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Aliases for MIR106A Gene

Subcategory (RNA class) for MIR106A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR106A Gene

  • MicroRNA 106a 2 3
  • Hsa-Mir-106a 3
  • Mir-106a 3
  • MIRN106A 3
  • Mir-106 3

External Ids for MIR106A Gene

Previous HGNC Symbols for MIR106A Gene

  • MIRN106A

Previous GeneCards Identifiers for MIR106A Gene

  • GC0XM133154
  • GC0XM133155
  • GC0XM133308
  • GC0XM133309
  • GC0XM133313
  • GC0XM133317
  • GC0XM133321
  • GC0XM133326
  • GC0XM133330
  • GC0XM133334
  • GC0XM133339
  • GC0XM133350
  • GC0XM133374
  • GC0XM134175

Summaries for MIR106A Gene

Entrez Gene Summary for MIR106A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR106A Gene

MIR106A (MicroRNA 106a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR106A Gene

Genomics for MIR106A Gene

Genomic Location for MIR106A Gene

Chromosome:
X
Start:
134,170,198 bp from pter
End:
134,170,278 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR106A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR106A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR106A Gene

No data available for Regulatory Elements for MIR106A Gene

Proteins for MIR106A Gene

Post-translational modifications for MIR106A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR106A Gene

Domains & Families for MIR106A Gene

Gene Families for MIR106A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR106A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR106A Gene

Function for MIR106A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR106A Gene

Localization for MIR106A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR106A Gene

Pathways & Interactions for MIR106A Gene

SuperPathways for MIR106A Gene

No Data Available

Interacting Proteins for MIR106A Gene

Gene Ontology (GO) - Biological Process for MIR106A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR106A Gene

Drugs & Compounds for MIR106A Gene

No Compound Related Data Available

Transcripts for MIR106A Gene

mRNA/cDNA for MIR106A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR106A Gene

No ASD Table

Relevant External Links for MIR106A Gene

GeneLoc Exon Structure for
MIR106A
ECgene alternative splicing isoforms for
MIR106A

Expression for MIR106A Gene

mRNA expression in normal human tissues for MIR106A Gene

genes like me logo Genes that share expression patterns with MIR106A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR106A Gene

Orthologs for MIR106A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR106A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-106a 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-106a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-17 36
  • 69 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mir106a 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-106 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-106a 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-106 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-17a-1 36
  • 43 (a)
ManyToMany
Species with no ortholog for MIR106A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR106A Gene

ENSEMBL:
Gene Tree for MIR106A (if available)
TreeFam:
Gene Tree for MIR106A (if available)

Paralogs for MIR106A Gene

No data available for Paralogs for MIR106A Gene

Variants for MIR106A Gene

Sequence variations from dbSNP and Humsavar for MIR106A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs377321718 -- 134,172,141(+) TTCTT(A/G)CCCAG upstream-variant-2KB
rs749413699 -- 134,172,188(+) CGGCC(C/T)GCCCC upstream-variant-2KB
rs750729298 -- 134,172,123(+) CCCCA(A/G)CGAAG upstream-variant-2KB
rs780538372 -- 134,172,152(+) CCACC(C/G)GCTCG upstream-variant-2KB

Relevant External Links for MIR106A Gene

HapMap Linkage Disequilibrium report
MIR106A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR106A Gene

Disorders for MIR106A Gene

Relevant External Links for MIR106A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR106A
genes like me logo Genes that share disorders with MIR106A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR106A Gene

Publications for MIR106A Gene

  1. miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. (PMID: 25531890) Imig J. … Hall J. (Nat. Chem. Biol. 2015) 67
  2. MicroRNA-106a confers cisplatin resistance in non-small cell lung cancer A549 cells by targeting adenosine triphosphatase-binding cassette A1. (PMID: 25339370) Ma Y. … Li Y. (Mol Med Rep 2015) 67
  3. Upregulated expression of miR-106a by DNA hypomethylation plays an oncogenic role in hepatocellular carcinoma. (PMID: 25510666) Yuan R. … Hu H. (Tumour Biol. 2015) 67
  4. Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2. (PMID: 24704830) Wang Z. … Bian X.W. (Oncogene 2015) 67
  5. MicroRNA expression patterns of tumors in early-onset colorectal cancer patients. (PMID: 24746948) Ak S. … Yerci O. (J. Surg. Res. 2014) 67

Products for MIR106A Gene

Sources for MIR106A Gene

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