Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR1181 Gene

Subcategory (RNA class) for MIR1181 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1181 Gene

  • MicroRNA 1181 2 3
  • Hsp90 Chaperone Protein Kinase-Targeting Subunit 4
  • Cell Division Cycle 37 5
  • Hsa-Mir-1181 3
  • P50CDC37 4
  • MIRN1181 3
  • CDC37A 4
  • CDC37 5

External Ids for MIR1181 Gene

Previous HGNC Symbols for MIR1181 Gene

  • MIRN1181

Previous GeneCards Identifiers for MIR1181 Gene

  • GC00U923040
  • GC19M010514

Summaries for MIR1181 Gene

Entrez Gene Summary for MIR1181 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1181 Gene

MIR1181 (MicroRNA 1181) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are HIV Life Cycle and Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants. An important paralog of this gene is CDC37L1.

UniProtKB/Swiss-Prot for MIR1181 Gene

  • Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1181 Gene

Genomics for MIR1181 Gene

Regulatory Elements for MIR1181 Gene

Enhancers for MIR1181 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010100 1.5 FANTOM5 ENCODE 27 +315.7 315734 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F011343 1.2 ENCODE 22.6 -925.6 -925626 5.0 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF548 FOS ZNF136 ZNF627 ZNF844 ZNF44 MIR1181 TIMM29 ZNF700 ZNF625 ZNF763 ZNF878
GH19F011317 1.4 Ensembl ENCODE 18.6 -901.6 -901562 9.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF627 ZNF136 ZNF844 ZNF625 ENSG00000267174 ZNF44 ZNF441 ZNF491 ZNF700 ZNF763
GH19F011293 1.7 FANTOM5 Ensembl ENCODE 14.5 -873.8 -873791 1.4 HDGF ATF1 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 ZNF143 ZNF548 ENSG00000267174 ZNF136 MIR1181 ZNF700 RAVER1 ZNF844 ZNF627 ELOF1 PLPPR2 EPOR
GH19F010379 1.1 ENCODE 18.5 +39.6 39595 1.9 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXL12 ZNF561 LOC100419831 RAVER1 TIMM29 ZNF426 YIPF2 ZNF121 ZNF562 EIF3G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1181 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417846 -479 1201 HDGF PKNOX1 ARNT CREB3L1 SIN3A ZNF2 ZNF207 ZNF263 SP3 REST
ENSR00001815978 721 401 YBX3 KLF17 ZEB1 ZNF23 GLIS2 ZNF207 KLF7 CREM MIER1 OVOL3

Genomic Location for MIR1181 Gene

Chromosome:
19
Start:
10,391,134 bp from pter
End:
10,420,121 bp from pter
Size:
28,988 bases
Orientation:
Minus strand

Genomic View for MIR1181 Gene

Genes around MIR1181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1181 Gene

Proteins for MIR1181 Gene

  • Protein details for MIR1181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16543-CDC37_HUMAN
    Recommended name:
    Hsp90 co-chaperone Cdc37
    Protein Accession:
    Q16543
    Secondary Accessions:
    • Q53YA2

    Protein attributes for MIR1181 Gene

    Size:
    378 amino acids
    Molecular mass:
    44468 Da
    Quaternary structure:
    • Interacts with HSP90AA1 (PubMed:23569206, PubMed:27353360,). Forms a complex with Hsp90/HSP90AB1 and CDK6 (PubMed:9482106). Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1 (PubMed:11036079, PubMed:11085988, PubMed:9150368, PubMed:9482106). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).
    • Interacts with HSP90AA1 (PubMed:23569206, PubMed:27353360,). Forms a complex with Hsp90/HSP90AB1 and CDK6 (PubMed:9482106). Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1 (PubMed:11036079, PubMed:11085988, PubMed:9150368, PubMed:9482106). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for MIR1181 Gene

neXtProt entry for MIR1181 Gene

Post-translational modifications for MIR1181 Gene

Other Protein References for MIR1181 Gene

No data available for DME Specific Peptides for MIR1181 Gene

Domains & Families for MIR1181 Gene

Gene Families for MIR1181 Gene

Protein Domains for MIR1181 Gene

Graphical View of Domain Structure for InterPro Entry

Q16543

UniProtKB/Swiss-Prot:

