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Aliases for MIR106B Gene

Subcategory (RNA class) for MIR106B Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR106B Gene

  • MicroRNA 106b 2 3
  • MIRN106B 3 6
  • Hsa-Mir-106b 3

External Ids for MIR106B Gene

Previous HGNC Symbols for MIR106B Gene

  • MIRN106B

Previous GeneCards Identifiers for MIR106B Gene

  • GC07M099538
  • GC07M099693
  • GC07M099695
  • GC07M099701
  • GC07M099721
  • GC07M099743
  • GC07M099786

Summaries for MIR106B Gene

Entrez Gene Summary for MIR106B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR106B Gene

MIR106B (MicroRNA 106b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR106B include adenomatous polyposis coli. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR106B Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR106B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR106B Gene

Genomics for MIR106B Gene

Genomic Location for MIR106B Gene

Start:
100,093,993 bp from pter
End:
100,094,074 bp from pter
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR106B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR106B Gene

ORGUL Member Location for MIR106B Gene

ORGUL Member Location for MIR106B gene

No data available for Regulatory Elements for MIR106B Gene

Proteins for MIR106B Gene

Post-translational modifications for MIR106B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR106B Gene

Domains for MIR106B Gene

Gene Families for MIR106B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR106B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR106B Gene

Function for MIR106B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR106B Gene

Localization for MIR106B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR106B Gene

Pathways for MIR106B Gene

genes like me logo Genes that share pathways with MIR106B: view

Pathways by source for MIR106B Gene

1 BioSystems pathway for MIR106B Gene
1 KEGG pathway for MIR106B Gene

Interacting Proteins for MIR106B Gene

Gene Ontology (GO) - Biological Process for MIR106B Gene

None

Transcripts for MIR106B Gene

fRNAdb Secondary structures for MIR106B Gene

  • FR385482
  • FR259064

mRNA/cDNA for MIR106B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR106B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR106B Gene

No ASD Table

Relevant External Links for MIR106B Gene

GeneLoc Exon Structure for
MIR106B
ECgene alternative splicing isoforms for
MIR106B

Expression for MIR106B Gene

mRNA expression in normal human tissues for MIR106B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR106B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR106B Gene

Orthologs for MIR106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR106B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-106b 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-106b 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-106b 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir106b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-18a 36
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-18a 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-18a 36
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-18a 36
  • 52 (a)
ManyToMany
Species with no ortholog for MIR106B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR106B Gene

ENSEMBL:
Gene Tree for MIR106B (if available)
TreeFam:
Gene Tree for MIR106B (if available)

Paralogs for MIR106B Gene

No data available for Paralogs for MIR106B Gene

Variants for MIR106B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR106B Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489

Relevant External Links for MIR106B Gene

HapMap Linkage Disequilibrium report
MIR106B
Human Gene Mutation Database (HGMD)
MIR106B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR106B Gene

Disorders for MIR106B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MIR106B Gene including...

Search for MIR106B Gene in MalaCards »

Relevant External Links for MIR106B

Genetic Association Database (GAD)
MIR106B
Human Genome Epidemiology (HuGE) Navigator
MIR106B
genes like me logo Genes that share disorders with MIR106B: view

No data available for UniProtKB/Swiss-Prot for MIR106B Gene

Publications for MIR106B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48
  2. Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. (PMID: 20388916) Poliseno L. … Pandolfi P.P. (Sci Signal 2010) 3
  3. Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy. (PMID: 20609231) Slaby O. … Vyzula R. (J. Exp. Clin. Cancer Res. 2010) 3
  4. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. (PMID: 20637509) De Santis G. … Granieri E. (J. Neuroimmunol. 2010) 3
  5. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3

Products for MIR106B Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR106B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR106B
    • Block miRNA regulation of MIR106B using miScript Target Protectors

    Sources for MIR106B Gene

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