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microRNA 106a
(Previous symbol: MIRN106A)
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Aliases
for MIR106A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 106a1 2 | | MIRN106A1 2 5 | | Hsa-Mir-106a1 | | Mir-1061 | | Mir-106a1 |
| External Ids: | HGNC: 314941 | Entrez Gene: 4068992 | Ensembl: ENSG000002076027 | OMIM: 3007925 |
Export aliases for MIR106A gene to outside databasesPrevious GC identifers: GC0XM133154 GC0XM133155 GC0XM133308 GC0XM133309 GC0XM133313 GC0XM133317 GC0XM133321 GC0XM133326 GC0XM133330 GC0XM133334
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Summaries
for MIR106A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for MIR106A:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR106A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR106A
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR106A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR106A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.2 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq26.2MIR106A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM133339: view genomic region (via miRBase)
(about GC identifiers)
Start:
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133,304,228 bp from pter |
End:
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133,304,308 bp from pter |
Size:
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81 bases |
Orientation:
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minus strand |
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Proteins
for MIR106A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR106A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR106A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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miRNA
Products: | | miRTarBase genes targeted by MIR106A:
RB1(MIRT001840), E2F1(MIRT000374), ARID4B(MIRT004028), MYLIP(MIRT001838), IL10(MIRT005082), HIPK3(MIRT001837), CDKN1A(MIRT001223), VEGFA(MIRT004465), RUNX1(MIRT003743), APP(MIRT001935) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR106A | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR106A | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
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Pathways & Interactions
for MIR106A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR106A
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Drugs & Compounds
for MIR106A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIR106A
Search CenterWatch for drugs/clinical trials and news about MIR106A 
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Transcripts
for MIR106A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000384870(miRNA)
GeneLoc Exon Structure
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Expression
for MIR106A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR106A:none
MIR106A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR106A
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR106A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR106A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR106A |
Orthologs
for MIR106A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for MIR106A (if available)
TreeFam Gene Tree for MIR106A (if available) |
Paralogs
for MIR106A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR106A gene
- MIR18B2 MIR20B2 MIR106B2 MIR18A2 MIR932 MIR172 MIR20A2
MIR106A for paralogs About GeneDecksing
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Genomic Variants
for MIR106A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MIR106A (133304228 - 133304308 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MIR106A: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR106A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR106A for disorders About GeneDecksing
OMIM gene information: 300792
OMIM disorders: --
5  diseases for MIR106A: About MalaCardsesophageal carcinoma esophagitis gastric cancer carcinoma
neuronitis
Export disorders for MIR106A gene to outside databases
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Publications
for MIR106A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIR106A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MIR106A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MiR-106a inhibits glioma cell growth by targeting E2F 1 independent of p53 status. (PubMed id 21656380)1 Yang G....Zhao S. (2011)
- MicroRNA cluster 302-367 enhances somatic cell reprog ramming by accelerating a mesenchymal-to-epithelial transition. (PubMed id 21454525)1 Liao B....Pei D. (2011)
- MiRNAs and their association with locoregional stagin g and survival following surgery for esophageal carcinoma. (PubMed id 20628822)1 Hummel R....Watson D.I. (2011)
- Induction of MiR-17-3p and MiR-106a [corrected] by TN FI+ and LPS. (PubMed id 21370248)1 Jiang X. and Li N. (2011)
- miR-17, miR-19b, miR-20a, and miR-106a are down-regul ated in human aging. (PubMed id 20089119)1 Hackl M....Grillari J. (2010)
- Detection of circulating tumor cells in peripheral bl ood from patients with gastric cancer using microRNA as a marker. (PubMed id 20349219)1 Zhou H....Xiao B.X. (2010)
- Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. (PubMed id 19307576)1 Sharma A....Ghosh B. (2009)
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (2007)
- miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (2006)
- Vertebrate microRNA genes. (PubMed id 12624257)1 Lim L.P....Bartel D.P. (2003)
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External Searches for MIR106A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR106A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MIR106A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR106A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIR106A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR106A gene:
Search GeneIP for patents involving MIR106A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR106A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR106A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR106A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR106A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR106A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR106A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR106A |
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| | | | Search Tocris compounds for MIR106A |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR106A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR106A |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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