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Aliases for MIR124-2 Gene

Subcategory (RNA class) for MIR124-2 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR124-2 Gene

  • MicroRNA 124-2 2 3 5
  • MicroRNA 124a-2 2 3
  • Hsa-Mir-124a-2 3
  • Hsa-Mir-124-2 3
  • Mir-124-2 3
  • MIRN124-2 3
  • MIRN124A2 3

External Ids for MIR124-2 Gene

Previous HGNC Symbols for MIR124-2 Gene

  • MIRN124A2
  • MIRN124-2

Previous GeneCards Identifiers for MIR124-2 Gene

  • GC08P065458
  • GC08P065291

Summaries for MIR124-2 Gene

Entrez Gene Summary for MIR124-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-2 Gene

MIR124-2 (MicroRNA 124-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-2 Gene

Genomics for MIR124-2 Gene

Genomic Location for MIR124-2 Gene

Chromosome:
8
Start:
64,379,149 bp from pter
End:
64,379,257 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR124-2 Gene

Genes around MIR124-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-2 Gene

No data available for Regulatory Elements for MIR124-2 Gene

Proteins for MIR124-2 Gene

Post-translational modifications for MIR124-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-2 Gene

Domains & Families for MIR124-2 Gene

Gene Families for MIR124-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-2 Gene

Function for MIR124-2 Gene

miRNA for MIR124-2 Gene

miRTarBase miRNAs that target MIR124-2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR124-2 Gene

Localization for MIR124-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-2 Gene

Pathways & Interactions for MIR124-2 Gene

SuperPathways for MIR124-2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR124-2: view

Pathways by source for MIR124-2 Gene

1 KEGG pathway for MIR124-2 Gene

Interacting Proteins for MIR124-2 Gene

Gene Ontology (GO) - Biological Process for MIR124-2 Gene

None

No data available for SIGNOR curated interactions for MIR124-2 Gene

Drugs & Compounds for MIR124-2 Gene

No Compound Related Data Available

Transcripts for MIR124-2 Gene

mRNA/cDNA for MIR124-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-2 Gene

No ASD Table

Relevant External Links for MIR124-2 Gene

GeneLoc Exon Structure for
MIR124-2
ECgene alternative splicing isoforms for
MIR124-2

Expression for MIR124-2 Gene

mRNA expression in normal human tissues for MIR124-2 Gene

genes like me logo Genes that share expression patterns with MIR124-2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR124-2 Gene

Orthologs for MIR124-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-124a-2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-124-2 36
  • 100 (a)
OneToMany
cfa-mir-124-3 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-2 36
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir124a-2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-124a-2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-124a 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-124c 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-5 36
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-1 36
  • 53 (a)
ManyToMany
csa-mir-124-2 36
  • 53 (a)
ManyToMany
Species with no ortholog for MIR124-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-2 Gene

ENSEMBL:
Gene Tree for MIR124-2 (if available)
TreeFam:
Gene Tree for MIR124-2 (if available)

Paralogs for MIR124-2 Gene

No data available for Paralogs for MIR124-2 Gene

Variants for MIR124-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR124-2 Gene

Variant ID Type Subtype PubMed ID
nsv523097 CNV Loss 19592680

Relevant External Links for MIR124-2 Gene

HapMap Linkage Disequilibrium report
MIR124-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR124-2 Gene

Disorders for MIR124-2 Gene

Relevant External Links for MIR124-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR124-2

No disorders were found for MIR124-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-2 Gene

Publications for MIR124-2 Gene

  1. MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. (PMID: 25818238) Taniguchi K. … Akao Y. (Cancer Lett. 2015) 3
  2. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. (PMID: 23334332) Wang P. … Liu L. (Oncogene 2014) 3
  3. Study of the effect of miRa89124 and the SOX9 target gene in Hirschsprung's disease. (PMID: 24604230) Mi J. … Gao H. (Mol Med Rep 2014) 3
  4. Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke. (PMID: 24650689) Leung L.Y. … Graham C.A. (Clin. Chim. Acta 2014) 3
  5. KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. (PMID: 24909917) Park S.Y. … Kim K.K. (Mol. Ther. 2014) 3

Products for MIR124-2 Gene

Sources for MIR124-2 Gene

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