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Aliases for MIR1247 Gene

Subcategory (RNA class) for MIR1247 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1247 Gene

  • MicroRNA 1247 2 3
  • DIO3 Opposite Strand/Antisense RNA (Head To Head) 5
  • Hsa-Mir-1247 3
  • Mir-1247 3
  • MIRN1247 3
  • DIO3OS 5

External Ids for MIR1247 Gene

Previous HGNC Symbols for MIR1247 Gene

  • MIRN1247

Previous GeneCards Identifiers for MIR1247 Gene

  • GC00U923082
  • GC14M101097
  • GC14M102026

Summaries for MIR1247 Gene

Entrez Gene Summary for MIR1247 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1247 Gene

MIR1247 (MicroRNA 1247) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1247 Gene

Genomics for MIR1247 Gene

Regulatory Elements for MIR1247 Gene

Enhancers for MIR1247 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F101521 0.2 ENCODE 11.9 +39.3 39293 0.2 MIR1247 DIO3 GC14P102748 LOC105370672
GH14F101518 0.2 ENCODE 11.8 +41.7 41713 0.2 ZBTB33 NR2F2 MIR1247 DIO3 GC14P102748 LOC105370672
GH14F101519 0.4 ENCODE 11.8 +41.5 41513 0.2 NR2F2 MIR1247 DIO3 GC14P102748 LOC105370672
GH14F101627 0.7 FANTOM5 11.4 -66.7 -66748 0.3 BCOR HDAC2 ZMYM3 KDM1A NFXL1 DIO3 MIR1247 ENSG00000258919 LOC105370675
GH14F101623 0.4 FANTOM5 11.4 -63.1 -63124 0.1 ZNF263 ZNF341 ZBTB33 ZNF16 ZNF600 DIO3 MIR1247 ENSG00000258919 LOC105370675
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1247 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1247 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001792509 -269 601 CTCF CBX2 RAD21

Genomic Location for MIR1247 Gene

Chromosome:
14
Start:
101,552,221 bp from pter
End:
101,560,431 bp from pter
Size:
8,211 bases
Orientation:
Minus strand

Genomic View for MIR1247 Gene

Genes around MIR1247 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1247 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1247 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1247 Gene

Proteins for MIR1247 Gene

Post-translational modifications for MIR1247 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1247 Gene

Domains & Families for MIR1247 Gene

Gene Families for MIR1247 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1247: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1247 Gene

Function for MIR1247 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1247 Gene

Localization for MIR1247 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1247 Gene

Pathways & Interactions for MIR1247 Gene

SuperPathways for MIR1247 Gene

No Data Available

Interacting Proteins for MIR1247 Gene

Gene Ontology (GO) - Biological Process for MIR1247 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1247 Gene

Transcripts for MIR1247 Gene

mRNA/cDNA for MIR1247 Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1247 Gene

No ASD Table

Relevant External Links for MIR1247 Gene

GeneLoc Exon Structure for
MIR1247
ECgene alternative splicing isoforms for
MIR1247

Expression for MIR1247 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1247 Gene:

MIR1247
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1247 Gene

Orthologs for MIR1247 Gene

Evolution for MIR1247 Gene

ENSEMBL:
Gene Tree for MIR1247 (if available)
TreeFam:
Gene Tree for MIR1247 (if available)

No data available for Orthologs for MIR1247 Gene

Paralogs for MIR1247 Gene

No data available for Paralogs for MIR1247 Gene

Variants for MIR1247 Gene

Sequence variations from dbSNP and Humsavar for MIR1247 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs113665653 -- 101,560,150(+) TCAGA(A/G)GGTCT downstream-variant-500B, upstream-variant-2KB
rs12892309 -- 101,559,955(+) AGTGT(A/C)TCGGG downstream-variant-500B, upstream-variant-2KB
rs138578713 -- 101,561,661(+) GGCAC(C/G/T)GCCTT upstream-variant-2KB, reference, synonymous-codon
rs140242267 -- 101,562,420(+) TCCAA(C/T)GGACA upstream-variant-2KB, utr-variant-3-prime
rs143432605 -- 101,562,043(+) AGCGC(C/G)TGGTC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR1247 Gene

Variant ID Type Subtype PubMed ID
dgv1978n100 CNV gain 25217958
dgv388n67 CNV gain 20364138
esv29376 CNV loss 19812545
nsv1047869 CNV gain 25217958
nsv565879 CNV loss 21841781
nsv565880 CNV loss 21841781
nsv565881 CNV gain+loss 21841781
nsv565882 CNV loss 21841781
nsv827060 CNV gain 20364138
nsv827061 CNV gain 20364138
nsv952247 CNV deletion 24416366

Relevant External Links for MIR1247 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1247

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1247 Gene

Disorders for MIR1247 Gene

Relevant External Links for MIR1247

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1247

No disorders were found for MIR1247 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1247 Gene

Publications for MIR1247 Gene

  1. MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2. (PMID: 25731699) Scaravilli M. … Visakorpi T. (Prostate 2015) 3 64
  2. MiRNA profile of osteosarcoma with CD117 and stro-1 expression: miR-1247 functions as an onco-miRNA by targeting MAP3K9. (PMID: 25973030) Zhao F. … Chen Y. (Int J Clin Exp Pathol 2015) 3 64
  3. Epigenetically regulated MIR941 and MIR1247 target gastric cancer cell growth and migration. (PMID: 24785261) Kim J.G. … Yi J.M. (Epigenetics 2014) 3 64
  4. miR-1247 functions by targeting cartilage transcription factor SOX9. (PMID: 24014021) Martinez-Sanchez A. … Murphy C.L. (J. Biol. Chem. 2013) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR1247 Gene

Sources for MIR1247 Gene

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