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Aliases for MIR1237 Gene

Subcategory (RNA class) for MIR1237 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1237 Gene

  • MicroRNA 1237 2 3 5
  • Hsa-Mir-1237 3
  • MIRN1237 3

External Ids for MIR1237 Gene

Previous HGNC Symbols for MIR1237 Gene

  • MIRN1237

Previous GeneCards Identifiers for MIR1237 Gene

  • GC00U922958
  • GC11P063894
  • GC11P064136

Summaries for MIR1237 Gene

Entrez Gene Summary for MIR1237 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1237 Gene

MIR1237 (MicroRNA 1237) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1237 include Spinal Chordoma.

Additional gene information for MIR1237 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1237 Gene

Genomics for MIR1237 Gene

GeneHancer (GH) Regulatory Elements for MIR1237 Gene

Promoters and enhancers for MIR1237 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064347 Enhancer 0.8 ENCODE 11.9 -20.2 -20221 1.9 BCOR KLF1 JUN CHD4 MAX ZMYM3 CEBPG POLR2A FOXK2 PATZ1 LOC102723878 MIR1237 TRMT112 PRDX5 ESRRA CATSPERZ ENSG00000207024 KCNK4-TEX40 KCNK4 BAD
GH11I064438 Enhancer 0.8 FANTOM5 ENCODE 11.2 +70.5 70511 1.3 SMARCE1 ZNF217 ZNF121 CTBP1 MTA1 ESR1 DPF2 HNF4A SLC22A12 NRXN2 SLC22A11 MIR1237 OTUB1 GC11P064445 ENSG00000231492
GH11I064501 Enhancer 0.8 ENCODE 10.7 +133.6 133619 1.9 HDAC1 HDGF ZFP64 RARA TCF12 RCOR1 THAP11 SP5 NCOA1 ZEB2 LOC105369342 ENSG00000237410 NRXN2 SLC22A11 SLC22A12 MIR1237 LOC100996455 ENSG00000237363
GH11I064394 Enhancer 0.7 Ensembl ENCODE 12.1 +27.2 27166 2.3 ZNF148 ZNF335 SIN3A ZIC2 NR2F2 ZBTB20 ENSG00000231680 RPS6KA4 MIR1237 LOC100996455 NRXN2 TRMT112 CCDC88B GC11M064381
GH11I064489 Enhancer 0.8 ENCODE 10.5 +121.4 121422 0.2 ATF1 RB1 SIN3A BMI1 RAD21 ARID2 ZNF143 CREM ZHX1 ZNF654 NRXN2 LOC100996455 SLC22A12 MIR1237 LOC105369342 GC11M064457
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1237 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1237 Gene

Genomic Locations for MIR1237 Gene
chr11:64,368,602-64,368,703
(GRCh38/hg38)
Size:
102 bases
Orientation:
Plus strand
chr11:64,136,074-64,136,175
(GRCh37/hg19)

Genomic View for MIR1237 Gene

Genes around MIR1237 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1237 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1237 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1237 Gene

Proteins for MIR1237 Gene

Post-translational modifications for MIR1237 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1237 Gene

Domains & Families for MIR1237 Gene

Gene Families for MIR1237 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1237: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1237 Gene

Function for MIR1237 Gene

Phenotypes From GWAS Catalog for MIR1237 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1237 Gene

Localization for MIR1237 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1237 Gene

Pathways & Interactions for MIR1237 Gene

SuperPathways for MIR1237 Gene

No Data Available

Interacting Proteins for MIR1237 Gene

Gene Ontology (GO) - Biological Process for MIR1237 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1237 Gene

Drugs & Compounds for MIR1237 Gene

No Compound Related Data Available

Transcripts for MIR1237 Gene

mRNA/cDNA for MIR1237 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1237 Gene

No ASD Table

Relevant External Links for MIR1237 Gene

GeneLoc Exon Structure for
MIR1237
ECgene alternative splicing isoforms for
MIR1237

Expression for MIR1237 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1237 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1237 Gene:

MIR1237
genes like me logo Genes that share expression patterns with MIR1237: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1237 Gene

Orthologs for MIR1237 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1237 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1237 34
  • 100 (a)
OneToOne
Species where no ortholog for MIR1237 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1237 Gene

ENSEMBL:
Gene Tree for MIR1237 (if available)
TreeFam:
Gene Tree for MIR1237 (if available)

Paralogs for MIR1237 Gene

No data available for Paralogs for MIR1237 Gene

Variants for MIR1237 Gene

Sequence variations from dbSNP and Humsavar for MIR1237 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001605310 -- 64,367,366(+) A/G upstream_transcript_variant
rs1002361819 -- 64,368,321(+) A/G upstream_transcript_variant
rs1004105434 -- 64,367,274(+) T/C/G upstream_transcript_variant
rs1004323380 -- 64,366,960(+) C/T upstream_transcript_variant
rs1005554008 -- 64,368,354(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1237 Gene

Variant ID Type Subtype PubMed ID
nsv832186 CNV loss 17160897
nsv832187 CNV loss 17160897

Additional Variant Information for MIR1237 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1237

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1237 Gene

Disorders for MIR1237 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1237 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinal chordoma
  • chordoma of spine
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1237

genes like me logo Genes that share disorders with MIR1237: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1237 Gene

Publications for MIR1237 Gene

  1. Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. (PMID: 25850393) Zou MX … Deng YW (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2015) 3 58
  2. Epigenetically silenced microRNAs in gastric cancer: Functional analysis and identification of their target genes. (PMID: 26043902) Bae JH … Yi JM (Oncology reports 2015) 3 58
  3. Mammalian mirtron genes. (PMID: 17964270) Berezikov E … Lai EC (Molecular cell 2007) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR1237 Gene

Sources for MIR1237 Gene

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