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Aliases for MIR1254-1 Gene

Subcategory (RNA class) for MIR1254-1 Gene


Quality Score for this RNA gene is


Aliases for MIR1254-1 Gene

  • MicroRNA 1254-1 2 3 5
  • MicroRNA 1254 2 3
  • Hsa-Mir-1254-1 3
  • Hsa-Mir-1254 3
  • MIRN1254 3
  • MIR1254 3

External Ids for MIR1254-1 Gene

Previous HGNC Symbols for MIR1254-1 Gene

  • MIRN1254
  • MIR1254

Previous GeneCards Identifiers for MIR1254-1 Gene

  • GC10P070520
  • GC10P070521
  • GC10P070524
  • GC10P070527

Summaries for MIR1254-1 Gene

Entrez Gene Summary for MIR1254-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1254-1 Gene

MIR1254-1 (MicroRNA 1254-1) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1254-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1254-1 Gene

Genomics for MIR1254-1 Gene

Regulatory Elements for MIR1254-1 Gene

Enhancers for MIR1254-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H069325 1.5 Ensembl ENCODE dbSUPER 11.5 +574.1 574084 16 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF2 ETS1 TCF12 GLIS2 GATA2 CCAR1 DDX50 SAR1A HK1 RPL26P27 MIR1254-1 ENSG00000231748 TYSND1 DDX21 STOX1
GH10H068899 1.2 ENCODE 11.5 +141.7 141731 3.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 DDX50 RPL26P27 CCAR1 MIR1254-1 DDX21 KIF1BP PIR62040 GC10M068913 RNU6-571P
GH10H067763 1.4 Ensembl ENCODE 9.7 -995.0 -994963 2.6 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 ZNF143 FOS SP3 CCAR1 HNRNPH3 SIRT1 RUFY2 HERC4 TET1 RPL12P8 MIR1254-1 CTNNA3 TRS-TGA1-1
GH10H068470 1.1 ENCODE 10 -288.0 -287961 2.5 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 DNA2 HERC4 SLC25A16 CCAR1 MIR1254-1 DDX50 GC10P068471 RNA5SP319
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1254-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1254-1 Gene

Genomic Locations for MIR1254-1 Gene
97 bases
Plus strand

Genomic View for MIR1254-1 Gene

Genes around MIR1254-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1254-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1254-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1254-1 Gene

Proteins for MIR1254-1 Gene

Post-translational modifications for MIR1254-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1254-1 Gene

Domains & Families for MIR1254-1 Gene

Gene Families for MIR1254-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1254-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1254-1 Gene

Function for MIR1254-1 Gene

Phenotypes From GWAS Catalog for MIR1254-1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1254-1 Gene

Localization for MIR1254-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1254-1 Gene

Pathways & Interactions for MIR1254-1 Gene

SuperPathways for MIR1254-1 Gene

No Data Available

Interacting Proteins for MIR1254-1 Gene

Gene Ontology (GO) - Biological Process for MIR1254-1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR1254-1 Gene

Drugs & Compounds for MIR1254-1 Gene

No Compound Related Data Available

Transcripts for MIR1254-1 Gene

mRNA/cDNA for MIR1254-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1254-1 Gene

No ASD Table

Relevant External Links for MIR1254-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1254-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1254-1 Gene

genes like me logo Genes that share expression patterns with MIR1254-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1254-1 Gene

Orthologs for MIR1254-1 Gene

Evolution for MIR1254-1 Gene

Gene Tree for MIR1254-1 (if available)
Gene Tree for MIR1254-1 (if available)

No data available for Orthologs for MIR1254-1 Gene

Paralogs for MIR1254-1 Gene

No data available for Paralogs for MIR1254-1 Gene

Variants for MIR1254-1 Gene

Sequence variations from dbSNP and Humsavar for MIR1254-1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000575540 -- 68,757,920(+) GTATT(C/T)TTAGT intron-variant, upstream-variant-2KB
rs1001954467 -- 68,758,739(+) GTGCA(A/G)TGGCA intron-variant, upstream-variant-2KB
rs1002541957 -- 68,759,527(+) GTTCA(A/G)GATCA intron-variant, downstream-variant-500B
rs1003064863 -- 68,759,153(+) TCATG(C/G)CTGTG intron-variant, upstream-variant-2KB
rs1003658785 -- 68,757,945(+) ACCGT(C/G/T)TTAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1254-1 Gene

Variant ID Type Subtype PubMed ID
esv2759764 CNV loss 17122850
nsv1047983 CNV gain 25217958
nsv1052569 CNV gain 25217958
nsv551435 CNV loss 21841781

Relevant External Links for MIR1254-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1254-1 Gene

Disorders for MIR1254-1 Gene

Relevant External Links for MIR1254-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR1254-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1254-1 Gene

Publications for MIR1254-1 Gene

  1. Reciprocal regulation of miR-1254 and c-Myc in oral squamous cell carcinoma suppresses EMT-mediated metastasis and tumor-initiating properties through MAPK signaling. (PMID: 28161631) Lu M … Wang J (Biochemical and biophysical research communications 2017) 3 60
  2. MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth. (PMID: 28749936) Pu M … Ren J (PLoS genetics 2017) 3 60
  3. miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer. (PMID: 21258252) Foss KM … Weiss GJ (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011) 3 60
  4. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR1254-1 Gene

Sources for MIR1254-1 Gene

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