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Aliases for MIR10B Gene

Subcategory (RNA class) for MIR10B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR10B Gene

  • MicroRNA 10b 2 3 5
  • Hsa-Mir-10b 3
  • MiRNA10B 3
  • Mir-10b 3
  • MIRN10B 3

External Ids for MIR10B Gene

ORGUL Members for MIR10B Gene

Previous HGNC Symbols for MIR10B Gene

  • MIRN10B

Previous GeneCards Identifiers for MIR10B Gene

  • GC02P176725
  • GC02P177015

Summaries for MIR10B Gene

Entrez Gene Summary for MIR10B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10B Gene

MIR10B (MicroRNA 10b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR10B Gene

Genomics for MIR10B Gene

Regulatory Elements for MIR10B Gene

Enhancers for MIR10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F176552 1.5 FANTOM5 Ensembl ENCODE 10.5 +403.4 403388 3.0 FEZF1 ZNF2 RAD21 YY1 EGR1 ZNF366 ZNF143 MIXL1 EGR2 ZNF654 HOXD4 HOXD3 HOXD-AS2 MIR10B HAGLR HOXD1 MIR7704 HOXD13 ENSG00000236231 GC02P176590
GH02F176455 1 Ensembl ENCODE 11.1 +305.6 305587 1.8 CTCF COPS2 BMI1 ZSCAN9 RAD21 ZFHX2 ZNF143 SMC3 NFE2 MAFK MIR10B HOXD4 HOXD3 HOXD11 HOXD10 ENSG00000229434 ENSG00000237260
GH02F176581 1.1 Ensembl ENCODE 10 +432.9 432906 3.3 INSM2 SIN3A KLF17 ZNF2 RAD21 GLIS2 ZNF366 SCRT2 RCOR1 FOS HOXD4 HOXD8 DNAJC19P5 HOXD3 HOXD-AS2 LOC105373753 MIR10B GC02P176590 ENSG00000236231
GH02F176177 1 Ensembl ENCODE 10.4 +28.1 28115 2.2 CTCF PKNOX1 ZSCAN18 SUZ12 JUN MAX FEZF1 E2F1 ZFHX2 CTBP1 HAGLROS HAGLR HOXD1 HOXD4 HOXD3 HOXD-AS2 MIR10B HOXD11 HOXD12 HOXD10
GH02F176565 1 Ensembl ENCODE 9.8 +415.8 415818 1.3 SOX13 JUN MAX CEBPG ZFHX2 NR2F6 FOS ZNF652 MAFK HOMEZ HOXD-AS2 HOXD3 HAGLR HOXD1 MIR7704 HOXD11 HOXD4 MIR10B GC02P176590 ENSG00000236231
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR10B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR10B Gene

Chromosome:
2
Start:
176,150,303 bp from pter
End:
176,150,412 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR10B Gene

Genes around MIR10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10B Gene

Proteins for MIR10B Gene

Post-translational modifications for MIR10B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10B Gene

Domains & Families for MIR10B Gene

Gene Families for MIR10B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR10B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR10B Gene

Function for MIR10B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10B Gene

Localization for MIR10B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR10B Gene

Pathways & Interactions for MIR10B Gene

genes like me logo Genes that share pathways with MIR10B: view

Pathways by source for MIR10B Gene

2 KEGG pathways for MIR10B Gene

Interacting Proteins for MIR10B Gene

Gene Ontology (GO) - Biological Process for MIR10B Gene

None

No data available for SIGNOR curated interactions for MIR10B Gene

Transcripts for MIR10B Gene

mRNA/cDNA for MIR10B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10B Gene

No ASD Table

Relevant External Links for MIR10B Gene

GeneLoc Exon Structure for
MIR10B
ECgene alternative splicing isoforms for
MIR10B

Expression for MIR10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR10B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR10B Gene:

MIR10B
genes like me logo Genes that share expression patterns with MIR10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR10B Gene

Orthologs for MIR10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-10b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-10b 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir10b 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-10b 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-10b 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-10b 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-10b 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-10b 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-10b-1 35
  • 87 (a)
OneToMany
dre-mir-10b-2 35
  • 72 (a)
OneToMany
dre-mir-10c 35
  • 71 (a)
OneToMany
Species where no ortholog for MIR10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR10B Gene

ENSEMBL:
Gene Tree for MIR10B (if available)
TreeFam:
Gene Tree for MIR10B (if available)

Paralogs for MIR10B Gene

No data available for Paralogs for MIR10B Gene

Variants for MIR10B Gene

Sequence variations from dbSNP and Humsavar for MIR10B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111762840 -- 176,149,221(+) GGAAA(C/T)TGGGG intron-variant, upstream-variant-2KB
rs111992329 -- 176,150,154(+) GAAGA(A/G)TGAGG intron-variant, upstream-variant-2KB
rs113754306 -- 176,150,261(+) AGAGA(C/T)TGGGG intron-variant, upstream-variant-2KB
rs138108736 -- 176,148,814(+) CCAGT(A/C)TGGAA intron-variant, upstream-variant-2KB
rs138423463 -- 176,150,514(+) CCAGG(A/G)GGATC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR10B Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV gain 20364138

Relevant External Links for MIR10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR10B Gene

Disorders for MIR10B Gene

Relevant External Links for MIR10B

Genetic Association Database (GAD)
MIR10B
Human Genome Epidemiology (HuGE) Navigator
MIR10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR10B

No disorders were found for MIR10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR10B Gene

Publications for MIR10B Gene

  1. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. (PMID: 17898713) Ma L. … Weinberg R.A. (Nature 2007) 3 22 64
  2. Up-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma. (PMID: 27002147) Bourguignon L.Y. … Shiina M. (J. Biol. Chem. 2016) 3 64
  3. microRNA-10b is a prognostic biomarker for melanoma. (PMID: 26743475) Saldanha G. … Pringle J.H. (Mod. Pathol. 2016) 3 64
  4. DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. (PMID: 24481854) Li Z. … Yu J. (Gastric Cancer 2015) 3 64
  5. Over-expression of miR-10b in NPC patients: correlation with LMP1 and Twist1. (PMID: 25597482) Allaya N. … Ayadi W. (Tumour Biol. 2015) 3 64

Products for MIR10B Gene

Sources for MIR10B Gene

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