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Aliases for MIR1236 Gene

Subcategory (RNA class) for MIR1236 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1236 Gene

  • MicroRNA 1236 2 3 5
  • Hsa-Mir-1236 3
  • MIRN1236 3

External Ids for MIR1236 Gene

Previous HGNC Symbols for MIR1236 Gene

  • MIRN1236

Previous GeneCards Identifiers for MIR1236 Gene

  • GC00U922986
  • GC06M032034
  • GC06M031924
  • GC06M031712
  • GC06M031957

Summaries for MIR1236 Gene

Entrez Gene Summary for MIR1236 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1236 Gene

MIR1236 (MicroRNA 1236) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene Expression.

Additional gene information for MIR1236 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1236 Gene

Genomics for MIR1236 Gene

GeneHancer (GH) Regulatory Elements for MIR1236 Gene

Promoters and enhancers for MIR1236 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 +92.8 92824 4.5 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NEU1 LY6G5B LSM2 DDX39B ATF6B GPANK1 MSH5 TCF19 CSNK2B MICA
GH06I031910 Enhancer 1 Ensembl ENCODE 11.6 +45.8 45762 2 INSM2 KLF17 BATF RFX5 GTF3C2 ZNF335 EGR1 ZNF366 FOS SMARCA5 C4A SKIV2L HLA-DRB5 HLA-C MICB MIR1236 NEU1 STK19 GPANK1 LY6G5B
GH06I031928 Enhancer 0.8 ENCODE 11.8 +27.5 27465 1.2 BCOR ELF3 PKNOX1 SAP130 ARID4B ZNF384 CEBPG E4F1 ZSCAN9 TRIM24 ENSG00000244255 SKIV2L MIR1236 STK19 C4A ZBTB12 NEU1 C2 EHMT2 VARS
GH06I032090 Enhancer 0.2 dbSUPER 10 -133.9 -133944 0.4 TNXB ATF6B FKBPL PPT2 PRRT1 EGFL8 AGPAT1 RNF5 MIR1236 SKIV2L
GH06I031944 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.4 +9.4 9402 6.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 E2F8 CFB SKIV2L ATF6B CSNK2B STK19 BAG6 CCHCR1 STK19B HLA-DRB1 LY6G5B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1236 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1236 Gene

Genomic Locations for MIR1236 Gene
chr6:31,956,839-31,956,940
(GRCh38/hg38)
Size:
102 bases
Orientation:
Minus strand
chr6:31,924,616-31,924,717
(GRCh37/hg19)

Genomic View for MIR1236 Gene

Genes around MIR1236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1236 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR1236 Gene

Post-translational modifications for MIR1236 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1236 Gene

Domains & Families for MIR1236 Gene

Gene Families for MIR1236 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1236: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1236 Gene

Function for MIR1236 Gene

Phenotypes From GWAS Catalog for MIR1236 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1236 Gene

Localization for MIR1236 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1236 Gene

Pathways & Interactions for MIR1236 Gene

genes like me logo Genes that share pathways with MIR1236: view

Interacting Proteins for MIR1236 Gene

Gene Ontology (GO) - Biological Process for MIR1236 Gene

None

No data available for SIGNOR curated interactions for MIR1236 Gene

Drugs & Compounds for MIR1236 Gene

No Compound Related Data Available

Transcripts for MIR1236 Gene

mRNA/cDNA for MIR1236 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1236 Gene

No ASD Table

Relevant External Links for MIR1236 Gene

GeneLoc Exon Structure for
MIR1236
ECgene alternative splicing isoforms for
MIR1236

Expression for MIR1236 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1236 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1236 Gene:

MIR1236
genes like me logo Genes that share expression patterns with MIR1236: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1236 Gene

Orthologs for MIR1236 Gene

Evolution for MIR1236 Gene

ENSEMBL:
Gene Tree for MIR1236 (if available)
TreeFam:
Gene Tree for MIR1236 (if available)

No data available for Orthologs for MIR1236 Gene

Paralogs for MIR1236 Gene

No data available for Paralogs for MIR1236 Gene

Variants for MIR1236 Gene

Sequence variations from dbSNP and Humsavar for MIR1236 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1050729511 uncertain-significance, Trichohepatoenteric syndrome 31,958,920(-) G/A upstream_transcript_variant
rs17201466 likely-benign, Trichohepatoenteric syndrome 31,958,823(-) C/T upstream_transcript_variant
rs182142262 uncertain-significance, Trichohepatoenteric syndrome 31,958,913(-) G/T upstream_transcript_variant
rs886061299 uncertain-significance, Trichohepatoenteric syndrome 31,958,924(-) T/C upstream_transcript_variant
rs1003248402 -- 31,957,432(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1236 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv428141 CNV gain+loss 18775914
nsv830628 CNV loss 17160897

Additional Variant Information for MIR1236 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1236

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1236 Gene

Disorders for MIR1236 Gene

Additional Disease Information for MIR1236

No disorders were found for MIR1236 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1236 Gene

Publications for MIR1236 Gene

  1. Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells. (PMID: 28631573) Li C … Chen Z (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  2. miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells. (PMID: 28842254) Bian T … Zhang J (Biochemical and biophysical research communications 2017) 3 58
  3. miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3. (PMID: 27177472) Chen SY … Wu KJ (Cancer letters 2016) 3 58
  4. miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma. (PMID: 24573236) Wang Y … Kong B (Oncology reports 2014) 3 58
  5. miRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. (PMID: 24932481) Ma L … Wang JH (PloS one 2014) 3 58

Products for MIR1236 Gene

Sources for MIR1236 Gene

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