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Aliases for MIR107 Gene

Subcategory (RNA class) for MIR107 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR107 Gene

  • MicroRNA 107 2 3 5
  • Hsa-Mir-107 3
  • MiR-107 3
  • MIRN107 3

External Ids for MIR107 Gene

Previous HGNC Symbols for MIR107 Gene

  • MIRN107

Previous GeneCards Identifiers for MIR107 Gene

  • GC10M091345
  • GC10M089594
  • GC10M089595
  • GC10M089596

Summaries for MIR107 Gene

Entrez Gene Summary for MIR107 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR107 Gene

MIR107 (MicroRNA 107) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR107 include Scleral Staphyloma. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR107 Gene

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR107

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR107 Gene

Genomics for MIR107 Gene

Regulatory Elements for MIR107 Gene

Enhancers for MIR107 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G089466 1 Ensembl ENCODE 9.3 +126.0 125966 0.5 CTCF PKNOX1 JUN ZSCAN4 ZBTB40 RAD21 RFX5 GATA3 SMC3 FOS IFIT5 LIPA KIF20B ENSG00000235100 MIR107 SLC16A12-AS1 GC10P089485
GH10G089564 0.6 ENCODE 10.5 +28.7 28749 0.1 CTCF ZNF654 TEAD1 HMBOX1 CEBPB SMC3 CEBPG RAD21 MIR107 SLC16A12-AS1 SLC16A12 GC10M089559
GH10G089529 0.5 dbSUPER 9.9 +62.7 62688 0.8 MAFF ZNF316 MAFG EMSY MAFK MIR107 SLC16A12 GC10P089485
GH10G089637 0.4 ENCODE 10.8 -44.5 -44512 0.2 CEBPA HLF MIR107 KIF20B ENSG00000235100 SLC16A12-AS1 ENSG00000249962 GC10M089598
GH10G089550 0.4 ENCODE 9.2 +42.1 42109 0.1 BHLHE40 SLC16A12-AS1 MIR107 SLC16A12 GC10P089485
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR107 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR107 Gene

Chromosome:
10
Start:
89,592,747 bp from pter
End:
89,592,827 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR107 Gene

Genes around MIR107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR107 Gene

ORGUL Member Location for MIR107 Gene

ORGUL Member Location for MIR107 gene

Proteins for MIR107 Gene

Post-translational modifications for MIR107 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR107 Gene

Domains & Families for MIR107 Gene

Gene Families for MIR107 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR107: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR107 Gene

Function for MIR107 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR107 Gene

Localization for MIR107 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR107 Gene

Pathways & Interactions for MIR107 Gene

genes like me logo Genes that share pathways with MIR107: view

Pathways by source for MIR107 Gene

1 BioSystems pathway for MIR107 Gene
1 KEGG pathway for MIR107 Gene

Interacting Proteins for MIR107 Gene

Gene Ontology (GO) - Biological Process for MIR107 Gene

None

No data available for SIGNOR curated interactions for MIR107 Gene

Transcripts for MIR107 Gene

fRNAdb Secondary structures for MIR107 Gene

  • hsa-miR-107_MIMAT0000104_Homo_sapiens_miR-107_mature

mRNA/cDNA for MIR107 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR107 Gene

No ASD Table

Relevant External Links for MIR107 Gene

GeneLoc Exon Structure for
MIR107
ECgene alternative splicing isoforms for
MIR107

Expression for MIR107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR107 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR107 Gene:

MIR107
genes like me logo Genes that share expression patterns with MIR107: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR107 Gene

Orthologs for MIR107 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR107 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-107 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-107 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-107 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir107 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-107 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-107 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-107 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-107 35
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-107a 35
  • 85 (a)
OneToMany
dre-mir-107b 35
  • 77 (a)
OneToMany
Species where no ortholog for MIR107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR107 Gene

ENSEMBL:
Gene Tree for MIR107 (if available)
TreeFam:
Gene Tree for MIR107 (if available)

Paralogs for MIR107 Gene

No data available for Paralogs for MIR107 Gene

Variants for MIR107 Gene

Sequence variations from dbSNP and Humsavar for MIR107 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000169241 -- 89,593,349(+) GTGTT(C/G)AAAAT intron-variant, upstream-variant-2KB
rs1000764287 -- 89,594,418(+) AAAAG(A/C)ATTTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001684664 -- 89,593,742(+) ACAAC(G/T)TAGTG intron-variant, upstream-variant-2KB
rs1002197704 -- 89,593,468(+) GAATT(A/G)TAGTA intron-variant, upstream-variant-2KB
rs1002972685 -- 89,592,591(+) GTGAA(C/G)AGTTC intron-variant, downstream-variant-500B

Relevant External Links for MIR107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR107 Gene

Disorders for MIR107 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR107 Gene - From: GeneCards

Disorder Aliases PubMed IDs
scleral staphyloma
  • scleral ectasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR107

Human Genome Epidemiology (HuGE) Navigator
MIR107
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR107
genes like me logo Genes that share disorders with MIR107: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR107 Gene

Publications for MIR107 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  2. miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42. (PMID: 28393193) Sharma P. … Sharma R. (Oncol. Rep. 2017) 3 64
  3. Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. (PMID: 28079796) Zhang Y. … Han L. (Medicine (Baltimore) 2017) 3 64
  4. Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression. (PMID: 26084601) Chen L. … Li W.P. (Cell. Mol. Neurobiol. 2016) 3 64
  5. MicroRNA-107: a novel promoter of tumor progression that targets the CPEB3/EGFR axis in human hepatocellular carcinoma. (PMID: 26497556) Zou C.D. … Gao X. (Oncotarget 2016) 3 64

Products for MIR107 Gene

Sources for MIR107 Gene

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