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Aliases for MIR1236 Gene

Subcategory (RNA class) for MIR1236 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1236 Gene

  • MicroRNA 1236 2 3
  • NELFE 4 5
  • Negative Elongation Factor Complex Member E 5
  • RNA-Binding Protein RD 4
  • Hsa-Mir-1236 3
  • MIRN1236 3
  • NELF-E 4
  • RDBP 4
  • RD 4

External Ids for MIR1236 Gene

Previous HGNC Symbols for MIR1236 Gene

  • MIRN1236

Previous GeneCards Identifiers for MIR1236 Gene

  • GC00U922986
  • GC06M032034
  • GC06M031924
  • GC06M031712

Summaries for MIR1236 Gene

Entrez Gene Summary for MIR1236 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1236 Gene

MIR1236 (MicroRNA 1236) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR1236 Gene

  • Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1236 Gene

Genomics for MIR1236 Gene

Regulatory Elements for MIR1236 Gene

Enhancers for MIR1236 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR1236 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1236 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR1236 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1236 Gene

Chromosome:
6
Start:
31,952,087 bp from pter
End:
31,959,110 bp from pter
Size:
7,024 bases
Orientation:
Minus strand

Genomic View for MIR1236 Gene

Genes around MIR1236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1236 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR1236 Gene

  • Protein details for MIR1236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18615-NELFE_HUMAN
    Recommended name:
    Negative elongation factor E
    Protein Accession:
    P18615
    Secondary Accessions:
    • A2BE08
    • B4DUN1
    • B4DYX9
    • Q5JP74
    • Q5JP75
    • Q96F56
    • Q9NPK2

    Protein attributes for MIR1236 Gene

    Size:
    380 amino acids
    Molecular mass:
    43240 Da
    Quaternary structure:
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE.
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE.

    Three dimensional structures from OCA and Proteopedia for MIR1236 Gene

    Alternative splice isoforms for MIR1236 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1236 Gene

Post-translational modifications for MIR1236 Gene

No data available for DME Specific Peptides for MIR1236 Gene

Domains & Families for MIR1236 Gene

Gene Families for MIR1236 Gene

Protein Domains for MIR1236 Gene

Graphical View of Domain Structure for InterPro Entry

P18615

UniProtKB/Swiss-Prot:

NELFE_HUMAN :
  • The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.
  • Belongs to the RRM NELF-E family.
Domain:
  • The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM NELF-E family.
genes like me logo Genes that share domains with MIR1236: view

No data available for Suggested Antigen Peptide Sequences for MIR1236 Gene

Function for MIR1236 Gene

Molecular function for MIR1236 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Gene Ontology (GO) - Molecular Function for MIR1236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding NAS --
GO:0005515 protein binding IPI --
GO:0044822 poly(A) RNA binding IDA --
genes like me logo Genes that share ontologies with MIR1236: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1236 Gene

Localization for MIR1236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1236 Gene

Gene Ontology (GO) - Cellular Components for MIR1236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS --
GO:0005654 nucleoplasm TAS --
GO:0032021 NELF complex IDA --
genes like me logo Genes that share ontologies with MIR1236: view

No data available for Subcellular locations from COMPARTMENTS for MIR1236 Gene

Pathways & Interactions for MIR1236 Gene

SuperPathways for MIR1236 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0008150 biological_process ND --
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MIR1236: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1236 Gene

Drugs & Compounds for MIR1236 Gene

No Compound Related Data Available

Transcripts for MIR1236 Gene

mRNA/cDNA for MIR1236 Gene

(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1236 Gene

No ASD Table

Relevant External Links for MIR1236 Gene

GeneLoc Exon Structure for
MIR1236
ECgene alternative splicing isoforms for
MIR1236

Expression for MIR1236 Gene

mRNA expression in normal human tissues for MIR1236 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1236 Gene:

MIR1236

mRNA Expression by UniProt/SwissProt for MIR1236 Gene:

P18615-NELFE_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with MIR1236: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1236 Gene

Orthologs for MIR1236 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1236 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NELFE 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NELFE 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NELFE 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nelfe 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NELFE 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RDBP 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves NELFE 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NELFE 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nelfe 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nelf-E 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.554 35
  • 31 (a)
OneToOne
Species where no ortholog for MIR1236 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR1236 Gene

ENSEMBL:
Gene Tree for MIR1236 (if available)
TreeFam:
Gene Tree for MIR1236 (if available)

Paralogs for MIR1236 Gene

No data available for Paralogs for MIR1236 Gene

Variants for MIR1236 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1236 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv428141 CNV gain+loss 18775914
nsv830628 CNV loss 17160897

Relevant External Links for MIR1236 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1236

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR1236 Gene

Disorders for MIR1236 Gene

Relevant External Links for MIR1236

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1236

No disorders were found for MIR1236 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1236 Gene

Publications for MIR1236 Gene

  1. miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma. (PMID: 24573236) Wang Y. … Kong B. (Oncol. Rep. 2014) 3 65
  2. miRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. (PMID: 24932481) Ma L. … Wang J.H. (PLoS ONE 2014) 3 65
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  4. Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. (PMID: 25114211) Impens F. … Ribet D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 4 65
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 65

Products for MIR1236 Gene

Sources for MIR1236 Gene

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