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Aliases for MIR1257 Gene

Subcategory (RNA class) for MIR1257 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1257 Gene

  • MicroRNA 1257 2 3
  • Transcription Initiation Factor TFIID 130 KDa Subunit 4
  • Transcription Initiation Factor TFIID 135 KDa Subunit 4
  • RNA Polymerase II TBP-Associated Factor Subunit C 4
  • TATA-Box Binding Protein Associated Factor 4 5
  • TBP-Associated Factor 4 4
  • Hsa-Mir-1257 3
  • TAF(II)130 4
  • TAF(II)135 4
  • TAFII-130 4
  • TAFII-135 4
  • MIRN1257 3
  • TAFII130 4
  • TAFII135 4
  • TAF2C1 4
  • TAF2C 4
  • TAF4A 4
  • TAF4 5

External Ids for MIR1257 Gene

Previous HGNC Symbols for MIR1257 Gene

  • MIRN1257

Previous GeneCards Identifiers for MIR1257 Gene

  • GC00U922880
  • GC20M059962
  • GC20M060528

Summaries for MIR1257 Gene

Entrez Gene Summary for MIR1257 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1257 Gene

MIR1257 (MicroRNA 1257) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. An important paralog of this gene is TAF4B.

UniProtKB/Swiss-Prot for MIR1257 Gene

  • Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1257 Gene

Genomics for MIR1257 Gene

Regulatory Elements for MIR1257 Gene

Enhancers for MIR1257 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062041 0.2 ENCODE 12.1 +22.9 22850 2.4 ELF3 ARID4B DMAP1 THRB ZSCAN9 RAD21 RARA YY1 GLIS2 CREM TAF4 MIR1257 LSM14B PSMA7 SS18L1 CDH4 RPL17P48 MIR3195
GH20F062003 0.2 ENCODE 11.7 +62.6 62591 0.2 MXI1 MLX SP5 ARID4B DMAP1 NR2F6 HNF4A MAFK PSMA7 SS18L1 MIR1257 LOC105372704 GC20M062040
GH20F061912 0.5 ENCODE 11.4 +153.0 152971 0.2 MTA2 JUNB EBF1 TBX21 EP300 SP1 ARID3A CBX5 POLR2A IKZF1 MIR1257 PIR38008 GC20P061938
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1257 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1257 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010657 110 3001 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 GLIS2

Genomic Location for MIR1257 Gene

Chromosome:
20
Start:
61,953,469 bp from pter
End:
62,065,810 bp from pter
Size:
112,342 bases
Orientation:
Minus strand

Genomic View for MIR1257 Gene

Genes around MIR1257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1257 Gene

Proteins for MIR1257 Gene

  • Protein details for MIR1257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00268-TAF4_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 4
    Protein Accession:
    O00268
    Secondary Accessions:
    • A6NGD9
    • Q5TBP6
    • Q99721
    • Q9BR40
    • Q9BX42

    Protein attributes for MIR1257 Gene

    Size:
    1085 amino acids
    Molecular mass:
    110114 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.

    Three dimensional structures from OCA and Proteopedia for MIR1257 Gene

neXtProt entry for MIR1257 Gene

Post-translational modifications for MIR1257 Gene

  • Ubiquitination at Lys 611
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR1257 Gene

No data available for DME Specific Peptides for MIR1257 Gene

Domains & Families for MIR1257 Gene

Gene Families for MIR1257 Gene

Graphical View of Domain Structure for InterPro Entry

O00268

UniProtKB/Swiss-Prot:

TAF4_HUMAN :
  • Contains 1 TAFH (NHR1) domain.
  • Belongs to the TAF4 family.
Domain:
  • Contains 1 TAFH (NHR1) domain.
Family:
  • Belongs to the TAF4 family.
genes like me logo Genes that share domains with MIR1257: view

No data available for Suggested Antigen Peptide Sequences for MIR1257 Gene

Function for MIR1257 Gene

Molecular function for MIR1257 Gene

UniProtKB/Swiss-Prot Function:
Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Gene Ontology (GO) - Molecular Function for MIR1257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0003713 transcription coactivator activity TAS --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with MIR1257: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1257 Gene

Localization for MIR1257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1257 Gene

Gene Ontology (GO) - Cellular Components for MIR1257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005669 transcription factor TFIID complex IEA --
GO:0005737 cytoplasm IDA --
GO:0033276 transcription factor TFTC complex IDA --
genes like me logo Genes that share ontologies with MIR1257: view

No data available for Subcellular locations from COMPARTMENTS for MIR1257 Gene

Pathways & Interactions for MIR1257 Gene

genes like me logo Genes that share pathways with MIR1257: view

Pathways by source for MIR1257 Gene

Gene Ontology (GO) - Biological Process for MIR1257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MIR1257: view

No data available for SIGNOR curated interactions for MIR1257 Gene

Transcripts for MIR1257 Gene

mRNA/cDNA for MIR1257 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1257 Gene

No ASD Table

Relevant External Links for MIR1257 Gene

GeneLoc Exon Structure for
MIR1257
ECgene alternative splicing isoforms for
MIR1257

Expression for MIR1257 Gene

mRNA expression in normal human tissues for MIR1257 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1257 Gene

This gene is overexpressed in Ovary (x43.1) and Kidney - Cortex (x9.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR1257 Gene:

MIR1257
genes like me logo Genes that share expression patterns with MIR1257: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1257 Gene

Orthologs for MIR1257 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1257 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TAF4 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF4 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF4 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF4 35
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf4a 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF4 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF4 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TAF4 (1 of 2) 35
  • 74 (a)
OneToMany
TAF4 (2 of 2) 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Taf4 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-4 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8870 35
  • 41 (a)
OneToMany
Species where no ortholog for MIR1257 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1257 Gene

ENSEMBL:
Gene Tree for MIR1257 (if available)
TreeFam:
Gene Tree for MIR1257 (if available)

Paralogs for MIR1257 Gene

Paralogs for MIR1257 Gene

genes like me logo Genes that share paralogs with MIR1257: view

Variants for MIR1257 Gene

Sequence variations from dbSNP and Humsavar for MIR1257 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs112189530 -- 61,954,734(+) CTACC(A/C)CCAGG upstream-variant-2KB
rs113267730 -- 61,953,963(+) GGCGC(A/G)GTGGT upstream-variant-2KB
rs114580352 -- 61,954,907(+) ACCCC(A/G)ATGGT upstream-variant-2KB
rs11483756 -- 61,955,251(+) GCCTC(-/A)GGTCA upstream-variant-2KB
rs116538157 -- 61,954,607(+) AGCTC(A/G)GCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1257 Gene

Variant ID Type Subtype PubMed ID
esv2758804 CNV gain+loss 17122850
esv3646283 CNV loss 21293372
nsv3439 CNV deletion 18451855
nsv428378 CNV loss 18775914
nsv509781 CNV insertion 20534489
nsv586451 CNV gain 21841781
nsv955146 CNV deletion 24416366

Relevant External Links for MIR1257 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1257

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1257 Gene

Disorders for MIR1257 Gene

Relevant External Links for MIR1257

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1257

No disorders were found for MIR1257 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1257 Gene

Publications for MIR1257 Gene

  1. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3 64
  4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64
  5. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64

Products for MIR1257 Gene

Sources for MIR1257 Gene

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