Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR10B Gene

Subcategory (RNA class) for MIR10B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR10B Gene

  • MicroRNA 10b 2 3 5
  • Hsa-Mir-10b 3
  • MiRNA10B 3
  • Mir-10b 3
  • MIRN10B 3

External Ids for MIR10B Gene

ORGUL Members for MIR10B Gene

Previous HGNC Symbols for MIR10B Gene

  • MIRN10B

Previous GeneCards Identifiers for MIR10B Gene

  • GC02P176725
  • GC02P177015

Summaries for MIR10B Gene

Entrez Gene Summary for MIR10B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10B Gene

MIR10B (MicroRNA 10b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR10B Gene

Genomics for MIR10B Gene

Genomic Location for MIR10B Gene

Chromosome:
2
Start:
176,150,303 bp from pter
End:
176,150,412 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR10B Gene

Genes around MIR10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10B Gene

No data available for Regulatory Elements for MIR10B Gene

Proteins for MIR10B Gene

Post-translational modifications for MIR10B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10B Gene

Domains & Families for MIR10B Gene

Gene Families for MIR10B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR10B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR10B Gene

Function for MIR10B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10B Gene

Localization for MIR10B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR10B Gene

Pathways & Interactions for MIR10B Gene

genes like me logo Genes that share pathways with MIR10B: view

Pathways by source for MIR10B Gene

2 KEGG pathways for MIR10B Gene

Interacting Proteins for MIR10B Gene

Gene Ontology (GO) - Biological Process for MIR10B Gene

None

No data available for SIGNOR curated interactions for MIR10B Gene

Drugs & Compounds for MIR10B Gene

No Compound Related Data Available

Transcripts for MIR10B Gene

mRNA/cDNA for MIR10B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10B Gene

No ASD Table

Relevant External Links for MIR10B Gene

GeneLoc Exon Structure for
MIR10B
ECgene alternative splicing isoforms for
MIR10B

Expression for MIR10B Gene

mRNA expression in normal human tissues for MIR10B Gene

genes like me logo Genes that share expression patterns with MIR10B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR10B Gene

Orthologs for MIR10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-10b 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-10b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-10b 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir10b 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-10b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-10b 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-10b 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-10b 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-10b-1 36
  • 87 (a)
OneToMany
dre-mir-10b-2 36
  • 72 (a)
OneToMany
dre-mir-10c 36
  • 71 (a)
OneToMany
Species with no ortholog for MIR10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR10B Gene

ENSEMBL:
Gene Tree for MIR10B (if available)
TreeFam:
Gene Tree for MIR10B (if available)

Paralogs for MIR10B Gene

No data available for Paralogs for MIR10B Gene

Variants for MIR10B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR10B Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875438 CNV Loss 21882294
nsv875446 CNV Loss 21882294

Relevant External Links for MIR10B Gene

HapMap Linkage Disequilibrium report
MIR10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR10B Gene

Disorders for MIR10B Gene

Relevant External Links for MIR10B

Genetic Association Database (GAD)
MIR10B
Human Genome Epidemiology (HuGE) Navigator
MIR10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR10B

No disorders were found for MIR10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR10B Gene

Publications for MIR10B Gene

  1. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. (PMID: 17898713) Ma L. … Weinberg R.A. (Nature 2007) 3 23 67
  2. DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. (PMID: 24481854) Li Z. … Yu J. (Gastric Cancer 2015) 3
  3. MicroRNA-10b is upregulated and has an invasive role in colorectal cancer through enhanced Rhoc expression. (PMID: 25606801) Wang Y.F. … Peng Z.H. (Oncol. Rep. 2015) 3
  4. Prognostic value of microRNA-10b overexpression in peripheral blood mononuclear cells of nonsmall-cell lung cancer patients. (PMID: 25869877) Yang Y.L. … Wang T.Y. (Tumour Biol. 2015) 3
  5. MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin. (PMID: 25875782) Zhang L. … Zhang T. (Appl. Biochem. Biotechnol. 2015) 3

Products for MIR10B Gene

Sources for MIR10B Gene

Content