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Aliases for MIR124-1 Gene

Subcategory (RNA class) for MIR124-1 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR124-1 Gene

  • MicroRNA 124-1 2 3 5
  • MicroRNA 124a-1 2 3
  • Hsa-Mir-124a-1 3
  • Hsa-Mir-124-1 3
  • Mir-124-1 3
  • MIRN124-1 3
  • MIRN124A1 3
  • MIR124A1 3
  • MIR124A 3

External Ids for MIR124-1 Gene

Previous HGNC Symbols for MIR124-1 Gene

  • MIRN124A1
  • MIRN124-1

Previous GeneCards Identifiers for MIR124-1 Gene

  • GC08M009803
  • GC08M009760

Summaries for MIR124-1 Gene

Entrez Gene Summary for MIR124-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-1 Gene

MIR124-1 (MicroRNA 124-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR124-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR124-1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR124-1 Gene

Genomics for MIR124-1 Gene

Regulatory Elements for MIR124-1 Gene

Promoters for MIR124-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR124-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR124-1 Gene

Chromosome:
8
Start:
9,903,388 bp from pter
End:
9,903,472 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR124-1 Gene

Genes around MIR124-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-1 Gene

ORGUL Member Location for MIR124-1 Gene

ORGUL Member Location for MIR124-1 gene

Proteins for MIR124-1 Gene

Post-translational modifications for MIR124-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-1 Gene

Domains & Families for MIR124-1 Gene

Gene Families for MIR124-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-1 Gene

Function for MIR124-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-1 Gene

Localization for MIR124-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-1 Gene

Pathways & Interactions for MIR124-1 Gene

SuperPathways for MIR124-1 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR124-1: view

Pathways by source for MIR124-1 Gene

1 KEGG pathway for MIR124-1 Gene

Interacting Proteins for MIR124-1 Gene

Gene Ontology (GO) - Biological Process for MIR124-1 Gene

None

No data available for SIGNOR curated interactions for MIR124-1 Gene

Drugs & Compounds for MIR124-1 Gene

No Compound Related Data Available

Transcripts for MIR124-1 Gene

fRNAdb Secondary structures for MIR124-1 Gene

  • hsa-mir-124-1_MI0000443_Homo_sapiens_miR-124-1_stem-loop_hairpin
  • FR344526

mRNA/cDNA for MIR124-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-1 Gene

No ASD Table

Relevant External Links for MIR124-1 Gene

GeneLoc Exon Structure for
MIR124-1
ECgene alternative splicing isoforms for
MIR124-1

Expression for MIR124-1 Gene

mRNA expression in normal human tissues for MIR124-1 Gene

genes like me logo Genes that share expression patterns with MIR124-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR124-1 Gene

Orthologs for MIR124-1 Gene

Evolution for MIR124-1 Gene

ENSEMBL:
Gene Tree for MIR124-1 (if available)
TreeFam:
Gene Tree for MIR124-1 (if available)

No data available for Orthologs for MIR124-1 Gene

Paralogs for MIR124-1 Gene

No data available for Paralogs for MIR124-1 Gene

Variants for MIR124-1 Gene

Sequence variations from dbSNP and Humsavar for MIR124-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs115515315 -- 9,905,470(+) CCGAA(C/T)TGCTT upstream-variant-2KB
rs530123797 -- 9,905,456(+) CGCCA(A/C)GGCCA upstream-variant-2KB
rs193109462 -- 9,905,439(+) AGCAT(C/T)CTGGG upstream-variant-2KB
rs543004504 -- 9,905,469(+) CCCGA(A/G)CTGCT upstream-variant-2KB
rs559727090 -- 9,905,411(+) TAAGG(A/C/G)GGGGG upstream-variant-2KB

Relevant External Links for MIR124-1 Gene

HapMap Linkage Disequilibrium report
MIR124-1
Human Gene Mutation Database (HGMD)
MIR124-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR124-1 Gene

Disorders for MIR124-1 Gene

Relevant External Links for MIR124-1

Genetic Association Database (GAD)
MIR124-1
Human Genome Epidemiology (HuGE) Navigator
MIR124-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR124-1

No disorders were found for MIR124-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-1 Gene

Publications for MIR124-1 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48 67
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3
  3. Label-free and amplification-free miR-124 detection in human cells. (PMID: 25405852) Smerkova K. … Kizek R. (Int. J. Oncol. 2015) 3
  4. Interleukin 7 up-regulates CD95 protein on CD4+ T cells by affecting mRNA alternative splicing: priming for a synergistic effect on HIV-1 reservoir maintenance. (PMID: 25411246) Yin Y. … Zhang H. (J. Biol. Chem. 2015) 3
  5. The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients. (PMID: 25531908) Li X. … Cui L. (Int. J. Oncol. 2015) 3

Products for MIR124-1 Gene

Sources for MIR124-1 Gene

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