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Aliases for MIR106B Gene

Subcategory (RNA class) for MIR106B Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR106B Gene

  • MicroRNA 106b 2 3 5
  • Hsa-Mir-106b 3
  • Mir-106b 3
  • MIRN106B 3

External Ids for MIR106B Gene

Previous HGNC Symbols for MIR106B Gene

  • MIRN106B

Previous GeneCards Identifiers for MIR106B Gene

  • GC07M099538
  • GC07M099693
  • GC07M099695
  • GC07M099701
  • GC07M099721
  • GC07M099743
  • GC07M099786
  • GC07M100095
  • GC07M100102

Summaries for MIR106B Gene

Entrez Gene Summary for MIR106B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR106B Gene

MIR106B (MicroRNA 106b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR106B Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR106B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR106B Gene

Genomics for MIR106B Gene

Regulatory Elements for MIR106B Gene

Enhancers for MIR106B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR106B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR106B Gene

Chromosome:
7
Start:
100,093,993 bp from pter
End:
100,094,074 bp from pter
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR106B Gene

Genes around MIR106B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR106B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR106B Gene

ORGUL Member Location for MIR106B Gene

ORGUL Member Location for MIR106B gene

Proteins for MIR106B Gene

Post-translational modifications for MIR106B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR106B Gene

Domains & Families for MIR106B Gene

Gene Families for MIR106B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR106B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR106B Gene

Function for MIR106B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR106B Gene

Localization for MIR106B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR106B Gene

Pathways & Interactions for MIR106B Gene

genes like me logo Genes that share pathways with MIR106B: view

Pathways by source for MIR106B Gene

1 BioSystems pathway for MIR106B Gene
1 KEGG pathway for MIR106B Gene

Interacting Proteins for MIR106B Gene

Gene Ontology (GO) - Biological Process for MIR106B Gene

None

No data available for SIGNOR curated interactions for MIR106B Gene

Drugs & Compounds for MIR106B Gene

No Compound Related Data Available

Transcripts for MIR106B Gene

fRNAdb Secondary structures for MIR106B Gene

  • FR385482
  • FR259064

mRNA/cDNA for MIR106B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR106B Gene

No ASD Table

Relevant External Links for MIR106B Gene

GeneLoc Exon Structure for
MIR106B
ECgene alternative splicing isoforms for
MIR106B

Expression for MIR106B Gene

mRNA expression in normal human tissues for MIR106B Gene

genes like me logo Genes that share expression patterns with MIR106B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR106B Gene

Orthologs for MIR106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR106B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-106b 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-106b 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-18a 36
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir106b 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-106b 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-18a 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-18a 36
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-18a 36
  • 52 (a)
ManyToMany
Species with no ortholog for MIR106B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR106B Gene

ENSEMBL:
Gene Tree for MIR106B (if available)
TreeFam:
Gene Tree for MIR106B (if available)

Paralogs for MIR106B Gene

No data available for Paralogs for MIR106B Gene

Variants for MIR106B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR106B Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489

Relevant External Links for MIR106B Gene

HapMap Linkage Disequilibrium report
MIR106B
Human Gene Mutation Database (HGMD)
MIR106B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR106B Gene

Disorders for MIR106B Gene

Relevant External Links for MIR106B

Genetic Association Database (GAD)
MIR106B
Human Genome Epidemiology (HuGE) Navigator
MIR106B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR106B

No disorders were found for MIR106B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR106B Gene

Publications for MIR106B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. MiR-106b expression determines the proliferation paradox of TGF-I^ in breast cancer cells. (PMID: 24292682) Gong C. … Song E. (Oncogene 2015) 3
  3. miR-106b is overexpressed in medulloblastomas and interacts directly with PTEN. (PMID: 25041637) Li K.K. … Ng H.K. (Neuropathol. Appl. Neurobiol. 2015) 3
  4. A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. (PMID: 25307786) Ye F. … Zhang G. (Int. J. Cancer 2015) 3
  5. Prognostic value of miR-106b expression in breast cancer patients. (PMID: 25619461) Zheng R. … Zheng W. (J. Surg. Res. 2015) 3

Products for MIR106B Gene

Sources for MIR106B Gene

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