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Aliases for MIR10A Gene

Subcategory (RNA class) for MIR10A Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR10A Gene

  • MicroRNA 10a 2 3 5
  • Hsa-Mir-10a 3
  • MiRNA10A 3
  • Mir-10a 3
  • MIRN10A 3

External Ids for MIR10A Gene

Previous HGNC Symbols for MIR10A Gene

  • MIRN10A

Previous GeneCards Identifiers for MIR10A Gene

  • GC17M044015
  • GC17M046657
  • GC17M046665

Summaries for MIR10A Gene

Entrez Gene Summary for MIR10A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10A Gene

MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Fluid shear stress and atherosclerosis and Proteoglycans in cancer.

fRNAdb sequence ontologies for MIR10A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR10A

Additional gene information for MIR10A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR10A Gene

Genomics for MIR10A Gene

GeneHancer (GH) Regulatory Elements for MIR10A Gene

Promoters and enhancers for MIR10A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I048491 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +87.2 87248 2 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF213 E2F8 ZNF207 ZNF143 HOXB2 SKAP1 SP2 HOXB4 MIR10A HOXB3 HOXB1 HOXB-AS1 HOXB-AS3 HOXB-AS2
GH17I048505 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.8 +73.9 73904 1.8 HDAC1 PKNOX1 ZSCAN4 NEUROD1 BMI1 BATF IRF4 RFX5 ZNF335 ZNF366 HOXB2 SKAP1 HOXB-AS1 HOXB1 HOXB4 MIR10A HOXB3 HOXB-AS3 HOXB-AS2 LOC105371808
GH17I048471 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +107.3 107265 1.7 HDGF KLF17 FEZF1 SCRT2 FOS IKZF2 ZBTB11 SP1 IKZF1 ZNF341 SKAP1 HOXB-AS2 HOXB3 HOXB4 MIR10A HOXB2 HOXB-AS1 HOXB1 MIR196A1 CDK5RAP3
GH17I048496 Enhancer 1 ENCODE dbSUPER 12.2 +81.8 81793 2.8 INSM2 KLF17 ZSCAN5C FOS RCOR1 KLF13 EGR2 ZNF362 ELF1 NR2F2 HOXB2 SKAP1 HOXB-AS1 HOXB4 MIR10A HOXB3 HOXB1 HOXB-AS2 HOXB-AS3 MIR1203
GH17I048500 Enhancer 0.9 ENCODE 11.6 +78.9 78919 1.9 HDAC1 HDGF PKNOX1 ATF1 RB1 ARNT RAD21 ARID2 ZNF366 SCRT2 HOXB2 HOXB-AS1 HOXB1 HOXB4 MIR10A HOXB3 HOXB-AS2 HOXB-AS3 SKAP1 MIR1203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR10A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR10A Gene

Genomic Locations for MIR10A Gene
chr17:48,579,838-48,579,947
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr17:46,656,992-46,659,621
(GRCh37/hg19)

Genomic View for MIR10A Gene

Genes around MIR10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10A Gene

ORGUL Member Location for MIR10A Gene

ORGUL Member Location for MIR10A gene

Proteins for MIR10A Gene

Post-translational modifications for MIR10A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10A Gene

Domains & Families for MIR10A Gene

Gene Families for MIR10A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR10A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR10A Gene

Function for MIR10A Gene

Phenotypes From GWAS Catalog for MIR10A Gene

Gene Ontology (GO) - Molecular Function for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25068583
genes like me logo Genes that share ontologies with MIR10A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10A Gene

Localization for MIR10A Gene

Gene Ontology (GO) - Cellular Components for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR10A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR10A Gene

Pathways & Interactions for MIR10A Gene

genes like me logo Genes that share pathways with MIR10A: view

Pathways by source for MIR10A Gene

Interacting Proteins for MIR10A Gene

Gene Ontology (GO) - Biological Process for MIR10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016525 negative regulation of angiogenesis ISS --
GO:0035195 gene silencing by miRNA IDA 25068583
GO:0043537 negative regulation of blood vessel endothelial cell migration ISS --
GO:0110023 negative regulation of cardiac muscle myoblast proliferation IDA 25068583
GO:0110059 negative regulation of blood vessel endothelial cell differentiation ISS --
genes like me logo Genes that share ontologies with MIR10A: view

No data available for SIGNOR curated interactions for MIR10A Gene

Drugs & Compounds for MIR10A Gene

No Compound Related Data Available

Transcripts for MIR10A Gene

fRNAdb Secondary structures for MIR10A Gene

  • FR084621

mRNA/cDNA for MIR10A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10A Gene

No ASD Table

Relevant External Links for MIR10A Gene

GeneLoc Exon Structure for
MIR10A
ECgene alternative splicing isoforms for
MIR10A

Expression for MIR10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR10A Gene

mRNA differential expression in normal tissues according to GTEx for MIR10A Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.4), Esophagus - Muscularis (x5.2), and Colon - Sigmoid (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR10A Gene:

MIR10A
genes like me logo Genes that share expression patterns with MIR10A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR10A Gene

Orthologs for MIR10A Gene

Evolution for MIR10A Gene

ENSEMBL:
Gene Tree for MIR10A (if available)
TreeFam:
Gene Tree for MIR10A (if available)

No data available for Orthologs for MIR10A Gene

Paralogs for MIR10A Gene

No data available for Paralogs for MIR10A Gene

Variants for MIR10A Gene

Sequence variations from dbSNP and Humsavar for MIR10A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000232979 -- 48,580,132(-) G/A upstream_transcript_variant
rs1000832381 -- 48,581,814(-) C/T upstream_transcript_variant
rs1001458729 -- 48,579,777(-) G/T downstream_transcript_variant
rs1001618462 -- 48,580,001(-) G/C upstream_transcript_variant
rs1001705407 -- 48,581,707(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR10A Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Additional Variant Information for MIR10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR10A Gene

Disorders for MIR10A Gene

Additional Disease Information for MIR10A

No disorders were found for MIR10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR10A Gene

Publications for MIR10A Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 58
  2. XRN2 promotes EMT and metastasis through regulating maturation of miR-10a. (PMID: 28319071) Zhang H … Liu P (Oncogene 2017) 3 58
  3. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis. (PMID: 28383561) Liu Y … Tang H (Cell death & disease 2017) 3 58
  4. Regulation of spindle and kinetochore-associated protein 1 by antitumor miR-10a-5p in renal cell carcinoma. (PMID: 28746769) Arai T … Seki N (Cancer science 2017) 3 58
  5. MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis. (PMID: 26628598) Xu D … Pachman LM (The Journal of rheumatology 2016) 3 58

Products for MIR10A Gene

Sources for MIR10A Gene

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