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Aliases for MIR122 Gene

Subcategory (RNA class) for MIR122 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR122 Gene

  • MicroRNA 122 2 3 5
  • MicroRNA 122a 2 3
  • Hsa-Mir-122a 3
  • Hsa-Mir-122 3
  • MiRNA122A 3
  • MiRNA122 3
  • MIRN122A 3
  • MIR122A 3
  • Mir-122 3
  • MIRN122 3

External Ids for MIR122 Gene

Previous HGNC Symbols for MIR122 Gene

  • MIRN122A
  • MIRN122

Previous GeneCards Identifiers for MIR122 Gene

  • GC18P054273
  • GC18P056118

Summaries for MIR122 Gene

Entrez Gene Summary for MIR122 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR122 Gene

MIR122 (MicroRNA 122) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR122 include Lipid Metabolism Disorder. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR122 Gene

Genomics for MIR122 Gene

Regulatory Elements for MIR122 Gene

Enhancers for MIR122 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR122 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR122 Gene

Chromosome:
18
Start:
58,446,275 bp from pter
End:
58,453,766 bp from pter
Size:
7,492 bases
Orientation:
Plus strand

Genomic View for MIR122 Gene

Genes around MIR122 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR122 Gene

Proteins for MIR122 Gene

Post-translational modifications for MIR122 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR122 Gene

Domains & Families for MIR122 Gene

Gene Families for MIR122 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR122: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR122 Gene

Function for MIR122 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR122 Gene

Localization for MIR122 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR122 Gene

Pathways & Interactions for MIR122 Gene

SuperPathways for MIR122 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR122: view

Pathways by source for MIR122 Gene

1 KEGG pathway for MIR122 Gene

Interacting Proteins for MIR122 Gene

Gene Ontology (GO) - Biological Process for MIR122 Gene

None

No data available for SIGNOR curated interactions for MIR122 Gene

Drugs & Compounds for MIR122 Gene

No Compound Related Data Available

Transcripts for MIR122 Gene

mRNA/cDNA for MIR122 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR122 Gene

No ASD Table

Relevant External Links for MIR122 Gene

GeneLoc Exon Structure for
MIR122
ECgene alternative splicing isoforms for
MIR122

Expression for MIR122 Gene

mRNA expression in normal human tissues for MIR122 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR122 Gene:

MIR122
genes like me logo Genes that share expression patterns with MIR122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR122 Gene

Orthologs for MIR122 Gene

Evolution for MIR122 Gene

ENSEMBL:
Gene Tree for MIR122 (if available)
TreeFam:
Gene Tree for MIR122 (if available)

No data available for Orthologs for MIR122 Gene

Paralogs for MIR122 Gene

No data available for Paralogs for MIR122 Gene

Variants for MIR122 Gene

Sequence variations from dbSNP and Humsavar for MIR122 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1135519 -- 58,449,913(+) GATAA(C/T)GAATC upstream-variant-2KB
rs3760546 -- 58,449,820(+) TGGCA(C/T)GGCCT upstream-variant-2KB
rs3834611 -- 58,449,939(+) GAAAG(-/A)AAAAA upstream-variant-2KB
rs71173053 -- 58,450,080(+) TTTTT(-/T)CTGAA upstream-variant-2KB
rs76821324 -- 58,450,494(+) AGATT(A/G)AACAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR122 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Relevant External Links for MIR122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR122

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR122 Gene

Disorders for MIR122 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR122 Gene - From: GeneCards

Disorder Aliases PubMed IDs
lipid metabolism disorder
  • dyslipidemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR122

Human Genome Epidemiology (HuGE) Navigator
MIR122
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR122
genes like me logo Genes that share disorders with MIR122: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR122 Gene

Publications for MIR122 Gene

  1. MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways. (PMID: 26655273) Xu Y. … Qian C. (Cancer Lett. 2016) 3 65
  2. Differential TGFI^ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. (PMID: 26987776) Yin S. … Xi J.J. (Nat Commun 2016) 3 65
  3. Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4I+ miR122 Pathway. (PMID: 27011261) Wei S. … Hatch G.M. (PLoS ONE 2016) 3 65
  4. Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. (PMID: 27077736) Salvoza N.C. … Baclig M.O. (PLoS ONE 2016) 3 65
  5. [Evaluation of miR-122 level in the plasma of chronically HCV infected patients]. (PMID: 27239848) Gholami M. … Moallemi S. (Mol. Biol. (Mosk.) 2016) 3 65

Products for MIR122 Gene

Sources for MIR122 Gene

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