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Aliases for MIR124-1 Gene

Subcategory (RNA class) for MIR124-1 Gene


Quality Score for this RNA gene is


Aliases for MIR124-1 Gene

  • MicroRNA 124-1 2 3
  • MicroRNA 124a-1 2 3
  • MIR124A 3 6
  • Hsa-Mir-124a-1 3
  • Hsa-Mir-124-1 3
  • MIRN124-1 3
  • MIRN124A1 3
  • MIR124A1 3

External Ids for MIR124-1 Gene

Previous HGNC Symbols for MIR124-1 Gene

  • MIRN124A1
  • MIRN124-1

Previous GeneCards Identifiers for MIR124-1 Gene

  • GC08M009803
  • GC08M009760

Summaries for MIR124-1 Gene

Entrez Gene Summary for MIR124-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-1 Gene

MIR124-1 (MicroRNA 124-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR124-1 include oral squamous cell carcinoma and myelodysplastic syndrome. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR124-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR124-1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR124-1 Gene

Genomics for MIR124-1 Gene

Genomic Location for MIR124-1 Gene

9,903,388 bp from pter
9,903,472 bp from pter
85 bases
Minus strand

Genomic View for MIR124-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR124-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-1 Gene

ORGUL Member Location for MIR124-1 Gene

ORGUL Member Location for MIR124-1 gene

No data available for Regulatory Elements for MIR124-1 Gene

Proteins for MIR124-1 Gene

Post-translational modifications for MIR124-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-1 Gene

Domains for MIR124-1 Gene

Gene Families for MIR124-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-1 Gene

Function for MIR124-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-1 Gene

Localization for MIR124-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-1 Gene

Pathways for MIR124-1 Gene

SuperPathways for MIR124-1 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR124-1: view

Pathways by source for MIR124-1 Gene

1 KEGG pathway for MIR124-1 Gene

Interacting Proteins for MIR124-1 Gene

Gene Ontology (GO) - Biological Process for MIR124-1 Gene


Transcripts for MIR124-1 Gene

fRNAdb Secondary structures for MIR124-1 Gene

  • hsa-mir-124-1_MI0000443_Homo_sapiens_miR-124-1_stem-loop_hairpin
  • FR344526

mRNA/cDNA for MIR124-1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-1 Gene

No ASD Table

Relevant External Links for MIR124-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR124-1 Gene

mRNA expression in normal human tissues for MIR124-1 Gene

genes like me logo Genes that share expressions with MIR124-1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR124-1 Gene

Orthologs for MIR124-1 Gene

Evolution for MIR124-1 Gene

Gene Tree for MIR124-1 (if available)
Gene Tree for MIR124-1 (if available)

No data available for Orthologs for MIR124-1 Gene

Paralogs for MIR124-1 Gene

No data available for Paralogs for MIR124-1 Gene

Variants for MIR124-1 Gene

Sequence variations from dbSNP and Humsavar for MIR124-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs115515315 -- 9,905,470(+) CCGAA(C/T)TGCTT upstream-variant-2KB
rs193109462 -- 9,905,439(+) AGCAT(C/T)CTGGG upstream-variant-2KB
rs530123797 -- 9,905,456(+) CGCCA(A/C)GGCCA upstream-variant-2KB
rs533031319 -- 9,905,337(+) GATTC(A/G)GCCGG upstream-variant-2KB
rs534841163 -- 9,905,416(+) GGGGG(C/G)ATGCT upstream-variant-2KB

Relevant External Links for MIR124-1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR124-1 Gene

Disorders for MIR124-1 Gene

Relevant External Links for MIR124-1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR124-1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR124-1 Gene

Publications for MIR124-1 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 48
  2. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 48
  3. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48
  4. MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression. (PMID: 19944075) SA/ber S. … Annilo T. (Biochem. Biophys. Res. Commun. 2010) 3
  5. Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulators. (PMID: 20599952) Maisel M. … Storch A. (Exp. Cell Res. 2010) 3

Products for MIR124-1 Gene

Sources for MIR124-1 Gene

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