Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR1234 Gene

Subcategory (RNA class) for MIR1234 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1234 Gene

  • MicroRNA 1234 2 3
  • Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit 4
  • Cleavage And Polyadenylation Specific Factor 1 5
  • CPSF 160 KDa Subunit 4
  • Hsa-Mir-1234 3
  • MIRN1234 3
  • CPSF160 4
  • CPSF1 5

External Ids for MIR1234 Gene

Previous HGNC Symbols for MIR1234 Gene

  • MIRN1234

Previous GeneCards Identifiers for MIR1234 Gene

  • GC00U923039
  • GC08M145598
  • GC08M145625

Summaries for MIR1234 Gene

Entrez Gene Summary for MIR1234 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1234 Gene

MIR1234 (MicroRNA 1234) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for MIR1234 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1234 Gene

Genomics for MIR1234 Gene

Regulatory Elements for MIR1234 Gene

Enhancers for MIR1234 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR1234 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1234 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR1234 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1234 Gene

Chromosome:
8
Start:
144,393,229 bp from pter
End:
144,409,349 bp from pter
Size:
16,121 bases
Orientation:
Minus strand

Genomic View for MIR1234 Gene

Genes around MIR1234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1234 Gene

Proteins for MIR1234 Gene

  • Protein details for MIR1234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10570-CPSF1_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 1
    Protein Accession:
    Q10570
    Secondary Accessions:
    • Q96AF0

    Protein attributes for MIR1234 Gene

    Size:
    1443 amino acids
    Molecular mass:
    160884 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.

neXtProt entry for MIR1234 Gene

Post-translational modifications for MIR1234 Gene

  • The N-terminus is blocked.
  • Ubiquitination at Lys 6, Lys 52, Lys 116, Lys 364, Lys 395, Lys 809, Lys 847, Lys 1104, Lys 1118, Lys 1241, and Lys 1421
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR1234 Gene

No data available for DME Specific Peptides for MIR1234 Gene

Domains & Families for MIR1234 Gene

Gene Families for MIR1234 Gene

Protein Domains for MIR1234 Gene

Graphical View of Domain Structure for InterPro Entry

Q10570

UniProtKB/Swiss-Prot:

CPSF1_HUMAN :
  • Belongs to the CPSF1 family.
Family:
  • Belongs to the CPSF1 family.
genes like me logo Genes that share domains with MIR1234: view

No data available for Suggested Antigen Peptide Sequences for MIR1234 Gene

Function for MIR1234 Gene

Molecular function for MIR1234 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Ontology (GO) - Molecular Function for MIR1234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0019899 enzyme binding IPI --
GO:0035925 mRNA 3-UTR AU-rich region binding IDA --
genes like me logo Genes that share ontologies with MIR1234: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1234 Gene

Localization for MIR1234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1234 Gene

Gene Ontology (GO) - Cellular Components for MIR1234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA --
genes like me logo Genes that share ontologies with MIR1234: view

No data available for Subcellular locations from COMPARTMENTS for MIR1234 Gene

Pathways & Interactions for MIR1234 Gene

SuperPathways for MIR1234 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with MIR1234: view

Pathways by source for MIR1234 Gene

1 BioSystems pathway for MIR1234 Gene

Gene Ontology (GO) - Biological Process for MIR1234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IMP --
GO:0006379 mRNA cleavage IBA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with MIR1234: view

No data available for SIGNOR curated interactions for MIR1234 Gene

Drugs & Compounds for MIR1234 Gene

No Compound Related Data Available

Transcripts for MIR1234 Gene

mRNA/cDNA for MIR1234 Gene

(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1234 Gene

No ASD Table

Relevant External Links for MIR1234 Gene

GeneLoc Exon Structure for
MIR1234
ECgene alternative splicing isoforms for
MIR1234

Expression for MIR1234 Gene

mRNA expression in normal human tissues for MIR1234 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1234 Gene:

MIR1234
genes like me logo Genes that share expression patterns with MIR1234: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1234 Gene

Orthologs for MIR1234 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR1234 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF1 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf1 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF1 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF1 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cpsf1 35
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cpsf160 35
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cpsf-1 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT1 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for MIR1234 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1234 Gene

ENSEMBL:
Gene Tree for MIR1234 (if available)
TreeFam:
Gene Tree for MIR1234 (if available)

Paralogs for MIR1234 Gene

Pseudogenes.org Pseudogenes for MIR1234 Gene

genes like me logo Genes that share paralogs with MIR1234: view

No data available for Paralogs for MIR1234 Gene

Variants for MIR1234 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1234 Gene

Variant ID Type Subtype PubMed ID
dgv3080n100 CNV gain 25217958
dgv3081n100 CNV gain 25217958
esv2422420 CNV duplication 17116639
esv2758673 CNV gain 17122850
esv3582465 CNV loss 25503493
nsv1064415 CNV gain 25217958
nsv1118744 CNV deletion 24896259
nsv509644 CNV insertion 20534489
nsv827852 CNV gain 20364138
nsv833332 CNV loss 17160897
nsv833333 CNV loss 17160897
nsv9489 CNV gain 18304495
nsv952096 CNV deletion 24416366

Relevant External Links for MIR1234 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1234

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR1234 Gene

Disorders for MIR1234 Gene

Relevant External Links for MIR1234

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1234

No disorders were found for MIR1234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1234 Gene

Publications for MIR1234 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas. (PMID: 23841503) HAPgfeldt T. … Moshfegh A. (Leuk. Lymphoma 2013) 3 65
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65
  5. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. (PMID: 21102410) Laishram R.S. … Anderson R.A. (EMBO J. 2010) 4 65

Products for MIR1234 Gene

Sources for MIR1234 Gene

Content