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Aliases for MIR1254-1 Gene

Subcategory (RNA class) for MIR1254-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1254-1 Gene

  • MicroRNA 1254-1 2 3 5
  • MicroRNA 1254 2 3
  • Hsa-Mir-1254-1 3
  • Hsa-Mir-1254 3
  • MIRN1254 3
  • MIR1254 3

External Ids for MIR1254-1 Gene

Previous HGNC Symbols for MIR1254-1 Gene

  • MIRN1254
  • MIR1254

Previous GeneCards Identifiers for MIR1254-1 Gene

  • GC10P070520
  • GC10P070521
  • GC10P070524
  • GC10P070527

Summaries for MIR1254-1 Gene

Entrez Gene Summary for MIR1254-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1254-1 Gene

MIR1254-1 (MicroRNA 1254-1) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1254-1 Gene

Genomics for MIR1254-1 Gene

Regulatory Elements for MIR1254-1 Gene

Enhancers for MIR1254-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G068091 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -665.2 -665200 4.6 TBP NFIB SIN3A RFX5 GTF3C2 GATA2 RCOR1 FOS ZHX1 ZNF202 CCAR1 SIRT1 DDX50 ATOH7 ENSG00000233590 HNRNPH3 PBLD MIR1254-1 RPL12P8 DDX21
GH10G068102 1.5 Ensembl ENCODE dbSUPER 9.8 -651.8 -651832 9.2 SIN3A FEZF1 GTF3C2 ZNF121 GATA2 ZMIZ1 FOS TSHZ1 MAFF CBX8 CCAR1 DDX50 HERC4 MYPN MIR1254-1 RPL12P8 DDX21 ATOH7 RN7SKP202
GH10G067763 1.4 Ensembl ENCODE 9.8 -995.0 -994963 2.6 HDGF CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CBX5 ZNF207 CCAR1 RPL12P8 MIR1254-1 CTNNA3 TRS-TGA1-1
GH10G069179 1.2 ENCODE 9.9 +421.3 421342 3.3 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D DDX50 DDX21 CCAR1 TYSND1 HKDC1 MIR1254-1 SUPV3L1 LOC101928994 VPS26A
GH10G068526 1.2 ENCODE 9.9 -232.0 -232023 2.2 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 MEF2D DDX50 DNA2 CCAR1 SUPV3L1 SIRT1 TET1 MIR1254-1 DDX21 RPL12P8 SLC25A16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1254-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1254-1 Gene

Chromosome:
10
Start:
68,759,318 bp from pter
End:
68,759,414 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR1254-1 Gene

Genes around MIR1254-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1254-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1254-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1254-1 Gene

Proteins for MIR1254-1 Gene

Post-translational modifications for MIR1254-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1254-1 Gene

Domains & Families for MIR1254-1 Gene

Gene Families for MIR1254-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1254-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1254-1 Gene

Function for MIR1254-1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1254-1 Gene

Localization for MIR1254-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1254-1 Gene

Pathways & Interactions for MIR1254-1 Gene

SuperPathways for MIR1254-1 Gene

No Data Available

Interacting Proteins for MIR1254-1 Gene

Gene Ontology (GO) - Biological Process for MIR1254-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1254-1 Gene

Drugs & Compounds for MIR1254-1 Gene

No Compound Related Data Available

Transcripts for MIR1254-1 Gene

mRNA/cDNA for MIR1254-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1254-1 Gene

No ASD Table

Relevant External Links for MIR1254-1 Gene

GeneLoc Exon Structure for
MIR1254-1
ECgene alternative splicing isoforms for
MIR1254-1

Expression for MIR1254-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1254-1 Gene

genes like me logo Genes that share expression patterns with MIR1254-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1254-1 Gene

Orthologs for MIR1254-1 Gene

Evolution for MIR1254-1 Gene

ENSEMBL:
Gene Tree for MIR1254-1 (if available)
TreeFam:
Gene Tree for MIR1254-1 (if available)

No data available for Orthologs for MIR1254-1 Gene

Paralogs for MIR1254-1 Gene

No data available for Paralogs for MIR1254-1 Gene

Variants for MIR1254-1 Gene

Sequence variations from dbSNP and Humsavar for MIR1254-1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000575540 -- 68,757,920(+) GTATT(C/T)TTAGT intron-variant, upstream-variant-2KB
rs1001954467 -- 68,758,739(+) GTGCA(A/G)TGGCA intron-variant, upstream-variant-2KB
rs1002541957 -- 68,759,527(+) GTTCA(A/G)GATCA intron-variant, downstream-variant-500B
rs1003064863 -- 68,759,153(+) TCATG(C/G)CTGTG intron-variant, upstream-variant-2KB
rs1003658785 -- 68,757,945(+) ACCGT(C/G/T)TTAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1254-1 Gene

Variant ID Type Subtype PubMed ID
esv2759764 CNV loss 17122850
nsv1047983 CNV gain 25217958
nsv1052569 CNV gain 25217958
nsv551435 CNV loss 21841781

Relevant External Links for MIR1254-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1254-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1254-1 Gene

Disorders for MIR1254-1 Gene

Relevant External Links for MIR1254-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1254-1

No disorders were found for MIR1254-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1254-1 Gene

Publications for MIR1254-1 Gene

  1. miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer. (PMID: 21258252) Foss K.M. … Weiss G.J. (J Thorac Oncol 2011) 3 64
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1254-1 Gene

Sources for MIR1254-1 Gene

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