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Aliases for MIR1249 Gene

Subcategory (RNA class) for MIR1249 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1249 Gene

  • MicroRNA 1249 2 3 5
  • Hsa-Mir-1249 3
  • MIRN1249 3

External Ids for MIR1249 Gene

Previous HGNC Symbols for MIR1249 Gene

  • MIRN1249

Previous GeneCards Identifiers for MIR1249 Gene

  • GC00U922971
  • GC22M043976
  • GC22M045596

Summaries for MIR1249 Gene

Entrez Gene Summary for MIR1249 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1249 Gene

MIR1249 (MicroRNA 1249) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1249 Gene

Genomics for MIR1249 Gene

Regulatory Elements for MIR1249 Gene

Enhancers for MIR1249 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F045220 1.1 Ensembl ENCODE 12.4 -21.4 -21382 3.2 ATF1 DDX20 TAL1 ZNF175 ZNF140 ZSCAN9 ZBTB40 ZIC2 FOSL1 GATA3 KIAA0930 MIR1249 NUP50 NUP50-AS1 FAM118A GC22P045213
GH22F045178 1.1 FANTOM5 ENCODE 12.4 +21.2 21153 1.8 GATAD2A HLF CEBPB CEBPG RARA ZNF121 ZFHX2 POLR2A CEBPA SMAD4 NUP50 MIR1249 KIAA0930 FAM118A ENSG00000273353
GH22F045224 1.4 FANTOM5 Ensembl ENCODE 12.3 -25.9 -25901 5.0 SOX13 ZNF146 MAX CEBPG ZFHX2 POLR2A PRDM10 E2F6 EGR2 HLF KIAA0930 MIR1249 NUP50 NUP50-AS1 GC22P045213
GH22F045169 0.5 ENCODE 12.3 +28.1 28073 7.5 HDAC1 ATF1 PKNOX1 INSM2 NFXL1 RARA SCRT2 ZNF548 ZNF263 USF2 NUP50 NUP50-AS1 MIR1249 KIAA0930 LINC00899 GC22P045164 ENSG00000273353
GH22F045229 1 Ensembl ENCODE 12 -29.7 -29700 2.3 SOX13 SAP130 ARID4B ZNF384 EBF1 RARA RERE POLR2A PRDM10 NR2F6 KIAA0930 MIR1249 GC22P045213
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1249 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1249 Gene

Chromosome:
22
Start:
45,200,954 bp from pter
End:
45,201,019 bp from pter
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR1249 Gene

Genes around MIR1249 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1249 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1249 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1249 Gene

Proteins for MIR1249 Gene

Post-translational modifications for MIR1249 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1249 Gene

Domains & Families for MIR1249 Gene

Gene Families for MIR1249 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1249: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1249 Gene

Function for MIR1249 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1249 Gene

Localization for MIR1249 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1249 Gene

Pathways & Interactions for MIR1249 Gene

SuperPathways for MIR1249 Gene

No Data Available

Interacting Proteins for MIR1249 Gene

Gene Ontology (GO) - Biological Process for MIR1249 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1249 Gene

Transcripts for MIR1249 Gene

mRNA/cDNA for MIR1249 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1249 Gene

No ASD Table

Relevant External Links for MIR1249 Gene

GeneLoc Exon Structure for
MIR1249
ECgene alternative splicing isoforms for
MIR1249

Expression for MIR1249 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1249 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1249 Gene:

MIR1249
genes like me logo Genes that share expression patterns with MIR1249: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1249 Gene

Orthologs for MIR1249 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1249 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1249 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1249 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir1249 35
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 53 (a)
OneToOne
Species where no ortholog for MIR1249 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1249 Gene

ENSEMBL:
Gene Tree for MIR1249 (if available)
TreeFam:
Gene Tree for MIR1249 (if available)

Paralogs for MIR1249 Gene

No data available for Paralogs for MIR1249 Gene

Variants for MIR1249 Gene

Sequence variations from dbSNP and Humsavar for MIR1249 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1139801 -- 45,203,005(-) GCTTC(A/G)CCCAT upstream-variant-2KB, reference, synonymous-codon
rs114688689 -- 45,202,346(+) GGAAG(C/G)AGAGT intron-variant, upstream-variant-2KB
rs115125276 -- 45,201,494(+) CACCC(A/G)GGTTT intron-variant, upstream-variant-2KB
rs115771159 -- 45,200,682(+) CCAAA(C/G)ATTCA intron-variant, downstream-variant-500B
rs116185906 -- 45,200,706(+) CCAGG(A/C)AGGCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR1249 Gene

Variant ID Type Subtype PubMed ID
esv2758843 CNV gain 17122850
nsv829278 CNV loss 20364138
nsv834220 CNV loss 17160897

Relevant External Links for MIR1249 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1249

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1249 Gene

Disorders for MIR1249 Gene

Relevant External Links for MIR1249

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1249

No disorders were found for MIR1249 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1249 Gene

Publications for MIR1249 Gene

  1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1249 Gene

Sources for MIR1249 Gene

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