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Aliases for MIR10A Gene

Subcategory (RNA class) for MIR10A Gene

miRNA

Quality Score for this RNA gene is

11.2

Aliases for MIR10A Gene

  • MicroRNA 10a 2 3
  • Hsa-Mir-10a 3
  • MiRNA10A 3
  • Mir-10a 3
  • MIRN10A 3

External Ids for MIR10A Gene

Previous HGNC Symbols for MIR10A Gene

  • MIRN10A

Previous GeneCards Identifiers for MIR10A Gene

  • GC17M044015
  • GC17M046657
  • GC17M046665

Summaries for MIR10A Gene

Entrez Gene Summary for MIR10A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR10A Gene

MIR10A (MicroRNA 10a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer.

fRNAdb sequence ontologies for MIR10A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR10A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR10A Gene

Genomics for MIR10A Gene

Genomic Location for MIR10A Gene

Chromosome:
17
Start:
48,579,838 bp from pter
End:
48,579,947 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR10A Gene

ORGUL Member Location for MIR10A Gene

ORGUL Member Location for MIR10A gene

No data available for Regulatory Elements for MIR10A Gene

Proteins for MIR10A Gene

Post-translational modifications for MIR10A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR10A Gene

Domains & Families for MIR10A Gene

Gene Families for MIR10A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR10A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR10A Gene

Function for MIR10A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR10A Gene

Localization for MIR10A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR10A Gene

Pathways & Interactions for MIR10A Gene

genes like me logo Genes that share pathways with MIR10A: view

Pathways by source for MIR10A Gene

2 KEGG pathways for MIR10A Gene

Interacting Proteins for MIR10A Gene

Gene Ontology (GO) - Biological Process for MIR10A Gene

None

No data available for SIGNOR curated interactions for MIR10A Gene

Drugs & Compounds for MIR10A Gene

No Compound Related Data Available

Transcripts for MIR10A Gene

fRNAdb Secondary structures for MIR10A Gene

  • FR084621

mRNA/cDNA for MIR10A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR10A Gene

No ASD Table

Relevant External Links for MIR10A Gene

GeneLoc Exon Structure for
MIR10A
ECgene alternative splicing isoforms for
MIR10A

Expression for MIR10A Gene

mRNA expression in normal human tissues for MIR10A Gene

mRNA differential expression in normal tissues according to GTEx for MIR10A Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.4), Esophagus - Muscularis (x5.2), and Colon - Sigmoid (x4.5).
genes like me logo Genes that share expression patterns with MIR10A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR10A Gene

Orthologs for MIR10A Gene

Evolution for MIR10A Gene

ENSEMBL:
Gene Tree for MIR10A (if available)
TreeFam:
Gene Tree for MIR10A (if available)

No data available for Orthologs for MIR10A Gene

Paralogs for MIR10A Gene

No data available for Paralogs for MIR10A Gene

Variants for MIR10A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR10A Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990

Relevant External Links for MIR10A Gene

HapMap Linkage Disequilibrium report
MIR10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR10A Gene

Disorders for MIR10A Gene

Relevant External Links for MIR10A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR10A
genes like me logo Genes that share disorders with MIR10A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR10A Gene

Publications for MIR10A Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 67
  2. MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA. (PMID: 25554417) Li C. … Hu D.H. (FEBS Lett. 2015) 67
  3. miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8. (PMID: 25683004) Yan Y. … Yang P. (FEBS Lett. 2015) 67
  4. Stress-related alcohol consumption in heavy drinkers correlates with expression of miR-10a, miR-21, and components of the TAR-RNA-binding protein-associated complex. (PMID: 25421511) Beech R.D. … Sinha R. (Alcohol. Clin. Exp. Res. 2014) 67
  5. miR-10a and miR-10b target the 3'-untranslated region of TBX5 to repress its expression. (PMID: 24714979) Wang F. … Gui Y.H. (Pediatr Cardiol 2014) 67

Products for MIR10A Gene

Sources for MIR10A Gene

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