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Aliases for MIR1245B Gene

Subcategory (RNA class) for MIR1245B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1245B Gene

  • MicroRNA 1245b 2 3 5
  • Hsa-Mir-1245b 3

External Ids for MIR1245B Gene

Previous GeneCards Identifiers for MIR1245B Gene

  • GC02U902419
  • GC02M189845

Summaries for MIR1245B Gene

Entrez Gene Summary for MIR1245B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1245B Gene

MIR1245B (MicroRNA 1245b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1245B Gene

Genomics for MIR1245B Gene

Regulatory Elements for MIR1245B Gene

Enhancers for MIR1245B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F188969 1 Ensembl ENCODE 0.8 +0.0 11 18.3 PKNOX1 SIN3A YBX1 FEZF1 ZNF121 FOS JUNB TSHZ1 TBX21 MAFF ENSG00000273240 MIR1245A MIR1245B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1245B on UCSC Golden Path with GeneCards custom track

Promoters for MIR1245B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001830592 1360 6400 PKNOX1 SIN3A YBX1 BMI1 RAD21 ZNF366 FOS CREM ZNF654 ZNF680

Genomic Location for MIR1245B Gene

Chromosome:
2
Start:
188,978,093 bp from pter
End:
188,978,161 bp from pter
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR1245B Gene

Genes around MIR1245B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1245B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1245B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1245B Gene

Proteins for MIR1245B Gene

Post-translational modifications for MIR1245B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1245B Gene

Domains & Families for MIR1245B Gene

Gene Families for MIR1245B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1245B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1245B Gene

Function for MIR1245B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1245B Gene

Localization for MIR1245B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1245B Gene

Pathways & Interactions for MIR1245B Gene

SuperPathways for MIR1245B Gene

No Data Available

Interacting Proteins for MIR1245B Gene

Gene Ontology (GO) - Biological Process for MIR1245B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1245B Gene

Transcripts for MIR1245B Gene

mRNA/cDNA for MIR1245B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1245B Gene

No ASD Table

Relevant External Links for MIR1245B Gene

GeneLoc Exon Structure for
MIR1245B
ECgene alternative splicing isoforms for
MIR1245B

Expression for MIR1245B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1245B Gene:

MIR1245B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1245B Gene

Orthologs for MIR1245B Gene

Evolution for MIR1245B Gene

ENSEMBL:
Gene Tree for MIR1245B (if available)
TreeFam:
Gene Tree for MIR1245B (if available)

No data available for Orthologs for MIR1245B Gene

Paralogs for MIR1245B Gene

No data available for Paralogs for MIR1245B Gene

Variants for MIR1245B Gene

Sequence variations from dbSNP and Humsavar for MIR1245B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs113906492 -- 188,978,096(+) TATTT(A/T)TGTAT intron-variant, nc-transcript-variant
rs12478121 -- 188,977,804(+) GTACA(C/T)GAACT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs13425379 -- 188,979,873(+) TGACT(A/G)TGTAA intron-variant, upstream-variant-2KB
rs140125616 -- 188,977,884(+) AGTAC(A/G)TTAAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs144781624 -- 188,979,237(+) ATGAC(A/G)GAGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1245B Gene

Variant ID Type Subtype PubMed ID
dgv7233n54 CNV loss 21841781
dgv7234n54 CNV loss 21841781
nsv459992 CNV loss 19166990

Relevant External Links for MIR1245B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1245B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1245B Gene

Disorders for MIR1245B Gene

Relevant External Links for MIR1245B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1245B

No disorders were found for MIR1245B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1245B Gene

Publications for MIR1245B Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1245B Gene

Sources for MIR1245B Gene

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