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Aliases for MIR105-1 Gene

Subcategory (RNA class) for MIR105-1 Gene


Quality Score for this RNA gene is


Aliases for MIR105-1 Gene

  • MicroRNA 105-1 2 3 5
  • Hsa-Mir-105-1 3
  • Mir-105-1 3
  • MIRN105-1 3

External Ids for MIR105-1 Gene

Previous HGNC Symbols for MIR105-1 Gene

  • MIRN105-1

Previous GeneCards Identifiers for MIR105-1 Gene

  • GC0XM151311
  • GC0XM151560

Summaries for MIR105-1 Gene

Entrez Gene Summary for MIR105-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR105-1 Gene

MIR105-1 (MicroRNA 105-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Toll-like receptor signaling pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR105-1 Gene

Genomics for MIR105-1 Gene

Genomic Location for MIR105-1 Gene

152,392,219 bp from pter
152,392,299 bp from pter
81 bases
Minus strand

Genomic View for MIR105-1 Gene

Genes around MIR105-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR105-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR105-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR105-1 Gene

No data available for Regulatory Elements for MIR105-1 Gene

Proteins for MIR105-1 Gene

Post-translational modifications for MIR105-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR105-1 Gene

Domains & Families for MIR105-1 Gene

Gene Families for MIR105-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR105-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR105-1 Gene

Function for MIR105-1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR105-1 Gene

Localization for MIR105-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR105-1 Gene

Pathways & Interactions for MIR105-1 Gene

genes like me logo Genes that share pathways with MIR105-1: view

Pathways by source for MIR105-1 Gene

1 BioSystems pathway for MIR105-1 Gene

Interacting Proteins for MIR105-1 Gene

Gene Ontology (GO) - Biological Process for MIR105-1 Gene


No data available for SIGNOR curated interactions for MIR105-1 Gene

Transcripts for MIR105-1 Gene

mRNA/cDNA for MIR105-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR105-1 Gene

No ASD Table

Relevant External Links for MIR105-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR105-1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR105-1 Gene

Orthologs for MIR105-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR105-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-105a 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-105a 35
  • 99 (a)
(Mus musculus)
Mammalia Mir105 35
  • 81 (a)
Species where no ortholog for MIR105-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR105-1 Gene

Gene Tree for MIR105-1 (if available)
Gene Tree for MIR105-1 (if available)

Paralogs for MIR105-1 Gene

No data available for Paralogs for MIR105-1 Gene

Variants for MIR105-1 Gene

Sequence variations from dbSNP and Humsavar for MIR105-1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs113259906 -- 152,392,541(+) TAGCC(A/G)GGGCT intron-variant, upstream-variant-2KB
rs113476249 -- 152,393,062(+) ATAAA(C/G)TAAAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs115727861 -- 152,393,591(+) GACAT(A/G)TGAAT intron-variant, upstream-variant-2KB
rs137915193 -- 152,393,906(+) ACTTA(C/T)ATAAT intron-variant, upstream-variant-2KB
rs140069654 -- 152,392,908(+) AGCCA(C/T)GGTAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR105-1 Gene

Variant ID Type Subtype PubMed ID
nsv1148948 CNV duplication 26484159
nsv516934 CNV gain+loss 19592680

Relevant External Links for MIR105-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR105-1 Gene

Disorders for MIR105-1 Gene

Relevant External Links for MIR105-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR105-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR105-1 Gene

Publications for MIR105-1 Gene

  1. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. (PMID: 24446170) Kamat V. … Diamond S.L. (Stem Cells 2014) 3 64
  2. MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma. (PMID: 25280563) Shen G. … Jia H. (Carcinogenesis 2014) 3 64
  3. miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. (PMID: 23950948) Honeywell D.R. … Addison C.L. (PLoS ONE 2013) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR105-1 Gene

Sources for MIR105-1 Gene

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