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Aliases for MIR1248 Gene

Subcategory (RNA class) for MIR1248 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1248 Gene

  • MicroRNA 1248 2 3
  • EIF4A2 4 5
  • Eukaryotic Translation Initiation Factor 4A2 5
  • ATP-Dependent RNA Helicase EIF4A-2 4
  • Hsa-Mir-1248 3
  • EC 3.6.4.13 4
  • EIF-4A-II 4
  • EIF4A-II 4
  • Mir-1248 3
  • MIRN1248 3
  • EC 3.6.1 61
  • EIF4F 4
  • DDX2B 4

External Ids for MIR1248 Gene

Previous HGNC Symbols for MIR1248 Gene

  • MIRN1248

Previous GeneCards Identifiers for MIR1248 Gene

  • GC00U922851
  • GC03P188000
  • GC03P186505
  • GC03P186508
  • GC03P186512
  • GC03P186515
  • GC03P186523
  • GC03P186529
  • GC03P186534
  • GC03P186540
  • GC03P186549
  • GC03U902061
  • GC03P186570
  • GC03P186787
  • GC03P186792
  • GC03P186798
  • GC03P186803

Summaries for MIR1248 Gene

Entrez Gene Summary for MIR1248 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1248 Gene

MIR1248 (MicroRNA 1248) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Interferon gamma signaling and Immune System. An important paralog of this gene is EIF4A1.

UniProtKB/Swiss-Prot for MIR1248 Gene

  • ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1248 Gene

Genomics for MIR1248 Gene

Regulatory Elements for MIR1248 Gene

Enhancers for MIR1248 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F186821 1.5 Ensembl ENCODE 11.7 +38.5 38478 0.6 SMARCA5 CTCF ZNF654 TRIM22 REST RAD21 RFX5 SMC3 ZBTB33 SNORA63 EIF4A2 ENSG00000200418 SNORA81 MIR1248 SNORD2 ADIPOQ AHSG KNG1 ADIPOQ-AS1
GH03F186822 0.4 ENCODE 11.7 +39.0 38982 0.2 HIC1 SCRT2 GLIS1 SNORA63 EIF4A2 ENSG00000200418 SNORA81 MIR1248 SNORD2 ADIPOQ AHSG KNG1 ADIPOQ-AS1
GH03F186824 0.8 ENCODE 11.4 +43.3 43317 3.3 ATF1 CREB3L1 ARID4B ZNF48 BRCA1 GLIS2 ZNF263 SP3 YY2 SP5 RFC4 SNORA63 SNORA81 MIR1248 EIF4A2 ENSG00000200418 ADIPOQ-AS1 AHSG KNG1 ENSG00000231982
GH03F186757 0.2 ENCODE 11.1 -25.4 -25442 1.5 GATA3 ZFHX2 PKNOX1 ATF3 PBX2 IKZF1 SPI1 KNG1 EIF4A2 ENSG00000200418 MIR1248 SNORA63 SNORA81 RFC4 FETUB AHSG ENSG00000231724
GH03F186760 0.2 ENCODE 11.1 -22.3 -22282 1.7 PKNOX1 ESRRA RARA GATA3 CTBP1 ZFHX2 POLR3A RCOR1 FOS EGR2 KNG1 EIF4A2 MIR1248 ENSG00000200418 SNORA63 SNORA81 RFC4 ENSG00000231724 HRG GPS2P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1248 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1248 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381884 895 3801 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MIR1248 Gene

Chromosome:
3
Start:
186,783,205 bp from pter
End:
186,789,900 bp from pter
Size:
6,696 bases
Orientation:
Plus strand

Genomic View for MIR1248 Gene

Genes around MIR1248 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1248 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1248 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1248 Gene

Proteins for MIR1248 Gene

  • Protein details for MIR1248 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14240-IF4A2_HUMAN
    Recommended name:
    Eukaryotic initiation factor 4A-II
    Protein Accession:
    Q14240
    Secondary Accessions:
    • D3DNU9
    • Q53XJ6
    • Q96B90
    • Q96EA8

    Protein attributes for MIR1248 Gene

    Size:
    407 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs.
    • eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs.

