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Aliases for MIR124-2 Gene

Subcategory (RNA class) for MIR124-2 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR124-2 Gene

  • MicroRNA 124-2 2 3
  • MicroRNA 124a-2 2 3
  • Hsa-Mir-124a-2 3
  • Hsa-Mir-124-2 3
  • MIRN124-2 3
  • MIRN124A2 3

External Ids for MIR124-2 Gene

Previous HGNC Symbols for MIR124-2 Gene

  • MIRN124A2
  • MIRN124-2

Previous GeneCards Identifiers for MIR124-2 Gene

  • GC08P065458
  • GC08P065291

Summaries for MIR124-2 Gene

Entrez Gene Summary for MIR124-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-2 Gene

MIR124-2 (MicroRNA 124-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR124-2 include oral squamous cell carcinoma. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-2 Gene

Genomics for MIR124-2 Gene

Genomic Location for MIR124-2 Gene

Start:
64,379,149 bp from pter
End:
64,379,257 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR124-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR124-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-2 Gene

No data available for Regulatory Elements for MIR124-2 Gene

Proteins for MIR124-2 Gene

Post-translational modifications for MIR124-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-2 Gene

Domains for MIR124-2 Gene

Gene Families for MIR124-2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-2 Gene

Function for MIR124-2 Gene

Animal Model Products

miRNA for MIR124-2 Gene

miRTarBase miRNAs that target MIR124-2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIR124-2 Gene

Localization for MIR124-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-2 Gene

Pathways for MIR124-2 Gene

SuperPathways for MIR124-2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR124-2: view

Pathways by source for MIR124-2 Gene

1 KEGG pathway for MIR124-2 Gene

Interacting Proteins for MIR124-2 Gene

Gene Ontology (GO) - Biological Process for MIR124-2 Gene

None

Transcripts for MIR124-2 Gene

mRNA/cDNA for MIR124-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR124-2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-2 Gene

No ASD Table

Relevant External Links for MIR124-2 Gene

GeneLoc Exon Structure for
MIR124-2
ECgene alternative splicing isoforms for
MIR124-2

Expression for MIR124-2 Gene

mRNA expression in normal human tissues for MIR124-2 Gene

genes like me logo Genes that share expressions with MIR124-2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR124-2 Gene

Orthologs for MIR124-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-124a 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-124a-2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-124-2 36
  • 100 (a)
OneToMany
cfa-mir-124-3 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mir124a-2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-2 36
  • 81 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-124a-2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-124c 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-5 36
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-1 36
  • 53 (a)
ManyToMany
csa-mir-124-2 36
  • 53 (a)
ManyToMany
Species with no ortholog for MIR124-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-2 Gene

ENSEMBL:
Gene Tree for MIR124-2 (if available)
TreeFam:
Gene Tree for MIR124-2 (if available)

Paralogs for MIR124-2 Gene

No data available for Paralogs for MIR124-2 Gene

Variants for MIR124-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR124-2 Gene

Variant ID Type Subtype PubMed ID
nsv523097 CNV Loss 19592680

Relevant External Links for MIR124-2 Gene

HapMap Linkage Disequilibrium report
MIR124-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR124-2 Gene

Disorders for MIR124-2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MIR124-2 Gene including...

Search for MIR124-2 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR124-2: view

No data available for UniProtKB/Swiss-Prot for MIR124-2 Gene

Publications for MIR124-2 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  3. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 3
  4. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR124-2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR124-2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR124-2
    • Block miRNA regulation of MIR124-2 using miScript Target Protectors

    Sources for MIR124-2 Gene

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