CDC37_HUMAN :
  • Belongs to the CDC37 family.
Family:
  • Belongs to the CDC37 family.
genes like me logo Genes that share domains with MIR1181: view

No data available for Suggested Antigen Peptide Sequences for MIR1181 Gene

Function for MIR1181 Gene

Molecular function for MIR1181 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

Gene Ontology (GO) - Molecular Function for MIR1181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity EXP --
GO:0005515 protein binding IPI --
GO:0019887 protein kinase regulator activity IEA --
GO:0019900 kinase binding IPI --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with MIR1181: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1181 Gene

Localization for MIR1181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1181 Gene

Gene Ontology (GO) - Cellular Components for MIR1181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA --
GO:1990565 HSP90-CDC37 chaperone complex IEA --
genes like me logo Genes that share ontologies with MIR1181: view

No data available for Subcellular locations from COMPARTMENTS for MIR1181 Gene

Pathways & Interactions for MIR1181 Gene

genes like me logo Genes that share pathways with MIR1181: view

Gene Ontology (GO) - Biological Process for MIR1181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0006605 protein targeting TAS --
GO:0010608 posttranscriptional regulation of gene expression IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0038128 ERBB2 signaling pathway TAS --
genes like me logo Genes that share ontologies with MIR1181: view

No data available for SIGNOR curated interactions for MIR1181 Gene

Transcripts for MIR1181 Gene

mRNA/cDNA for MIR1181 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1181 Gene

No ASD Table

Relevant External Links for MIR1181 Gene

GeneLoc Exon Structure for
MIR1181
ECgene alternative splicing isoforms for
MIR1181

Expression for MIR1181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1181 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1181 Gene:

MIR1181
genes like me logo Genes that share expression patterns with MIR1181: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1181 Gene

Orthologs for MIR1181 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1181 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC37 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC37 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc37 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC37 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC37 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC37 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC37 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01043370.1 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdc37 35
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-37 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for MIR1181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1181 Gene

ENSEMBL:
Gene Tree for MIR1181 (if available)
TreeFam:
Gene Tree for MIR1181 (if available)

Paralogs for MIR1181 Gene

Paralogs for MIR1181 Gene

Pseudogenes.org Pseudogenes for MIR1181 Gene

genes like me logo Genes that share paralogs with MIR1181: view

Variants for MIR1181 Gene

Sequence variations from dbSNP and Humsavar for MIR1181 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs112201078 -- 10,403,178(+) AGGGA(C/G)TGGGG intron-variant, downstream-variant-500B
rs112814888 -- 10,403,111(+) CTAGG(A/G)GACTC intron-variant, downstream-variant-500B
rs113284665 -- 10,403,376(+) GCCTT(A/G/T)CCTGA downstream-variant-500B, splice-donor-variant
rs113524861 -- 10,404,577(+) AGGGT(A/G)CTCCC upstream-variant-2KB
rs145262055 -- 10,404,542(+) TGTTG(C/T)AGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1181 Gene

Variant ID Type Subtype PubMed ID
nsv518008 CNV gain 19592680

Relevant External Links for MIR1181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1181

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1181 Gene

Disorders for MIR1181 Gene

Relevant External Links for MIR1181

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1181

No disorders were found for MIR1181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1181 Gene

Publications for MIR1181 Gene

  1. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford M.R. … Mollapour M. (Nat. Commun. 2016) 4 64
  2. MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer. (PMID: 25444909) Jiang J. … Sun C. (Cancer Lett. 2015) 3 64
  3. Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer. (PMID: 26151663) Zhang H.Y. … Wang S.R. (Oncol. Rep. 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MIR1181 Gene

Sources for MIR1181 Gene

Content
Loading form....