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Aliases for MIR1257 Gene

Subcategory (RNA class) for MIR1257 Gene


Quality Score for this RNA gene is


Aliases for MIR1257 Gene

  • MicroRNA 1257 2 3 5
  • Hsa-Mir-1257 3
  • MIRN1257 3

External Ids for MIR1257 Gene

Previous HGNC Symbols for MIR1257 Gene

  • MIRN1257

Previous GeneCards Identifiers for MIR1257 Gene

  • GC00U922880
  • GC20M059962
  • GC20M060528

Summaries for MIR1257 Gene

Entrez Gene Summary for MIR1257 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1257 Gene

MIR1257 (MicroRNA 1257) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle.

Additional gene information for MIR1257 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1257 Gene

Genomics for MIR1257 Gene

Regulatory Elements for MIR1257 Gene

Enhancers for MIR1257 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H061912 0.8 ENCODE 11.6 +40.8 40823 0.2 BACH1 EBF1 BATF ZNF143 ZNF207 ATF7 RUNX3 IKZF2 ZNF687 NR2F1 MIR1257 PIR38008 GC20P061938
GH20H062003 0.7 ENCODE 10.8 -49.6 -49558 0.2 MXI1 FOXA2 MLX SP5 RNF2 ARID4B ZHX2 MAX DMAP1 JUND SS18L1 PSMA7 MIR1257 LOC105372704 GC20M062040
GH20H061956 0.9 ENCODE 0.7 -3.4 -3377 1.2 PKNOX1 FOXA2 ATF1 ARNT INSM2 FEZF1 RARA ZNF366 ZSCAN5C SCRT2 CDH4 MIR1257 GC20P061972
GH20H061964 1.1 Ensembl ENCODE 0.4 -12.4 -12406 2.5 BCOR TFAP4 MXI1 SAP130 ARID4B ZMYM3 RAD21 THRB RARA ADNP CDH4 GC20P061972 MIR1257
GH20H061958 0.9 FANTOM5 ENCODE 0.4 -5.7 -5722 0.8 PKNOX1 NFYC SP2 MBD2 SCRT2 NFYB CREB1 FOS CDH4 CABLES2 MIR1257 GC20P061972
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1257 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1257 Gene

Genomic Locations for MIR1257 Gene
117 bases
Minus strand

Genomic View for MIR1257 Gene

Genes around MIR1257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1257 Gene

Proteins for MIR1257 Gene

Post-translational modifications for MIR1257 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1257 Gene

Domains & Families for MIR1257 Gene

Gene Families for MIR1257 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1257: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1257 Gene

Function for MIR1257 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1257 Gene

Localization for MIR1257 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1257 Gene

Drugs & Compounds for MIR1257 Gene

No Compound Related Data Available

Transcripts for MIR1257 Gene

mRNA/cDNA for MIR1257 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1257 Gene

No ASD Table

Relevant External Links for MIR1257 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1257 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1257 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1257 Gene

This gene is overexpressed in Ovary (x43.1) and Kidney - Cortex (x9.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR1257 Gene:

genes like me logo Genes that share expression patterns with MIR1257: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1257 Gene

Orthologs for MIR1257 Gene

Evolution for MIR1257 Gene

Gene Tree for MIR1257 (if available)
Gene Tree for MIR1257 (if available)

No data available for Orthologs for MIR1257 Gene

Paralogs for MIR1257 Gene

No data available for Paralogs for MIR1257 Gene

Variants for MIR1257 Gene

Sequence variations from dbSNP and Humsavar for MIR1257 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000431169 -- 61,954,005(+) TGAGG(C/T)GGGAG upstream-variant-2KB
rs1000480498 -- 61,955,012(+) TGCTC(A/G)CTTTG upstream-variant-2KB
rs1000623060 -- 61,955,324(+) CAATC(C/T)CTTTT upstream-variant-2KB
rs1001594037 -- 61,953,451(+) TGCCC(C/T)GTGAA downstream-variant-500B
rs1001663530 -- 61,954,817(+) TCCTG(G/T)TGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1257 Gene

Variant ID Type Subtype PubMed ID
nsv955146 CNV deletion 24416366
nsv586451 CNV gain 21841781
nsv509781 CNV insertion 20534489
nsv428378 CNV loss 18775914
nsv3439 CNV deletion 18451855
esv3646283 CNV loss 21293372
esv2758804 CNV gain+loss 17122850

Relevant External Links for MIR1257 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1257 Gene

Disorders for MIR1257 Gene

Relevant External Links for MIR1257

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR1257 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1257 Gene

Publications for MIR1257 Gene

  1. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B … Wang LS (Journal of proteome research 2012) 3 60
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR1257 Gene

Sources for MIR1257 Gene

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