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Aliases for MIR124-3 Gene

Subcategory (RNA class) for MIR124-3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR124-3 Gene

  • MicroRNA 124-3 2 3 5
  • MicroRNA 124a-3 2 3
  • Hsa-Mir-124a-3 3
  • Hsa-Mir-124-3 3
  • Mir-124-3 3
  • MIRN124-3 3
  • MIRN124A3 3

External Ids for MIR124-3 Gene

ORGUL Members for MIR124-3 Gene

Previous HGNC Symbols for MIR124-3 Gene

  • MIRN124A3
  • MIRN124-3

Previous GeneCards Identifiers for MIR124-3 Gene

  • GC20P061284
  • GC20P061812
  • GC20P063179

Summaries for MIR124-3 Gene

Entrez Gene Summary for MIR124-3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-3 Gene

MIR124-3 (MicroRNA 124-3) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-3 Gene

Genomics for MIR124-3 Gene

Regulatory Elements for MIR124-3 Gene

Enhancers for MIR124-3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F063258 0.8 ENCODE 11.3 +80.4 80429 1.0 HDGF SIX4 PKNOX1 YBX1 PLRG1 ZKSCAN1 CTBP1 ZNF366 FOXK2 SCRT2 BIRC7 COL20A1 RNU6-994P ENSG00000231977 MIR124-3 TNFRSF6B ARFGAP1 GC20M063249 GC20P063264
GH20F063255 0.8 ENCODE 11.3 +77.7 77718 1.0 CTCF ZNF2 RAD21 TEAD3 ZEB1 ZNF335 FOXK2 SCRT2 ZNF143 SMC3 BIRC7 COL20A1 RNU6-994P ENSG00000231977 MIR124-3 ARFGAP1 GC20M063249 GC20P063264
GH20F063206 0.6 ENCODE 12.3 +28.5 28532 0.4 ESRRA MNT DPF2 FEZF1 CTBP1 FOS ZBTB33 TCF7L2 ENSG00000231977 MIR124-3 BIRC7 NKAIN4 YTHDF1 GC20P063194
GH20F063256 0.5 ENCODE 11.4 +76.5 76528 0.5 CTCF SMARCA4 CTBP2 ZNF600 NKAIN4 COL20A1 RNU6-994P ENSG00000231977 MIR124-3 BIRC7 FLJ16779 GC20M063249
GH20F063179 1.2 FANTOM5 ENCODE 0.8 +0.9 944 0.2 TBL1XR1 KLF17 SIN3A RAD21 GLIS2 EGR1 ZNF366 SCRT2 ZNF143 EGR2 KCNQ2 CHRNA4 STMN3 NKAIN4 EEF1A2 COL20A1 ENSG00000231977 MIR124-3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR124-3 on UCSC Golden Path with GeneCards custom track

Promoters for MIR124-3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001839194 300 401 MAZ RFX1 SUZ12 REST MNT ZFHX2 EGR1 ZNF692 ZBTB26 EZH2

Genomic Location for MIR124-3 Gene

Chromosome:
20
Start:
63,178,500 bp from pter
End:
63,178,586 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR124-3 Gene

Genes around MIR124-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-3 Gene

Proteins for MIR124-3 Gene

Post-translational modifications for MIR124-3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-3 Gene

Domains & Families for MIR124-3 Gene

Gene Families for MIR124-3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-3 Gene

Function for MIR124-3 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-3 Gene

Localization for MIR124-3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-3 Gene

Pathways & Interactions for MIR124-3 Gene

genes like me logo Genes that share pathways with MIR124-3: view

Pathways by source for MIR124-3 Gene

1 BioSystems pathway for MIR124-3 Gene
1 KEGG pathway for MIR124-3 Gene

Interacting Proteins for MIR124-3 Gene

Gene Ontology (GO) - Biological Process for MIR124-3 Gene

None

No data available for SIGNOR curated interactions for MIR124-3 Gene

Transcripts for MIR124-3 Gene

mRNA/cDNA for MIR124-3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-3 Gene

No ASD Table

Relevant External Links for MIR124-3 Gene

GeneLoc Exon Structure for
MIR124-3
ECgene alternative splicing isoforms for
MIR124-3

Expression for MIR124-3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR124-3 Gene

genes like me logo Genes that share expression patterns with MIR124-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR124-3 Gene

Orthologs for MIR124-3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-124b 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-3 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir124a-3 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-124a-2 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-124a-3 35
  • 79 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-2 35
  • 86 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-2 35
  • 53 (a)
ManyToMany
csa-mir-124-1 35
  • 48 (a)
ManyToMany
Species where no ortholog for MIR124-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-3 Gene

ENSEMBL:
Gene Tree for MIR124-3 (if available)
TreeFam:
Gene Tree for MIR124-3 (if available)

Paralogs for MIR124-3 Gene

No data available for Paralogs for MIR124-3 Gene

Variants for MIR124-3 Gene

Sequence variations from dbSNP and Humsavar for MIR124-3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111794065 -- 63,177,878(+) CCGCC(A/G)GGACT upstream-variant-2KB
rs113097760 -- 63,178,815(+) AGGGC(C/G)GCCGA downstream-variant-500B
rs113707656 -- 63,178,160(+) GGAGC(A/G)GTTCT upstream-variant-2KB
rs113795835 -- 63,177,983(+) TCGCG(A/G)GCCCG upstream-variant-2KB
rs115833423 -- 63,177,147(+) CCGAG(G/T)GCGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR124-3 Gene

Variant ID Type Subtype PubMed ID
nsv9825 CNV gain 18304495
nsv953306 CNV deletion 24416366
nsv834031 CNV loss 17160897
dgv7664n54 CNV loss 21841781
dgv68n68 CNV loss 17160897
dgv519n27 CNV loss 19166990

Relevant External Links for MIR124-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR124-3 Gene

Disorders for MIR124-3 Gene

Relevant External Links for MIR124-3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR124-3

No disorders were found for MIR124-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-3 Gene

Publications for MIR124-3 Gene

  1. MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway. (PMID: 26745800) Wang Y. … Guo D. (PLoS ONE 2016) 3 64
  2. The feedback loop between miR-124 and TGF-I^ pathway plays a significant role in non-small cell lung cancer metastasis. (PMID: 26818357) Zu L. … Wang J. (Carcinogenesis 2016) 3 64
  3. High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs. (PMID: 26819412) Karali M. … Banfi S. (Nucleic Acids Res. 2016) 3 64
  4. Decreased miR-124-3p Expression Prompted Breast Cancer Cell Progression Mainly by Targeting Beclin-1. (PMID: 27468577) Zhang F. … Yang Q. (Clin. Lab. 2016) 3 64
  5. MicroRNA-124-3p inhibits the growth and metastasis of nasopharyngeal carcinoma cells by targeting STAT3. (PMID: 26707908) Xu S. … Jiang X.J. (Oncol. Rep. 2016) 3 64

Products for MIR124-3 Gene

Sources for MIR124-3 Gene

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