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Aliases for MIR105-2 Gene

Subcategory (RNA class) for MIR105-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR105-2 Gene

  • MicroRNA 105-2 2 3 5
  • Hsa-Mir-105-2 3
  • Mir-105-2 3
  • MIRN105-2 3

External Ids for MIR105-2 Gene

Previous HGNC Symbols for MIR105-2 Gene

  • MIRN105-2

Previous GeneCards Identifiers for MIR105-2 Gene

  • GC0XM151314
  • GC0XM151562

Summaries for MIR105-2 Gene

Entrez Gene Summary for MIR105-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR105-2 Gene

MIR105-2 (MicroRNA 105-2) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR105-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR105-2 Gene

Genomics for MIR105-2 Gene

Genomic Location for MIR105-2 Gene

Chromosome:
X
Start:
152,394,412 bp from pter
End:
152,394,492 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR105-2 Gene

Genes around MIR105-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR105-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR105-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR105-2 Gene

No data available for Regulatory Elements for MIR105-2 Gene

Proteins for MIR105-2 Gene

Post-translational modifications for MIR105-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR105-2 Gene

Domains & Families for MIR105-2 Gene

Gene Families for MIR105-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR105-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR105-2 Gene

Function for MIR105-2 Gene

Gene Ontology (GO) - Molecular Function for MIR105-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23874542
genes like me logo Genes that share ontologies with MIR105-2: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR105-2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR105-2 Gene

Localization for MIR105-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR105-2 Gene

Pathways & Interactions for MIR105-2 Gene

SuperPathways for MIR105-2 Gene

No Data Available

Interacting Proteins for MIR105-2 Gene

Gene Ontology (GO) - Biological Process for MIR105-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23874542
genes like me logo Genes that share ontologies with MIR105-2: view

No data available for Pathways by source and SIGNOR curated interactions for MIR105-2 Gene

Drugs & Compounds for MIR105-2 Gene

No Compound Related Data Available

Transcripts for MIR105-2 Gene

mRNA/cDNA for MIR105-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR105-2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR105-2 Gene

No ASD Table

Relevant External Links for MIR105-2 Gene

GeneLoc Exon Structure for
MIR105-2
ECgene alternative splicing isoforms for
MIR105-2

Expression for MIR105-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR105-2 Gene

genes like me logo Genes that share expression patterns with MIR105-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR105-2 Gene

Orthologs for MIR105-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR105-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-105 34 34
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia bta-mir-105b 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-105b 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir105 34
  • 84 (a)
OneToMany
Species where no ortholog for MIR105-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR105-2 Gene

ENSEMBL:
Gene Tree for MIR105-2 (if available)
TreeFam:
Gene Tree for MIR105-2 (if available)

Paralogs for MIR105-2 Gene

No data available for Paralogs for MIR105-2 Gene

Variants for MIR105-2 Gene

Sequence variations from dbSNP and Humsavar for MIR105-2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1001620423 -- 152,394,180(+) ATGAA(A/G)ATACG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001627316 -- 152,394,685(+) AAATA(C/T)GTAGT intron-variant, upstream-variant-2KB
rs1003073590 -- 152,395,901(+) CCTCG(C/G)ATGAA intron-variant, upstream-variant-2KB
rs1003239537 -- 152,394,842(+) AAATA(C/T)GGGTA intron-variant, upstream-variant-2KB
rs1008413820 -- 152,395,576(+) GACAC(C/T)TCATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR105-2 Gene

Variant ID Type Subtype PubMed ID
nsv1148948 CNV duplication 26484159
nsv516934 CNV gain+loss 19592680

Relevant External Links for MIR105-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR105-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR105-2 Gene

Disorders for MIR105-2 Gene

Relevant External Links for MIR105-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR105-2

No disorders were found for MIR105-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR105-2 Gene

Publications for MIR105-2 Gene

  1. Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production. (PMID: 27185878) Wu C … Newton-Cheh C (Molecular and cellular biology 2016) 3 60
  2. A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. (PMID: 25089631) Loriot A … De Smet C (Epigenetics 2014) 3 60
  3. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. (PMID: 24446170) Kamat V … Diamond SL (Stem cells (Dayton, Ohio) 2014) 3 60
  4. miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. (PMID: 23950948) Honeywell DR … Addison CL (PloS one 2013) 3 60
  5. Large-scale screens of miRNA-mRNA interactions unveiled that the 3'UTR of a gene is targeted by multiple miRNAs. (PMID: 23874542) Zhou P … Jiang S (PloS one 2013) 3 60

Products for MIR105-2 Gene

Sources for MIR105-2 Gene

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