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Aliases for MIR1224 Gene

Subcategory (RNA class) for MIR1224 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1224 Gene

  • MicroRNA 1224 2 3 5
  • Hsa-Mir-1224 3
  • Mir-1224 3
  • MIRN1224 3

External Ids for MIR1224 Gene

Previous HGNC Symbols for MIR1224 Gene

  • MIRN1224

Previous GeneCards Identifiers for MIR1224 Gene

  • GC03U901145
  • GC03P185443
  • GC03P183959

Summaries for MIR1224 Gene

Entrez Gene Summary for MIR1224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1224 Gene

MIR1224 (MicroRNA 1224) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

Additional gene information for MIR1224 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1224 Gene

Genomics for MIR1224 Gene

Regulatory Elements for MIR1224 Gene

Enhancers for MIR1224 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H184171 1.6 Ensembl ENCODE dbSUPER 10.4 -66.2 -66244 8 HDGF ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS SP3 SP5 VWA5B2 ABCF3 EIF2B5 DVL3 ALG3 ECE2 EEF1AKMT4-ECE2 EEF1AKMT4 MIR1224 CAMK2N2
GH03H184184 1.4 ENCODE dbSUPER 10.7 -55.3 -55308 3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766 ZNF143 VWA5B2 POLR2H ABCF3 EIF2B5 ECE2 EEF1AKMT4 EEF1AKMT4-ECE2 ALG3 MIR1224 CAMK2N2
GH03H184154 1.3 ENCODE dbSUPER 10.4 -85.0 -85009 4 HDGF ARID4B SIN3A DMAP1 ZNF121 SLC30A9 GLIS2 ELK1 ZNF143 KLF7 EIF2B5 EEF1AKMT4-ECE2 EEF1AKMT4 ECE2 ALG3 ABCF3 CAMK2N2 PSMD2 VWA5B2 MIR1224
GH03H184160 1.1 Ensembl ENCODE dbSUPER 10.4 -80.5 -80548 1 FOXA2 JUNB BATF EED GLIS1 ZBTB33 FOS RUNX3 IKZF2 EIF2B5 ABCF3 CAMK2N2 ALG3 EEF1AKMT4-ECE2 EEF1AKMT4 ECE2 VWA5B2 MIR1224 EIF4G1
GH03H184347 1.1 ENCODE dbSUPER 9.5 +106.8 106787 1 HDGF TBP TAL1 JUN BACH1 FOSL1 TCF12 ZNF316 CTBP1 POLR2A VWA5B2 SNORD66 EIF4G1 ALG3 CAMK2N2 EIF2B5 MIR1224 ABCF3 GC03P184344 PIR35526
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1224 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1224 Gene

Chromosome:
3
Start:
184,241,405 bp from pter
End:
184,241,489 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR1224 Gene

Genes around MIR1224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1224 Gene

Proteins for MIR1224 Gene

Post-translational modifications for MIR1224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1224 Gene

Domains & Families for MIR1224 Gene

Gene Families for MIR1224 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1224 Gene

Function for MIR1224 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR1224
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1224 Gene

Localization for MIR1224 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1224 Gene

Pathways & Interactions for MIR1224 Gene

SuperPathways for MIR1224 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR1224: view

Pathways by source for MIR1224 Gene

1 BioSystems pathway for MIR1224 Gene

Interacting Proteins for MIR1224 Gene

Gene Ontology (GO) - Biological Process for MIR1224 Gene

None

No data available for SIGNOR curated interactions for MIR1224 Gene

Drugs & Compounds for MIR1224 Gene

No Compound Related Data Available

Transcripts for MIR1224 Gene

mRNA/cDNA for MIR1224 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR1224
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1224 Gene

No ASD Table

Relevant External Links for MIR1224 Gene

GeneLoc Exon Structure for
MIR1224
ECgene alternative splicing isoforms for
MIR1224

Expression for MIR1224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1224 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1224 Gene:

MIR1224
genes like me logo Genes that share expression patterns with MIR1224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1224 Gene

Orthologs for MIR1224 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR1224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1224 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1224 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir1224 34
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
OneToOne
Species where no ortholog for MIR1224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1224 Gene

ENSEMBL:
Gene Tree for MIR1224 (if available)
TreeFam:
Gene Tree for MIR1224 (if available)

Paralogs for MIR1224 Gene

No data available for Paralogs for MIR1224 Gene

Variants for MIR1224 Gene

Sequence variations from dbSNP and Humsavar for MIR1224 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1001347533 -- 184,240,050(+) CTCAT(A/G)GGTCC intron-variant, upstream-variant-2KB
rs1001777404 -- 184,239,869(+) GGGTG(G/T)TGGGC upstream-variant-2KB, reference, missense
rs1002741465 -- 184,239,544(+) GTCCT(A/G)AGCCA upstream-variant-2KB, reference, missense
rs1003424367 -- 184,241,504(+) CAGGA(A/G)GCACC downstream-variant-500B, reference, synonymous-codon
rs1005769492 -- 184,241,177(+) TGATC(C/G)CCACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1224 Gene

Variant ID Type Subtype PubMed ID
nsv528639 CNV loss 19592680
nsv592666 CNV loss 21841781
nsv829812 CNV loss 17160897

Relevant External Links for MIR1224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1224 Gene

Disorders for MIR1224 Gene

Relevant External Links for MIR1224

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1224

No disorders were found for MIR1224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1224 Gene

Publications for MIR1224 Gene

  1. MiR-1224-5p acts as a tumor suppressor by targeting CREB1 in malignant gliomas. (PMID: 25648114) Qian J … You YP (Molecular and cellular biochemistry 2015) 3 60
  2. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium … Sullivan PF (Molecular psychiatry 2013) 3 60
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  4. Mammalian mirtron genes. (PMID: 17964270) Berezikov E … Lai EC (Molecular cell 2007) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR1224 Gene

Sources for MIR1224 Gene

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