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Aliases for MIR1251 Gene

Subcategory (RNA class) for MIR1251 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1251 Gene

  • MicroRNA 1251 2 3 5
  • Hsa-Mir-1251 3
  • MIRN1251 3

External Ids for MIR1251 Gene

Previous HGNC Symbols for MIR1251 Gene

  • MIRN1251

Previous GeneCards Identifiers for MIR1251 Gene

  • GC00U923021
  • GC12P096410
  • GC12P097885

Summaries for MIR1251 Gene

Entrez Gene Summary for MIR1251 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1251 Gene

MIR1251 (MicroRNA 1251) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1251 Gene

Genomics for MIR1251 Gene

Regulatory Elements for MIR1251 Gene

Enhancers for MIR1251 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F097565 1 ENCODE 10.2 +77.9 77904 7.8 PKNOX1 ATF1 MLX ARID4B ZNF48 YY1 ELK1 FOS SP5 ZHX2 RMST MIR1251 ENSG00000277081 ENSG00000257157
GH12F097464 0.6 ENCODE 11.5 -26.7 -26704 2.3 JUND SMARCA4 POLR2A POU5F1 REST EZH2 MIR1251 RMST GC12P097473
GH12F097462 0.5 Ensembl 11.5 -28.7 -28709 0.8 JUND ZNF652 ZZZ3 EZH2 MIR1251 RMST GC12P097473
GH12F097513 0.2 ENCODE 11.4 +22.3 22307 0.8 MIR1251 RMST MIR135A2 ENSG00000275971 ENSG00000273570
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1251 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1251 Gene

Chromosome:
12
Start:
97,491,909 bp from pter
End:
97,491,978 bp from pter
Size:
70 bases
Orientation:
Plus strand

Genomic View for MIR1251 Gene

Genes around MIR1251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1251 Gene

Proteins for MIR1251 Gene

Post-translational modifications for MIR1251 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1251 Gene

Domains & Families for MIR1251 Gene

Gene Families for MIR1251 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1251: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1251 Gene

Function for MIR1251 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1251 Gene

Localization for MIR1251 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1251 Gene

Pathways & Interactions for MIR1251 Gene

SuperPathways for MIR1251 Gene

No Data Available

Interacting Proteins for MIR1251 Gene

Gene Ontology (GO) - Biological Process for MIR1251 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1251 Gene

Transcripts for MIR1251 Gene

mRNA/cDNA for MIR1251 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1251 Gene

No ASD Table

Relevant External Links for MIR1251 Gene

GeneLoc Exon Structure for
MIR1251
ECgene alternative splicing isoforms for
MIR1251

Expression for MIR1251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1251 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1251 Gene:

MIR1251
genes like me logo Genes that share expression patterns with MIR1251: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1251 Gene

Orthologs for MIR1251 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1251 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir1251 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1251 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1251 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-1251 35
  • 89 (a)
OneToOne
Species where no ortholog for MIR1251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1251 Gene

ENSEMBL:
Gene Tree for MIR1251 (if available)
TreeFam:
Gene Tree for MIR1251 (if available)

Paralogs for MIR1251 Gene

No data available for Paralogs for MIR1251 Gene

Variants for MIR1251 Gene

Sequence variations from dbSNP and Humsavar for MIR1251 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs112216404 -- 97,490,623(+) TCACT(A/G)AAATA intron-variant, upstream-variant-2KB
rs117602033 -- 97,490,596(+) TCCAC(C/T)GCCGT intron-variant, upstream-variant-2KB
rs139228599 -- 97,492,133(+) AGTAA(C/T)TTATA intron-variant, downstream-variant-500B
rs140954380 -- 97,491,307(+) AAAGT(C/G)TATAA intron-variant, upstream-variant-2KB
rs142030363 -- 97,490,903(+) TGAAC(A/G)CTTAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1251 Gene

Variant ID Type Subtype PubMed ID
nsv832495 CNV gain 17160897
nsv7234 OTHER inversion 18451855
nsv438229 CNV loss 16468122

Relevant External Links for MIR1251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1251 Gene

Disorders for MIR1251 Gene

Relevant External Links for MIR1251

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1251

No disorders were found for MIR1251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1251 Gene

Publications for MIR1251 Gene

  1. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64
  3. Hidden layers of human small RNAs. (PMID: 18402656) Kawaji H. … Hayashizaki Y. (BMC Genomics 2008) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1251 Gene

Sources for MIR1251 Gene

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