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Aliases for MIR122 Gene

Subcategory (RNA class) for MIR122 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR122 Gene

  • MicroRNA 122 2 3 5
  • MicroRNA 122a 2 3
  • Hsa-Mir-122a 3
  • Hsa-Mir-122 3
  • MiRNA122A 3
  • MiRNA122 3
  • MIRN122A 3
  • MIR122A 3
  • Mir-122 3
  • MIRN122 3

External Ids for MIR122 Gene

Previous HGNC Symbols for MIR122 Gene

  • MIRN122A
  • MIRN122

Previous GeneCards Identifiers for MIR122 Gene

  • GC18P054273
  • GC18P056118

Summaries for MIR122 Gene

Entrez Gene Summary for MIR122 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR122 Gene

MIR122 (MicroRNA 122) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR122 Gene

Genomics for MIR122 Gene

Regulatory Elements for MIR122 Gene

Enhancers for MIR122 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F058415 1.1 Ensembl ENCODE 11.2 -29.3 -29344 2.0 THRB ZNF48 DNMT3B RAD21 RARA YY1 CREM PAF1 PPARG NR2F2 MIR122 MIR3591 ENSG00000267675 GC18P058443
GH18F058396 0.2 ENCODE 11.1 -49.0 -48998 0.6 PAF1 SCRT1 SAP130 SCRT2 DNMT3B MIR122 MIR3591 GC18P058402 ENSG00000267504
GH18F058400 0.2 ENCODE 11.1 -45.5 -45505 1.4 CTCF ZNF792 JUN THRB RAD21 RARA ZNF157 POLR2A SMC3 NR2F6 MIR122 MIR3591 ENSG00000267396 ENSG00000267675
GH18F058389 0.5 ENCODE 11 -54.8 -54837 4.5 PAF1 ZNF121 CTCF PKNOX1 L3MBTL2 MNT MIR122 MIR3591 ENSG00000267504 GC18P058402
GH18F058485 0.9 Ensembl ENCODE 10.9 +39.3 39314 1.1 SOX13 GATAD2A CTCF DRAP1 MBD1 RAD21 MIR3591 MIR122 ENSG00000252284 FECH ENSG00000276403 ENSG00000274354
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR122 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR122 Gene

Chromosome:
18
Start:
58,446,275 bp from pter
End:
58,453,766 bp from pter
Size:
7,492 bases
Orientation:
Plus strand

Genomic View for MIR122 Gene

Genes around MIR122 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR122 Gene

Proteins for MIR122 Gene

Post-translational modifications for MIR122 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR122 Gene

Domains & Families for MIR122 Gene

Gene Families for MIR122 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR122: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR122 Gene

Function for MIR122 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR122 Gene

Localization for MIR122 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR122 Gene

Pathways & Interactions for MIR122 Gene

SuperPathways for MIR122 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR122: view

Pathways by source for MIR122 Gene

1 KEGG pathway for MIR122 Gene

Interacting Proteins for MIR122 Gene

Gene Ontology (GO) - Biological Process for MIR122 Gene

None

No data available for SIGNOR curated interactions for MIR122 Gene

Transcripts for MIR122 Gene

mRNA/cDNA for MIR122 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR122 Gene

No ASD Table

Relevant External Links for MIR122 Gene

GeneLoc Exon Structure for
MIR122
ECgene alternative splicing isoforms for
MIR122

Expression for MIR122 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR122 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR122 Gene:

MIR122
genes like me logo Genes that share expression patterns with MIR122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR122 Gene

Orthologs for MIR122 Gene

Evolution for MIR122 Gene

ENSEMBL:
Gene Tree for MIR122 (if available)
TreeFam:
Gene Tree for MIR122 (if available)

No data available for Orthologs for MIR122 Gene

Paralogs for MIR122 Gene

No data available for Paralogs for MIR122 Gene

Variants for MIR122 Gene

Sequence variations from dbSNP and Humsavar for MIR122 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10605417 -- 58,450,082(+) TTTTT(-/TTT)CTGAA nc-transcript-variant, upstream-variant-2KB
rs111237676 -- 58,450,353(+) TTATT(C/T)GGAGC downstream-variant-500B, upstream-variant-2KB
rs111316406 -- 58,451,046(+) GGTGA(A/T)GTTAA downstream-variant-500B, upstream-variant-2KB
rs111436359 -- 58,451,011(+) TTCCC(C/T)TATTA downstream-variant-500B, upstream-variant-2KB
rs111673925 -- 58,451,565(+) GAGGT(G/T)GGAGG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR122 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Relevant External Links for MIR122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR122

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR122 Gene

Disorders for MIR122 Gene

Relevant External Links for MIR122

Human Genome Epidemiology (HuGE) Navigator
MIR122
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR122

No disorders were found for MIR122 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR122 Gene

Publications for MIR122 Gene

  1. Micro RNAs mir-106a, mir-122 and mir-197 are increased in severe acute viral hepatitis with coagulopathy. (PMID: 26352910) Weseslindtner L. … Odenthal M. (Liver Int. 2016) 3 64
  2. Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease. (PMID: 26752469) BAcres N.J. … Veres G. (Inflamm. Bowel Dis. 2016) 3 64
  3. Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. (PMID: 27077736) Salvoza N.C. … Baclig M.O. (PLoS ONE 2016) 3 64
  4. [Evaluation of miR-122 level in the plasma of chronically HCV infected patients]. (PMID: 27239848) Gholami M. … Moallemi S. (Mol. Biol. (Mosk.) 2016) 3 64
  5. Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4I+ miR122 Pathway. (PMID: 27011261) Wei S. … Hatch G.M. (PLoS ONE 2016) 3 64

Products for MIR122 Gene

Sources for MIR122 Gene

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