Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR124-1 Gene

Subcategory (RNA class) for MIR124-1 Gene


Quality Score for this RNA gene is


Aliases for MIR124-1 Gene

  • MicroRNA 124-1 2 3 5
  • MicroRNA 124a-1 2 3
  • Hsa-Mir-124a-1 3
  • Hsa-Mir-124-1 3
  • Mir-124-1 3
  • MIRN124-1 3
  • MIRN124A1 3
  • MIR124A1 3
  • MIR124A 3

External Ids for MIR124-1 Gene

Previous HGNC Symbols for MIR124-1 Gene

  • MIRN124A1
  • MIRN124-1

Previous GeneCards Identifiers for MIR124-1 Gene

  • GC08M009803
  • GC08M009760
  • GC08M009904

Summaries for MIR124-1 Gene

Entrez Gene Summary for MIR124-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-1 Gene

MIR124-1 (MicroRNA 124-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR124-1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR124-1

Additional gene information for MIR124-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR124-1 Gene

Genomics for MIR124-1 Gene

Regulatory Elements for MIR124-1 Gene

Enhancers for MIR124-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H010279 0.6 ENCODE 9.9 -376.4 -376374 0.2 ZBTB21 CEBPB CEBPG ATF2 JUND POLR2A ZNF629 ZNF512 FOS MSRA LINC00599 MIR124-1 LOC100420053 GC08M010081
GH08H009945 0.4 FANTOM5 11 -41.9 -41903 0.2 POLR2A MSRA MIR124-1 LINC00599 LOC105379234
GH08H009902 1.3 Ensembl ENCODE dbSUPER 0.7 -0.2 -219 2.6 CTCF SUZ12 ZFHX2 GLIS2 ZBTB48 ZNF366 POLR2A PATZ1 ZBTB20 EGR2 RPL10P19 MIR124-1 LINC00599
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR124-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR124-1 Gene

Genomic Locations for MIR124-1 Gene
85 bases
Minus strand

Genomic View for MIR124-1 Gene

Genes around MIR124-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-1 Gene

ORGUL Member Location for MIR124-1 Gene

ORGUL Member Location for MIR124-1 gene

Proteins for MIR124-1 Gene

Post-translational modifications for MIR124-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-1 Gene

Domains & Families for MIR124-1 Gene

Gene Families for MIR124-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-1 Gene

Function for MIR124-1 Gene

Phenotypes From GWAS Catalog for MIR124-1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-1 Gene

Localization for MIR124-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR124-1 Gene

Pathways & Interactions for MIR124-1 Gene

genes like me logo Genes that share pathways with MIR124-1: view

Pathways by source for MIR124-1 Gene

1 BioSystems pathway for MIR124-1 Gene
1 KEGG pathway for MIR124-1 Gene

Interacting Proteins for MIR124-1 Gene

Gene Ontology (GO) - Biological Process for MIR124-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 24122720
GO:0010764 negative regulation of fibroblast migration IDA 24122720
GO:0035195 gene silencing by miRNA IDA 24122720
GO:0048147 negative regulation of fibroblast proliferation IDA 24122720
genes like me logo Genes that share ontologies with MIR124-1: view

No data available for SIGNOR curated interactions for MIR124-1 Gene

Drugs & Compounds for MIR124-1 Gene

No Compound Related Data Available

Transcripts for MIR124-1 Gene

fRNAdb Secondary structures for MIR124-1 Gene

  • hsa-mir-124-1_MI0000443_Homo_sapiens_miR-124-1_stem-loop_hairpin
  • FR344526

mRNA/cDNA for MIR124-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-1 Gene

No ASD Table

Relevant External Links for MIR124-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR124-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR124-1 Gene

genes like me logo Genes that share expression patterns with MIR124-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR124-1 Gene

Orthologs for MIR124-1 Gene

Evolution for MIR124-1 Gene

Gene Tree for MIR124-1 (if available)
Gene Tree for MIR124-1 (if available)

No data available for Orthologs for MIR124-1 Gene

Paralogs for MIR124-1 Gene

No data available for Paralogs for MIR124-1 Gene

Variants for MIR124-1 Gene

Sequence variations from dbSNP and Humsavar for MIR124-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000181729 -- 9,903,741(+) TCGCA(A/T)CCAGG upstream-variant-2KB
rs1000464980 -- 9,903,992(+) GAAGA(A/G)GAGAG upstream-variant-2KB
rs1002215341 -- 9,904,265(+) GAGGA(A/C/G)GAAGA upstream-variant-2KB
rs1002589775 -- 9,905,295(+) TTTTT(C/G)TTCTC upstream-variant-2KB
rs1003735474 -- 9,905,317(+) GACTG(A/G)CCGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR124-1 Gene

Variant ID Type Subtype PubMed ID
nsv951098 CNV deletion 24416366

Relevant External Links for MIR124-1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR124-1 Gene

Disorders for MIR124-1 Gene

Relevant External Links for MIR124-1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR124-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-1 Gene

Publications for MIR124-1 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 45 60
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 45 60
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 45 60
  4. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 60
  5. MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1. (PMID: 27743351) Zhou Y … Jia X (Human cell 2017) 3 60

Products for MIR124-1 Gene

Sources for MIR124-1 Gene

Loading form....