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Aliases for MIR124-3 Gene

Subcategory (RNA class) for MIR124-3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR124-3 Gene

  • MicroRNA 124-3 2 3 5
  • MicroRNA 124a-3 2 3
  • Hsa-Mir-124a-3 3
  • Hsa-Mir-124-3 3
  • Mir-124-3 3
  • MIRN124-3 3
  • MIRN124A3 3

External Ids for MIR124-3 Gene

ORGUL Members for MIR124-3 Gene

Previous HGNC Symbols for MIR124-3 Gene

  • MIRN124A3
  • MIRN124-3

Previous GeneCards Identifiers for MIR124-3 Gene

  • GC20P061284
  • GC20P061812
  • GC20P063179

Summaries for MIR124-3 Gene

Entrez Gene Summary for MIR124-3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-3 Gene

MIR124-3 (MicroRNA 124-3) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Additional gene information for MIR124-3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-3 Gene

Genomics for MIR124-3 Gene

GeneHancer (GH) Regulatory Elements for MIR124-3 Gene

Promoters and enhancers for MIR124-3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I063172 Enhancer 1.4 FANTOM5 Ensembl ENCODE 550.8 -1.9 -1870 8.3 SIN3A ZNF48 ZNF121 GLIS2 ZNF143 ATF7 RUNX3 KLF13 SP3 MXD4 MIR124-3 GC20P063181 ARFRP1 TNFRSF6B BIRC7 CHRNA4 ENSG00000231977 RTEL1 KCNQ2 ZNF512B
GH20I063252 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.4 +76.0 76039 4.3 CTCF ZBTB6 ZBTB8A ATF2 POLR2A SCRT2 ZNF143 CTBP2 ZNF600 ZBTB26 NKAIN4 FLJ16779 GC20M063249 GC20M063246 BIRC7 COL20A1 RNU6-994P ENSG00000231977 MIR124-3 ARFGAP1
GH20I063206 Enhancer 0.6 ENCODE 12.4 +28.5 28532 0.4 ESRRA SIN3A GATAD2B DPF2 MNT FEZF1 CTBP1 MTA1 FOS ZBTB33 MIR124-3 ENSG00000231977 BIRC7 NKAIN4 YTHDF1 GC20P063194
GH20I063258 Enhancer 0.3 ENCODE 11.3 +80.4 80428 1 SCRT2 BIRC7 COL20A1 RNU6-994P ENSG00000231977 MIR124-3 ARFGAP1 FLJ16779 GC20M063249 GC20P063264 NKAIN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR124-3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR124-3 Gene

Genomic Locations for MIR124-3 Gene
chr20:63,178,500-63,178,586
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr20:61,809,852-61,809,938
(GRCh37/hg19)

Genomic View for MIR124-3 Gene

Genes around MIR124-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-3 Gene

Proteins for MIR124-3 Gene

Post-translational modifications for MIR124-3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-3 Gene

Domains & Families for MIR124-3 Gene

Gene Families for MIR124-3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-3 Gene

Function for MIR124-3 Gene

Phenotypes From GWAS Catalog for MIR124-3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-3 Gene

Localization for MIR124-3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR124-3 Gene

Pathways & Interactions for MIR124-3 Gene

genes like me logo Genes that share pathways with MIR124-3: view

Pathways by source for MIR124-3 Gene

1 BioSystems pathway for MIR124-3 Gene
1 KEGG pathway for MIR124-3 Gene

Interacting Proteins for MIR124-3 Gene

Gene Ontology (GO) - Biological Process for MIR124-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 24122720
GO:0010764 negative regulation of fibroblast migration IDA 24122720
GO:0035195 gene silencing by miRNA IDA 24122720
GO:0048147 negative regulation of fibroblast proliferation IDA 24122720
genes like me logo Genes that share ontologies with MIR124-3: view

No data available for SIGNOR curated interactions for MIR124-3 Gene

Drugs & Compounds for MIR124-3 Gene

No Compound Related Data Available

Transcripts for MIR124-3 Gene

mRNA/cDNA for MIR124-3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-3 Gene

No ASD Table

Relevant External Links for MIR124-3 Gene

GeneLoc Exon Structure for
MIR124-3
ECgene alternative splicing isoforms for
MIR124-3

Expression for MIR124-3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR124-3 Gene

genes like me logo Genes that share expression patterns with MIR124-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-3 Gene

Orthologs for MIR124-3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-124b 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-3 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir124a-3 34
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-124a-2 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-124a-3 34
  • 79 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-2 34
  • 86 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-2 34
  • 53 (a)
ManyToMany
csa-mir-124-1 34
  • 48 (a)
ManyToMany
Species where no ortholog for MIR124-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-3 Gene

ENSEMBL:
Gene Tree for MIR124-3 (if available)
TreeFam:
Gene Tree for MIR124-3 (if available)

Paralogs for MIR124-3 Gene

No data available for Paralogs for MIR124-3 Gene

Variants for MIR124-3 Gene

Sequence variations from dbSNP and Humsavar for MIR124-3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1002340948 -- 63,179,024(+) C/G downstream_transcript_variant
rs1002716492 -- 63,178,799(+) G/C downstream_transcript_variant
rs1002965020 -- 63,176,777(+) T/G upstream_transcript_variant
rs1003305830 -- 63,177,657(+) G/C upstream_transcript_variant
rs1003754388 -- 63,177,889(+) TT/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR124-3 Gene

Variant ID Type Subtype PubMed ID
dgv519n27 CNV loss 19166990
dgv68n68 CNV loss 17160897
dgv7664n54 CNV loss 21841781
nsv834031 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Additional Variant Information for MIR124-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR124-3 Gene

Disorders for MIR124-3 Gene

Additional Disease Information for MIR124-3

No disorders were found for MIR124-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-3 Gene

Publications for MIR124-3 Gene

  1. MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1. (PMID: 27743351) Zhou Y … Jia X (Human cell 2017) 3 58
  2. Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. (PMID: 27889233) Jin L … Han X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  3. miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA. (PMID: 28242198) Qiao W … Dong B (Biochemical and biophysical research communications 2017) 3 58
  4. A MicroRNA-124 Polymorphism is Associated with Fracture Healing via Modulating BMP6 Expression. (PMID: 28441666) Zou L … Cai J (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1. (PMID: 28667053) Tang Y … Xu Z (American journal of physiology. Heart and circulatory physiology 2017) 3 58

Products for MIR124-3 Gene

Sources for MIR124-3 Gene

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