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Aliases for MIR106B Gene

Subcategory (RNA class) for MIR106B Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR106B Gene

  • MicroRNA 106b 2 3 5
  • Hsa-Mir-106b 3
  • Mir-106b 3
  • MIRN106B 3

External Ids for MIR106B Gene

Previous HGNC Symbols for MIR106B Gene

  • MIRN106B

Previous GeneCards Identifiers for MIR106B Gene

  • GC07M099538
  • GC07M099693
  • GC07M099695
  • GC07M099701
  • GC07M099721
  • GC07M099743
  • GC07M099786
  • GC07M100095
  • GC07M100102
  • GC07M100106
  • GC07M100112

Summaries for MIR106B Gene

Entrez Gene Summary for MIR106B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR106B Gene

MIR106B (MicroRNA 106b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and DNA damage response.

fRNAdb sequence ontologies for MIR106B Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR106B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR106B Gene

Genomics for MIR106B Gene

Regulatory Elements for MIR106B Gene

Enhancers for MIR106B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100040 1 Ensembl ENCODE 11 +52.5 52514 1.9 BCOR CTCF PKNOX1 ESRRA TAL1 JUN THRB RAD21 ZNF644 CTBP1 AP4M1 ZSCAN21 ZKSCAN1 MCM7 COPS6 MIR106B MIR25 MIR93 PILRA GC07P100039
GH07F100044 0.9 Ensembl ENCODE 11 +49.2 49175 0.2 CTCF ZNF687 NRF1 SIN3A MNT RAD21 FOS MLLT1 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 ZSCAN21 GC07P100039
GH07F100061 0.8 ENCODE 11.9 +32.2 32246 0.8 BCOR PKNOX1 CBX3 ARNT TAL1 POLR2A GATA2 NCOR1 NR2F6 ZNF600 COPS6 MIR106B MIR25 MIR93 MCM7 ZKSCAN1 TRIM4 GC07M100077 PIR44616 PIR43713
GH07F100137 0.8 Ensembl ENCODE 10.8 -44.1 -44111 0.8 GATA3 PKNOX1 IKZF1 TCF7 NFE2 TCF7L2 PVRIG C7orf43 MIR4658 GAL3ST4 GPC2 STAG3 GATS MCM7 AP4M1 MIR106B
GH07F100048 0.4 ENCODE 11 +45.2 45151 0.0 ZNF610 ZKSCAN1 MIR25 MIR93 COPS6 MIR106B MCM7 ZSCAN21 GC07P100039
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR106B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR106B Gene

Chromosome:
7
Start:
100,093,993 bp from pter
End:
100,094,074 bp from pter
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR106B Gene

Genes around MIR106B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR106B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR106B Gene

ORGUL Member Location for MIR106B Gene

ORGUL Member Location for MIR106B gene

Proteins for MIR106B Gene

Post-translational modifications for MIR106B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR106B Gene

Domains & Families for MIR106B Gene

Gene Families for MIR106B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR106B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR106B Gene

Function for MIR106B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR106B Gene

Localization for MIR106B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR106B Gene

Pathways & Interactions for MIR106B Gene

genes like me logo Genes that share pathways with MIR106B: view

Pathways by source for MIR106B Gene

2 BioSystems pathways for MIR106B Gene
1 KEGG pathway for MIR106B Gene

Interacting Proteins for MIR106B Gene

Gene Ontology (GO) - Biological Process for MIR106B Gene

None

No data available for SIGNOR curated interactions for MIR106B Gene

Transcripts for MIR106B Gene

fRNAdb Secondary structures for MIR106B Gene

  • FR385482
  • FR259064

mRNA/cDNA for MIR106B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR106B Gene

No ASD Table

Relevant External Links for MIR106B Gene

GeneLoc Exon Structure for
MIR106B
ECgene alternative splicing isoforms for
MIR106B

Expression for MIR106B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR106B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR106B Gene:

MIR106B
genes like me logo Genes that share expression patterns with MIR106B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR106B Gene

Orthologs for MIR106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR106B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-106b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-106b 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-106b 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir106b 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-18a 35
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-18a 35
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-18a 35
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-18a 35
  • 52 (a)
ManyToMany
Species where no ortholog for MIR106B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR106B Gene

ENSEMBL:
Gene Tree for MIR106B (if available)
TreeFam:
Gene Tree for MIR106B (if available)

Paralogs for MIR106B Gene

No data available for Paralogs for MIR106B Gene

Variants for MIR106B Gene

Sequence variations from dbSNP and Humsavar for MIR106B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11552033 -- 100,095,408(-) TGAAC(C/T)TCTGG upstream-variant-2KB, reference, missense
rs116060549 -- 100,094,381(+) GAGAT(A/G)GGGAA intron-variant, upstream-variant-2KB
rs116794737 -- 100,095,588(+) TTTCC(C/T)GGGAA intron-variant, upstream-variant-2KB
rs117088758 -- 100,095,125(+) AGAGA(A/G)CTGAG intron-variant, upstream-variant-2KB
rs12267 -- 100,095,455(-) CACAT(C/T)ACCTA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR106B Gene

Variant ID Type Subtype PubMed ID
nsv607931 CNV loss 21841781
nsv510966 OTHER complex 20534489
nsv469687 CNV loss 16826518
esv2734888 CNV deletion 23290073

Relevant External Links for MIR106B Gene

Human Gene Mutation Database (HGMD)
MIR106B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR106B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR106B Gene

Disorders for MIR106B Gene

Relevant External Links for MIR106B

Genetic Association Database (GAD)
MIR106B
Human Genome Epidemiology (HuGE) Navigator
MIR106B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR106B

No disorders were found for MIR106B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR106B Gene

Publications for MIR106B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. MiR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300. (PMID: 26573761) Hu Y. … YagA1e E. (Oncol. Rep. 2016) 3 64
  3. Negative correlation of ITCH E3 ubiquitin ligase and miRNA-106b dictates metastatic progression in pancreatic cancer. (PMID: 26621835) Luo Z.L. … Tang L.J. (Oncotarget 2016) 3 64
  4. MicroRNA-106b is involved in transforming growth factor I^1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma. (PMID: 26769181) Cheng Y. … Geng L. (J. Exp. Clin. Cancer Res. 2016) 3 64
  5. MicroRNA-106b functions as an oncogene in renal cell carcinoma by affecting cell proliferation, migration and apoptosis. (PMID: 26648244) Li Y. … Lai Y. (Mol Med Rep 2016) 3 64

Products for MIR106B Gene

Sources for MIR106B Gene

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