer. (PMID: 22488243) Liu H … Jiang G (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012) 3 60
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60

Products for MIR1258 Gene

Sources for MIR1258 Gene

Loading form....