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Aliases for MIR1178 Gene

Subcategory (RNA class) for MIR1178 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1178 Gene

  • MicroRNA 1178 2 3
  • CIT 4 5
  • Citron Rho-Interacting Serine/Threonine Kinase 5
  • Serine/Threonine-Protein Kinase 21 4
  • Hsa-Mir-1178 3
  • EC 2.7.11.1 4
  • EC 2.7.11 61
  • KIAA0949 4
  • MIRN1178 3
  • STK21 4
  • CRIK 4

External Ids for MIR1178 Gene

Previous HGNC Symbols for MIR1178 Gene

  • MIRN1178

Previous GeneCards Identifiers for MIR1178 Gene

  • GC00U922977
  • GC12M118636
  • GC12M120151

Summaries for MIR1178 Gene

Entrez Gene Summary for MIR1178 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1178 Gene

MIR1178 (MicroRNA 1178) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Semaphorin interactions and Signaling by GPCR. An important paralog of this gene is CDC42BPB.

UniProtKB/Swiss-Prot for MIR1178 Gene

  • Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1178 Gene

Genomics for MIR1178 Gene

Regulatory Elements for MIR1178 Gene

Enhancers for MIR1178 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F119715 1.2 FANTOM5 Ensembl ENCODE 12.4 +160.9 160857 2.0 ELF3 MLX ARID4B SIN3A THRB RAD21 RARA YY1 SCRT2 RCOR1 CIT MIR1178 TMEM233 PRKAB1 GC12P119728 ENSG00000255692
GH12F119678 1 Ensembl ENCODE 12.1 +193.9 193861 9.7 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PRKAB1 CIT MIR1178 LOC105370027 TMEM233 ENSG00000255692
GH12F119876 0.2 ENCODE 0.8 +0.1 117 1.9 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLIS2 ZNF143 KLF7 FOS GCN1 CIT MIR1178 GC12P119728
GH12F119868 0.9 Ensembl ENCODE 0.4 +7.6 7610 2.6 ELK4 CTCF KLF1 ZNF362 ZNF384 ZNF664 ZNF121 SMARCA4 POLR2A FOS MIR1178 GC12P119728
GH12F119802 0.9 ENCODE 0.2 +74.6 74640 0.2 SCRT1 ZNF263 CTCF GATA3 SCRT2 NR2F6 NR2F2 RARA GC12P119728 MIR1178
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR1178 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1178 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091362 91 1600 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLIS2 ZNF143 KLF7 FOS

Genomic Location for MIR1178 Gene

Chromosome:
12
Start:
119,685,790 bp from pter
End:
119,877,291 bp from pter
Size:
191,502 bases
Orientation:
Minus strand

Genomic View for MIR1178 Gene

Genes around MIR1178 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1178 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1178 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1178 Gene

Proteins for MIR1178 Gene

  • Protein details for MIR1178 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14578-CTRO_HUMAN
    Recommended name:
    Citron Rho-interacting kinase
    Protein Accession:
    O14578
    Secondary Accessions:
    • Q2M5E1
    • Q6XUH8
    • Q86UQ9
    • Q9UPZ7

    Protein attributes for MIR1178 Gene

    Size:
    2027 amino acids
    Molecular mass:
    231431 Da
    Quaternary structure:
    • Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
    • Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
    SequenceCaution:
    • Sequence=BAA76793.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR1178 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1178 Gene

Selected DME Specific Peptides for MIR1178 Gene

Post-translational modifications for MIR1178 Gene

  • Ubiquitination at Lys 350 and Lys 518
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR1178 Gene

Domains & Families for MIR1178 Gene

Gene Families for MIR1178 Gene

Graphical View of Domain Structure for InterPro Entry

O14578

UniProtKB/Swiss-Prot:

CTRO_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with MIR1178: view

No data available for Suggested Antigen Peptide Sequences for MIR1178 Gene

Function for MIR1178 Gene

Molecular function for MIR1178 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Enzyme Numbers (IUBMB) for MIR1178 Gene

Gene Ontology (GO) - Molecular Function for MIR1178 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MIR1178: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1178 Gene

Localization for MIR1178 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1178 Gene

Gene Ontology (GO) - Cellular Components for MIR1178 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA --
genes like me logo Genes that share ontologies with MIR1178: view

No data available for Subcellular locations from COMPARTMENTS for MIR1178 Gene

Pathways & Interactions for MIR1178 Gene

genes like me logo Genes that share pathways with MIR1178: view

Pathways by source for MIR1178 Gene

1 BioSystems pathway for MIR1178 Gene

Gene Ontology (GO) - Biological Process for MIR1178 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP --
GO:0006468 protein phosphorylation IEA --
GO:0007030 Golgi organization IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division ISS --
genes like me logo Genes that share ontologies with MIR1178: view

No data available for SIGNOR curated interactions for MIR1178 Gene

Transcripts for MIR1178 Gene

mRNA/cDNA for MIR1178 Gene

(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1178 Gene

No ASD Table

Relevant External Links for MIR1178 Gene

GeneLoc Exon Structure for
MIR1178
ECgene alternative splicing isoforms for
MIR1178

Expression for MIR1178 Gene

mRNA expression in normal human tissues for MIR1178 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1178 Gene:

MIR1178
genes like me logo Genes that share expression patterns with MIR1178: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1178 Gene

Orthologs for MIR1178 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1178 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CIT 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CIT 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cit 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CIT 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CIT 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CIT 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CIT 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CIT 35
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CIT (2 of 2) 35
  • 72 (a)
OneToMany
CIT (1 of 2) 35
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sti 35
  • 27 (a)
OneToOne
Species where no ortholog for MIR1178 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR1178 Gene

ENSEMBL:
Gene Tree for MIR1178 (if available)
TreeFam:
Gene Tree for MIR1178 (if available)

Paralogs for MIR1178 Gene

Paralogs for MIR1178 Gene

genes like me logo Genes that share paralogs with MIR1178: view

Variants for MIR1178 Gene

Sequence variations from dbSNP and Humsavar for MIR1178 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs112014286 -- 119,714,637(+) ACACC(A/G)CTTCA intron-variant, upstream-variant-2KB
rs113612648 -- 119,713,398(+) CTTCC(C/T)TAGAA intron-variant, downstream-variant-500B
rs114250758 -- 119,714,102(+) CACTA(C/T)ATGAT intron-variant, upstream-variant-2KB
rs114508496 -- 119,713,347(+) CATCC(A/G)GCTGG intron-variant, downstream-variant-500B
rs114588037 -- 119,715,543(+) AATGG(C/T)GGGGG intron-variant, upstream-variant-2KB

Relevant External Links for MIR1178 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1178

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR1178 Gene

Disorders for MIR1178 Gene

Relevant External Links for MIR1178

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1178

No disorders were found for MIR1178 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1178 Gene

Publications for MIR1178 Gene

  1. MiR-1178 promotes the proliferation, G1/S transition, migration and invasion of pancreatic cancer cells by targeting CHIP. (PMID: 25635996) Cao Z. … Zhao Y. (PLoS ONE 2015) 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64

Products for MIR1178 Gene

Sources for MIR1178 Gene

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