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Aliases for MIR1228 Gene

Subcategory (RNA class) for MIR1228 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1228 Gene

  • MicroRNA 1228 2 3 5
  • Hsa-Mir-1228 3
  • Mir-1228 3
  • MIRN1228 3

External Ids for MIR1228 Gene

Previous HGNC Symbols for MIR1228 Gene

  • MIRN1228

Previous GeneCards Identifiers for MIR1228 Gene

  • GC00U922937
  • GC12P055876
  • GC12P057588

Summaries for MIR1228 Gene

Entrez Gene Summary for MIR1228 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1228 Gene

MIR1228 (MicroRNA 1228) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1228 Gene

Genomics for MIR1228 Gene

Regulatory Elements for MIR1228 Gene

Enhancers for MIR1228 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057233 1.2 Ensembl ENCODE 12.2 +40.9 40942 3.8 ZNF48 YY1 GLIS2 KLF7 PAF1 ZNF263 SP3 SP5 ZNF623 SREBF1 MIR1228 ZBTB39 CNPY2 METTL21B OS9 ENSG00000276727 NDUFA4L2
GH12F057228 1.1 ENCODE 12.2 +36.1 36063 3.4 HDGF ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 LOC283387 RNU6-343P MIR1228 RBMS2 STAT6 ENSG00000224713 ENSG00000276727 NDUFA4L2
GH12F057170 0.2 ENCODE 12 -22.9 -22863 1.5 LRP1 MIR1228 STAT6 NDUFA4L2 INHBE GLI1 GC12P057183 PIR32415 LRP1-AS
GH12F057212 1.2 Ensembl ENCODE 0.3 +19.2 19214 2.7 PKNOX1 SIN3A ZNF48 RAD21 ZBTB40 GLIS2 SCRT2 ZNF143 CREM EGR2 ENSG00000224713 NXPH4 MIR1228
GH12F057182 0.9 ENCODE 0.4 -10.7 -10660 1.9 HDGF WRNIP1 KLF17 ARID4B SIN3A DMAP1 ZNF2 RAD21 ZNF366 ZNF143 ENSG00000224713 GC12P057183 PIR32415 MIR1228
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1228 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1228 Gene

Chromosome:
12
Start:
57,194,504 bp from pter
End:
57,194,576 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR1228 Gene

Genes around MIR1228 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1228 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1228 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1228 Gene

Proteins for MIR1228 Gene

Post-translational modifications for MIR1228 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1228 Gene

Domains & Families for MIR1228 Gene

Gene Families for MIR1228 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1228: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1228 Gene

Function for MIR1228 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1228 Gene

Localization for MIR1228 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1228 Gene

Pathways & Interactions for MIR1228 Gene

SuperPathways for MIR1228 Gene

No Data Available

Interacting Proteins for MIR1228 Gene

Gene Ontology (GO) - Biological Process for MIR1228 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1228 Gene

Transcripts for MIR1228 Gene

mRNA/cDNA for MIR1228 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1228 Gene

No ASD Table

Relevant External Links for MIR1228 Gene

GeneLoc Exon Structure for
MIR1228
ECgene alternative splicing isoforms for
MIR1228

Expression for MIR1228 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1228 Gene:

MIR1228
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1228 Gene

Orthologs for MIR1228 Gene

Evolution for MIR1228 Gene

ENSEMBL:
Gene Tree for MIR1228 (if available)
TreeFam:
Gene Tree for MIR1228 (if available)

No data available for Orthologs for MIR1228 Gene

Paralogs for MIR1228 Gene

No data available for Paralogs for MIR1228 Gene

Variants for MIR1228 Gene

Sequence variations from dbSNP and Humsavar for MIR1228 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs112163432 -- 57,192,971(+) CCGAG(C/G)TGAGA upstream-variant-2KB, splice-donor-variant
rs113311142 -- 57,194,300(+) CCCCA(C/G)TCGGG intron-variant, upstream-variant-2KB
rs113379328 -- 57,193,256(+) GCGAC(A/G)GCGTC upstream-variant-2KB, reference, missense
rs113606238 -- 57,192,824(+) CCTGC(A/G)CCCAC intron-variant, upstream-variant-2KB
rs12424288 -- 57,194,872(+) TGAGC(A/C/T)CCCCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR1228 Gene

Variant ID Type Subtype PubMed ID
nsv952189 CNV deletion 24416366
nsv559023 CNV loss 21841781
nsv519293 CNV loss 19592680
nsv482992 CNV gain+loss 15286789
dgv96n21 CNV loss 19592680

Relevant External Links for MIR1228 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1228

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1228 Gene

Disorders for MIR1228 Gene

Relevant External Links for MIR1228

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1228

No disorders were found for MIR1228 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1228 Gene

Publications for MIR1228 Gene

  1. MiR-1228 promotes breast cancer cell growth and metastasis through targeting SCAI protein. (PMID: 26261546) Lin L. … Liu M. (Int J Clin Exp Pathol 2015) 3 64
  2. miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop. (PMID: 25422913) Zhang Y. … Tang H. (Br. J. Cancer 2015) 3 64
  3. Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients. (PMID: 24488924) Hu J. … Wang J. (Int. J. Cancer 2014) 3 64
  4. Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts. (PMID: 23362149) Lisse T.S. … Hewison M. (J. Bone Miner. Res. 2013) 3 64
  5. Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. (PMID: 23554909) Jia L. … Cai J. (PLoS ONE 2013) 3 64

Products for MIR1228 Gene

Sources for MIR1228 Gene

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