    Three dimensional structures from OCA and Proteopedia for MIR1248 Gene

    Alternative splice isoforms for MIR1248 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1248 Gene

Post-translational modifications for MIR1248 Gene

  • Ubiquitination at Lys 310 and Lys 370
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR1248 Gene

Gene Families for MIR1248 Gene

Graphical View of Domain Structure for InterPro Entry

Q14240

UniProtKB/Swiss-Prot:

IF4A2_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. eIF4A subfamily.
genes like me logo Genes that share domains with MIR1248: view

No data available for Suggested Antigen Peptide Sequences for MIR1248 Gene

Function for MIR1248 Gene

Molecular function for MIR1248 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Enzyme Numbers (IUBMB) for MIR1248 Gene

Gene Ontology (GO) - Molecular Function for MIR1248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003743 translation initiation factor activity TAS --
GO:0004004 ATP-dependent RNA helicase activity IEA --
GO:0004386 helicase activity TAS --
genes like me logo Genes that share ontologies with MIR1248: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1248 Gene

Localization for MIR1248 Gene

Gene Ontology (GO) - Cellular Components for MIR1248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016281 eukaryotic translation initiation factor 4F complex TAS --
GO:0048471 perinuclear region of cytoplasm IDA --
genes like me logo Genes that share ontologies with MIR1248: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MIR1248 Gene

Pathways & Interactions for MIR1248 Gene

genes like me logo Genes that share pathways with MIR1248: view

Gene Ontology (GO) - Biological Process for MIR1248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with MIR1248: view

No data available for SIGNOR curated interactions for MIR1248 Gene

Transcripts for MIR1248 Gene

mRNA/cDNA for MIR1248 Gene

(28) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1248 Gene

No ASD Table

Relevant External Links for MIR1248 Gene

GeneLoc Exon Structure for
MIR1248
ECgene alternative splicing isoforms for
MIR1248

Expression for MIR1248 Gene

mRNA expression in normal human tissues for MIR1248 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1248 Gene:

MIR1248
genes like me logo Genes that share expression patterns with MIR1248: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1248 Gene

Orthologs for MIR1248 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR1248 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4A2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF4A2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif4a2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF4A2 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF4A2 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EIF4A2 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF4A2 35
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii eif4a2 35
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eIF-4a 35
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea inf-1 35
  • 70 (a)
ManyToMany
F57B9.3 35
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAL1 35
  • 57 (a)
OneToMany
TIF2 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10997 35
  • 80 (a)
OneToMany
Species where no ortholog for MIR1248 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1248 Gene

ENSEMBL:
Gene Tree for MIR1248 (if available)
TreeFam:
Gene Tree for MIR1248 (if available)

Paralogs for MIR1248 Gene

Paralogs for MIR1248 Gene

Pseudogenes.org Pseudogenes for MIR1248 Gene

genes like me logo Genes that share paralogs with MIR1248: view

Variants for MIR1248 Gene

Sequence variations from dbSNP and Humsavar for MIR1248 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111446641 -- 186,786,424(+) AAGAC(-/AG)AGACG intron-variant, upstream-variant-2KB
rs111802039 -- 186,787,112(+) TTAAC(C/T)TCTAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs112227828 -- 186,786,968(+) CTTTC(-/T)TTGAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs112754953 -- 186,786,052(+) CCTTT(C/G)TAAGT upstream-variant-2KB, splice-donor-variant
rs112852782 -- 186,786,427(+) ACAGA(-/GA)CGCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1248 Gene

Variant ID Type Subtype PubMed ID
dgv5005n100 CNV gain 25217958
esv2759206 CNV loss 17122850
esv34136 CNV loss 18971310
esv3893839 CNV gain 25118596
nsv1012615 CNV gain 25217958

Relevant External Links for MIR1248 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1248

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1248 Gene

Disorders for MIR1248 Gene

Relevant External Links for MIR1248

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1248

No disorders were found for MIR1248 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1248 Gene

Publications for MIR1248 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. Comparative structural analysis of human DEAD-box RNA helicases. (PMID: 20941364) Schutz P. … Schuler H. (PLoS ONE 2010) 4 64

Products for MIR1248 Gene

Sources for MIR1248 Gene

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