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Aliases for MIR124-1 Gene

Subcategory (RNA class) for MIR124-1 Gene


Quality Score for this RNA gene is


Aliases for MIR124-1 Gene

  • MicroRNA 124-1 2 3
  • MicroRNA 124a-1 2 3
  • Long Intergenic Non-Protein Coding RNA 599 5
  • Hsa-Mir-124a-1 3
  • Hsa-Mir-124-1 3
  • Mir-124-1 3
  • MIRN124-1 3
  • MIRN124A1 3
  • LINC00599 5
  • MIR124A1 3
  • MIR124A 3

External Ids for MIR124-1 Gene

Previous HGNC Symbols for MIR124-1 Gene

  • MIRN124A1
  • MIRN124-1

Previous GeneCards Identifiers for MIR124-1 Gene

  • GC08M009803
  • GC08M009760
  • GC08M009904

Summaries for MIR124-1 Gene

Entrez Gene Summary for MIR124-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR124-1 Gene

MIR124-1 (MicroRNA 124-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR124-1 Gene

Genomics for MIR124-1 Gene

Regulatory Elements for MIR124-1 Gene

Enhancers for MIR124-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F010279 0.6 ENCODE 9.9 -374.5 -374480 0.2 JUND ATF3 ZNF512 BHLHE40 CEBPB FOS ATF2 MSRA LINC00599 MIR124-1 LOC100420053 GC08M010081
GH08F009945 0.5 FANTOM5 11 -40.0 -40009 0.2 ATF1 POLR2A MSRA MIR124-1 LINC00599 LOC105379234
GH08F009902 1.1 Ensembl ENCODE 0.8 +1.8 1781 2.8 CTCF SUZ12 RAD21 ZFHX2 GLIS2 ZBTB48 ZNF366 POLR2A PATZ1 SMC3 RPL10P19 GC08M009905 MIR124-1 LINC00599
GH08F009906 0.8 FANTOM5 0.8 -1.4 -1371 0.4 CTCF ZBTB10 KLF17 ZBTB8A ZNF324 POLR2A PATZ1 GLIS1 ZBTB26 EZH2 MSRA LINC00599 MIR124-1 LOC105379234
GH08F009933 1.4 FANTOM5 Ensembl ENCODE 0.3 -28.4 -28370 0.9 PKNOX1 ZNF76 KLF17 ZBTB40 KLF7 EGR2 SP3 ZBTB11 NFYC ZNF518A MSRA LINC00599 MIR124-1 LOC105379234
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR124-1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR124-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001385623 1466 601 CTCF ZBTB10 MAZ SP2 ZBTB8A ZFHX2 ZNF366 PATZ1 CTBP2 KDM1A

Genomic Location for MIR124-1 Gene

9,900,064 bp from pter
9,905,366 bp from pter
5,303 bases
Minus strand

Genomic View for MIR124-1 Gene

Genes around MIR124-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR124-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR124-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR124-1 Gene

Proteins for MIR124-1 Gene

Post-translational modifications for MIR124-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR124-1 Gene

Domains & Families for MIR124-1 Gene

Gene Families for MIR124-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR124-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR124-1 Gene

Function for MIR124-1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR124-1 Gene

Localization for MIR124-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR124-1 Gene

Pathways & Interactions for MIR124-1 Gene

genes like me logo Genes that share pathways with MIR124-1: view

Pathways by source for MIR124-1 Gene

1 BioSystems pathway for MIR124-1 Gene
1 KEGG pathway for MIR124-1 Gene

Interacting Proteins for MIR124-1 Gene

Gene Ontology (GO) - Biological Process for MIR124-1 Gene


No data available for SIGNOR curated interactions for MIR124-1 Gene

Transcripts for MIR124-1 Gene

mRNA/cDNA for MIR124-1 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR124-1 Gene

No ASD Table

Relevant External Links for MIR124-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR124-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR124-1 Gene

genes like me logo Genes that share expression patterns with MIR124-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR124-1 Gene

Orthologs for MIR124-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR124-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-124a-1 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-124-1 35
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-mir-124a-1 35
  • 100 (a)
(Mus musculus)
Mammalia Mir124a-1 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-124a-1 35
  • 79 (a)
(Gallus gallus)
Aves gga-mir-124b 35
  • 68 (a)
(Anolis carolinensis)
Reptilia aca-mir-124b 35
  • 94 (a)
(Danio rerio)
Actinopterygii dre-mir-124-5 35
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-124-2 35
  • 53 (a)
csa-mir-124-1 35
  • 50 (a)
Species where no ortholog for MIR124-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR124-1 Gene

Gene Tree for MIR124-1 (if available)
Gene Tree for MIR124-1 (if available)

Paralogs for MIR124-1 Gene

No data available for Paralogs for MIR124-1 Gene

Variants for MIR124-1 Gene

Sequence variations from dbSNP and Humsavar for MIR124-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs113799242 -- 9,903,836(+) ACCCC(A/G)GCTCC upstream-variant-2KB
rs114605409 -- 9,903,946(+) TGTCG(C/T)CCTCT upstream-variant-2KB
rs115515315 -- 9,905,470(+) CCGAA(C/T)TGCTT upstream-variant-2KB
rs116003011 -- 9,904,110(+) GTGCC(A/G)CAGGG upstream-variant-2KB
rs138390796 -- 9,904,019(+) CAGCG(A/G)GGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR124-1 Gene

Variant ID Type Subtype PubMed ID
nsv951098 CNV deletion 24416366

Relevant External Links for MIR124-1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR124-1 Gene

Disorders for MIR124-1 Gene

Relevant External Links for MIR124-1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR124-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR124-1 Gene

Publications for MIR124-1 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 46 64
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 46 64
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 46 64
  4. MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway. (PMID: 26745800) Wang Y. … Guo D. (PLoS ONE 2016) 3 64
  5. The feedback loop between miR-124 and TGF-I^ pathway plays a significant role in non-small cell lung cancer metastasis. (PMID: 26818357) Zu L. … Wang J. (Carcinogenesis 2016) 3 64

Products for MIR124-1 Gene

Sources for MIR124-1 Gene

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