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Aliases for MIR122 Gene

Subcategory (RNA class) for MIR122 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR122 Gene

  • MicroRNA 122 2 3
  • MicroRNA 122a 2 3
  • MIRN122A 3 6
  • MIR122A 3 6
  • Hsa-Mir-122a 3
  • Hsa-Mir-122 3
  • MiRNA122A 3
  • MiRNA122 3
  • MIRN122 3

External Ids for MIR122 Gene

ORGUL Members for MIR122 Gene

Previous HGNC Symbols for MIR122 Gene

  • MIRN122A
  • MIRN122

Previous GeneCards Identifiers for MIR122 Gene

  • GC18P054273
  • GC18P056118

Summaries for MIR122 Gene

Entrez Gene Summary for MIR122 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR122 Gene

MIR122 (MicroRNA 122) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR122 include borna disease and adenomatous polyposis coli. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR122 Gene

Genomics for MIR122 Gene

Genomic Location for MIR122 Gene

Start:
58,451,068 bp from pter
End:
58,451,176 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR122 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR122 Gene

No data available for Regulatory Elements for MIR122 Gene

Proteins for MIR122 Gene

Post-translational modifications for MIR122 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR122 Gene

Domains for MIR122 Gene

Gene Families for MIR122 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR122: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR122 Gene

Function for MIR122 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR122 Gene

Localization for MIR122 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR122 Gene

Pathways for MIR122 Gene

SuperPathways for MIR122 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR122: view

Pathways by source for MIR122 Gene

1 KEGG pathway for MIR122 Gene

Interacting Proteins for MIR122 Gene

Gene Ontology (GO) - Biological Process for MIR122 Gene

None

Transcripts for MIR122 Gene

mRNA/cDNA for MIR122 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR122 Gene

No ASD Table

Relevant External Links for MIR122 Gene

GeneLoc Exon Structure for
MIR122
ECgene alternative splicing isoforms for
MIR122

Expression for MIR122 Gene

mRNA expression in normal human tissues for MIR122 Gene

genes like me logo Genes that share expressions with MIR122: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR122 Gene

Orthologs for MIR122 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR122 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-122 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-122 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-122 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir122a 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-122 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-122 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-122-1 36
  • 96 (a)
OneToMany
gga-mir-122-2 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-122 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-122 36
  • 84 (a)
OneToOne
Species with no ortholog for MIR122:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR122 Gene

ENSEMBL:
Gene Tree for MIR122 (if available)
TreeFam:
Gene Tree for MIR122 (if available)

Paralogs for MIR122 Gene

No data available for Paralogs for MIR122 Gene

Variants for MIR122 Gene

Sequence variations from dbSNP and Humsavar for MIR122 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1135519 -- 58,449,913(+) GATAA(C/T)GAATC upstream-variant-2KB
rs3760546 -- 58,449,820(+) TGGCA(C/T)GGCCT upstream-variant-2KB
rs3834611 -- 58,449,939(+) GAAAG(-/A)AAAAA upstream-variant-2KB
rs7229759 -- 58,450,220(+) CTTTT(C/T)AGCAT upstream-variant-2KB
rs9966765 -- 58,449,558(+) GGTGG(C/G)GATTT upstream-variant-2KB

Relevant External Links for MIR122 Gene

HapMap Linkage Disequilibrium report
MIR122

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR122 Gene

Disorders for MIR122 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MIR122 Gene including...

Search for MIR122 Gene in MalaCards »

Relevant External Links for MIR122

Human Genome Epidemiology (HuGE) Navigator
MIR122
genes like me logo Genes that share disorders with MIR122: view

No data available for UniProtKB/Swiss-Prot for MIR122 Gene

Publications for MIR122 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 3
  2. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H. … Zheng X. (FEBS Lett. 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. (PMID: 16924677) Kutay H. … Ghoshal K. (J. Cell. Biochem. 2006) 3
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3

Products for MIR122 Gene

Sources for MIR122 Gene

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