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Aliases for MIR105-2 Gene

Subcategory (RNA class) for MIR105-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR105-2 Gene

  • MicroRNA 105-2 2 3
  • MIRN105-2 3 6
  • Hsa-Mir-105-2 3

External Ids for MIR105-2 Gene

Previous HGNC Symbols for MIR105-2 Gene

  • MIRN105-2

Previous GeneCards Identifiers for MIR105-2 Gene

  • GC0XM151314
  • GC0XM151562

Summaries for MIR105-2 Gene

Entrez Gene Summary for MIR105-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR105-2 Gene

MIR105-2 (MicroRNA 105-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR105-2 Gene

Genomics for MIR105-2 Gene

Genomic Location for MIR105-2 Gene

Start:
152,394,412 bp from pter
End:
152,394,492 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR105-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR105-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR105-2 Gene

No data available for Regulatory Elements for MIR105-2 Gene

Proteins for MIR105-2 Gene

Post-translational modifications for MIR105-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR105-2 Gene

Domains for MIR105-2 Gene

Gene Families for MIR105-2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR105-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR105-2 Gene

Function for MIR105-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR105-2 Gene

Localization for MIR105-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR105-2 Gene

Pathways for MIR105-2 Gene

SuperPathways for MIR105-2 Gene

No Data Available

Interacting Proteins for MIR105-2 Gene

Gene Ontology (GO) - Biological Process for MIR105-2 Gene

None

No data available for Pathways by source for MIR105-2 Gene

Transcripts for MIR105-2 Gene

mRNA/cDNA for MIR105-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR105-2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR105-2 Gene

No ASD Table

Relevant External Links for MIR105-2 Gene

GeneLoc Exon Structure for
MIR105-2
ECgene alternative splicing isoforms for
MIR105-2

Expression for MIR105-2 Gene

mRNA expression in normal human tissues for MIR105-2 Gene

genes like me logo Genes that share expressions with MIR105-2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR105-2 Gene

Orthologs for MIR105-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR105-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-105b 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-105b 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir105 36
  • 84 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-105 36
  • 100 (a)
OneToMany
ptr-mir-105 36
  • 100 (a)
OneToMany
Species with no ortholog for MIR105-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR105-2 Gene

ENSEMBL:
Gene Tree for MIR105-2 (if available)
TreeFam:
Gene Tree for MIR105-2 (if available)

Paralogs for MIR105-2 Gene

No data available for Paralogs for MIR105-2 Gene

Variants for MIR105-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR105-2 Gene

Variant ID Type Subtype PubMed ID
nsv516934 CNV Gain+Loss 19592680

Relevant External Links for MIR105-2 Gene

HapMap Linkage Disequilibrium report
MIR105-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR105-2 Gene

Disorders for MIR105-2 Gene

No disorders were found for MIR105-2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR105-2 Gene

Publications for MIR105-2 Gene

  1. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. (PMID: 11914277) Mourelatos Z. … Dreyfuss G. (Genes Dev. 2002) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. (PMID: 23950948) Honeywell D.R. … Addison C.L. (PLoS ONE 2013) 3
  5. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. (PMID: 24446170) Kamat V. … Diamond S.L. (Stem Cells 2014) 3

Products for MIR105-2 Gene

Sources for MIR105-2 Gene

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