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Aliases for MIR1257 Gene

Subcategory (RNA class) for MIR1257 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1257 Gene

  • MicroRNA 1257 2 3 5
  • Hsa-Mir-1257 3
  • MIRN1257 3

External Ids for MIR1257 Gene

Previous HGNC Symbols for MIR1257 Gene

  • MIRN1257

Previous GeneCards Identifiers for MIR1257 Gene

  • GC00U922880
  • GC20M059962
  • GC20M060528

Summaries for MIR1257 Gene

Entrez Gene Summary for MIR1257 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1257 Gene

MIR1257 (MicroRNA 1257) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression.

Additional gene information for MIR1257 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1257 Gene

Genomics for MIR1257 Gene

GeneHancer (GH) Regulatory Elements for MIR1257 Gene

Promoters and enhancers for MIR1257 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I061952 Enhancer 0.9 ENCODE 550.8 +1.5 1512 0.2 ZFP64 ARID4B SIN3A ZBTB7B ZNF48 SLC30A9 GLIS2 ZNF143 NFYC MXD4 MIR1257 PIR52459 CDH4 PIR50269 GC20M061929
GH20I061912 Enhancer 0.7 ENCODE 11.6 +40.8 40822 0.2 BACH1 EBF1 BATF IRF4 ZNF207 ZNF143 ATF7 BCLAF1 IKZF2 RUNX3 MIR1257 PIR38008 GC20P061938 CDH4
GH20I062003 Enhancer 0.6 ENCODE 10.9 -49.6 -49558 0.2 MXI1 FOXA2 RNF2 MLX SP5 ARID4B MAX ZHX2 DMAP1 ETS1 LOC105372704 PSMA7 SS18L1 MIR1257 GC20M062040 GC20P061972 TAF4
GH20I061956 Enhancer 0.9 ENCODE 0.8 -3.4 -3377 1.2 PKNOX1 ATF1 FOXA2 ARNT INSM2 FEZF1 RARA ZNF366 ZSCAN5C SCRT2 CDH4 MIR1257 GC20P061972 GC20M061929 TAF4
GH20I061964 Enhancer 1 Ensembl ENCODE 0.4 -12.4 -12406 2.5 CTCF BCOR TFAP4 MXI1 USF1 SAP130 ARID4B ZMYM3 RAD21 THRB CDH4 GC20P061972 MIR1257 GC20M061929 TAF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1257 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1257 Gene

Genomic Locations for MIR1257 Gene
chr20:61,953,546-61,953,662
(GRCh38/hg38)
Size:
117 bases
Orientation:
Minus strand
chr20:60,528,602-60,528,718
(GRCh37/hg19)

Genomic View for MIR1257 Gene

Genes around MIR1257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1257 Gene

Proteins for MIR1257 Gene

Post-translational modifications for MIR1257 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1257 Gene

Domains & Families for MIR1257 Gene

Gene Families for MIR1257 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1257: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1257 Gene

Function for MIR1257 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1257 Gene

Localization for MIR1257 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1257 Gene

Drugs & Compounds for MIR1257 Gene

No Compound Related Data Available

Transcripts for MIR1257 Gene

mRNA/cDNA for MIR1257 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1257 Gene

No ASD Table

Relevant External Links for MIR1257 Gene

GeneLoc Exon Structure for
MIR1257
ECgene alternative splicing isoforms for
MIR1257

Expression for MIR1257 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1257 Gene

mRNA differential expression in normal tissues according to GTEx for MIR1257 Gene

This gene is overexpressed in Ovary (x43.1) and Kidney - Cortex (x9.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR1257 Gene:

MIR1257
genes like me logo Genes that share expression patterns with MIR1257: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1257 Gene

Orthologs for MIR1257 Gene

Evolution for MIR1257 Gene

ENSEMBL:
Gene Tree for MIR1257 (if available)
TreeFam:
Gene Tree for MIR1257 (if available)

No data available for Orthologs for MIR1257 Gene

Paralogs for MIR1257 Gene

No data available for Paralogs for MIR1257 Gene

Variants for MIR1257 Gene

Sequence variations from dbSNP and Humsavar for MIR1257 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000431169 -- 61,954,005(-) C/T upstream_transcript_variant
rs1000480498 -- 61,955,012(-) A/G upstream_transcript_variant
rs1000623060 -- 61,955,324(-) C/T upstream_transcript_variant
rs1001594037 -- 61,953,451(-) C/T downstream_transcript_variant
rs1001663530 -- 61,954,817(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1257 Gene

Variant ID Type Subtype PubMed ID
esv2758804 CNV gain+loss 17122850
esv3646283 CNV loss 21293372
nsv3439 CNV deletion 18451855
nsv428378 CNV loss 18775914
nsv509781 CNV insertion 20534489
nsv586451 CNV gain 21841781
nsv955146 CNV deletion 24416366

Additional Variant Information for MIR1257 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1257

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1257 Gene

Disorders for MIR1257 Gene

Additional Disease Information for MIR1257

No disorders were found for MIR1257 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1257 Gene

Publications for MIR1257 Gene

  1. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B … Wang LS (Journal of proteome research 2012) 3 58
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR1257 Gene

Sources for MIR1257 Gene

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