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Aliases for MIR1253 Gene

Subcategory (RNA class) for MIR1253 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1253 Gene

  • MicroRNA 1253 2 3
  • Hsa-Mir-1253 3
  • MIRN1253 3

External Ids for MIR1253 Gene

Previous HGNC Symbols for MIR1253 Gene

  • MIRN1253

Previous GeneCards Identifiers for MIR1253 Gene

  • GC00U922941
  • GC17M002599
  • GC17M002651

Summaries for MIR1253 Gene

Entrez Gene Summary for MIR1253 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1253 Gene

MIR1253 (MicroRNA 1253) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1253 Gene

Genomics for MIR1253 Gene

Genomic Location for MIR1253 Gene

Start:
2,748,078 bp from pter
End:
2,748,182 bp from pter
Size:
105 bases
Orientation:
Minus strand

Genomic View for MIR1253 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR1253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1253 Gene

No data available for Regulatory Elements for MIR1253 Gene

Proteins for MIR1253 Gene

Post-translational modifications for MIR1253 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1253 Gene

Domains for MIR1253 Gene

Gene Families for MIR1253 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1253: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1253 Gene

Function for MIR1253 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR1253 Gene

Localization for MIR1253 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1253 Gene

Pathways for MIR1253 Gene

SuperPathways for MIR1253 Gene

No Data Available

Interacting Proteins for MIR1253 Gene

Gene Ontology (GO) - Biological Process for MIR1253 Gene

None

No data available for Pathways by source for MIR1253 Gene

Transcripts for MIR1253 Gene

mRNA/cDNA for MIR1253 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR1253

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1253 Gene

No ASD Table

Relevant External Links for MIR1253 Gene

GeneLoc Exon Structure for
MIR1253
ECgene alternative splicing isoforms for
MIR1253

Expression for MIR1253 Gene

mRNA expression in normal human tissues for MIR1253 Gene

genes like me logo Genes that share expressions with MIR1253: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR1253 Gene

Orthologs for MIR1253 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1253 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1253 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR1253:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1253 Gene

ENSEMBL:
Gene Tree for MIR1253 (if available)
TreeFam:
Gene Tree for MIR1253 (if available)

Paralogs for MIR1253 Gene

No data available for Paralogs for MIR1253 Gene

Variants for MIR1253 Gene

Sequence variations from dbSNP and Humsavar for MIR1253 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1009050 -- 2,749,081(+) GGTTG(C/G/T)GGGGG upstream-variant-2KB
rs2079713 -- 2,749,952(+) GCCCA(G/T)GCCGC upstream-variant-2KB
rs7217038 -- 2,748,083(+) TGGCT(A/T)CTCAT nc-transcript-variant
rs9898615 -- 2,748,047(+) TAGAA(G/T)CACCC downstream-variant-500B
rs9909173 -- 2,749,487(+) CCCCC(C/T)ACGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1253 Gene

Variant ID Type Subtype PubMed ID
nsv833339 CNV Loss 17160897
dgv3037n71 CNV Loss 21882294
esv2660206 CNV Deletion 23128226
nsv833340 CNV Gain+Loss 17160897

Relevant External Links for MIR1253 Gene

HapMap Linkage Disequilibrium report
MIR1253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR1253 Gene

Disorders for MIR1253 Gene

No disorders were found for MIR1253 Gene.

No data available for UniProtKB/Swiss-Prot for MIR1253 Gene

Publications for MIR1253 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3

Products for MIR1253 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR1253
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR1253
    • Block miRNA regulation of MIR1253 using miScript Target Protectors

    Sources for MIR1253 Gene

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