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Aliases for MIR1227 Gene

Subcategory (RNA class) for MIR1227 Gene


Quality Score for this RNA gene is


Aliases for MIR1227 Gene

  • MicroRNA 1227 2 3 5
  • Hsa-Mir-1227 3
  • Mir-1227 3
  • MIRN1227 3

External Ids for MIR1227 Gene

Previous HGNC Symbols for MIR1227 Gene

  • MIRN1227

Previous GeneCards Identifiers for MIR1227 Gene

  • GC00U923077
  • GC19M002189

Summaries for MIR1227 Gene

Entrez Gene Summary for MIR1227 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1227 Gene

MIR1227 (MicroRNA 1227) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1227 Gene

Genomics for MIR1227 Gene

Regulatory Elements for MIR1227 Gene

Enhancers for MIR1227 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G002263 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -30.2 -30249 1.8 HDGF FOXA2 CREB3L1 ARNT ARID4B YBX1 ZNF766 CBX5 KLF13 REST SF3A2 MIR1227 TMPRSS9 SPPL2B LOC105372240 MIR4321
GH19G002268 1.7 Ensembl ENCODE dbSUPER 13 -38.1 -38066 7.4 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SF3A2 ZNF77 LOC100288123 ENSG00000267139 ENSG00000267317 LINGO3 MIR1227 RPS15 JSRP1 C19orf35
GH19G002184 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +46.9 46947 5.0 HDGF FEZF1 HIC1 POLR2A EED FOS RELB IKZF2 MAFK NFE2L2 AMH SF3A2 MIR1227 PLEKHJ1 IZUMO4 AP3D1 GC19M002178 LOC105372239
GH19G002255 1.4 Ensembl ENCODE dbSUPER 12.8 -23.9 -23872 6.0 HDGF PKNOX1 FEZF1 ZNF263 JUNB REST TBX21 PRDM4 SP7 CTCF MIR1227 SF3A2 PLEKHJ1 C19orf35 JSRP1 MIR4321 LOC105372240
GH19G002315 1.1 Ensembl ENCODE 12.3 -82.2 -82193 1.6 HDAC1 ELF3 CBX3 ARID4B ZNF48 THRB RAD21 PCBP1 KLF13 MIXL1 LSM7 C19orf35 SF3A2 MIR1227 LINGO3 SPPL2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1227 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1227 Gene

2,234,062 bp from pter
2,234,149 bp from pter
88 bases
Minus strand

Genomic View for MIR1227 Gene

Genes around MIR1227 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1227 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1227 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1227 Gene

ORGUL Member Location for MIR1227 Gene

ORGUL Member Location for MIR1227 gene

Proteins for MIR1227 Gene

Post-translational modifications for MIR1227 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1227 Gene

Domains & Families for MIR1227 Gene

Gene Families for MIR1227 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1227: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1227 Gene

Function for MIR1227 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1227 Gene

Localization for MIR1227 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1227 Gene

Pathways & Interactions for MIR1227 Gene

SuperPathways for MIR1227 Gene

No Data Available

Interacting Proteins for MIR1227 Gene

Gene Ontology (GO) - Biological Process for MIR1227 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR1227 Gene

Drugs & Compounds for MIR1227 Gene

No Compound Related Data Available

Transcripts for MIR1227 Gene

mRNA/cDNA for MIR1227 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1227 Gene

No ASD Table

Relevant External Links for MIR1227 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1227 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1227 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1227 Gene:

genes like me logo Genes that share expression patterns with MIR1227: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1227 Gene

Orthologs for MIR1227 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1227 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-1227 35
  • 99 (a)
Species where no ortholog for MIR1227 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1227 Gene

Gene Tree for MIR1227 (if available)
Gene Tree for MIR1227 (if available)

Paralogs for MIR1227 Gene

No data available for Paralogs for MIR1227 Gene

Variants for MIR1227 Gene

Sequence variations from dbSNP and Humsavar for MIR1227 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001289804 -- 2,236,120(+) CCGCC(C/G)CTGGC intron-variant, upstream-variant-2KB
rs1002710351 -- 2,235,525(+) GGAAC(A/G)AAGAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002961560 -- 2,235,140(+) ACAAG(C/T)CAAGG intron-variant, upstream-variant-2KB
rs1004342826 -- 2,234,760(+) TTTGG(C/G)AGGCC intron-variant, upstream-variant-2KB
rs1007199736 -- 2,235,426(+) CCATA(C/T)AACAA intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1227 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
nsv2389 CNV insertion 18451855
nsv578382 CNV loss 21841781
nsv578383 CNV loss 21841781
nsv833706 CNV loss 17160897
nsv833707 CNV loss 17160897
nsv953943 CNV deletion 24416366

Relevant External Links for MIR1227 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1227 Gene

Disorders for MIR1227 Gene

Relevant External Links for MIR1227

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR1227 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1227 Gene

Publications for MIR1227 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Mammalian mirtron genes. (PMID: 17964270) Berezikov E. … Lai E.C. (Mol. Cell 2007) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1227 Gene

Sources for MIR1227 Gene

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