Subcategory (RNA class) for MIR1248 Gene
Quality Score for this RNA gene is
Aliases for MIR1248 Gene
External Ids for MIR1248 Gene
Previous HGNC Symbols for MIR1248 Gene
Previous GeneCards Identifiers for MIR1248 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR1248 Gene
MIR1248 (MicroRNA 1248) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Interferon gamma signaling and Immune System. An important paralog of this gene is EIF4A1.
UniProtKB/Swiss-Prot for MIR1248 Gene
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.