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Aliases for MIR124-2 Gene

Subcategory (RNA class) for MIR124-2 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR124-2 Gene

  • MicroRNA 124-2 2 3 5
  • MicroRNA 124a-2 2 3
  • Hsa-Mir-124a-2 3
  • Hsa-Mir-124-2 3
  • Mir-124-2 3
  • MIRN124-2 3
  • MIRN124A2 3

External Ids for MIR124-2 Gene

Previous HGNC Symbols for MIR124-2 Gene

  • MIRN124A2
  • MIRN124-2

Previous GeneCards Identifiers for MIR124-2 Gene

  • GC08P065458
  • GC08P065291

Summaries for MIR124-2 Gene

Entrez Gene Summary for MIR124-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-2 Gene

MIR124-2 (MicroRNA 124-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-2 Gene

Genomics for MIR124-2 Gene

Regulatory Elements for MIR124-2 Gene

Enhancers for MIR124-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G064379 0.9 ENCODE dbSUPER 0.7 -1.1 -1141 0.2 RING1 RNF2 SUZ12 CBX2 RBBP5 POLR2A HDAC2 EZH2 MIR124-2 MIR124-2HG
GH08G064380 0.9 ENCODE dbSUPER 0.7 -1.0 -971 0.0 RNF2 SUZ12 CBX2 RBBP5 REST HDAC2 CTBP2 EZH2 MIR124-2HG MIR124-2
GH08G064382 0.9 ENCODE dbSUPER 0.7 -0.9 -871 0.2 RNF2 SUZ12 CBX2 RBBP5 REST HDAC2 SMARCA4 POLR2A CTBP2 EZH2 MIR124-2 MIR124-2HG
GH08G064377 0.8 ENCODE dbSUPER 0.7 -1.4 -1391 0.2 RING1 HDAC2 POLR2A CHD1 CBX2 RBBP5 EZH2 MIR124-2 MIR124-2HG
GH08G064381 0.8 ENCODE dbSUPER 0.7 -1.9 -1931 0.2 POLR2A SUZ12 CHD1 CBX2 CREB1 ATF2 MIR124-2HG MIR124-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR124-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR124-2 Gene

Chromosome:
8
Start:
64,379,149 bp from pter
End:
64,379,257 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR124-2 Gene

Genes around MIR124-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-2 Gene

Proteins for MIR124-2 Gene

Post-translational modifications for MIR124-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-2 Gene

Domains & Families for MIR124-2 Gene

Gene Families for MIR124-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-2 Gene

Function for MIR124-2 Gene

Animal Model Products

miRNA for MIR124-2 Gene

miRTarBase miRNAs that target MIR124-2

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR124-2 Gene

Localization for MIR124-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-2 Gene

Pathways & Interactions for MIR124-2 Gene

genes like me logo Genes that share pathways with MIR124-2: view

Pathways by source for MIR124-2 Gene

1 BioSystems pathway for MIR124-2 Gene
1 KEGG pathway for MIR124-2 Gene

Interacting Proteins for MIR124-2 Gene

Gene Ontology (GO) - Biological Process for MIR124-2 Gene

None

No data available for SIGNOR curated interactions for MIR124-2 Gene

Drugs & Compounds for MIR124-2 Gene

No Compound Related Data Available

Transcripts for MIR124-2 Gene

mRNA/cDNA for MIR124-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-2 Gene

No ASD Table

Relevant External Links for MIR124-2 Gene

GeneLoc Exon Structure for
MIR124-2
ECgene alternative splicing isoforms for
MIR124-2

Expression for MIR124-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR124-2 Gene

genes like me logo Genes that share expression patterns with MIR124-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-2 Gene

Orthologs for MIR124-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-124-2 35
  • 100 (a)
OneToMany
cfa-mir-124-3 35
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-124a 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir124a-2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-124a-2 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-124a-2 35
  • 81 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia bta-mir-124a-2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-124c 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 100 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-124-5 35
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-1 35
  • 53 (a)
ManyToMany
csa-mir-124-2 35
  • 53 (a)
ManyToMany
Species where no ortholog for MIR124-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-2 Gene

ENSEMBL:
Gene Tree for MIR124-2 (if available)
TreeFam:
Gene Tree for MIR124-2 (if available)

Paralogs for MIR124-2 Gene

No data available for Paralogs for MIR124-2 Gene

Variants for MIR124-2 Gene

Sequence variations from dbSNP and Humsavar for MIR124-2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000037419 -- 64,377,557(+) CGATC(G/T)TTTCG intron-variant, upstream-variant-2KB
rs1003143006 -- 64,378,478(+) CTCTC(A/G)GGACT nc-transcript-variant, upstream-variant-2KB
rs1003449461 -- 64,379,689(+) CCAAA(A/C)TTTGG intron-variant, downstream-variant-500B
rs1003653099 -- 64,378,703(+) TGGCA(A/G)TGGTT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1004840270 -- 64,378,081(+) TCTGC(G/T)CAAGA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR124-2 Gene

Variant ID Type Subtype PubMed ID
nsv523097 CNV loss 19592680

Relevant External Links for MIR124-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR124-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR124-2 Gene

Disorders for MIR124-2 Gene

Relevant External Links for MIR124-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR124-2

No disorders were found for MIR124-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-2 Gene

Publications for MIR124-2 Gene

  1. Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. (PMID: 27889233) Jin L. … Han X. (Biomed. Pharmacother. 2017) 3 64
  2. MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1. (PMID: 27743351) Zhou Y. … Jia X. (Hum. Cell 2017) 3 64
  3. miRNA-124 modulates lung carcinoma cell migration and invasion. (PMID: 27251409) Li Z. … Chen H. (Int J Clin Pharmacol Ther 2016) 3 64
  4. MicroRNA-124 inhibits cell proliferation and migration by regulating SNAI2 in breast cancer. (PMID: 27748910) Du S. … Liu K. (Oncol. Rep. 2016) 3 64
  5. MiR-124 inhibits cell proliferation, migration and invasion by directly targeting SOX9 in lung adenocarcinoma. (PMID: 26935152) Wang X. … Zhou C. (Oncol. Rep. 2016) 3 64

Products for MIR124-2 Gene

Sources for MIR124-2 Gene

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